LOCUS       NM_001100778            2643 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus E2F transcription factor 1 (E2f1), mRNA.
ACCESSION   NM_001100778 XM_001065036 XM_230765
VERSION     NM_001100778.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2643)
  AUTHORS   Ding,Y., Chen,F., Yang,W., Fu,X. and Xie,Y.
  TITLE     SENP5 deteriorates traumatic brain injury via SUMO2-dependent
            suppression of E2F1 SUMOylation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (8), 1193-1203 (2023)
   PUBMED   37403456
  REMARK    GeneRIF: SENP5 deteriorates traumatic brain injury via
            SUMO2-dependent suppression of E2F1 SUMOylation.
REFERENCE   2  (bases 1 to 2643)
  AUTHORS   Zhu,R., Hou,M., Zhou,Y., Ye,H., Chen,L., Ge,C., Duan,S., Yin,L. and
            Chen,Y.
  TITLE     Spherical alpha-helical polypeptide-mediated E2F1 silencing against
            myocardial ischemia-reperfusion injury (MIRI)
  JOURNAL   Biomater Sci 10 (21), 6258-6266 (2022)
   PUBMED   36111777
  REMARK    GeneRIF: Spherical alpha-helical polypeptide-mediated E2F1
            silencing against myocardial ischemia-reperfusion injury (MIRI).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2643)
  AUTHORS   Dzreyan,V., Eid,M., Rodkin,S., Pitinova,M. and Demyanenko,S.
  TITLE     E2F1 Expression and Apoptosis Initiation in Crayfish and Rat
            Peripheral Neurons and Glial Cells after Axonal Injury
  JOURNAL   Int J Mol Sci 23 (8), 4451 (2022)
   PUBMED   35457270
  REMARK    GeneRIF: E2F1 Expression and Apoptosis Initiation in Crayfish and
            Rat Peripheral Neurons and Glial Cells after Axonal Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2643)
  AUTHORS   Su,D. and Meng,Y.
  TITLE     Biological effects of miRNA-24/E2F1 on myocardial
            ischemia-reperfusion injury
  JOURNAL   Minerva Surg 77 (2), 187-188 (2022)
   PUBMED   34342400
  REMARK    GeneRIF: Biological effects of miRNA-24/E2F1 on myocardial
            ischemia-reperfusion injury.
REFERENCE   5  (bases 1 to 2643)
  AUTHORS   Jackson,D.P., Ting,J.H., Pozniak,P.D., Meurice,C., Schleidt,S.S.,
            Dao,A., Lee,A.H., Klinman,E. and Jordan-Sciutto,K.L.
  TITLE     Identification and characterization of two novel alternatively
            spliced E2F1 transcripts in the rat CNS
  JOURNAL   Mol Cell Neurosci 92, 1-11 (2018)
   PUBMED   29936143
  REMARK    GeneRIF: Two novel alternatively spliced E2F1 transcripts were
            identified in rat hippocampus.
REFERENCE   6  (bases 1 to 2643)
  AUTHORS   Field,S.J., Tsai,F.Y., Kuo,F., Zubiaga,A.M., Kaelin,W.G. Jr.,
            Livingston,D.M., Orkin,S.H. and Greenberg,M.E.
  TITLE     E2F-1 functions in mice to promote apoptosis and suppress
            proliferation
  JOURNAL   Cell 85 (4), 549-561 (1996)
   PUBMED   8653790
REFERENCE   7  (bases 1 to 2643)
  AUTHORS   Yamasaki,L., Jacks,T., Bronson,R., Goillot,E., Harlow,E. and
            Dyson,N.J.
  TITLE     Tumor induction and tissue atrophy in mice lacking E2F-1
  JOURNAL   Cell 85 (4), 537-548 (1996)
   PUBMED   8653789
REFERENCE   8  (bases 1 to 2643)
  AUTHORS   Hosokawa,Y., Yang,M., Kaneko,S., Tanaka,M. and Nakashima,K.
  TITLE     Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1
            during the prolactin-induced G1/S transition in rat Nb2 pre-T
            lymphoma cells
  JOURNAL   Biochem Mol Biol Int 37 (2), 393-399 (1995)
   PUBMED   8673024
REFERENCE   9  (bases 1 to 2643)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2643)
  AUTHORS   Takeuchi,Y. and Harada,F.
  TITLE     Cloning and characterization of rat 4.5S RNAI genes
  JOURNAL   Nucleic Acids Res 14 (4), 1643-1656 (1986)
   PUBMED   3951992
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Jun 1, 2008 this sequence version replaced
            XM_230765.4, XM_001065036.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.14078.1,
                                           SRR26643297.13477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               JAXUCZ010000003.1  163535156-163535563 c
            409-499             JAXUCZ010000003.1  163529844-163529934 c
            500-719             JAXUCZ010000003.1  163529301-163529520 c
            720-872             JAXUCZ010000003.1  163528382-163528534 c
            873-987             JAXUCZ010000003.1  163526583-163526697 c
            988-1204            JAXUCZ010000003.1  163526273-163526489 c
            1205-2643           JAXUCZ010000003.1  163524739-163526177 c
FEATURES             Location/Qualifiers
     source          1..2643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2643
                     /gene="E2f1"
                     /note="E2F transcription factor 1"
                     /db_xref="GeneID:399489"
                     /db_xref="RGD:728892"
     exon            1..408
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1452
                     /gene="E2f1"
                     /note="E2F-1"
                     /codon_start=1
                     /product="transcription factor E2F1"
                     /protein_id="NP_001094248.1"
                     /db_xref="GeneID:399489"
                     /db_xref="RGD:728892"
                     /translation="MAVAPAGGQHAPALEALLGAGALRLLDSSQIVIISTAPDVGAPQ
                     VPTGPAAPPAGPRDPDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGS
                     SGPFRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKV
                     QKRRIYDITNVLEGIQLIAKKSKNHIQWLGSRTMVGIGQRLEGLTQDLQQLQESEQQL
                     DHLMHICTTQLQLLSEDSDIQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAVDS
                     AETFQISLKSKQGPIDVFLCPEESAEGISPGRTSYQETSGEDRNADSGTAGPPPSPPS
                     TSPTLDPSQSLLGLEQEAVLPRIGNLRAPMEEDRLSPLVAADSLLEHVKEDFSGLLPG
                     EFISLSPPHEAVDYHFGLEEGEGIRDLFDCDFGDLTPLDF"
     exon            409..499
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..719
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..872
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..987
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1204
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..2643
                     /gene="E2f1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcaaaaa ggatttggcg cgtaaaagtg gcccggactt tgcaggcagc ggcggccggg
       61 gcggagcggg atcgagccct cgccgcggcc tgccgtcatg ggcccgcgcc gccgccgccg
      121 cctgcctccc gggccacgcg ggccgtgagt gccatggccg tagcccccgc gggcggccag
      181 cacgcgccgg cgctggaggc cctgctcggg gcgggcgcgc tgcggctgct cgactcctcg
      241 cagatcgtca tcatctccac cgcgcccgat gtcggcgccc cgcaggtccc caccggcccc
      301 gccgcgccgc ccgctggccc tcgagatcct gacgtgctgc tcttcgcaac gccgcaggcg
      361 ccccgacccg cgcctagtgc accgcgcccg gctctcggcc gcccgccggt gaaacggagg
      421 ctggatctgg aaactgacca tcagtacctt gctggtagca gcgggccatt ccggggcaga
      481 ggccgccacc cagggaaagg tgtgaaatct ccaggggaga agtcacgcta tgagacctca
      541 ctaaatctga ccaccaaacg cttcttggag ctgctgagcc actcagctga tggtgttgtt
      601 gatctgaact gggcagccga ggtgctgaag gtgcagaaac gacgcatcta tgacatcacc
      661 aatgtcctgg agggcatcca actcattgcc aagaagtcca agaatcatat ccagtggcta
      721 ggcagccgca ccatggtggg gatcggtcag cggcttgaag gcctgaccca ggacctgcaa
      781 caactgcagg agagtgagca gcagctggat cacctgatgc acatctgtac cactcagctg
      841 caactgcttt ctgaggactc agacatccag cgcctggcct atgtgacctg ccaagatctc
      901 cgcagcattg cagaccctgc agaacaaatg gtcatagtga tcaaggcccc tcctgagacc
      961 caactacaag ctgtggattc tgcagagaca tttcagatct cccttaagag caaacaaggc
     1021 cccatcgatg ttttcctgtg ccctgaggaa agtgcagagg ggattagccc tgggaggacc
     1081 tcataccagg agacatctgg ggaggacagg aatgctgact ctggcacagc agggcctcca
     1141 ccatcacctc cctccacatc cccaaccttg gatcccagcc agtccctgtt aggcctggag
     1201 caagaagctg tattgcctcg aataggcaac ctgagggccc ccatggaaga agaccggttg
     1261 tcaccactgg tggctgctga ctcactcctg gagcatgtta aagaagactt ctctgggctc
     1321 ctccctgggg agttcatcag cctttcccca ccccatgagg ctgttgacta tcactttggt
     1381 ctcgaggagg gtgagggcat tagagatctc tttgactgtg actttgggga cttgacccct
     1441 ctggatttct gacagaagcc tagggactcg gtgtctggag atgcccacct tgtctgctgc
     1501 agctttggag cgtcctgccc tgggccatcc ttcctgcctc gttggaatag catgattcat
     1561 actctcttct ctgtccagta gcttctagct ctggggtttg gttgctgcca cattgagcag
     1621 accaaagggg gaggatgttg tacagtgtat gtgcatgcac cccatactgc gcactgtgta
     1681 cctggggtgt gtgtgtgttt atgtgtgtgt atgtgtgtgt gccggggaat gaaggtgaac
     1741 acatctgtat gtgtgctgca gacacatcct ggtgtgtcca catgtgtgca tgagtccatg
     1801 tgtgcgcatt ggggtggggt gggctctaac agcacttttg gtgtccttgc tgcaggggcc
     1861 ctgtgaggcc cagggtggct gcctgcttcc agaatcctgt gtcagccagg ccgggtggtg
     1921 cagcttggct gactgggttt gcagggcagc aagagcactg cttaaaggtt ttccgatcga
     1981 agctttaatg gaacgtttat ttatttatcg aggcctctgg caaacctggg gaataagcaa
     2041 agagtgggga gatgtggggg ccgatacccc aaatccctgt tctctgaagc aagggcaggg
     2101 tcccctactc aaggagctga ggcccaagca gtttatttat tgggagagag ggagacagac
     2161 tgacagccat ggatgggctg gagaaagtcc ctttttagaa ggtagtacca gcaccctggc
     2221 cacatgcatg catgtggatc tgagatggag agggtgagtg agggccttgg ctgatagggt
     2281 gggcaggagg ggtagatgtg ggtccctcct gtggttggag cgctccactg cccttcccac
     2341 tggccagtct gcactttggt ttattttcta acagttctgt tccctcctgc tttgattttt
     2401 aataaatatt ttgatggtgt taggctgggt tggggactct gtgaggctag tgttgggggg
     2461 aatgttcatt ccctgtacct gacttaattt cctttcaatt tgtaacccct tgagaagagg
     2521 aaaactgacc aagtgatggg taggagatta tgtgtgttac ctaagtacag aaaagtgtca
     2581 gtctgcttgt tgcgcacctt ctggtcattt ctgagcatta gtaaagatgc aacacacagt
     2641 gaa
//
