LOCUS       NM_001100717            2178 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus E2F transcription factor 6 (E2f6), mRNA.
ACCESSION   NM_001100717 XM_001069459
VERSION     NM_001100717.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Dong,H.M. and Xu,C.S.
  TITLE     Analysis of the relevance of e2fs and their target genes with rat
            liver regeneration
  JOURNAL   Indian J Gastroenterol 27 (1), 31-32 (2008)
   PUBMED   18541936
  REMARK    GeneRIF: E2F transcription factor genes and their 34 target genes
            have a role in liver regeneration.
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Deshpande,A.M., Akunowicz,J.D., Reveles,X.T., Patel,B.B.,
            Saria,E.A., Gorlick,R.G., Naylor,S.L., Leach,R.J. and Hansen,M.F.
  TITLE     PHC3, a component of the hPRC-H complex, associates with E2F6
            during G0 and is lost in osteosarcoma tumors
  JOURNAL   Oncogene 26 (12), 1714-1722 (2007)
   PUBMED   17001316
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Movassagh,M., Bicknell,K.A. and Brooks,G.
  TITLE     Characterisation and regulation of E2F-6 and E2F-6b in the rat
            heart: a potential target for myocardial regeneration?
  JOURNAL   J Pharm Pharmacol 58 (1), 73-82 (2006)
   PUBMED   16393466
  REMARK    GeneRIF: isolation and characterization of E2F6 and splice variant
            named E2F6b in cardiomyocytes as down-reg. in neonate and up-reg.
            in development of cardiomyocyte hypertrophy
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Giangrande,P.H., Zhu,W., Schlisio,S., Sun,X., Mori,S., Gaubatz,S.
            and Nevins,J.R.
  TITLE     A role for E2F6 in distinguishing G1/S- and G2/M-specific
            transcription
  JOURNAL   Genes Dev 18 (23), 2941-2951 (2004)
   PUBMED   15574595
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Trimarchi,J.M., Fairchild,B., Verona,R., Moberg,K., Andon,N. and
            Lees,J.A.
  TITLE     E2F-6, a member of the E2F family that can behave as a
            transcriptional repressor
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2850-2855 (1998)
   PUBMED   9501179
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001100717.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data from several strains because no single
            transcript was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000006.1  45321258-45321365
            109-163             JAXUCZ010000006.1  45326374-45326428
            164-380             JAXUCZ010000006.1  45328729-45328945
            381-536             JAXUCZ010000006.1  45330608-45330763
            537-651             JAXUCZ010000006.1  45332606-45332720
            652-799             JAXUCZ010000006.1  45335235-45335382
            800-2178            JAXUCZ010000006.1  45336057-45337435
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2178
                     /gene="E2f6"
                     /note="E2F transcription factor 6"
                     /db_xref="GeneID:313978"
                     /db_xref="RGD:631412"
     CDS             1..819
                     /gene="E2f6"
                     /codon_start=1
                     /product="transcription factor E2F6"
                     /protein_id="NP_001094187.1"
                     /db_xref="GeneID:313978"
                     /db_xref="RGD:631412"
                     /translation="MSQQRTARKLPSLLVDPAQETVRRRCRDPINVENLLPSKIRINL
                     EENVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRR
                     VYDITNVLDGIELVEKKSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDEL
                     IKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIAVKAPEETRLDVPAPRED
                     SITVHIRSTKGPIDVYLCEVEQNHSNGKTADGVGASPSDSKHLQSPEKEDKPLQ"
     exon            1..108
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            109..163
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            164..380
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            381..536
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            537..651
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            652..799
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
     exon            800..2178
                     /gene="E2f6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtcagc agcggacggc gcggaaactg cccagcctgc tggtggaccc ggctcaggag
       61 accgtgcgcc gccgctgccg ggaccccatc aacgtagaga acctactgcc atcaaaaata
      121 aggatcaatc tagaagaaaa tgtacagtat gtgtccatga gaaaagctct gaaggtgaag
      181 aggccccggt ttgatgtgtc gctggtctac ttaactcgga agtttatgga tcttgtcaga
      241 tccgccccgg ggggcattct tgacctaaac aaggttgcca caaaactggg tgtccggaag
      301 aggcgtgtgt atgacatcac caatgtcttg gacggcatcg aactggtgga aaagaaatct
      361 aagaaccaca ttcggtggat aggatctgac ctgaacaact ttggggcagc accccaacag
      421 aagaagctgc aggctgagct ctccgacctg tcggcgatgg aagacgctct ggacgagttg
      481 attaaagatt gtgctcagca actgctggag ttaacagatg acaaagaaaa cgaaagacta
      541 gcctacgtga cctatcagga tattcacggc attcaagctt tccacgaaca gattgtcatt
      601 gcagtgaagg ctccagagga aaccagactg gatgttccgg ctcccagaga agattctatc
      661 acagtgcata tcaggagcac caaaggaccc attgatgttt atttgtgtga agtagaacag
      721 aaccactcaa atggtaaaac agctgatgga gtaggggcct ctccatctga cagcaaacat
      781 ctacaaagcc cagagaaaga agacaagcct cttcagtgag tgaagatttc tcagagtgag
      841 cggctgatag cagttcagtg atgaaggtct ttggatcatg ccccgtgggt gaatcatgtg
      901 ccccatcccg agtgggtgaa tcatgtgccc gtctgatcct cagcaataag tctccttgga
      961 gtgcccttgt gaccgacctt attctagact tgtagcagca ctgaaggcca gtagtgtcct
     1021 cccacatagc ctcaagcaca ggttcccgat ggcttcccca ttcagaatca gctcctttga
     1081 taattcttca ctgccttttg tcagtgaaat agacctcttg cctcctaaaa tcatcttata
     1141 acaaagacta gcacaaggac agacagctgg ccagctggtc gtggactgtg ccctgacgga
     1201 tatagatagt gtccgcttca caggagaatt gccttacact ggttcacatt tgcagttagg
     1261 tgtcgtgcac tggtgaggtg tacgcacagg accaaatgtg gcacctttgt ccatatgtgt
     1321 atcatgtgta gtttgtttat gaaatatgtc taagtgacac ttccacccta gaacacccaa
     1381 aataatgtat gtaggaaaaa tgaccaacag atggctagtc cctcagttcc tgtaacttat
     1441 tagaaccctc tggatggggg tgagaggagt tttctaaagt tttacatgta gaagtttcac
     1501 agatgcctgt acatttaggt tatatactta aagtgtttta atacggtctg cagtgctaca
     1561 attgaagcca catactcctg attttaagct gcctacagag tcatgcccca gtagattgat
     1621 ggcatgcctc aaaagcactg ggggcaagta cagaattctg tctggcaaca gatcagttca
     1681 ctacaatgtg aatttggtcc tggtgatatt aaaagcatta ttgtgctttt catgagcaga
     1741 ttttataatg tgtttccgtg tgtagccttg ctcctcagtc agaggacctt acctcctgtg
     1801 cattgtaccc cgctccagct ctcatcccgc cttcccagtc acctagcgct ctctacctca
     1861 gtgggtaagt catttacctc tctgtgcctc aatcaactca gtaatttacc actagactgt
     1921 gagctccgcg agagacattt gttcatagtc gctctcagcg ccctgtacca cgcctagtcc
     1981 aaaacaagcg cccagtgaat gtccagcaaa ctcatgaatg ggcgagtgca acgtggggct
     2041 gatggaacct ggtttgtgca gaagtctggg agcatcctta gtgtgttaaa cctctcctgc
     2101 tttacaagag atttgaagca gcctgaaata acaatcatgt atacaaagta gggatccaaa
     2161 attaaagtat taaaaaaa
//
