LOCUS       NM_001108092            5377 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus E2F transcription factor 7 (E2f7), mRNA.
ACCESSION   NM_001108092 XM_001080823 XM_006241320 XM_235118
VERSION     NM_001108092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Chen,H.Z., Ouseph,M.M., Li,J., Pecot,T., Chokshi,V., Kent,L.,
            Bae,S., Byrne,M., Duran,C., Comstock,G., Trikha,P., Mair,M.,
            Senapati,S., Martin,C.K., Gandhi,S., Wilson,N., Liu,B., Huang,Y.W.,
            Thompson,J.C., Raman,S., Singh,S., Leone,M., Machiraju,R.,
            Huang,K., Mo,X., Fernandez,S., Kalaszczynska,I., Wolgemuth,D.J.,
            Sicinski,P., Huang,T., Jin,V. and Leone,G.
  TITLE     Canonical and atypical E2Fs regulate the mammalian endocycle
  JOURNAL   Nat Cell Biol 14 (11), 1192-1202 (2012)
   PUBMED   23064266
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   Weijts,B.G., Bakker,W.J., Cornelissen,P.W., Liang,K.H.,
            Schaftenaar,F.H., Westendorp,B., de Wolf,C.A., Paciejewska,M.,
            Scheele,C.L., Kent,L., Leone,G., Schulte-Merker,S. and de Bruin,A.
  TITLE     E2F7 and E2F8 promote angiogenesis through transcriptional
            activation of VEGFA in cooperation with HIF1
  JOURNAL   EMBO J 31 (19), 3871-3884 (2012)
   PUBMED   22903062
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Carvajal,L.A., Hamard,P.J., Tonnessen,C. and Manfredi,J.J.
  TITLE     E2F7, a novel target, is up-regulated by p53 and mediates DNA
            damage-dependent transcriptional repression
  JOURNAL   Genes Dev 26 (14), 1533-1545 (2012)
   PUBMED   22802528
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Ouseph,M.M., Li,J., Chen,H.Z., Pecot,T., Wenzel,P., Thompson,J.C.,
            Comstock,G., Chokshi,V., Byrne,M., Forde,B., Chong,J.L., Huang,K.,
            Machiraju,R., de Bruin,A. and Leone,G.
  TITLE     Atypical E2F repressors and activators coordinate placental
            development
  JOURNAL   Dev Cell 22 (4), 849-862 (2012)
   PUBMED   22516201
REFERENCE   5  (bases 1 to 5377)
  AUTHORS   Westendorp,B., Mokry,M., Groot Koerkamp,M.J., Holstege,F.C.,
            Cuppen,E. and de Bruin,A.
  TITLE     E2F7 represses a network of oscillating cell cycle genes to control
            S-phase progression
  JOURNAL   Nucleic Acids Res 40 (8), 3511-3523 (2012)
   PUBMED   22180533
REFERENCE   6  (bases 1 to 5377)
  AUTHORS   Dong,H.M. and Xu,C.S.
  TITLE     Analysis of the relevance of e2fs and their target genes with rat
            liver regeneration
  JOURNAL   Indian J Gastroenterol 27 (1), 31-32 (2008)
   PUBMED   18541936
  REMARK    GeneRIF: E2F transcription factor genes and their 34 target genes
            have a role in liver regeneration.
REFERENCE   7  (bases 1 to 5377)
  AUTHORS   Logan,N., Delavaine,L., Graham,A., Reilly,C., Wilson,J.,
            Brummelkamp,T.R., Hijmans,E.M., Bernards,R. and La Thangue,N.B.
  TITLE     E2F-7: a distinctive E2F family member with an unusual organization
            of DNA-binding domains
  JOURNAL   Oncogene 23 (30), 5138-5150 (2004)
   PUBMED   15133492
REFERENCE   8  (bases 1 to 5377)
  AUTHORS   de Bruin,A., Maiti,B., Jakoi,L., Timmers,C., Buerki,R. and Leone,G.
  TITLE     Identification and characterization of E2F7, a novel mammalian E2F
            family member capable of blocking cellular proliferation
  JOURNAL   J Biol Chem 278 (43), 42041-42049 (2003)
   PUBMED   12893818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Mar 31, 2021 this sequence version replaced
            XM_006241320.3, NM_001108092.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.26635.1,
                                           SRR26643292.29181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000007.1  48036903-48037108
            207-299             JAXUCZ010000007.1  48037749-48037841
            300-578             JAXUCZ010000007.1  48044764-48045042
            579-747             JAXUCZ010000007.1  48051521-48051689
            748-1038            JAXUCZ010000007.1  48055811-48056101
            1039-1197           JAXUCZ010000007.1  48057472-48057630
            1198-1332           JAXUCZ010000007.1  48058939-48059073
            1333-1518           JAXUCZ010000007.1  48068257-48068442
            1519-1588           JAXUCZ010000007.1  48068926-48068995
            1589-2069           JAXUCZ010000007.1  48070566-48071046
            2070-2325           JAXUCZ010000007.1  48072455-48072710
            2326-2747           JAXUCZ010000007.1  48074018-48074439
            2748-5377           JAXUCZ010000007.1  48076426-48079055
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..5377
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /note="E2F transcription factor 7"
                     /db_xref="GeneID:314818"
                     /db_xref="RGD:1310258"
     exon            1..206
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2915
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /codon_start=1
                     /product="transcription factor E2F7"
                     /protein_id="NP_001101562.2"
                     /db_xref="GeneID:314818"
                     /db_xref="RGD:1310258"
                     /translation="MEVNCLTLKDLISPRQTRLDFAVEDAETAQKENIFVDRSRMTPK
                     TPMKNEPIDLSKQRIFTPERSPITPVKLVDRQPQVEPWTPTANLKMLISAASPDIRDR
                     EKKKELFRPIENKGDAFVNSLQLDVVGDSAVDDYEKRRPSRKQKSLGLLCQKFLARYP
                     SYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPK
                     TLRTLQRLGEEQKYEEQMACLQQKELDLMEYRFGERRKDGSPDPRDQHLLDFSESDYP
                     SSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDTPDHSKFKTKVR
                     RLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSIDEELLDVSASVLPELKK
                     ETYGQIRVCAKERLARYGSFNTVQTSEKIQRKVNSEPSSPQGGKQGPAYSLEIGSLAA
                     IYRQKVEDSSQGEAFVNKRAAPPASVLDPTLPVDSEYCVKPLAQPVFSVAQTDLQAFS
                     AQNGLNGQVGVPVPSAASDAETLKSALLASQPLVYVPSTSLFMLYGSVQEALSPESRS
                     EEDGSGSDVPADLSLAPTAQKRLCEERNPLEDDEPAVKRQSREFEDSPLSLVMPKKPS
                     NSTDLAFPVTTGNGRATPLEDACVKGQLPAAEDASGRAVPNGFIASECGNPSRNPDTE
                     KSSNDNEITKDPSLLQYLYVQSPAGLNGFNMLLPGGQTPHAVAPSSAAMPSFGVPCMF
                     LPSPGLGPFPVLYSPAIPGPISSAPGTLPNTGPMNFGLSTLASASHLLISPAAMVNPK
                     SSTLPSADPQLRCQPPLNPNPVMPGSHGVIHPESPGYMRHPVSMVKAEQSPAPATPKS
                     IQRRHRETFFKTPGSLGDPAFRRERNQSRNTSSAQRRLEISSSGPD"
     exon            207..299
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            300..578
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            579..747
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1038
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1197
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1332
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1518
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1588
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2069
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2325
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2747
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..5377
                     /gene="E2f7"
                     /gene_synonym="E2F-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttttagc ggggaccgcg atcccgggct ggagcttgtc ttaggcgggt aggaaacgct
       61 gtcgctacca cgggtggagc ggagggtctg cgaactttgc cctgtcctgc ccatgtcgcc
      121 agtcggccgc tgagatctac acggtctgcc ggcgcacgcg tgcggctgcg ggcgtccccg
      181 gagatagcct ccatcgcgct gcggcaatgg aggtaaattg tttaacacta aaagacttga
      241 tcagccccag gcagaccaga ctagattttg ccgttgaaga tgcagagacc gcacaaaagg
      301 aaaatatatt cgtcgatcga tcaaggatga ccccaaagac gccaatgaaa aatgaaccca
      361 tcgatctgtc aaagcaaaga atctttactc cggaaagaag tcccattact ccggtaaagc
      421 tggtggaccg gcagccgcag gtggaaccgt ggacacccac ggccaacctg aagatgctca
      481 tcagtgcggc cagcccagac ataagggacc gggagaagaa aaaggagctg ttcagaccca
      541 ttgagaataa gggggatgca tttgtgaact ccctgcagct tgatgtggtt ggcgacagtg
      601 ctgtggatga ctacgagaag cgaaggccaa gcaggaaaca gaagagcttg gggctgctgt
      661 gccagaagtt tctagctcgc tatccaagct accccttgtc cacggagaaa accaccatct
      721 ccctggatga ggtcgccgtc agccttggtg tggaaaggag acgcatctat gacatcgtaa
      781 atgtgctgga gtctctgcat ctggtcagcc gggtagctaa gaatcagtat ggttggcatg
      841 gtcggcacag ccttcccaaa accctgcgga ccctacagag actgggagag gaacagaaat
      901 acgaggagca gatggcctgc ctccagcaga aggagctgga cctgatggag tataggtttg
      961 gagaacgcag gaaagatggg tctccagatc cccgagatca acacctactc gatttttctg
     1021 aatccgacta cccctcttca tctgcaaaca gtcgaaaaga taaatctcta agaattatga
     1081 gccagaagtt tgtcatgctg ttcctcgtct ctaaaaccaa gattgttacc ctggatgtag
     1141 ctgccaaaat cctcatagaa gaaagccaag ataccccgga ccacagtaaa ttcaaaacaa
     1201 aggtacggag gctctatgac atagccaatg tgctgaccag cttggctctg ataaagaaag
     1261 ttcacgtgac agaagagcga ggccgcaaac cagccttcaa atggatcggg cccgtggact
     1321 tcagctccat tgatgaagaa ctcttggacg tctctgcatc tgtcttaccg gaactgaaga
     1381 aggaaacata tggtcagatt cgagtgtgtg caaaagagag gctggcgcgg tacggttcct
     1441 ttaacacggt tcagacatct gagaagatac agagaaaagt gaactccgag cccagcagcc
     1501 cacagggagg aaaacaaggg ccagcctatt ccctggaaat tgggagtctg gccgccatct
     1561 acagacagaa agtagaagac agttcgcagg gggaagcctt tgtcaataag agagctgcac
     1621 ctccagcaag tgtcttggac cctaccctcc ctgttgactc cgaatactgt gttaagcctt
     1681 tagcccagcc agtattttct gtcgcgcaaa cagatttgca ggccttctcc gcacagaatg
     1741 gtctaaacgg acaagtaggt gtccccgttc cttctgcagc ctcggatgcg gagaccttaa
     1801 agtcagctct gcttgccagc cagcccctgg tatacgtgcc ctccacgtca ctcttcatgc
     1861 tatacgggag tgtgcaggag gcactgtccc cagagtcaag gtcagaggag gatggtagtg
     1921 gctccgatgt cccagctgac ctgtccctgg cacccactgc tcagaagcgc ctgtgtgagg
     1981 agaggaatcc tctggaggat gatgagcctg ctgtgaaaag gcaaagtcgg gaatttgaag
     2041 acagcccctt atccctagtt atgcccaaga aaccctcaaa ttccacagac ctcgcctttc
     2101 ctgtgaccac gggaaatggg agagctacac ccctggaaga tgcctgtgtc aagggtcagc
     2161 tccctgctgc agaagacgct tccggaaggg ctgtcccaaa tggcttcatt gcttctgaat
     2221 gtggaaaccc atcaagaaat ccagacactg aaaagtcttc caacgacaac gagatcacca
     2281 aagacccctc cctgctgcag tatctgtatg ttcagtctcc cgcaggttta aatggtttta
     2341 acatgctctt accgggcggt caaacccccc atgcggtggc accatcatcg gctgcgatgc
     2401 cgtccttcgg tgtgccttgc atgttcttac cgtctccagg attgggcccc tttccagttc
     2461 tctattctcc cgcaataccc gggcccatct cttcagctcc cggcactctc ccaaacaccg
     2521 gacccatgaa cttcggcttg tccaccctgg catcggcctc ccatcttctc atcagtccag
     2581 cagccatggt caatccaaag tcatccaccc tcccttccgc agatcctcag cttcggtgtc
     2641 agcccccact aaacccgaat ccagtgatgc caggctcaca tggtgtcatc cacccggagt
     2701 cccctggtta catgagacat ccagtgtcca tggtgaaggc agaacagtcc cctgcaccag
     2761 cgactcccaa gagcatccaa cggagacatc gggagacgtt cttcaagact cctggcagcc
     2821 tcggtgatcc ggcctttaga agagaaagga accaatcccg gaacactagc tcagcccaga
     2881 ggagactaga aatctctagc agcgggcctg actaacctga atcttcagtg ggtggggtgg
     2941 cttcagtacc tgacattccc tgtgtcccag acaaatgtcc taagtggaac acgggccacc
     3001 ccagtcctca actggtgtcc ttgctctcac gctcgaatcc actggttctg ctaacttccc
     3061 gatatcatga gtcatctgtt ttcctggaag taattattac taattatgca tttaatacca
     3121 cctagcgtcc aggctgtgtg cggtgtcacc gtggtattgc tctgtgactg ctgtggtttt
     3181 tctgaagggg gagttgccta gcacttaacc agggtaaggt ttggtgtcta agcctttcca
     3241 cctgccctga gcaagtctgt agtgagaact gtctctgcag cctaaacgtg ctaccgcttc
     3301 cttaggctcc gggaagccgt cttcagtgag gaatcctacg gtattattta ttctgtccct
     3361 gcaacgggac tttactgcac aaagtttaca acatcatcct aacattttca gggtattgcg
     3421 acttgaatgt ttatactttt gttgttattg ttgttgttat gatttgccct gcacttactc
     3481 tacagcttat taataatgtg gataaatgta tatacgtgat aaatgtcaag accaaaataa
     3541 ctgtgaatgc tacacctagc cattaatgaa ctgtgctgat gcatctggag gtgtgggaac
     3601 gaaaactgaa gtctaggtgc cttgtgactg ttcctccagc aacgatgaac gaggtcttgc
     3661 catttgttta aaacaaaaca aatcctcctt gtgctcatct cccttcactc tgcacccgtg
     3721 tatcctaatt taaatgttct ctgtagcgtg ccagggtgtg tgccttctca cggctgccgt
     3781 ttataagaca aatcaggacg acattgcgga acggaggccg tgggaacctg gataagagtt
     3841 ttggttgaat tatgaagcac aatgagaggg agacagagcg atagacaatt atcttctttt
     3901 ttcctttcca catttccctg tgtccagagg agaacgggca ttctgtccat ttctaacagt
     3961 gttcattcat acatcccgtg gtcctcccag aaccagcaca gtgagcacgg tgttggttgt
     4021 tctaatagtt gttctgcaaa gtgcacaagg ccctctgtga gccgcattgc tctagggttc
     4081 cccgtgttct acactgaagt taccacacgc ttgtctcttc tacttccttt tctcctctat
     4141 tttagtctgt cttctattta aacttcttag actctagtct taatataagg ctatttttcc
     4201 cctttgtatt tttgtaccct gtgaaatact atataaaagg ataaaaaata ttaatttaag
     4261 agactctggg agtccgatca gagtagcttt atattaacta caggatgctt ttagcctcac
     4321 tacacccaac actagctttg ggaaacttga gataggtaaa gcctgtttaa cacattcgct
     4381 acttcatcaa attcttcatc aacactaagc ttataaagtt gaaaaaaaag gtattgttcc
     4441 ttttttaaat ttttttttct tgagttaggt aaaaattgca tgctgtctat gactctgaag
     4501 ccacactgct ggtcccttgc tggaacatga aagtgacccc ctttccagga gtgtatcaga
     4561 cgtgcagcaa gtgagtctcc tatgcactgc ttgcttttaa gatccctgga gcatagggac
     4621 ttccacaaag catttccgtc aagaaatgca catctcccca tagacacaga cctgtcttct
     4681 ctcgttcctg gatagccttc atttatcttt aaccttttgc tatcccttct tattatactc
     4741 agttaccctg tgaattgacc attattaacc tcagagaatt tatgattctt gggaggcgtc
     4801 aagcaattcc acccatggga aacgaaagtt aacttctgga ttagggtccc actcgccgtg
     4861 gcttctgact ctgccagaag accggtctct gaagctttat ggctagacct gagtgcctga
     4921 gacagagaag cagtggcttc tcatttagtg caagaagaaa taagggaggg catgggcttt
     4981 gagtcagcac tgagggggcg tgctacctca aaccgtgccg tccggggttt ccaaaaccct
     5041 tgcattccgg tacaagagct ggggatataa cttatacttg aacctaccta cgaagtttac
     5101 attgctcgat gcaaggtgct atttttggac ttaagcggct gtgatgtgaa gctgcttcct
     5161 gcttctcttg ttgcactgct agacttacgt aggtgttgac ttcattgctg cttgtcgctt
     5221 cttcgttgtc atggggcttg ggctctgctc tttcctagtg gctgtattat ctatggccat
     5281 ctacttgtaa cgctactaca tgtaaaccaa tctttccttt tagaaaagta ctaagcttta
     5341 taaagtagcc atggaaataa atgtatttag taaggca
//
