LOCUS       NM_001109421            1204 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Epstein-Barr virus induced 3 (Ebi3), mRNA.
ACCESSION   NM_001109421 XM_001057970
VERSION     NM_001109421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Shu,C., Yan,D., Chen,C., Mo,Y., Wu,L., Gu,J., Shah,N.K., He,J. and
            Dong,S.
  TITLE     Metformin exhibits its therapeutic effect in the treatment of
            pre-eclampsia via modulating the Met/H19/miR-148a-5p/P28 and
            Met/H19/miR-216-3p/EBI3 signaling pathways
  JOURNAL   Int Immunopharmacol 74, 105693 (2019)
   PUBMED   31203154
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Houshmandi,N., Najafipour,H., Joukar,S., Dabiri,S., Abbasloo,E.,
            Abdi,E. and Safi,Z.
  TITLE     The effect of interleukins 27 and 35 and their role on mediating
            the action of insulin Like Growth Factor -1 on the inflammation and
            blood flow of chronically inflamed rat knee joint
  JOURNAL   Cytokine 81, 117-126 (2016)
   PUBMED   26994309
  REMARK    GeneRIF: Data show that endogenous interleukins IL-27 and IL-35
            (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin
            like growth factor -1 (IGF-1) had no effect.
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Dokmeci,E., Xu,L., Robinson,E., Golubets,K., Bottomly,K. and
            Herrick,C.A.
  TITLE     EBI3 deficiency leads to diminished T helper type 1 and increased T
            helper type 2 mediated airway inflammation
  JOURNAL   Immunology 132 (4), 559-566 (2011)
   PUBMED   21255010
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Pflanz,S., Timans,J.C., Cheung,J., Rosales,R., Kanzler,H.,
            Gilbert,J., Hibbert,L., Churakova,T., Travis,M., Vaisberg,E.,
            Blumenschein,W.M., Mattson,J.D., Wagner,J.L., To,W., Zurawski,S.,
            McClanahan,T.K., Gorman,D.M., Bazan,J.F., de Waal Malefyt,R.,
            Rennick,D. and Kastelein,R.A.
  TITLE     IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein,
            induces proliferation of naive CD4+ T cells
  JOURNAL   Immunity 16 (6), 779-790 (2002)
   PUBMED   12121660
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Devergne,O., Birkenbach,M. and Kieff,E.
  TITLE     Epstein-Barr virus-induced gene 3 and the p35 subunit of
            interleukin 12 form a novel heterodimeric hematopoietin
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 12041-12046 (1997)
   PUBMED   9342359
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001109421.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2818440.1,
                                           SRR26360186.743588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               JAXUCZ010000009.1  870762-871095
            335-464             JAXUCZ010000009.1  871723-871852
            465-643             JAXUCZ010000009.1  872135-872313
            644-798             JAXUCZ010000009.1  873812-873966
            799-1204            JAXUCZ010000009.1  874326-874731
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1204
                     /gene="Ebi3"
                     /note="Epstein-Barr virus induced 3"
                     /db_xref="GeneID:680609"
                     /db_xref="RGD:1589467"
     exon            1..334
                     /gene="Ebi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..954
                     /gene="Ebi3"
                     /note="Epstein-Barr virus induced gene 3 (similar to
                     Interleukin-27 beta chain precursor); interleukin-27
                     subunit beta"
                     /codon_start=1
                     /product="interleukin-27 subunit beta precursor"
                     /protein_id="NP_001102891.1"
                     /db_xref="GeneID:680609"
                     /db_xref="RGD:1589467"
                     /translation="MSKLLLLSLALWASCSPGNTGTALVDLSQPRVRCHASRYPVAVD
                     CSWMPLQAPNSTRAMSFIATYRLGVAAQQQSQPCLQRTPQASRCTIPHVHLFSTVPYL
                     LNVTVVHPGGANSSLLAFVAERIIKPDPPEGVRLRKAGQRLQVLWHPPASWPFPDIFS
                     LKYRLRYRRRGASHFRQVGPIEATTFTLRNTQPHAKYCIQVSAQDLTDYGKPSDWSLP
                     GQVERAPQKP"
     exon            335..464
                     /gene="Ebi3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..643
                     /gene="Ebi3"
                     /inference="alignment:Splign:2.1.0"
     exon            644..798
                     /gene="Ebi3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1204
                     /gene="Ebi3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctccccc tacctcaggc ctttacacat acacacacac acacacacac acacacatac
       61 acacacacac tcacacacac acacacacac acacagcagc tggtgacaga ctcagggttc
      121 ccgtcactat caccatcttc tgccccatac cctgggcaac tgagtcacac tgggcaggtc
      181 cttacgtagg gccaggtttc ctgtgggagt ccctggtcct tcaccccttc tctgatgggt
      241 cactaactcg gatccaaaga acagagtatg tccaagctgc tcctcctgtc acttgctctc
      301 tgggccagct gctcccctgg taacactggg acagcgctag tggatctgag ccagcccaga
      361 gtgcgatgcc atgcttctcg gtaccctgtg gctgtggact gctcctggat gccactccag
      421 gctcccaact ccaccagagc catgtccttc attgccactt acaggctcgg tgtggccgcc
      481 cagcagcaga gccagccctg cctgcaacgg accccccagg catcccgttg caccatcccc
      541 cacgtgcacc tgttttccac agtgccctac ttgctaaatg tcactgtagt gcaccctggc
      601 ggcgccaaca gcagccttct agcctttgtg gcggaacgaa tcatcaagcc cgaccctccg
      661 gaaggcgtgc gcctgcgcaa agcgggacag cgcctgcagg ttctctggca tccccctgct
      721 tcctggccct tcccggacat cttctctctc aagtaccgac ttcgctaccg gcgccgagga
      781 gcctctcact tccgccaggt gggacctatt gaagccacga ctttcaccct caggaacaca
      841 caaccccatg ccaagtattg catccaggtg tcagcccagg acctcaccga ttatgggaaa
      901 ccaagtgact ggagcctccc tgggcaagta gagagggcgc cccagaagcc ctgaagaggg
      961 actgcatcct tgatatcaga ccgtgatgtt gactacttga gggtggctga gtggcctgtc
     1021 ctgagttcga attctgactt cgcatgtact gtgctgctcc gaagcattgg ataattcact
     1081 tgacctctcc agaccttaat ttccaaaact gtagggatct tctttctcct tccatcagtg
     1141 cgggactttg tgaactttaa atgtgattta tttcgaaaac ctaattaaat aagaataatt
     1201 ctca
//
