LOCUS       NM_001108506            4802 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus EBF transcription factor 3 (Ebf3), transcript
            variant 1, mRNA.
ACCESSION   NM_001108506 XM_001056705 XM_341951
VERSION     NM_001108506.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4802)
  AUTHORS   Harms,F.L., Girisha,K.M., Hardigan,A.A., Kortum,F., Shukla,A.,
            Alawi,M., Dalal,A., Brady,L., Tarnopolsky,M., Bird,L.M.,
            Ceulemans,S., Bebin,M., Bowling,K.M., Hiatt,S.M., Lose,E.J.,
            Primiano,M., Chung,W.K., Juusola,J., Akdemir,Z.C., Bainbridge,M.,
            Charng,W.L., Drummond-Borg,M., Eldomery,M.K., El-Hattab,A.W.,
            Saleh,M.A.M., Bezieau,S., Cogne,B., Isidor,B., Kury,S.,
            Lupski,J.R., Myers,R.M., Cooper,G.M. and Kutsche,K.
  TITLE     Mutations in EBF3 Disturb Transcriptional Profiles and Cause
            Intellectual Disability, Ataxia, and Facial Dysmorphism
  JOURNAL   Am J Hum Genet 100 (1), 117-127 (2017)
   PUBMED   28017373
REFERENCE   2  (bases 1 to 4802)
  AUTHORS   Chao,H.T., Davids,M., Burke,E., Pappas,J.G., Rosenfeld,J.A.,
            McCarty,A.J., Davis,T., Wolfe,L., Toro,C., Tifft,C., Xia,F.,
            Stong,N., Johnson,T.K., Warr,C.G., Yamamoto,S., Adams,D.R.,
            Markello,T.C., Gahl,W.A., Bellen,H.J., Wangler,M.F. and
            Malicdan,M.C.V.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants
            in EBF3
  JOURNAL   Am J Hum Genet 100 (1), 128-137 (2017)
   PUBMED   28017372
REFERENCE   3  (bases 1 to 4802)
  AUTHORS   Sleven,H., Welsh,S.J., Yu,J., Churchill,M.E.A., Wright,C.F.,
            Henderson,A., Horvath,R., Rankin,J., Vogt,J., Magee,A.,
            McConnell,V., Green,A., King,M.D., Cox,H., Armstrong,L., Lehman,A.,
            Nelson,T.N., Williams,J., Clouston,P., Hagman,J. and Nemeth,A.H.
  CONSRTM   Deciphering Developmental Disorders study; CAUSES study
  TITLE     De Novo Mutations in EBF3 Cause a Neurodevelopmental Syndrome
  JOURNAL   Am J Hum Genet 100 (1), 138-150 (2017)
   PUBMED   28017370
REFERENCE   4  (bases 1 to 4802)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2023 this sequence version replaced NM_001108506.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               JAXUCZ010000001.1  201543804-201544305 c
            503-659             JAXUCZ010000001.1  201543542-201543698 c
            660-723             JAXUCZ010000001.1  201543123-201543186 c
            724-779             JAXUCZ010000001.1  201542380-201542435 c
            780-853             JAXUCZ010000001.1  201539375-201539448 c
            854-922             JAXUCZ010000001.1  201537646-201537714 c
            923-1004            JAXUCZ010000001.1  201467195-201467276 c
            1005-1149           JAXUCZ010000001.1  201463482-201463626 c
            1150-1280           JAXUCZ010000001.1  201458000-201458130 c
            1281-1407           JAXUCZ010000001.1  201457382-201457508 c
            1408-1496           JAXUCZ010000001.1  201438948-201439036 c
            1497-1562           JAXUCZ010000001.1  201433783-201433848 c
            1563-1740           JAXUCZ010000001.1  201433040-201433217 c
            1741-1929           JAXUCZ010000001.1  201431803-201431991 c
            1930-2127           JAXUCZ010000001.1  201431199-201431396 c
            2128-4802           JAXUCZ010000001.1  201426450-201429124 c
FEATURES             Location/Qualifiers
     source          1..4802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4802
                     /gene="Ebf3"
                     /note="EBF transcription factor 3"
                     /db_xref="GeneID:361668"
                     /db_xref="RGD:1304956"
     exon            1..502
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..2159
                     /gene="Ebf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor COE3; early B-cell factor 3"
                     /codon_start=1
                     /product="transcription factor COE3 isoform 1"
                     /protein_id="NP_001101976.1"
                     /db_xref="GeneID:361668"
                     /db_xref="RGD:1304956"
                     /translation="MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNE
                     KTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTT
                     GGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQ
                     FCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYG
                     MPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNTPAHTGMMGVNSFSSQLAVNVSE
                     TSQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGSGAMANLGVPGSPG
                     FLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPV
                     VRPQASPPPSCTSANGNGLQAMSGLVVPPM"
     exon            503..659
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..723
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..779
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..853
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..922
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1004
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1149
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1280
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1407
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1496
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1562
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1740
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1929
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2127
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..4802
                     /gene="Ebf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcgggc gatcccgcag tgtcctgcag ccgcggacgc cgcctggcta ggatgacacc
       61 acgttgagcg cgcctgcaaa caacaacaac aacaagcgcc gccgcggcca ccgcgtccac
      121 cgcgccctgc tcctccgaag cgccgcgccg ccgccggtgc agtccgcccg cgtccccggc
      181 cgtccgcagc gcccggccgc cggtgtatgc cgcgcctgcc cgggacgggc tgaagccggc
      241 ggcgggccgc accgcaggcg ccgagcaggg ccagggcggc cagggcagcc tcctgccgcc
      301 gagccccgag cgccgccgac cgcggacgcg ctttcggctg ggagtcgcgg ccgctgccag
      361 cagtgttcat gtttgggatt caggagaata ttccgcgcgg ggggacgacc atgaaggagg
      421 agccgctggg cagcggcatg aacccggtgc gctcgtggat gcacacggca ggcgtggtgg
      481 acgccaacac ggccgcccag agcggcgtgg ggctggcgcg ggcgcacttc gagaagcagc
      541 ctccttccaa cctccggaaa tccaatttct tccacttcgt gctggcgctc tacgacaggc
      601 aggggcagcc ggtggagatc gaaaggaccg cttttgtgga ctttgtggag aaagagaaag
      661 agccgaataa cgagaaaacc aacaacggca ttcactacaa gctgcagcta ctgtacagca
      721 atggcgtcag gacagagcaa gatctgtatg tccgcctcat agattcaatg accaaacagg
      781 ccatcgtgta tgaaggccag gacaaaaatc cggagatgtg ccgcgtgctg ctgacccatg
      841 agatcatgtg cagccggtgc tgtgacaaga agagttgtgg caataggaac gaaacaccct
      901 cagaccctgt aatcattgac agattctttc taaagttctt cctcaagtgc aatcagaact
      961 gcttgaagaa tgcgggcaac cctcgggaca tgcggaggtt ccaggtcgtt gtatcgacaa
     1021 ccgtcaacgt ggacggccac gtgctggccg tgtctgacaa catgtttgtg cacaacaatt
     1081 ccaaacacgg gaggcgggcc cgccgcctag acccgtcaga aggtacggcc ccttcttatc
     1141 tggaaaatgc cactccatgc atcaaggcca tcagccccag tgaaggctgg accacggggg
     1201 gcgccactgt gatcataatc ggggacaact tctttgacgg tctccaagtt gtgttcggaa
     1261 ctatgttggt gtggagtgag ctgataaccc cccacgccat ccgagtgcag acgccgccgc
     1321 gacacatccc tggagttgtt gaagtgaccc tctcctacaa gtctaagcag ttctgcaaag
     1381 gcgctcctgg acgctttgtc tacactgccc ttaatgagcc aaccatagat tacggcttcc
     1441 agaggttgca gaaagtgata cccagacatc caggtgaccc cgaaaggtta cccaaggaag
     1501 tgttactgaa gagggcggca gaccttgtgg aagccttgta tgggatgcct cataacaacc
     1561 aggagatcat cctgaagaga gcagccgaca ttgctgaggc actgtacagc gttccccgca
     1621 atcacaacca gatccccacc ttgggcaaca ctccagcaca cactggcatg atgggtgtga
     1681 actccttcag cagccagcta gccgttaatg tgtcagagac ctcacaagcc aatgaccaag
     1741 tcggctacag tcgcaataca agcagcgtgt ccccgcgagg ctacgtcccc agcagtactc
     1801 cccagcagtc caattacaac acagtcagca ctagcatgaa tggatatgga agtggcgcca
     1861 tggccaatct aggggtccct ggctcgcctg gatttcttaa tggctcctcc gctaactctc
     1921 cctacggcat agtgccgtcc agccccacca tggcagcctc ttcggtcacc ctcccttcaa
     1981 actgtagcag cacacacggc attttctcat tctcacctgc caatgtcatc tccgcagtga
     2041 aacagaagag cgctttcgcg cccgtggtcc ggccccaagc ctcgcctcct ccttcctgca
     2101 ccagcgccaa tgggaacgga cttcaagcta tgtctgggct ggtagtcccg cccatgtgag
     2161 ggactctgtt taccttcaca gcacccagca tccaaggacg gacttcaggg gacacgtgta
     2221 gtgtgctaag acgtgctgat ggaaatgcta tctccaaaac taaaaatcag caacggttga
     2281 atgctacaaa agacatttaa agattttatt taaactgtta agaatcaaca cgcgaacaag
     2341 cctactcctt catgaacaat tccattttat tgactgaact tttctcacat cttcacattt
     2401 ctcagtcctg aagattaagg aaaacaaagc gatgcctatt ttgtataaag tttctgattc
     2461 cgtcttggct gtctagtgcg tgctatctgt gtggggagaa gcttcgtgaa tatgcaccgt
     2521 tttgatgccc atgcaacact gaggaagaaa gcctcgaaac atttttctgt actcatattt
     2581 agattcacaa tggttgtgta tctctataat gtgaaatatt tttttgtggt gaaaaaaagg
     2641 gggccaagga ggtatgagcc attaactgga acagaggagg attatgacta ggtgaatttg
     2701 gggtggcagg gagggaggga gggtttatca ttgcttaact tcatcttaat gaaatgaaac
     2761 tttgtaactt attgtagtta gaaattgtaa ctttgatatc gaatctcttg ccttcaacaa
     2821 gcacactgac agagaaaaag attatgctac tgtctgttgg ttccaatatt ctcccaccta
     2881 gagcttcctg ttaaagcaag tgcggtcagc aacatttttt caactttcac gcactgtaaa
     2941 cctattgcat tcttaggcta ctgtgaggtc tatgtttctt gtacctgaaa ttgtcctttt
     3001 gacttctaga cccttcttcc ccgatgtgtt ttgtatgtgg ttataaaatt gtagactttt
     3061 gtgattttgc caaagttgta gctaaatatt tatacacttg tcttgaattt ttttcagatc
     3121 cacttaaaat atttagaaaa atgagtttta ttccttatgt gtcttatagg ggataaaatg
     3181 ctctctcacg tgacgcttcc tttcccatga acacttgcag ttgctaaggg actttatttt
     3241 gtaacatatc aattataaat attgtattta tctttgaaat tttgtacatt gctttccctg
     3301 ccttcttttt ttcacgtctg tattggtgtt tgatctgccc agtgttgaag catagggaac
     3361 gagcagacac caagagcttg tctctttaat ccgttttgtt gaagtgaacc aatgtcctta
     3421 catttcattt gtacctaaac catttgctat cgtttagact ttccatcccc cacccctttt
     3481 tttatgttga ggaaaagtca aattcattgt ttatttttat attattttta agttatctga
     3541 acaaatactt ttgaaaagaa aagtttgttg tatagtcaaa agaaaacggt gtcagccggc
     3601 cgtgacaaat tctagtaggt tctgtgcatg tggagcggcc gtgaaggggc cacaccgtcc
     3661 aggctgtgtt cttattttat ttttaatttt taattttttt cgtagaatgt aaaaaaaaag
     3721 tcattttagc tgccacctat gactttgcca catagctgaa ctgtgtttac tggaaaaatt
     3781 cagaggccta aagtttaaaa taaaatttac ttccgacgtt ttaattacaa atgtttgcca
     3841 cattaacttc tctgatgcct taaaagtgga cttctttgaa gaacttctgt gctattttat
     3901 cacaggctca caccacaatt gttaatatct ggagatgggt gatgaacaca cacacacaca
     3961 cacacacaca cacacacaca cacacacaca cacacaggcc aaaagcacaa acctccagtc
     4021 tgccagtcac ttcttcctgg gtctgcctgc tgctttctgc tctctttagc tcaccttgga
     4081 gttagagagg cattggggga cactgctggt tagttcattt ttattttaaa caggaccttt
     4141 ttgtggtcag atccaacagc actgtctgta catttttaac tggaaagacc tccttcagac
     4201 actccgcctc ttagtgccaa acccaccgtg agaccaagaa acaggactct tttttttccc
     4261 ttcacactca ttgctctcac agacagcgca ggccttgcaa acagcagcag aagtcacatt
     4321 taaaacaaaa aggaggggac ttacaaaact tagacaaaca ccttcacgaa ggaatgacat
     4381 agagcttagc aagtgttcat tcgagggact caatacgagt aacagaacgt ccccaagggt
     4441 cagtgggcca cactctggct ttgtggctgc tgacagggct tagctacatg aacagcctga
     4501 gaagtcactt tggaactaaa ttgcctcgat ttattttgtg taaggaaggg tttgacctaa
     4561 aaagagctca tgtgcacatt agtccgcatc ctcatgtccg cacccggttt gtgttttaga
     4621 tcaactagtc aacgccctca ttgcttcatt gtgtcaaaaa ccgagagctt cactaaatgg
     4681 tagattttgc tgtcagagac cctacaataa gattgtttta tctgtacatt ttttcagata
     4741 tttaactgta taaaatgttc attttacaca atatttaatt aaagtatttc ttgtctgtga
     4801 at
//
