LOCUS       NM_001398639            1832 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus E2F transcription factor 5 (E2f5), mRNA.
ACCESSION   NM_001398639 XM_039103581
VERSION     NM_001398639.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Qi,J.C., Yang,Z., Lin,T., Ma,L., Wang,Y.X., Zhang,Y., Gao,C.C.,
            Liu,K.L., Li,W., Zhao,A.N., Shi,B., Zhang,H., Wang,D.D., Wang,X.L.,
            Wen,J.K. and Qu,C.B.
  TITLE     CDK13 upregulation-induced formation of the positive feedback loop
            among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to
            prostate carcinogenesis
  JOURNAL   J Exp Clin Cancer Res 40 (1), 2 (2021)
   PUBMED   33390186
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Xu,Q., Liang,Y., Liu,X., Zhang,C., Liu,X., Li,H., Liang,J., Yang,G.
            and Ge,Z.
  TITLE     miR-132 inhibits high glucose-induced vascular smooth muscle cell
            proliferation and migration by targeting E2F5
  JOURNAL   Mol Med Rep 20 (2), 2012-2020 (2019)
   PUBMED   31257477
  REMARK    GeneRIF: miR132 was proposed to inhibit the proliferation and
            migration of diabetic rat or highglucosetreated vascular smooth
            muscle cells (VSMCs) by targeting E2F5
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Dong,H.M. and Xu,C.S.
  TITLE     Analysis of the relevance of e2fs and their target genes with rat
            liver regeneration
  JOURNAL   Indian J Gastroenterol 27 (1), 31-32 (2008)
   PUBMED   18541936
  REMARK    GeneRIF: E2F transcription factor genes and their 34 target genes
            have a role in liver regeneration.
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   5  (bases 1 to 1832)
  AUTHORS   Ebelt,H., Liu,Z., Muller-Werdan,U., Werdan,K. and Braun,T.
  TITLE     Making omelets without breaking eggs: E2F-mediated induction of
            cardiomyoycte cell proliferation without stimulation of apoptosis
  JOURNAL   Cell Cycle 5 (21), 2436-2439 (2006)
   PUBMED   17102628
  REMARK    GeneRIF: E2F2, unlike E2F1, E2F3 and E2F5, does not induce
            apoptosis but even suppresses expression of several pro-apoptotic
            genes in primary cardiomyocytes; E2F1, E2F2, and E2F3 and E2F4
            induce S-phase entry of primary cardiomyocytes
REFERENCE   6  (bases 1 to 1832)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J Cell Sci 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
REFERENCE   7  (bases 1 to 1832)
  AUTHORS   Gaubatz,S., Lindeman,G.J., Ishida,S., Jakoi,L., Nevins,J.R.,
            Livingston,D.M. and Rempel,R.E.
  TITLE     E2F4 and E2F5 play an essential role in pocket protein-mediated G1
            control
  JOURNAL   Mol Cell 6 (3), 729-735 (2000)
   PUBMED   11030352
REFERENCE   8  (bases 1 to 1832)
  AUTHORS   Gill,R.M. and Hamel,P.A.
  TITLE     Subcellular compartmentalization of E2F family members is required
            for maintenance of the postmitotic state in terminally
            differentiated muscle
  JOURNAL   J Cell Biol 148 (6), 1187-1201 (2000)
   PUBMED   10725332
REFERENCE   9  (bases 1 to 1832)
  AUTHORS   Lindeman,G.J., Dagnino,L., Gaubatz,S., Xu,Y., Bronson,R.T.,
            Warren,H.B. and Livingston,D.M.
  TITLE     A specific, nonproliferative role for E2F-5 in choroid plexus
            function revealed by gene targeting
  JOURNAL   Genes Dev 12 (8), 1092-1098 (1998)
   PUBMED   9553039
REFERENCE   10 (bases 1 to 1832)
  AUTHORS   Itoh,A., Levinson,S.F., Morita,T., Kourembanas,S., Brody,J.S. and
            Mitsialis,S.A.
  TITLE     Structural characterization and specificity of expression of E2F-5:
            a new member of the E2F family of transcription factors
  JOURNAL   Cell Mol Biol Res 41 (3), 147-154 (1995)
   PUBMED   8589754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2021 this sequence version replaced XM_039103581.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31668.1, SRR26643299.9158.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840107
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               JAXUCZ010000002.1  88733710-88734143   c
            435-544             JAXUCZ010000002.1  88725338-88725447   c
            545-706             JAXUCZ010000002.1  88724560-88724721   c
            707-750             JAXUCZ010000002.1  88723910-88723953   c
            751-815             JAXUCZ010000002.1  88722280-88722344   c
            816-1083            JAXUCZ010000002.1  88721143-88721410   c
            1084-1128           JAXUCZ010000002.1  88719726-88719770   c
            1129-1832           JAXUCZ010000002.1  88718567-88719270   c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1832
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /note="E2F transcription factor 5"
                     /db_xref="GeneID:116651"
                     /db_xref="RGD:621357"
     exon            1..434
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1238
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /codon_start=1
                     /product="transcription factor E2F5"
                     /protein_id="NP_001385568.1"
                     /db_xref="GeneID:116651"
                     /db_xref="RGD:621357"
                     /translation="MAAAEPTSSAQPTPQAQAQPPPPPPHGAPSSHQSAALAGGSSRH
                     EKSLGLLTTKFVSLLQEAQDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSK
                     NSIQWKGVGAGCNTKEVIDRLRCLKAEIEDLELKERELDQQKLWLQQSIKNVMEDSIN
                     NRFSYVTHEDICSCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIH
                     VLLINKESNSSKPVVFPVPPPDDLTQPSSQSSTSVTPPKSTMAAQNLPEQHVSERSQN
                     FQQTPATEISSGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQ
                     ILNY"
     exon            435..544
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..706
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     exon            707..750
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     exon            751..815
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1083
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1128
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1832
                     /gene="E2f5"
                     /gene_synonym="E2f-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgcc atttaaactc aggcccaccc tcgcggcact ggccgctcgc tagagtccgc
       61 gcgctctgta gtgcggcgcg ttctgtggta ccgcgcgcga gcttcgcggc tccagggact
      121 ggtgaacgcg gggagcgccg cgggccggag cggagtccgc gcacctcctc tgccggcggc
      181 cgaggggttc ccgggcagcg gacgtcaggg ccgcggcggt gatggcggcg gcggagccca
      241 cgagctctgc tcagcccacg ccgcaggccc aggcccagcc gccgccgccg ccgccgcatg
      301 gggcgccttc ttcccatcag tccgcggcgc tcgcgggggg cagcagccgg cacgagaaga
      361 gcctggggtt gctcaccacc aagttcgtgt cgttgctgca ggaggcgcag gacggcgtcc
      421 tggatctcaa agcggctgca gatactttgg ctgtgaggca aaagcgaaga atttatgata
      481 tcaccaacgt cttagaagga attgatctaa ttgaaaaaaa atcaaagaac agtatccagt
      541 ggaagggtgt aggtgctggc tgtaatacta aagaagttat agatagatta agatgtctta
      601 aagctgaaat tgaagatcta gaattgaagg aaagagaact tgaccagcag aagttgtggc
      661 tacagcaaag catcaaaaac gtgatggaag actccattaa taacagattt tcttatgtaa
      721 ctcacgaaga catctgcagt tgctttaatg gtgatacact gttggccatt caggcaccct
      781 ctggtacaca gctggaagta cctattccag aaatgggaca gaatggacaa aagaaatacc
      841 agataaatct gaagagtcac tcaggaccaa tccatgtgct acttataaat aaagagtcca
      901 actcatctaa gccggtggtt tttcctgtcc ccccacctga tgacctcaca caaccttcct
      961 cccagtcctc aacttcagtg actccaccga aatccaccat ggctgctcaa aacctgcccg
     1021 agcagcatgt ttctgaaaga agccagaatt tccagcagac accagctaca gaaatatctt
     1081 caggatctat tagtggagac atcattgatg aactgatgtc ttctgacgtg tttcctctct
     1141 tacggctgtc tcctacccca gcagatgact acaactttaa tttagatgat aatgaaggag
     1201 tttgtgatct gtttgatgtt cagatactaa attattagat tccacggaaa cttgggactg
     1261 ttatctacct ctaactgtaa cattttagaa ttcttaataa cctaagtatt taaaattatg
     1321 aatgtaacac ctttttagtt cactgactct aaagtgtttt cctaacattt tacttttact
     1381 tcacaaaact tgaaagggct ctgactgctt caggggggga taattaactg tccaccagca
     1441 tgcccctcca gtgattacac tcagtttcat tcagtgctga attctgtagc ttcttcttag
     1501 aggacagtta cagcaggctt cagttcatca taacaaaaca ttgtccaaaa gatcacttac
     1561 ttgtcttatg tttttactgc cgcaaagctg tttctatgta tccttcaaac agacattcac
     1621 tgccatatat aaagtgaagg atatcactgt tgagtgaaca gattttgtga agtgccttct
     1681 gttttagcac tttaagtcta tcagtttgtt gattctgaca ttccactttc ctagagtata
     1741 ggaaagatct gtttatgtag tttgttttta aaatgtgcca atgcctgtac attaacaaga
     1801 tttaaagaaa taaagttgta tgaaacattg aa
//
