LOCUS       NM_001108383            5439 bp    mRNA    linear   ROD 27-FEB-2025
DEFINITION  Rattus norvegicus EBF transcription factor 2 (Ebf2), transcript
            variant 3, mRNA.
ACCESSION   NM_001108383 XM_001068246 XM_341343
VERSION     NM_001108383.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5439)
  AUTHORS   Stine,R.R., Shapira,S.N., Lim,H.W., Ishibashi,J., Harms,M.,
            Won,K.J. and Seale,P.
  TITLE     EBF2 promotes the recruitment of beige adipocytes in white adipose
            tissue
  JOURNAL   Mol Metab 5 (1), 57-65 (2015)
   PUBMED   26844207
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5439)
  AUTHORS   Rajakumari,S., Wu,J., Ishibashi,J., Lim,H.W., Giang,A.H., Won,K.J.,
            Reed,R.R. and Seale,P.
  TITLE     EBF2 determines and maintains brown adipocyte identity
  JOURNAL   Cell Metab 17 (4), 562-574 (2013)
   PUBMED   23499423
REFERENCE   3  (bases 1 to 5439)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
REFERENCE   4  (bases 1 to 5439)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474023.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068246.1, XM_341343.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345329
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..5439
                     /gene="Ebf2"
                     /note="EBF transcription factor 2"
                     /db_xref="GeneID:361060"
                     /db_xref="RGD:1310805"
     exon            1..661
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1099
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             969..2696
                     /gene="Ebf2"
                     /note="early B-cell factor 2"
                     /codon_start=1
                     /product="transcription factor COE2"
                     /protein_id="NP_001101853.1"
                     /db_xref="GeneID:361060"
                     /db_xref="RGD:1310805"
                     /translation="MFGIQDTLGRGPVLKEKSLGAEMDSVRSWVRNVGVVDANVAAQS
                     GVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEK
                     TNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMC
                     SRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTV
                     NVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGD
                     NFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFI
                     YTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIIL
                     KRAADIAEALYSVPRNPSQIPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYI
                     RNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPY
                     GIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRA
                     MTGLVVPPM"
     exon            1100..1256
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1320
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1376
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1450
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1519
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1601
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1719
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1850
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1977
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2066
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2132
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2310
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2496
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2664
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..5439
                     /gene="Ebf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatggagag tcgcagtctc tgaaagcgca agcttcccct tcgctcgcct agcaaacctg
       61 caccgcaggc gctgtatcct ctagcggcta actctcgtag ttcttctgtg agcgctcacc
      121 tacagctagg gggtccggtc aggagtcaat tggcactcaa acaagagccc agagtagaga
      181 ggagagtctc ccgaatgtaa tgatgctggg aggctcgggt gcagccgctc gaaccgcggt
      241 gcagctgatt gtctcctcta cggcagatgg tctttgagca cagatttgca ttcattgtct
      301 tcaaatctgt tttcgctctg gtgttctaga tttcagcagc agatctacgc gcagatcaga
      361 atacaaaaag agaagcgaga aaataacacc cagccaggag gatttttttt tttaataggc
      421 acctccagcc gtctagggtt tcagctattt tgtggagccg ctgcttcccg accaccaacc
      481 ttcgtgacca cagcgcatgg cggacaaagt ttccaggact tcttcacaga cgcctcgtgt
      541 ctcctccgca gggttccccg ggcttcaatg attggggagg gaagataaaa aggggggatt
      601 tgaaactaca cccgcagttc tcagccagcc acgctgtcag caacctctcc catctgcaaa
      661 gaacaggtga tgcttctaaa ttgtggccac tttctggaga acgctctgca gctggaagga
      721 tgcgggcgac ctagagtgga agccccgagg cgacagatct gaagctaccg aggataaaaa
      781 cgcaaagttt gcattgtgcg tggaggaaag ggctggctat ttctttccag gagggcccca
      841 aacttcggcc ctctgccgct tttctcggat tgctttggag aacaccattt gctggcagcg
      901 ctggaaagtc gggacggtgt tgtcgtaaag tcacttttaa ggcgacagta gaggactaga
      961 ctttttaaat gtttgggatt caagatacgc taggaagagg accagttctg aaagaaaagt
     1021 cgctgggtgc cgagatggat tcggtcaggt cctgggtccg gaatgtcggc gtggtggatg
     1081 ccaatgtcgc ggctcagagt ggcgttgccc tgtctcgggc ccactttgaa aagcaacctc
     1141 cttctaactt gaggaaatcc aacttcttcc attttgtcct ggcgctctac gacaggcagg
     1201 gacagccggt ggagattgag cgcacagcct tcgtggactt tgtggagaat gacaaagagc
     1261 aaggcaacga gaaaaccaac aatggcactc actacaagtt acagctcctt tacagcaatg
     1321 gtgtccgcac agagcaggac ctctatgtca ggctcataga ctcagtcaca aaacagccta
     1381 ttgcctatga gggacagaat aagaatccag aaatgtgcag agttctgctg acacacgagg
     1441 tgatgtgcag ccgatgctgc gagaaaaaga gctgtgggaa ccggaatgag accccgtcag
     1501 accccgtcat catcgacaga ttctttttaa aatttttcct gaagtgcaat cagaattgtt
     1561 tgaaaacagc aggaaaccca agggacatga gacggtttca ggtcgtgttg tctacaacgg
     1621 tcaatgtgga tggacatgtg ctggctgttt ctgacaacat gtttgttcat aacaactcta
     1681 agcatggaag gagagcgaga aggcttgacc catcagaagc tacaccctgc atcaaagcca
     1741 tcagtccaag tgaaggctgg accacgggag gggccatggt catcatcatt ggtgacaact
     1801 tttttgatgg tctccaagtt gtatttggta ccatgctcgt atggagtgag cttataaccc
     1861 ctcatgccat cagagtacag acccctcccc ggcatatccc tggagttgtg gaagtgacac
     1921 tatcttataa atccaaacag ttctgcaaag gagccccagg caggttcatc tacacagcct
     1981 taaatgaacc caccatagac tatggcttcc aaagactgca gaaagtcatc ccaaggcacc
     2041 caggagaccc tgagaggcta gctaaggaaa tgctattgaa aagagctgca gacctggtgg
     2101 aagccctcta cggcacaccc cacaataacc aggacatcat tttaaagcgt gctgcagaca
     2161 ttgcagaagc cctgtacagt gtcccccgga accccagcca gattccagct ctctccagct
     2221 ccccagctca tagcggcatg atgggtatca actcttacgg cagccagctg ggggtcagca
     2281 tttcagagtc tacacaagga aataaccaag gatacatccg caacacaagc agcatctccc
     2341 ctcggggata ctcctccagc tccacgcccc agcagtctaa ttacagcacc tccagtaaca
     2401 gcatgaatgg ctacagcaac gttcctatgg ccaacctggg tgtgccagga tcaccgggtt
     2461 ttctgaacgg ctcacctaca ggctccccat atggaatcat gtcttcaagc cccaccgtgg
     2521 gatcctccag cacatcctcc atcctcccgt tctcctcttc agtttttcct gctgtcaaac
     2581 agaagagtgc ctttgcccct gtcatcaggc cccaaggctc cccttcgcct gcctgctcca
     2641 gtggcaatgg gaatggattc agagccatga cgggacttgt tgtacccccg atgtaaagta
     2701 gaggaagaac tgctttctca tagcacaaaa ctacttattc caatggacca attatgaagg
     2761 aagcactctg agcttgttgg ggagacttgc acccccaagc ggccatgttg gacagatttg
     2821 ggaaggcaga gagccgccat cttggtctcg tgttcctcat gaagcattga cagtcactac
     2881 acaaactgac ccttttggag acaagaacag agaaatgtca ttctctgacg tggtcagtgc
     2941 taagagcaga aacgcaattc tttgttatga acattacgaa aaccaccttc ctatgtttgt
     3001 aaaatattta agaaaaacat tggcaaacat tcatgcttaa tattttggat actatttgtt
     3061 tttctttgta ggaaaaaagt tgaaagtttc tattttctat gaatcctttc agataccaat
     3121 ttagtttatg cagaaaaaag ttgaacaaaa cagggtacca acatggaaga ctttcttaaa
     3181 atgaaacctg aattgaatga ggaaatgttg tgtgtgtgtt tgcttatact ttaagctctt
     3241 taaaagaaaa agggaaaaaa ttttaaatgt tttacagtta tttaaataaa taaacgtgta
     3301 acttattgta agtagacgta gaaattaaga ccttttttaa gaagagaaga attctcttcc
     3361 tgatgtaaaa tgaaattgac aacacgtagt gacaagtttt aaaggtgtgt tgcttattag
     3421 attcttatcc tacatcccac accccctctt tgtccatcat tttatccacc tatgcacaag
     3481 aacatgtaac ttgtgcagat tcccacagaa caatccacca cagaaaccag actcagataa
     3541 atgccagcac accaacactt cagtccacaa cttcattccc agatctgctt tctggttcac
     3601 aaatcacttg tggtatccac tcttggtaaa gcattttaaa aactatattc ttccctgagg
     3661 aaatgcaggg aatccccacg ttaccatctc agctttgaac attcccaggc aagaagtatc
     3721 tcacctctag gaagagccaa agccacacgg ctacactgac caaggactcc acaattttcc
     3781 tccgacagag cggtatagtc cttcctcttt gggtacctga ttcaggtatg gcagcaggaa
     3841 gctccacaga actttgcaga aagagcttgg ggaggttgcc tatgtttctt ggactcttaa
     3901 gactcggtct ttgactgctt cctttctagg cagttttcat tttatgttac taaactcccc
     3961 tggaaaagca tgtatctcac ctgacacttg tttctgaggt gagtgggatg gggtgaagaa
     4021 ggaagaactt aaaaatccct aagcggctct cctactggga gatttgtggc agctgtgttc
     4081 caagcctgcc ccgggagcct tgtgctacct acctagttct tagcagggaa acctttgcag
     4141 tagttgctaa cagtggtaga ctcttgaaaa tgtgtggtcc tggagatgca tctagacttg
     4201 cttggcttgc caataggatg tcatgatttt ccaggtcagg tgtcttctct ttgcttccac
     4261 tgacttagct tggggttctt ggttaggctt ctagcgttgg atgcagcttt tgtgaaaaaa
     4321 gcaaaaccat cattagtact tctgagccat tttagatgac cctctcattg cccctctgat
     4381 gtagtcctcc cccaaacccg caactgtctt atttgccttc agtttgctct ggagttaccc
     4441 aatacgacac ttttttctat gcacatgaga atccacattt ttgaaacctg gcatgctcat
     4501 aactactgct gacagtcctc cacagtcagg gctcacagtg ccaaaatata cggaaatgca
     4561 tgagagaaac ttccctggct aacaacatgg tacagggaac ggatgtgtgg aatacgtaaa
     4621 ttaccatccc aaaatggagg cagactacaa ttaagcatgt ttagacctgg ctttgagcca
     4681 atccaaccta agaattttct ttctttcttt catttttttt ttaaagtagc atagctttta
     4741 gaacctgtga atctttctct tgcatgagga ttagtgcagt actgtctcca gaatgatcgt
     4801 agaatctgtc agtagcttta caccgaaaac tgtgtgtaac taaataccag acatctttga
     4861 ccattcacta ggacatcagc agccacagat ctatttaatt gtacaaacgt gtgtaagggt
     4921 tatttttagt gtactaataa attaaaaaca aagccactct gtcctcttta gtcattgcta
     4981 ttaaatgatt ctggtcccag gttgtttttg tgctacttgg cagacaagta tctctatagg
     5041 taatgacaaa attctgttct atttttgaga ggagctgtgt aagattttca tttaaaggga
     5101 caacttactg cattatttat catatttctt ttgttacagc atcgaaattc ttcccagttt
     5161 ttctttgcac atttcaacat gcatggttta aaaaccatta tctttacctt ttgtacagta
     5221 aggtctcatt tccaaactgt atagttttgt tgtttttgct ttgtcagtta catacagtat
     5281 aaagttgcta tgcacagagc tttttgtaaa gacagctttt ttttgtttac tgtttttaat
     5341 ggtcttcctt atgaaagaat atcttgtttg taaaatgaat atgtctactt cagttttaaa
     5401 ctttaaatta tcctaacaaa aaataaaatt tttgtactg
//
