LOCUS       NM_001107869            6319 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dysferlin (Dysf), mRNA.
ACCESSION   NM_001107869 XM_001069038 XM_232123
VERSION     NM_001107869.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6319)
  AUTHORS   Hofhuis,J., Bersch,K., Wagner,S., Molina,C., Fakuade,F.E.,
            Iyer,L.M., Streckfuss-Bomeke,K., Toischer,K., Zelarayan,L.C.,
            Voigt,N., Nikolaev,V.O., Maier,L.S., Klinge,L. and Thoms,S.
  TITLE     Dysferlin links excitation-contraction coupling to structure and
            maintenance of the cardiac transverse-axial tubule system
  JOURNAL   Europace 22 (7), 1119-1131 (2020)
   PUBMED   32572487
  REMARK    GeneRIF: Dysferlin links excitation-contraction coupling to
            structure and maintenance of the cardiac transverse-axial tubule
            system.
REFERENCE   2  (bases 1 to 6319)
  AUTHORS   Li,L., Zhang,H., Wang,W., Hong,Y., Wang,J., Zhang,S., Xu,S.,
            Shu,Q., Li,J., Yang,F., Zheng,M., Qian,Z. and Liu,P.
  TITLE     Comparative proteomics reveals abnormal binding of ATGL and
            dysferlin on lipid droplets from pressure overload-induced
            dysfunctional rat hearts
  JOURNAL   Sci Rep 6, 19782 (2016)
   PUBMED   26795240
  REMARK    GeneRIF: These findings highlight an association between the
            altered lipid droplets protein localization of dysferlin and ATGL
            and myocardial dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6319)
  AUTHORS   McDade,J.R., Archambeau,A. and Michele,D.E.
  TITLE     Rapid actin-cytoskeleton-dependent recruitment of plasma
            membrane-derived dysferlin at wounds is critical for muscle
            membrane repair
  JOURNAL   FASEB J 28 (8), 3660-3670 (2014)
   PUBMED   24784578
REFERENCE   4  (bases 1 to 6319)
  AUTHORS   Grounds,M.D., Terrill,J.R., Radley-Crabb,H.G., Robertson,T.,
            Papadimitriou,J., Spuler,S. and Shavlakadze,T.
  TITLE     Lipid accumulation in dysferlin-deficient muscles
  JOURNAL   Am J Pathol 184 (6), 1668-1676 (2014)
   PUBMED   24685690
REFERENCE   5  (bases 1 to 6319)
  AUTHORS   Kerr,J.P., Ziman,A.P., Mueller,A.L., Muriel,J.M.,
            Kleinhans-Welte,E., Gumerson,J.D., Vogel,S.S., Ward,C.W.,
            Roche,J.A. and Bloch,R.J.
  TITLE     Dysferlin stabilizes stress-induced Ca2+ signaling in the
            transverse tubule membrane
  JOURNAL   Proc Natl Acad Sci U S A 110 (51), 20831-20836 (2013)
   PUBMED   24302765
REFERENCE   6  (bases 1 to 6319)
  AUTHORS   Hernandez-Deviez,D.J., Martin,S., Laval,S.H., Lo,H.P., Cooper,S.T.,
            North,K.N., Bushby,K. and Parton,R.G.
  TITLE     Aberrant dysferlin trafficking in cells lacking caveolin or
            expressing dystrophy mutants of caveolin-3
  JOURNAL   Hum Mol Genet 15 (1), 129-142 (2006)
   PUBMED   16319126
REFERENCE   7  (bases 1 to 6319)
  AUTHORS   Lennon,N.J., Kho,A., Bacskai,B.J., Perlmutter,S.L., Hyman,B.T. and
            Brown,R.H. Jr.
  TITLE     Dysferlin interacts with annexins A1 and A2 and mediates
            sarcolemmal wound-healing
  JOURNAL   J Biol Chem 278 (50), 50466-50473 (2003)
   PUBMED   14506282
REFERENCE   8  (bases 1 to 6319)
  AUTHORS   Bansal,D., Miyake,K., Vogel,S.S., Groh,S., Chen,C.C.,
            Williamson,R., McNeil,P.L. and Campbell,K.P.
  TITLE     Defective membrane repair in dysferlin-deficient muscular dystrophy
  JOURNAL   Nature 423 (6936), 168-172 (2003)
   PUBMED   12736685
REFERENCE   9  (bases 1 to 6319)
  AUTHORS   Davis,D.B., Doherty,K.R., Delmonte,A.J. and McNally,E.M.
  TITLE     Calcium-sensitive phospholipid binding properties of normal and
            mutant ferlin C2 domains
  JOURNAL   J Biol Chem 277 (25), 22883-22888 (2002)
   PUBMED   11959863
REFERENCE   10 (bases 1 to 6319)
  AUTHORS   Liu,J., Aoki,M., Illa,I., Wu,C., Fardeau,M., Angelini,C.,
            Serrano,C., Urtizberea,J.A., Hentati,F., Hamida,M.B., Bohlega,S.,
            Culper,E.J., Amato,A.A., Bossie,K., Oeltjen,J., Bejaoui,K.,
            McKenna-Yasek,D., Hosler,B.A., Schurr,E., Arahata,K., de Jong,P.J.
            and Brown,R.H. Jr.
  TITLE     Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi
            myopathy and limb girdle muscular dystrophy
  JOURNAL   Nat Genet 20 (1), 31-36 (1998)
   PUBMED   9731526
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232123.4, XM_001069038.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..6319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..6319
                     /gene="Dysf"
                     /note="dysferlin"
                     /db_xref="GeneID:312492"
                     /db_xref="RGD:1311023"
     CDS             1..6090
                     /gene="Dysf"
                     /codon_start=1
                     /product="dysferlin"
                     /protein_id="NP_001101339.1"
                     /db_xref="GeneID:312492"
                     /db_xref="RGD:1311023"
                     /translation="MLCCLLARASNLPNVKKDRRSDPVASLIFREAKIPLQEVLATPS
                     LSASFNAPLLDSKQQPTGASLVLQVSYTPPPGAAPLFPPPASLAPSPTLPDMDLVADT
                     GGEEDTEDQGLTGDEAELFPDPSVAVGPGGPTTPKKPPSHPPPHYPGGKRKRSSAPPR
                     KLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIQKGNSPLFNETLFF
                     NVFDSPLELFDEPIFITVVDSRSLRTDALLGEFRMDVGTVYREPRHAYLRKWLLLSDP
                     DDFSAGARGYLKASLCVLGPGDEAPLDKKDPSEDKEDIEGNLLRPTGVALRGAHFCLK
                     LFRAEDLPQMDDAVMDNVKQIFGFDSNKKNLVDPFVEVSFAGKMLCSKILEKTANPQW
                     NQNITLPAMFPSMCEKMRIRVMDWDRLTHNDTVATTYLGMSKISATGGEIEEEPAGVL
                     KSPATDLDDNLGFLPTFGPCYVNLYGSPREFTGFPDPYAELNTGKGEGVAYRGRLLLS
                     LETKLVEHSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSI
                     GNYGNKFDTTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRVETQ
                     NQLLRIADRLEANLEQVHLALKAQCSSEDVDALVAQLTDELLADCSQPLCDIHEIPSA
                     THLDQYLFRLRSRHLSQIKEAALALKLGHSELSTALEQAEDWLLHLRALAEEPQNSLP
                     DIIIWMLQGDKRVAYQRVPAHEVLFSRRGPSYCGRNCGNLQTIFLKYPMEGMPGPRMP
                     VQIRIKLWFGLSVDEKEFNQFAEGKLSVFAETYENQTKLALVGNWGTTGLTYPKFSDV
                     TGKIKLPKDSFRPSAGWAWAGDWFVCPEKTLLHDADAGHLSFVEEVFENQTRLPGGQW
                     IYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPDRK
                     PKHWVPVEKMYYTHRRRRWVRLRRRDLSQMEALKKHRQAEAEGEGWEYASLFGWKFHL
                     EYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGMVDDKSEDSMSVSTLSFGVNR
                     PTISCIFDYGNRYHLRCYLYQARDLPAMDKDSFSDPYAIVSFLHQSQKTVVEKNTLNP
                     TWDQTLIFYEIEIFGEPASVAERPPSIVVELYDHDTYGADEFMGRCICQPSLERMPRL
                     AWFPLTRGSQPAGELLAAFELIQREKPAIHHIPGFEMHETSRILDETEDTDLPYPPPQ
                     REANIYMVPQNIKPALQRTAIEILAWGLRNIKSYQMASVSSPSLVVECGGQTVQSCVI
                     RNLRKNPNFDVCTLFMEVMLPREDLYCPPIVVKVIDNRQFGRRPVVGQCTIRSLENFL
                     CDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPVQEEEFIDWWSKFFASIGE
                     REKCGSYLEKDFDTLKVYDTQLENVEAFGGLSDFCNTFKLYRGKTQEDTEDPSVIGEF
                     KGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIIRAFGLQPKDPNGKCDPYI
                     KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGE
                     TVIDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD
                     RVTFQDKEYTIQEIEAGRLPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPD
                     IEQGKLQMWIDIFPKVLGRPGPPFNITPRKARRFFLRCIIWNTKDVILDDLSLTGEKM
                     SDIYVKGWMVGFEEHKQKTDVHYRSLGGEGNFNWRFVFPFDYLPAEQVCAVAKKDAFW
                     RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAEKCSLDQLDDTF
                     HPEWFVSLFEQKTVKGWWPCVTEEGAKKILAGKLEMTLEIVAESEHEERPAGQGRDEP
                     NMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRCAIILFIILFILLLFLGVFVYAF
                     PNYAAMKLVKPFR"
     exon            1..91
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            92..186
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            187..301
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            302..513
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            514..642
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            643..705
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            706..756
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            757..787
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            788..903
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1030
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1134
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1203
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1247
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1330
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1369
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1485
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1599
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1777
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1902
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2009
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2202
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2358
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2490
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2657
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2772
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2878
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3021
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3195
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3289
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3367
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3549
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3690
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3720
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3750
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3852
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..4014
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4180
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4257
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4356
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4485
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4641
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4733
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4734..4904
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            4905..5047
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5187
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5188..5276
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5277..5372
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5373..5514
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5515..5614
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5615..5793
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5794..5903
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            5904..6051
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
     exon            6052..6319
                     /gene="Dysf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctctgct gcctgctggc aagggccagc aacctcccca atgtgaagaa ggaccggcgc
       61 agtgaccctg ttgccagcct gatttttcga gaagccaaga tcccactcca ggaggtcctt
      121 gccaccccca gcctatctgc cagcttcaac gcacctctgc tggactccaa gcagcaaccc
      181 acaggggcct ctctggtcct gcaggtatcc tacacaccgc ccccaggagc tgcgcccttg
      241 ttcccaccac ccgcttccct ggcaccgtcc ccaacactgc ctgacatgga cctggtggct
      301 gacacaggag gagaggaaga cacggaagac cagggcctga ctggagatga agctgagctc
      361 ttcccagatc cgagtgttgc tgtgggccca gggggaccaa cgacgcccaa gaagccacct
      421 tcccatcctc ctccccacta tccagggggg aaaaggaaaa gaagctctgc tccacctaga
      481 aagctgctgt cagacaagcc acaggacttc cagatcagag tccaggtgat tgaggggcgt
      541 cagctgcctg gggtgaacat caagcctgtg gtcaaggtca cagctgctgg gcagaccaag
      601 cggactcgaa tccagaaggg aaatagccca cttttcaatg agactctttt cttcaacgta
      661 tttgactctc ccttggaact gtttgatgag cccatcttca tcacggtggt agactcacgc
      721 tccctcagga cagatgccct ccttggcgag ttccggatgg atgtgggcac cgtgtacaga
      781 gagccccgac atgcttatct ccggaagtgg ctgctgctct ccgatcccga tgacttctct
      841 gcaggggcca gaggctacct caaagccagc ctgtgtgtgc tggggcctgg ggacgaagct
      901 cccctagaca agaaagaccc ttctgaagac aaagaggaca ttgaaggcaa cctgcttagg
      961 cccactggtg tggcccttcg tggtgcccat ttttgcctga agctcttccg ggctgaggac
     1021 ttaccacaga tggacgatgc tgtgatggac aacgtcaagc aaatctttgg ctttgatagc
     1081 aacaagaaga acctggtgga cccctttgtg gaagtcagct ttgctgggaa aatgctttgc
     1141 agcaagatcc tggagaagac tgctaaccct cagtggaacc agaacatcac attgcctgcg
     1201 atgtttccct ctatgtgtga aaaaatgagg attcgtgtca tggactggga ccgcctcact
     1261 cacaatgaca ctgtggctac cacctacttg ggtatgtcga aaatctctgc cactggagga
     1321 gaaatagaag aggagcctgc aggtgtactc aagagtccag ccactgacct ggatgacaac
     1381 ctgggcttcc tccccacttt tgggccctgc tatgtgaacc tctatggcag tccccgagag
     1441 ttcacgggct tcccagatcc ttatgcggag ctcaacacag gaaagggaga aggtgtggca
     1501 tataggggca ggcttctgtt gtccctggag accaaactgg tggagcacag tgaacagaag
     1561 gtggaagacc ttcctgctga tgacatcttg agagtggaga agtacctgcg gaggcgcaaa
     1621 tattccctct ttgctgcctt ctactcagcc acaatgctgc aggatgtgga tgatgccatc
     1681 cagttcgagg tcagcattgg gaactacgga aacaagtttg acaccacctg cttgccgttg
     1741 gcctctacca cccaatacag ccgggcagtc tttgatggat gccactacta ttatttgccc
     1801 tggggcaacg tgaagcctgt ggtagtactg tcctcatact gggaagacat cagccatcga
     1861 gtcgagactc agaaccagct cctcaggatc gctgaccgac tggaagctaa cctggagcaa
     1921 gtccacctgg ctctgaaggc acagtgttcc tctgaggatg tggacgccct ggtggctcag
     1981 ttgacagatg agctccttgc agactgcagc cagcccctgt gtgacatcca tgaaatacct
     2041 tctgccaccc accttgatca gtacctgttc cgcctccgct cccgtcacct gagccagatc
     2101 aaagaagctg ccctggcctt gaagcttggc cacagtgagc tctccactgc cctggagcag
     2161 gccgaggact ggcttctgca tctccgtgcc ctggctgagg agccccagaa cagcctgcca
     2221 gatatcatca tctggatgct gcagggtgac aagcgtgtgg cctaccaacg ggtgcctgcc
     2281 catgaagtcc tcttctcccg gcggggcccc agctactgcg gcaggaactg tgggaatctg
     2341 cagaccatct ttctgaaata tcctatggaa ggcatgcctg ggccccggat gccggtgcag
     2401 atccggatca agctctggtt tgggctctca gtggatgaga aggaattcaa tcagtttgca
     2461 gaggggaagc tctctgtctt tgctgaaacg tatgagaacc agacaaagct ggcgctggtc
     2521 gggaactggg gcacgacggg cctcacctac cccaagtttt ctgacgtcac aggcaagatc
     2581 aaactaccga aggatagctt ccgcccctca gctggctggg cctgggcagg agactggttc
     2641 gtgtgtccag agaagaccct gctccatgat gctgacgccg gtcatctgag ctttgtggag
     2701 gaggtgtttg agaaccagac tcggctacct ggaggccagt ggatctatat gagtgacaac
     2761 tacaccgacg tgaatgggga gaaggtgctt ccaaaggacg atattgaatg cccgctgggt
     2821 tggaagtggg aagatgaaga atggtccaca gacctcaatc gggctgttga tgaacaaggc
     2881 tgggagtaca gcatcaccat acccccagac cgaaagccca aacactgggt ccctgttgag
     2941 aagatgtatt acactcacag gcgtcgacgc tgggtccgac tgcgcaggag ggacctcagc
     3001 cagatggagg cactgaagaa gcacaggcag gcagaggctg agggcgaggg ctgggaatac
     3061 gcctctctct ttggctggaa gttccacctg gagtaccgca agacagatgc ctttcgccgc
     3121 cgccgctggc gccgccgcat ggagccactg gagaagacgg ggcctgcagc ggtgtttgcc
     3181 cttgaggggg ccctgggcgg catggtggat gacaagagcg aagattccat gtctgtgtct
     3241 accctgagct ttggcgttaa cagacccaca atctcctgca tctttgacta tgggaaccgc
     3301 taccatctgc gttgctacct gtaccaggcc cgggacctgc ccgccatgga caaagactcc
     3361 ttctctgatc cctatgccat tgtctccttc ctgcatcaaa gccagaagac ggtggtggag
     3421 aagaacaccc tgaaccccac ctgggatcaa accctcatct tctatgagat agagatcttt
     3481 ggcgagccgg ccagtgtcgc cgagcggcca cccagcattg tggtggagct gtatgaccat
     3541 gacacctatg gcgctgacga gttcatgggc cgctgtattt gtcagccaag cctggaacgg
     3601 atgccccgcc tggcctggtt cccactgacc aggggcagcc agcctgccgg agagctgctg
     3661 gcagcgttcg agcttatcca gagagagaag ccagccatcc atcacatccc tggctttgag
     3721 atgcacgaaa cttcaaggat tttggatgag acggaggaca cagacttgcc ttacccacca
     3781 cctcaaaggg aggccaacat ctacatggtt ccccagaaca tcaagccagc tctccagcgt
     3841 acagccatcg agatcctggc ctggggcctt cggaacataa agagctatca gatggccagc
     3901 gtgtcttccc ccagcctcgt ggtggagtgt ggtgggcaga cagtgcagtc ctgtgtcatc
     3961 agaaaccttc ggaagaaccc caactttgac gtctgtactc tgttcatgga agtgatgtta
     4021 cccagagagg acctctactg tccccctatt gtggtcaagg tcattgataa tcgccagttt
     4081 ggccgcaggc cagttgtggg tcagtgcacc attcgctccc tggagaactt cctgtgtgac
     4141 ccgtactcag cagagagtcc atccccgcaa ggtggcccag atgacgtgag cttactcagc
     4201 cctggggaag acgtgctcat tgacattgat gacaaggagc ctctcatccc tgtccaggag
     4261 gaggagttca ttgactggtg gagcaaattc tttgcttcta tcggggagag agaaaagtgt
     4321 ggttcctacc tggagaagga ttttgacacc ctgaaggtct atgacacaca gctggagaat
     4381 gtggaggcct ttggaggcct gtccgacttt tgtaatacct tcaagctcta ccggggcaag
     4441 actcaggagg acacagaaga tccatctgtc atcggagaat ttaagggtct cttcaaaatt
     4501 tatcccctcc cagaagatcc agccatccct atgcccccga gacaattcca tcagctggct
     4561 gctcagggtc cccaggaatg cttggtccgg atttacatca tccgagcatt tggcttacag
     4621 cccaaggacc ccaatggcaa gtgcgaccct tacatcaaga tctctatagg gaagaaatca
     4681 gtgagtgacc aggataacta catcccttgt accctggagc ctgtatttgg aaagatgttt
     4741 gaactcacct gcactctacc tctggagaag gacttgaaga tcacactcta tgactatgac
     4801 ctgctctcca aggatgagaa gattggggag acagtcattg atctggagaa taggctgctg
     4861 tccaagtttg gggctcgctg tggccttcca cagacctact gtgtctctgg accaaatcag
     4921 tggagagatc aactccgccc ttcccagctc ctccacctct tctgccagca gcacagggtc
     4981 aaggcccccg tgtaccggac agaccgagtg acgtttcagg ataaggaata caccattcag
     5041 gagatagagg ctggcagact cccaaaccca cacctgggcc cggtggagga acgcttagcc
     5101 ctgcatgtcc ttcaacaaca aggcttggtc cctgagcatg tggagtctcg gcctctgtac
     5161 agtcctctgc agccagatat tgagcagggg aagctacaga tgtggattga catatttcca
     5221 aaggtgctgg gccggcctgg acctcccttc aacatcaccc cacggaaagc tcgaaggttt
     5281 tttctgcgtt gtattatttg gaacacaaaa gatgtgatct tggatgacct cagcctcacg
     5341 ggggagaaga tgagtgacat ctatgtgaaa ggctggatgg tgggattcga agaacacaaa
     5401 cagaagacag atgtgcacta ccgttccctg ggcggggagg gcaatttcaa ctggaggttc
     5461 gtgtttccct tcgactatct gcccgctgag caagtctgtg ctgttgccaa gaaggatgct
     5521 ttctggagac tcgacaagac agagagcaag atcccagcac gtgtggtctt ccagatttgg
     5581 gacaatgaca agttctcctt tgatgacttt ctgggctccc tgcagctgga tctcaaccga
     5641 atgcccaagc cagccaagac ggctgagaag tgctccttgg accagctgga tgacaccttc
     5701 cacccagaat ggtttgtgtc cctttttgag cagaagacag tgaaaggatg gtggccttgt
     5761 gtgacagagg agggcgcgaa gaagatcctg gcggggaagc tggaaatgac cttggagatc
     5821 gttgcagaaa gtgaacatga ggagcggcct gctggccagg gtcgggatga acccaacatg
     5881 aatccaaagc tagaagatcc caggcgccct gacacctctt tcctgtggtt cacctcacca
     5941 tacaagacca tgaagttcat cttgtggcga cgattccggt gtgccatcat cctcttcatc
     6001 atcctcttca tcctcctgct cttcctgggt gtctttgtct acgccttccc gaactatgct
     6061 gccatgaagc tggtgaagcc ctttagatga agacatctgc tgtggagaag ggggcgcagg
     6121 ctgcctcctg gcccaggact agctgctcct ccattgctct ggggcctggt ggtcttgcgc
     6181 atgtccacgg agttcttggg atcacaccgt tttcatcttc tctttctccc ctaacccaac
     6241 tctcctctgg ataaactctt gactatctca gtataaagca gacagaacct gagaatatat
     6301 cactatgtgt ctccagtcc
//
