LOCUS       NM_001415982            4671 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus EBF transcription factor 3 (Ebf3), transcript
            variant 2, mRNA.
ACCESSION   NM_001415982 XM_006230465
VERSION     NM_001415982.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4671)
  AUTHORS   Harms,F.L., Girisha,K.M., Hardigan,A.A., Kortum,F., Shukla,A.,
            Alawi,M., Dalal,A., Brady,L., Tarnopolsky,M., Bird,L.M.,
            Ceulemans,S., Bebin,M., Bowling,K.M., Hiatt,S.M., Lose,E.J.,
            Primiano,M., Chung,W.K., Juusola,J., Akdemir,Z.C., Bainbridge,M.,
            Charng,W.L., Drummond-Borg,M., Eldomery,M.K., El-Hattab,A.W.,
            Saleh,M.A.M., Bezieau,S., Cogne,B., Isidor,B., Kury,S.,
            Lupski,J.R., Myers,R.M., Cooper,G.M. and Kutsche,K.
  TITLE     Mutations in EBF3 Disturb Transcriptional Profiles and Cause
            Intellectual Disability, Ataxia, and Facial Dysmorphism
  JOURNAL   Am J Hum Genet 100 (1), 117-127 (2017)
   PUBMED   28017373
REFERENCE   2  (bases 1 to 4671)
  AUTHORS   Chao,H.T., Davids,M., Burke,E., Pappas,J.G., Rosenfeld,J.A.,
            McCarty,A.J., Davis,T., Wolfe,L., Toro,C., Tifft,C., Xia,F.,
            Stong,N., Johnson,T.K., Warr,C.G., Yamamoto,S., Adams,D.R.,
            Markello,T.C., Gahl,W.A., Bellen,H.J., Wangler,M.F. and
            Malicdan,M.C.V.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants
            in EBF3
  JOURNAL   Am J Hum Genet 100 (1), 128-137 (2017)
   PUBMED   28017372
REFERENCE   3  (bases 1 to 4671)
  AUTHORS   Sleven,H., Welsh,S.J., Yu,J., Churchill,M.E.A., Wright,C.F.,
            Henderson,A., Horvath,R., Rankin,J., Vogt,J., Magee,A.,
            McConnell,V., Green,A., King,M.D., Cox,H., Armstrong,L., Lehman,A.,
            Nelson,T.N., Williams,J., Clouston,P., Hagman,J. and Nemeth,A.H.
  CONSRTM   Deciphering Developmental Disorders study; CAUSES study
  TITLE     De Novo Mutations in EBF3 Cause a Neurodevelopmental Syndrome
  JOURNAL   Am J Hum Genet 100 (1), 138-150 (2017)
   PUBMED   28017370
REFERENCE   4  (bases 1 to 4671)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2023 this sequence version replaced XM_006230465.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               JAXUCZ010000001.1  201543804-201544305 c
            503-659             JAXUCZ010000001.1  201543542-201543698 c
            660-723             JAXUCZ010000001.1  201543123-201543186 c
            724-779             JAXUCZ010000001.1  201542380-201542435 c
            780-853             JAXUCZ010000001.1  201539375-201539448 c
            854-922             JAXUCZ010000001.1  201537646-201537714 c
            923-1004            JAXUCZ010000001.1  201467195-201467276 c
            1005-1122           JAXUCZ010000001.1  201463509-201463626 c
            1123-1253           JAXUCZ010000001.1  201458000-201458130 c
            1254-1380           JAXUCZ010000001.1  201457382-201457508 c
            1381-1469           JAXUCZ010000001.1  201438948-201439036 c
            1470-1535           JAXUCZ010000001.1  201433783-201433848 c
            1536-1713           JAXUCZ010000001.1  201433040-201433217 c
            1714-1902           JAXUCZ010000001.1  201431803-201431991 c
            1903-1992           JAXUCZ010000001.1  201431199-201431288 c
            1993-4671           JAXUCZ010000001.1  201426446-201429124 c
FEATURES             Location/Qualifiers
     source          1..4671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4671
                     /gene="Ebf3"
                     /note="EBF transcription factor 3"
                     /db_xref="GeneID:361668"
                     /db_xref="RGD:1304956"
     exon            1..502
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..2024
                     /gene="Ebf3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor COE3; early B-cell factor 3"
                     /codon_start=1
                     /product="transcription factor COE3 isoform 2"
                     /protein_id="NP_001402911.1"
                     /db_xref="GeneID:361668"
                     /db_xref="RGD:1304956"
                     /translation="MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNE
                     KTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIG
                     DNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRF
                     VYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEII
                     LKRAADIAEALYSVPRNHNQIPTLGNTPAHTGMMGVNSFSSQLAVNVSETSQANDQVG
                     YSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGSGAMANLGVPGSPGFLNGSSANS
                     PYGMKQKSAFAPVVRPQASPPPSCTSANGNGLQAMSGLVVPPM"
     exon            503..659
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..723
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..779
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..853
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..922
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1004
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1122
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1253
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1380
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1469
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1535
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1713
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1902
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1992
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..4671
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcgggc gatcccgcag tgtcctgcag ccgcggacgc cgcctggcta ggatgacacc
       61 acgttgagcg cgcctgcaaa caacaacaac aacaagcgcc gccgcggcca ccgcgtccac
      121 cgcgccctgc tcctccgaag cgccgcgccg ccgccggtgc agtccgcccg cgtccccggc
      181 cgtccgcagc gcccggccgc cggtgtatgc cgcgcctgcc cgggacgggc tgaagccggc
      241 ggcgggccgc accgcaggcg ccgagcaggg ccagggcggc cagggcagcc tcctgccgcc
      301 gagccccgag cgccgccgac cgcggacgcg ctttcggctg ggagtcgcgg ccgctgccag
      361 cagtgttcat gtttgggatt caggagaata ttccgcgcgg ggggacgacc atgaaggagg
      421 agccgctggg cagcggcatg aacccggtgc gctcgtggat gcacacggca ggcgtggtgg
      481 acgccaacac ggccgcccag agcggcgtgg ggctggcgcg ggcgcacttc gagaagcagc
      541 ctccttccaa cctccggaaa tccaatttct tccacttcgt gctggcgctc tacgacaggc
      601 aggggcagcc ggtggagatc gaaaggaccg cttttgtgga ctttgtggag aaagagaaag
      661 agccgaataa cgagaaaacc aacaacggca ttcactacaa gctgcagcta ctgtacagca
      721 atggcgtcag gacagagcaa gatctgtatg tccgcctcat agattcaatg accaaacagg
      781 ccatcgtgta tgaaggccag gacaaaaatc cggagatgtg ccgcgtgctg ctgacccatg
      841 agatcatgtg cagccggtgc tgtgacaaga agagttgtgg caataggaac gaaacaccct
      901 cagaccctgt aatcattgac agattctttc taaagttctt cctcaagtgc aatcagaact
      961 gcttgaagaa tgcgggcaac cctcgggaca tgcggaggtt ccaggtcgtt gtatcgacaa
     1021 ccgtcaacgt ggacggccac gtgctggccg tgtctgacaa catgtttgtg cacaacaatt
     1081 ccaaacacgg gaggcgggcc cgccgcctag acccgtcaga agccactcca tgcatcaagg
     1141 ccatcagccc cagtgaaggc tggaccacgg ggggcgccac tgtgatcata atcggggaca
     1201 acttctttga cggtctccaa gttgtgttcg gaactatgtt ggtgtggagt gagctgataa
     1261 ccccccacgc catccgagtg cagacgccgc cgcgacacat ccctggagtt gttgaagtga
     1321 ccctctccta caagtctaag cagttctgca aaggcgctcc tggacgcttt gtctacactg
     1381 cccttaatga gccaaccata gattacggct tccagaggtt gcagaaagtg atacccagac
     1441 atccaggtga ccccgaaagg ttacccaagg aagtgttact gaagagggcg gcagaccttg
     1501 tggaagcctt gtatgggatg cctcataaca accaggagat catcctgaag agagcagccg
     1561 acattgctga ggcactgtac agcgttcccc gcaatcacaa ccagatcccc accttgggca
     1621 acactccagc acacactggc atgatgggtg tgaactcctt cagcagccag ctagccgtta
     1681 atgtgtcaga gacctcacaa gccaatgacc aagtcggcta cagtcgcaat acaagcagcg
     1741 tgtccccgcg aggctacgtc cccagcagta ctccccagca gtccaattac aacacagtca
     1801 gcactagcat gaatggatat ggaagtggcg ccatggccaa tctaggggtc cctggctcgc
     1861 ctggatttct taatggctcc tccgctaact ctccctacgg catgaaacag aagagcgctt
     1921 tcgcgcccgt ggtccggccc caagcctcgc ctcctccttc ctgcaccagc gccaatggga
     1981 acggacttca agctatgtct gggctggtag tcccgcccat gtgagggact ctgtttacct
     2041 tcacagcacc cagcatccaa ggacggactt caggggacac gtgtagtgtg ctaagacgtg
     2101 ctgatggaaa tgctatctcc aaaactaaaa atcagcaacg gttgaatgct acaaaagaca
     2161 tttaaagatt ttatttaaac tgttaagaat caacacgcga acaagcctac tccttcatga
     2221 acaattccat tttattgact gaacttttct cacatcttca catttctcag tcctgaagat
     2281 taaggaaaac aaagcgatgc ctattttgta taaagtttct gattccgtct tggctgtcta
     2341 gtgcgtgcta tctgtgtggg gagaagcttc gtgaatatgc accgttttga tgcccatgca
     2401 acactgagga agaaagcctc gaaacatttt tctgtactca tatttagatt cacaatggtt
     2461 gtgtatctct ataatgtgaa atattttttt gtggtgaaaa aaagggggcc aaggaggtat
     2521 gagccattaa ctggaacaga ggaggattat gactaggtga atttggggtg gcagggaggg
     2581 agggagggtt tatcattgct taacttcatc ttaatgaaat gaaactttgt aacttattgt
     2641 agttagaaat tgtaactttg atatcgaatc tcttgccttc aacaagcaca ctgacagaga
     2701 aaaagattat gctactgtct gttggttcca atattctccc acctagagct tcctgttaaa
     2761 gcaagtgcgg tcagcaacat tttttcaact ttcacgcact gtaaacctat tgcattctta
     2821 ggctactgtg aggtctatgt ttcttgtacc tgaaattgtc cttttgactt ctagaccctt
     2881 cttccccgat gtgttttgta tgtggttata aaattgtaga cttttgtgat tttgccaaag
     2941 ttgtagctaa atatttatac acttgtcttg aatttttttc agatccactt aaaatattta
     3001 gaaaaatgag ttttattcct tatgtgtctt ataggggata aaatgctctc tcacgtgacg
     3061 cttcctttcc catgaacact tgcagttgct aagggacttt attttgtaac atatcaatta
     3121 taaatattgt atttatcttt gaaattttgt acattgcttt ccctgccttc tttttttcac
     3181 gtctgtattg gtgtttgatc tgcccagtgt tgaagcatag ggaacgagca gacaccaaga
     3241 gcttgtctct ttaatccgtt ttgttgaagt gaaccaatgt ccttacattt catttgtacc
     3301 taaaccattt gctatcgttt agactttcca tcccccaccc ctttttttat gttgaggaaa
     3361 agtcaaattc attgtttatt tttatattat ttttaagtta tctgaacaaa tacttttgaa
     3421 aagaaaagtt tgttgtatag tcaaaagaaa acggtgtcag ccggccgtga caaattctag
     3481 taggttctgt gcatgtggag cggccgtgaa ggggccacac cgtccaggct gtgttcttat
     3541 tttattttta atttttaatt tttttcgtag aatgtaaaaa aaaagtcatt ttagctgcca
     3601 cctatgactt tgccacatag ctgaactgtg tttactggaa aaattcagag gcctaaagtt
     3661 taaaataaaa tttacttccg acgttttaat tacaaatgtt tgccacatta acttctctga
     3721 tgccttaaaa gtggacttct ttgaagaact tctgtgctat tttatcacag gctcacacca
     3781 caattgttaa tatctggaga tgggtgatga acacacacac acacacacac acacacacac
     3841 acacacacac acacacacac aggccaaaag cacaaacctc cagtctgcca gtcacttctt
     3901 cctgggtctg cctgctgctt tctgctctct ttagctcacc ttggagttag agaggcattg
     3961 ggggacactg ctggttagtt catttttatt ttaaacagga cctttttgtg gtcagatcca
     4021 acagcactgt ctgtacattt ttaactggaa agacctcctt cagacactcc gcctcttagt
     4081 gccaaaccca ccgtgagacc aagaaacagg actctttttt ttcccttcac actcattgct
     4141 ctcacagaca gcgcaggcct tgcaaacagc agcagaagtc acatttaaaa caaaaaggag
     4201 gggacttaca aaacttagac aaacaccttc acgaaggaat gacatagagc ttagcaagtg
     4261 ttcattcgag ggactcaata cgagtaacag aacgtcccca agggtcagtg ggccacactc
     4321 tggctttgtg gctgctgaca gggcttagct acatgaacag cctgagaagt cactttggaa
     4381 ctaaattgcc tcgatttatt ttgtgtaagg aagggtttga cctaaaaaga gctcatgtgc
     4441 acattagtcc gcatcctcat gtccgcaccc ggtttgtgtt ttagatcaac tagtcaacgc
     4501 cctcattgct tcattgtgtc aaaaaccgag agcttcacta aatggtagat tttgctgtca
     4561 gagaccctac aataagattg ttttatctgt acattttttc agatatttaa ctgtataaaa
     4621 tgttcatttt acacaatatt taattaaagt atttcttgtc tgtgaatttc a
//
