LOCUS       NM_001185046            2595 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus E4F transcription factor 1 (E4f1), mRNA.
ACCESSION   NM_001185046 XM_001061399 XM_002724655
VERSION     NM_001185046.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Paul C, Lacroix M, Iankova I, Julien E, Schafer BW, Labalette C,
            Wei Y, Le Cam A, Le Cam L and Sardet C.
  TITLE     The LIM-only protein FHL2 is a negative regulator of E4F1
  JOURNAL   Oncogene 25 (40), 5475-5484 (2006)
   PUBMED   16652157
REFERENCE   2  (bases 1 to 2595)
  AUTHORS   Le Cam L, Lacroix M, Ciemerych MA, Sardet C and Sicinski P.
  TITLE     The E4F protein is required for mitotic progression during
            embryonic cell cycles
  JOURNAL   Mol Cell Biol 24 (14), 6467-6475 (2004)
   PUBMED   15226446
REFERENCE   3  (bases 1 to 2595)
  AUTHORS   Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno
            C, Caretti G, Imbriano C, Mantovani R, Del Sal G, Giancotti V and
            Manfioletti G.
  TITLE     Transcriptional activation of the cyclin A gene by the
            architectural transcription factor HMGA2
  JOURNAL   Mol Cell Biol 23 (24), 9104-9116 (2003)
   PUBMED   14645522
REFERENCE   4  (bases 1 to 2595)
  AUTHORS   Rooney RJ, Raychaudhuri P and Nevins JR.
  TITLE     E4F and ATF, two transcription factors that recognize the same
            site, can be distinguished both physically and functionally: a role
            for E4F in E1A trans activation
  JOURNAL   Mol Cell Biol 10 (10), 5138-5149 (1990)
   PUBMED   2169022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473948.1.
            
            On or before May 30, 2010 this sequence version replaced
            XM_002724655.1, XM_001061399.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2595
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /note="E4F transcription factor 1"
                     /db_xref="GeneID:681359"
                     /db_xref="RGD:1596731"
     exon            1..235
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2433
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /EC_number="6.3.2.-"
                     /note="gene_id=rCG34623.0 transcript_id=rCT34623.0
                     protein_id=rCP44728.0; deoxyribonuclease 1-like 2"
                     /codon_start=1
                     /product="transcription factor E4F1"
                     /protein_id="NP_001171975.1"
                     /db_xref="GeneID:681359"
                     /db_xref="RGD:1596731"
                     /translation="MEGAMAVRVTAAHTAEARAEAGHEAGEGGVAAAAALSNGGFLGL
                     PAPFSEEDEDDVHRCGRCQVEFTALEDFVQHKIQKTCHRAPQEALPTTSAATSLLGQE
                     VVPTAAEEGPEEPITVAHIVVEATSLAEDMSHAPDLVGSGHIKEVIVAAEAEPGDGEM
                     AEAPGSPNHQELGLIGEGEQAQVKLLVNKEGRYVCMLCHKTFKTGSILKAHMVTHSSR
                     KDHECKLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESGALTRHLKSLTPCTE
                     KIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGEPMETSPVIHLVTDAKGTVIHEV
                     HVQMQELPLGMKALTPESADCEELPCSRENSRENLLHQAMQNSGIVLDRVAGEESTLQ
                     PAPPSGSSPQSLGDGPSELPLLEVEQIETQVASEAATVPRTHPCSQCSETFPSAATLE
                     AHKRGHIGPRPFTCTQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVRGH
                     RRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVR
                     HHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLAEDP
                     HTVLVEFSSVVADTQEYIIEATADDTETSEATEIIEGTQTEVDSHIMKVVQQIVHQAG
                     AGHQIIVQNVTMDQEAALGSEAAAADTITIATPESLTEQVAMTLASAISEGTVLTARA
                     GPNSTEQATVTMVSSEDIEILEHGGELVIASPEGQLEVQTVIV"
     exon            236..387
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..499
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..693
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..814
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..967
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1134
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1344
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1453
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1671
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1870
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2013
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2076
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2595
                     /gene="E4f1"
                     /gene_synonym="Dnase1l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggacacgc agccctcggt gcggcccgtt gttatgacga catggtcgta aatccgccat
       61 cttcctgtgg cgcgttgcga catggagggc gcgatggcag tgcgggtgac ggccgctcat
      121 acggcagaag cccgggccga agccgggcat gaagcgggcg agggcggggt tgcagcggcg
      181 gcggccttgt ccaacggcgg ctttcttggg ctcccagcgc ccttcagcga ggaagatgag
      241 gatgacgtac acagatgtgg acgctgccaa gtggaattca ctgccttgga ggactttgtc
      301 cagcacaaga ttcagaagac ctgccatcgg gccccacaag aggccctgcc caccacctct
      361 gctgccactt cgttgctggg ccaggaggtg gtgccaacag cagcagagga aggtccagag
      421 gaacccatca ctgtggccca catcgtggtg gaggccacct ctctggcaga agacatgagc
      481 catgctcctg accttgttgg aagtgggcac atcaaagagg tcattgtggc tgctgaggca
      541 gagccagggg atggcgagat ggcagaggct ccaggcagtc ctaaccatca ggaacttggg
      601 cttattgggg agggcgagca ggcccaagtc aagctgctgg tgaacaagga aggccgctac
      661 gtgtgcatgc tatgtcacaa gaccttcaaa acgggcagca tcctcaaggc tcacatggta
      721 acacacagca gccgcaagga ccacgagtgc aagctctgtg gggcctcctt tcggaccaag
      781 ggctctctga tccggcacca ccgacggcac actgatgagc gtccctacaa atgtgccaag
      841 tgtgggaaga gtttccgaga gtcaggcgca ctgactcggc acctcaaatc tctcactcca
      901 tgcacagaaa agatccgttt cagcataagc aaggacacag ccgtgggcaa agaggaagtg
      961 cctgcagggt ccagtgcctc cactgtgggg acagtgacat cgtcagtggc aggagaaccc
     1021 atggagacat cacctgtgat tcacctggtg acagatgcca agggcactgt catccatgaa
     1081 gtccatgtcc agatgcagga gcttcccctg ggcatgaaag ccctgacccc agagtcggca
     1141 gactgtgagg agcttccctg ctcccgtgag aacagccggg agaacctgct acatcaggcc
     1201 atgcagaatt ctggcatcgt cctcgacagg gttgctgggg aggagagtac cctgcagcca
     1261 gcccctcctt ctgggtccag tccccagtcc ctgggagatg gaccctcaga gctgccactg
     1321 ctggaggtgg agcagataga gacacaggta gccagtgagg cagccactgt gcccaggacc
     1381 cacccgtgct ctcagtgcag tgagactttc ccatcagcgg ctaccttgga ggcccacaag
     1441 agaggtcata tagggccgag gccattcacc tgcacacagt gtggcaaggc cttccccaaa
     1501 gcctacctgc tcaagaagca ccaggaggtg catgtgcacg agcgccgctt ccgttgtgga
     1561 gactgtggga agctttataa gaccattgcc catgtgcggg gccaccggcg tgtccactcc
     1621 gacgagaggc ctttcccttg tccccagtgt ggcaagcgtt acaagaccaa gaatgcccag
     1681 caagtgcact tccggacaca tttggaagaa aagccccacg tgtgccagtt ctgcagccga
     1741 ggcttccggg agaagggctc tctagtgcgg catgtgaggc accacaccgg cgagaaacct
     1801 ttcaagtgct acaaatgtgg ccgtggcttt gcagagcatg gcacactcaa ccggcacctg
     1861 cgcactaaag ggggctgcct gctcgaagtg gaggagttgc tggtatccga ggagagcccc
     1921 tctgcggctg ctactgtgct tgcagaagac ccccacacgg tgctggtgga gttctcatct
     1981 gtggtggctg atacccaaga gtacattatt gaggctactg cggatgacac agagaccagt
     2041 gaagccactg agatcattga gggcacgcag acagaggtgg atagtcacat catgaaggtg
     2101 gtccagcaga tcgtgcacca ggctggcgct gggcaccaga tcattgtgca gaatgtgacc
     2161 atggaccagg aggcagcact gggctcagag gcagctgccg cggacacgat caccattgcc
     2221 actcctgaga gtcttactga gcaggtggcc atgacgctgg cttcagccat cagtgagggc
     2281 actgtgctca cagcccgggc agggccaaac agtactgaac aggccactgt gacaatggtg
     2341 tcatcagagg acatcgagat ccttgagcac ggaggggagc tggtcattgc ttcaccagag
     2401 ggccagcttg aggtgcagac agtcattgta tagtttgagg gattctgctg tggaagagtg
     2461 agaaccccga gtgtctgccc acgcccgtct ggtcagaaga catccacgtt caggcagcca
     2521 gaggagagag agagtgaaca cgtactcagt tttgttgttt ttttgttttg ttttgttttc
     2581 tgctttacaa taaaa
//
