LOCUS       NM_172047               1132 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ELL associated factor 2 (Eaf2), mRNA.
ACCESSION   NM_172047
VERSION     NM_172047.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Luo,Z., Lin,C. and Shilatifard,A.
  TITLE     The super elongation complex (SEC) family in transcriptional
            control
  JOURNAL   Nat Rev Mol Cell Biol 13 (9), 543-547 (2012)
   PUBMED   22895430
  REMARK    Review article
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Xiao,W., Zhang,Q., Habermacher,G., Yang,X., Zhang,A.Y., Cai,X.,
            Hahn,J., Liu,J., Pins,M., Doglio,L., Dhir,R., Gingrich,J. and
            Wang,Z.
  TITLE     U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma,
            hepatocellular carcinoma and prostatic intraepithelial neoplasia
  JOURNAL   Oncogene 27 (11), 1536-1544 (2008)
   PUBMED   17873910
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Xiao,W., Jiang,F. and Wang,Z.
  TITLE     ELL binding regulates U19/Eaf2 intracellular localization,
            stability, and transactivation
  JOURNAL   Prostate 66 (1), 1-12 (2006)
   PUBMED   16114057
REFERENCE   5  (bases 1 to 1132)
  AUTHORS   Xiao,W., Zhang,Q., Jiang,F., Pins,M., Kozlowski,J.M. and Wang,Z.
  TITLE     Suppression of prostate tumor growth by U19, a novel
            testosterone-regulated apoptosis inducer
  JOURNAL   Cancer Res 63 (15), 4698-4704 (2003)
   PUBMED   12907652
REFERENCE   6  (bases 1 to 1132)
  AUTHORS   Saso,K., Ito,T., Natori,S. and Sekimizu,K.
  TITLE     Identification of a novel tissue-specific transcriptional activator
            FESTA as a protein that interacts with the transcription elongation
            factor S-II
  JOURNAL   J Biochem 133 (4), 493-500 (2003)
   PUBMED   12761297
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY049022.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1132
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /note="ELL associated factor 2"
                     /db_xref="GeneID:266787"
                     /db_xref="RGD:628879"
     exon            1..234
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..917
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /note="transcription factor; testosterone-regulated
                     apoptosis inducer and tumor suppressor protein;
                     testosterone regulated apoptosis inducer and tumor
                     suppressor"
                     /codon_start=1
                     /product="ELL-associated factor 2"
                     /protein_id="NP_742044.1"
                     /db_xref="GeneID:266787"
                     /db_xref="RGD:628879"
                     /translation="MNGPAGLAYLDRRERILKLGESFEKQPRCAFHTVRYDFKPASVD
                     ASCEGNLEVGKGEQVTITLPNIEGSTPPVTVFKGSKRPYLKECILIINHDTGECRLEK
                     LSSNITVKKTRGEGSSKIQCRLEQQQQQMWNPPRTSNLVQHSPSEDKLSPTSLMDDIE
                     RELKAEASLMDQMSSCDSSSDSRSSSSSSSEDSSSDSEDDDRSSPSGPRRYSSEHPSV
                     SAGPQYRTSDADTTCNRLYDNSALLMSTLRSDLQLSESDSDSED"
     exon            235..329
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /inference="alignment:Splign:2.1.0"
     exon            330..466
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /inference="alignment:Splign:2.1.0"
     exon            467..612
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /inference="alignment:Splign:2.1.0"
     exon            613..870
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1107
                     /gene="Eaf2"
                     /gene_synonym="Traits"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacgcgtct ggagagagat gaacggagcc cgccccggtt ccgagctcag gctcgcggcc
       61 agtgcaagct actccagaag gctgcggcgg cgggacagtg aaggcgaagc gggaggcaga
      121 ggaagaggat gaatggacca gcgggactcg catacctcga ccgtcgcgag cggattctca
      181 aattaggcga aagtttcgag aagcagccgc gctgtgcttt ccacaccgtg cgctatgact
      241 tcaaacctgc ttctgttgat gcctcttgtg aaggaaatct tgaggttggc aaaggtgaac
      301 aggtgacaat aactcttcca aatatagaag gttcaactcc accagtcaca gttttcaaag
      361 gttccaagag accttactta aaagagtgca ttttgattat taaccatgat actggggaat
      421 gtcgcctaga aaaactcagc agcaacatca ctgtgaaaaa aacaagagga gaaggaagta
      481 gcaaaatcca gtgcagacta gaacaacagc aacaacaaat gtggaatcca cccaggacat
      541 ccaaccttgt acagcattct ccatcagaag ataagctgtc cccaacgtct ctaatggatg
      601 atattgaaag agagctgaag gcggaagcta gtcttatgga ccagatgagt agttgtgata
      661 gttcatccga ttccagaagt tcttcatctt caagtagtga ggacagttct agtgattccg
      721 aagatgatga ccgatcctct ccttccggtc caaggaggta cagctcagag caccccagcg
      781 tatctgctgg gccacagtac aggacttcag atgctgacac tacttgtaac agactttacg
      841 acaacagtgc ccttctgatg agtactttac gaagtgatct gcagctgagt gagtcagaca
      901 gcgacagtga ggactgaagc aatatcaagc cataaggaaa acacttgctg caaagcttct
      961 agggaagctt ggggggaaaa aagaaaaaga aaacatttgt aagatgtttg agaatctgtt
     1021 ttgtattgag aataaatatt cctatgttca ttgaaaatat gcaacttttg ctgataaaat
     1081 aaagttggtt cagggttttc aactcttaaa aaaaaaaaaa aaaaaaaaaa aa
//
