LOCUS       NM_053820               2895 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus EBF transcription factor 1 (Ebf1), mRNA.
ACCESSION   NM_053820 XM_001067993 XM_001068049 XM_001068094 XM_001068146
VERSION     NM_053820.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2895)
  AUTHORS   Plessy,C., Pascarella,G., Bertin,N., Akalin,A., Carrieri,C.,
            Vassalli,A., Lazarevic,D., Severin,J., Vlachouli,C., Simone,R.,
            Faulkner,G.J., Kawai,J., Daub,C.O., Zucchelli,S., Hayashizaki,Y.,
            Mombaerts,P., Lenhard,B., Gustincich,S. and Carninci,P.
  TITLE     Promoter architecture of mouse olfactory receptor genes
  JOURNAL   Genome Res 22 (3), 486-497 (2012)
   PUBMED   22194471
REFERENCE   2  (bases 1 to 2895)
  AUTHORS   Merluzzi,S., Moretti,M., Altamura,S., Zwollo,P., Sigvardsson,M.,
            Vitale,G. and Pucillo,C.
  TITLE     CD40 stimulation induces Pax5/BSAP and EBF activation through a
            APE/Ref-1-dependent redox mechanism
  JOURNAL   J Biol Chem 279 (3), 1777-1786 (2004)
   PUBMED   14594818
REFERENCE   3  (bases 1 to 2895)
  AUTHORS   Sigvardsson,M., Clark,D.R., Fitzsimmons,D., Doyle,M., Akerblad,P.,
            Breslin,T., Bilke,S., Li,R., Yeamans,C., Zhang,G. and Hagman,J.
  TITLE     Early B-cell factor, E2A, and Pax-5 cooperate to activate the early
            B cell-specific mb-1 promoter
  JOURNAL   Mol Cell Biol 22 (24), 8539-8551 (2002)
   PUBMED   12446773
REFERENCE   4  (bases 1 to 2895)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
REFERENCE   5  (bases 1 to 2895)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Identification of DNA recognition sequences and protein interaction
            domains of the multiple-Zn-finger protein Roaz
  JOURNAL   Mol Cell Biol 18 (11), 6447-6456 (1998)
   PUBMED   9774661
REFERENCE   6  (bases 1 to 2895)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
REFERENCE   7  (bases 1 to 2895)
  AUTHORS   Wang,M.M. and Reed,R.R.
  TITLE     Molecular cloning of the olfactory neuronal transcription factor
            Olf-1 by genetic selection in yeast
  JOURNAL   Nature 364 (6433), 121-126 (1993)
   PUBMED   8321284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ175272.1, L24051.1, FQ232013.1 and FQ177833.1.
            
            On Aug 9, 2012 this sequence version replaced NM_053820.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L24051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               FQ175272.1         1-258
            259-2479            L24051.1           1-2221
            2480-2807           FQ232013.1         762-1089
            2808-2895           FQ177833.1         1-88                c
FEATURES             Location/Qualifiers
     source          1..2895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2895
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /note="EBF transcription factor 1"
                     /db_xref="GeneID:116543"
                     /db_xref="RGD:620953"
     exon            1..422
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2043
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /note="OE-1; o/E-1; olf-1; olfactory neuronal
                     transcription factor; early B-cell factor (olfactory
                     neuronal transcription factor 1); early B-cell factor 1"
                     /codon_start=1
                     /product="transcription factor COE1"
                     /protein_id="NP_446272.2"
                     /db_xref="GeneID:116543"
                     /db_xref="RGD:620953"
                     /translation="MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSE
                     KTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPSEGWTTGGATVIII
                     GDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR
                     FIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEI
                     ILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQG
                     FTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPY
                     AIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCT
                     STNGNSLQAISGMIVPPM"
     exon            423..579
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..643
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..699
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..773
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..842
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..924
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1042
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1176
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1303
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1392
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1458
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1636
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1816
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2011
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2883
                     /gene="Ebf1"
                     /gene_synonym="Ebf; Olf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccaaacaa cccccaacag ccaagcatac atctctgttt tttcttaatt ttggtctttt
       61 cgttggattt tccctttctt ttttttccct cgcccccccc tccttgttat cgctcagttt
      121 tgagcgaagg tttacatttt taaaaatttt gcttttcagc ccgccttgat gtagcgcgag
      181 tttcatcgac tcaaaaaaaa aaaatctgtg gttggagttt tttttttcct tttttttttt
      241 taatattttc aaaggggagg agattttcca caagaaaagg ttgttttcat gtttgggatc
      301 caggaaagca tccaacggag tggaagcagt atgaaggaag agccgctggg cagcggcatg
      361 aacgcggtgc ggacgtggat gcagggcgcc ggggtgctgg acgccaacac agcggcgcag
      421 agcggggtgg gtctggcccg ggctcacttt gagaagcagc cgccttctaa cctgcggaaa
      481 tccaacttct tccacttcgt cctggccctc tacgacagac agggccagcc cgtggagatt
      541 gagaggacgg cctttgtggg gttcgtggag aaggaaaaag aagccaacag cgaaaagacc
      601 aataatggga tccactaccg gctccagctc ctctacagca atgggataag gaccgaacag
      661 gatttctacg tgcgcctcat cgactccatg acaaaacaag ccatagtgta tgaaggccaa
      721 gacaagaacc cggaaatgtg ccgagtactg ctcacacacg agatcatgtg cagccgctgt
      781 tgtgacaaga aaagctgtgg caaccgaaat gagactccct cagatccagt gataattgac
      841 agattcttcc tgaagttttt ccttaagtgt aaccaaaatt gcctaaagaa tgcggggaac
      901 ccacgtgaca tgcggagatt ccaggtcgtg gtgtctacca cagtcaacgt ggatggccat
      961 gtcctggcag tctctgataa catgtttgtc cacaataact ccaaacacgg gcggagggct
     1021 aggaggcttg acccctcgga agcagctact ccctgtatca aagccatcag cccgagtgaa
     1081 ggatggacga cgggaggcgc gactgtgatc atcatagggg acaatttctt tgatgggtta
     1141 caggtcatat tcggtaccat gctggtctgg agtgagttga taactcctca tgccatccgt
     1201 gttcagacac ctcctcggca catccctggt gttgtggaag tcacattgtc ctacaagtcc
     1261 aagcagttct gcaaagggac accaggcaga ttcatctata cagcactcaa tgaacccacc
     1321 atcgactatg gtttccagag gttacagaag gtcattcccc ggcatcctgg tgacccagag
     1381 cgtttgccaa aggaagtgat ccttaaaagg gctgcagatc tggttgaagc cctgtatggg
     1441 atgccccaca acaaccagga gattatcctg aagagagctg ccgacattgc tgaggctctg
     1501 tacagtgtcc ctcgaaacca caaccagctc ccggccctcg ctaacacttc ggtccacgca
     1561 gggatgatgg gcgtgaactc cttcagtgga caactggctg tgaatgtctc tgaggcatca
     1621 caagccacca atcaaggttt cacccgcaac tcaagcagtg tgtcaccaca tggatatgtg
     1681 cctagcacca ccccacagca gaccaactat aactctgtca ccacaagcat gaacggctac
     1741 ggctctgccg ccatgtccaa tttgggcggc tccccaacct tcctcaatgg ctcagctgcc
     1801 aactcaccct acgccattgt gccatccagc cccaccatgg cctcatctac aagcctcccc
     1861 tccaactgca gcagctcctc gggcatcttc tccttctcac cagccaacat ggtctctgct
     1921 gtgaaacaga agagtgcttt cgcaccagtt gtcagacccc agacctcccc gcctcccacc
     1981 tgcaccagca ccaacgggaa cagcctgcaa gcgatttctg gcatgattgt ccctcccatg
     2041 tgaaagaatt gccttgaaga attttattaa tgaagaggtt ggatcctgct acgaaagtaa
     2101 tctgacatga gtcccagagt ggaactttta actcaggcct ttttaagagg aaatcacaca
     2161 ataactgcag atttttaaac aaagtcaccg accttgcaaa tactgagatt ggaaagggga
     2221 cctgccagag cggggtgttg gatagagtcg gactccccga gtgtctgggg gatatattta
     2281 ttctgtattg ataaaaaaaa gaacaagccc accttttctt tttttctttc tcttttcttt
     2341 ctttaagctt aactctgcaa ccatttgtct tttgtaaacc attaagctac acacaagggc
     2401 cactctaaat aagactccat gttttaattt atgatgtttt taaagctatg taaggggaga
     2461 atgaagtggt gatatttaca aaaaaaaaag aaaaaaaaga aaaaagaaaa aaagctaaaa
     2521 aggaaaaaaa aaagaaaaac agggaaaaat aaattaaaaa aaaaaaaaag ctcgtaaggg
     2581 acagaatagg agaatgccag ttagattttt tagaaaacta agggtcggct tctgcgcctt
     2641 aaagcatatc agtggtaatt agctcagaca gtgcatttcc aatatctaac ttaacacgcc
     2701 atcccttagc agtgcaagct tctctctctc ttttgtatgg ttgtcttaag taactgtgta
     2761 aataggtgta gcctggaaag ttaccaagca acatacatga tcatattttc ccttgtactc
     2821 agaaaatcca gtgcctctag acagattgtt taaaaacgaa caaaagaaca aaaaacaaaa
     2881 aaaaaaaaaa aaaaa
//
