LOCUS       NM_001271345            2020 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus E2F transcription factor 4 (E2f4), mRNA.
ACCESSION   NM_001271345 XM_002728596 XM_003753101
VERSION     NM_001271345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Miles,W.O., Korenjak,M., Griffiths,L.M., Dyer,M.A., Provero,P. and
            Dyson,N.J.
  TITLE     Post-transcriptional gene expression control by NANOS is
            up-regulated and functionally important in pRb-deficient cells
  JOURNAL   EMBO J 33 (19), 2201-2215 (2014)
   PUBMED   25100735
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Dingar,D., Konecny,F., Zou,J., Sun,X. and von Harsdorf,R.
  TITLE     Anti-apoptotic function of the E2F transcription factor 4
            (E2F4)/p130, a member of retinoblastoma gene family in cardiac
            myocytes
  JOURNAL   J Mol Cell Cardiol 53 (6), 820-828 (2012)
   PUBMED   22985930
  REMARK    GeneRIF: E2F4 is part of a transcriptional repressor complex
            comprising p130 and HDAC1 in cardiac myocytes. Relief from
            E2F4-dependent gene silencing induces the expression of
            pro-apoptotic genes.
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Faure,A.J., Schmidt,D., Watt,S., Schwalie,P.C., Wilson,M.D., Xu,H.,
            Ramsay,R.G., Odom,D.T. and Flicek,P.
  TITLE     Cohesin regulates tissue-specific expression by stabilizing highly
            occupied cis-regulatory modules
  JOURNAL   Genome Res 22 (11), 2163-2175 (2012)
   PUBMED   22780989
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Ofir,M., Hacohen,D. and Ginsberg,D.
  TITLE     MiR-15 and miR-16 are direct transcriptional targets of E2F1 that
            limit E2F-induced proliferation by targeting cyclin E
  JOURNAL   Mol Cancer Res 9 (4), 440-447 (2011)
   PUBMED   21454377
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Rempel,R.E., Saenz-Robles,M.T., Storms,R., Morham,S., Ishida,S.,
            Engel,A., Jakoi,L., Melhem,M.F., Pipas,J.M., Smith,C. and
            Nevins,J.R.
  TITLE     Loss of E2F4 activity leads to abnormal development of multiple
            cellular lineages
  JOURNAL   Mol Cell 6 (2), 293-306 (2000)
   PUBMED   10983977
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Humbert,P.O., Rogers,C., Ganiatsas,S., Landsberg,R.L.,
            Trimarchi,J.M., Dandapani,S., Brugnara,C., Erdman,S., Schrenzel,M.,
            Bronson,R.T. and Lees,J.A.
  TITLE     E2F4 is essential for normal erythrocyte maturation and neonatal
            viability
  JOURNAL   Mol Cell 6 (2), 281-291 (2000)
   PUBMED   10983976
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Wang,D., Russell,J.L. and Johnson,D.G.
  TITLE     E2F4 and E2F1 have similar proliferative properties but different
            apoptotic and oncogenic properties in vivo
  JOURNAL   Mol Cell Biol 20 (10), 3417-3424 (2000)
   PUBMED   10779331
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Tommasi,S. and Pfeifer,G.P.
  TITLE     In vivo structure of two divergent promoters at the human PCNA
            locus. Synthesis of antisense RNA and S phase-dependent binding of
            E2F complexes in intron 1
  JOURNAL   J Biol Chem 274 (39), 27829-27838 (1999)
   PUBMED   10488129
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Sep 19, 2012 this sequence version replaced
            XM_003753101.1, XM_002728596.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1864514.1,
                                           SRR26360186.1788743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000019.1  50084335-50084555
            222-331             JAXUCZ010000019.1  50084958-50085067
            332-493             JAXUCZ010000019.1  50085193-50085354
            494-537             JAXUCZ010000019.1  50085645-50085688
            538-599             JAXUCZ010000019.1  50086515-50086576
            600-897             JAXUCZ010000019.1  50086775-50087072
            898-1116            JAXUCZ010000019.1  50087690-50087908
            1117-1164           JAXUCZ010000019.1  50090530-50090577
            1165-1209           JAXUCZ010000019.1  50090781-50090825
            1210-2020           JAXUCZ010000019.1  50090921-50091731
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2020
                     /gene="E2f4"
                     /note="E2F transcription factor 4"
                     /db_xref="GeneID:100360427"
                     /db_xref="RGD:2322129"
     exon            1..221
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1325
                     /gene="E2f4"
                     /note="E2F transcription factor 4, p107/p130-binding"
                     /codon_start=1
                     /product="transcription factor E2F4"
                     /protein_id="NP_001258274.1"
                     /db_xref="GeneID:100360427"
                     /db_xref="RGD:2322129"
                     /translation="MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLK
                     LAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKA
                     EIEELQQREQELDQHKVWVQQSIRNVAEDVQNSCLAYVTHEDICRCFAGDTLLAIRAP
                     SGTSLEVPIPEGLNGQKKYQIHLKSMSGPIEVLLVNKEAWSSPPVAVPVPPPDDLLQS
                     PPAVSTPPPLPKPALAHPQETSRPSSPQITTPTPVLGSTEVSDVAGQTAEIAVSGSPG
                     TENKGSGELSSLPLGLTALDTRPLQSSALLDSSSSSSSSSSSSSSSSSSSGPNPSTSF
                     EPIKADPTGVLDLPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYI
                     YNLDESEGVCDLFDVPVLKL"
     exon            222..331
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            332..493
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..537
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            538..599
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            600..897
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1116
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1164
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1209
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2020
                     /gene="E2f4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgactag gaacggaagc ggaagtggtg ccgccgccgg cctggcctgg cctggctgag
       61 gggaggctgg cgggcgggca ggcgcgatgg cggaggccgg gccacaggcg ccgccgcccc
      121 cgggtactcc aagccggcac gagaagagtc tgggacttct caccaccaag ttcgtgtcgc
      181 ttctgcagga agccaaggac ggcgtgcttg acctcaagtt ggcagccgac actcttgctg
      241 tacgccagaa acggcggatt tacgacatca ccaacgtgtt ggaaggtatt ggtctgatcg
      301 agaaaaaatc caagaacagc atccagtgga agggcgtcgg gccaggttgc aatacccggg
      361 agattgccga caaactgatt gagctcaagg cagagatcga ggagctacag cagcgggagc
      421 aagaacttga ccagcacaag gtgtgggtgc agcagagcat ccggaatgtc gcagaggacg
      481 tccagaacag ctgcttggcc tacgtgactc atgaagacat ctgcaggtgc tttgctggag
      541 ataccctcct tgctatccga gccccatcgg gcaccagcct ggaggtgccc atcccagagg
      601 gtctcaatgg tcagaagaag taccagattc acttaaagag catgagtggt cccattgagg
      661 tcctgctagt gaacaaggag gcctggagtt caccacctgt ggctgtgccc gtacctcccc
      721 ctgacgatct actccagagc ccacctgctg tgtctacacc tccacctctg cccaagcctg
      781 ccttagctca tccccaagaa acctctcgtc caagcagccc ccagataact acccccactc
      841 ctgtccttgg cagcactgaa gtctcagatg tggcaggcca gacagctgag attgcagtga
      901 gtggtagccc tggaactgag aacaagggca gtggtgaact cagttcactc ccactgggcc
      961 tgacagcact ggacactcga cctctgcagt cctctgcact actggatagt agcagcagca
     1021 gcagcagcag tagcagcagc agcagcagca gcagcagttc atctggaccc aacccttcta
     1081 cctcctttga gcccatcaag gcagacccca caggcgttct ggatctcccc aaagagctgt
     1141 cagaaatctt cgaccccaca agagagtgca tgagctccga gctgctggaa gaattgatgt
     1201 cttcagaagt gtttgccccc ctcctccgac tttctccacc tcccggagac cacgattaca
     1261 tctacaacct ggacgagagt gaaggtgtct gtgatctctt tgatgttcct gttctcaaac
     1321 tctgacttac agggatatgt cctgtgcagc tgcaacccag actgtctggg ctgggagcca
     1381 actaggaact gccccctacc ctcgccctga ccccgagagc ccaactcttg gtttacttgg
     1441 ccttttctgg ttgctcagtt ctggcagtgc tcttctgtct tgtactggta cttgtaactg
     1501 tgctagcata gctggacaga gagctcagcc gtctacatgg agccaaaccg tttgcctttt
     1561 ctttcttgga gccttctcca gccaggctca gctgccactc agtggcattt ctgccctgtt
     1621 actaccagtc actacgaagg ttcagaaagg agggggagct ggttggttgc cagcaatctc
     1681 ccttccttcc ttcctgctca ccctgcagct tctggacctc tctcagctat gccctgagtc
     1741 ctgggatctc tgggtagcca tggagtggat taatagggaa tcggtgtgtc tagctaggag
     1801 tctgggtggg ttggtacctg gagtggctcc acctcctgcc ctccattctc cttcacttcc
     1861 acttattcac ttaccctcat ttagagccat tgcagagatt tagaaagatt tacagtaacg
     1921 aatgaattcc tatataaaga ttatttttat acttttttca gtaaaaggaa attgtaatat
     1981 ttgtacagca ttcaagtgaa taaagacatg cctaaggcta
//
