LOCUS       NM_001024767            2146 bp    mRNA    linear   ROD 06-MAY-2024
DEFINITION  Rattus norvegicus dual specificity tyrosine phosphorylation
            regulated kinase 3 (Dyrk3), transcript variant 1, mRNA.
ACCESSION   NM_001024767 XM_222607
VERSION     NM_001024767.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Rai,A.K., Chen,J.X., Selbach,M. and Pelkmans,L.
  TITLE     Kinase-controlled phase transition of membraneless organelles in
            mitosis
  JOURNAL   Nature 559 (7713), 211-216 (2018)
   PUBMED   29973724
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Kim,K., Cha,J.S., Cho,Y.S., Kim,H., Chang,N., Kim,H.J. and Cho,H.S.
  TITLE     Crystal Structure of Human Dual-Specificity Tyrosine-Regulated
            Kinase 3 Reveals New Structural Features and Insights into its
            Auto-phosphorylation
  JOURNAL   J Mol Biol 430 (10), 1521-1530 (2018)
   PUBMED   29634919
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Wippich,F., Bodenmiller,B., Trajkovska,M.G., Wanka,S., Aebersold,R.
            and Pelkmans,L.
  TITLE     Dual specificity kinase DYRK3 couples stress granule
            condensation/dissolution to mTORC1 signaling
  JOURNAL   Cell 152 (4), 791-805 (2013)
   PUBMED   23415227
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Guo,X., Williams,J.G., Schug,T.T. and Li,X.
  TITLE     DYRK1A and DYRK3 promote cell survival through phosphorylation and
            activation of SIRT1
  JOURNAL   J Biol Chem 285 (17), 13223-13232 (2010)
   PUBMED   20167603
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Wojchowski,D.M., Menon,M.P., Sathyanarayana,P., Fang,J., Karur,V.,
            Houde,E., Kapelle,W. and Bogachev,O.
  TITLE     Erythropoietin-dependent erythropoiesis: New insights and questions
  JOURNAL   Blood Cells Mol Dis 36 (2), 232-238 (2006)
   PUBMED   16524748
  REMARK    Review article
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Li,K., Zhao,S., Karur,V. and Wojchowski,D.M.
  TITLE     DYRK3 activation, engagement of protein kinase A/cAMP response
            element-binding protein, and modulation of progenitor cell survival
  JOURNAL   J Biol Chem 277 (49), 47052-47060 (2002)
   PUBMED   12356771
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Lord,K.A., Creasy,C.L., King,A.G., King,C., Burns,B.M., Lee,J.C.
            and Dillon,S.B.
  TITLE     REDK, a novel human regulatory erythroid kinase
  JOURNAL   Blood 95 (9), 2838-2846 (2000)
   PUBMED   10779429
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097474.1.
            
            On Jun 10, 2005 this sequence version replaced XM_222607.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097474.1, CV115198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132286, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2146
                     /gene="Dyrk3"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 3"
                     /db_xref="GeneID:304775"
                     /db_xref="RGD:1310924"
     exon            1..195
                     /gene="Dyrk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1879
                     /gene="Dyrk3"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dual-specificity tyrosine-(Y)-phosphorylation regulated
                     kinase 3"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 3 isoform 1"
                     /protein_id="NP_001019938.1"
                     /db_xref="GeneID:304775"
                     /db_xref="RGD:1310924"
                     /translation="MGGAARERGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKCP
                     PYTNTLCNPSEAPVSRRLNITTEPFTRGHTQHFVSGGVMKVEQLFQEFGSRRTSTLQS
                     DGVSNSEKSSPASQGKSSDSLGTVKCSLSSRPSKVLPLTPEQALKQYKHHLTAYEKLE
                     IISYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGS
                     FGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
                     FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCD
                     LKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIW
                     SFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLPRY
                     CSVTTQTDGRVVLLGGRSRRGKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDPSA
                     RLTPAQALRHPWISKSAPRPLTTDKVSGKRVVNPTNAFQGLGSKLPPVVGIASKLKAN
                     LMSETSGSIPLCSVLPKLIS"
     exon            196..307
                     /gene="Dyrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            308..2108
                     /gene="Dyrk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcggacc gcgcgagccc atctcagagc cgcggcttgt agtgaagcct gcaggtgcgg
       61 ggctagaggc gacccaccgg gccaaccgcc gcctctgtgc ccgcggggcg agctcgcgat
      121 gggaggcgca gcccgcgagc gcgggaggaa ggacgcggcg ctgccggggg ccgggctccc
      181 gccgcagcag cggaggttgg gggatggtgt ctatgatacc ttcatgatga tagatgaaac
      241 caagtgccca ccctatacaa acacactttg caatccctct gaagcacctg tctccagaag
      301 gctaaatatt accactgagc cattcacgag aggccacact cagcacttcg tgagtggggg
      361 tgtgatgaag gtggagcaac tgtttcaaga atttggcagc agaagaacca gtactctcca
      421 gtccgatggc gtcagcaact ccgaaaagtc ctctcctgct tctcagggga agagttcaga
      481 cagcctgggt acagtgaagt gcagcctctc atccagacca tctaaggtgc tcccgctgac
      541 tcctgagcaa gctctgaagc agtacaagca ccacctcacc gcctacgaga agctggagat
      601 catcagctac ccagaaatct acttcgtggg cccgaatgcc aagaagcggc aaggagttat
      661 tggtggtccc aataacgggg ggtacgacga tgcggacggg gcctatatcc acgtgcctcg
      721 agaccatctg gcttaccgct atgaggtgct gaaaattatt ggcaagggga gttttggaca
      781 ggtagcccgg gtctacgatc acaaactccg acagtacgtg gccctgaaaa tggtgcgcaa
      841 cgagaagcgc tttcaccgcc aggcagccga ggagatccgg attctggagc atcttaaaaa
      901 gcaagacaaa actgggagca tgaatgtcat ccacatgtta gaaagcttca ccttccggaa
      961 ccacgtgtgc atggcctttg agttgctaag catagacctg tacgagctca ttaaaaaaaa
     1021 caagtttcag ggcttcagcg tccagttggt ccggaagttc gcccagtcca tcctgcagtc
     1081 cttggacgcc cttcacaaaa ataagatcat tcactgtgat ctgaagcctg agaacattct
     1141 cctgaagcat cacggacgga gcgcgaccaa ggtcattgac ttcgggtcca gctgttttga
     1201 gtatcagaaa ctttacacgt acatccagtc ccgtttctac agagccccgg aaatcatctt
     1261 ggggtgccgc tacagcacgc caattgacat atggagtttt ggttgcatcc tcgcagaact
     1321 tttgacagga cagcccctgt tcccaggaga ggatgaagga gaccagttgg cctgcatgat
     1381 ggagttgcta ggaatgccac cacagaaact tctggagcaa tccaaacgtg ccaagtactt
     1441 tattaactcc aaaggcttgc ctcgatactg ctccgtaact acccagacgg acgggagggt
     1501 tgtgcttctc gggggccgct cacgcagggg taaaaagcga ggcccaccag gcagcaaaga
     1561 ctgggcagcc gcgctgaagg ggtgcgatga ctacttgttc atagagtttc tgaaaaggtg
     1621 ccttcagtgg gacccctctg cccgcctcac cccagctcaa gcattaagac atccttggat
     1681 tagcaagtct gcacccaggc ccctcaccac ggacaaggtg tcagggaaac gggtagttaa
     1741 tcctacaaat gctttccagg gactgggctc caagctgcct ccagtcgttg gaatcgccag
     1801 taagcttaaa gctaacctaa tgtcggaaac cagtggtagt atacctctgt gcagtgtatt
     1861 gccaaagctg atcagctaat ggaccactca gactcataca tacgtatttt taattacctt
     1921 acagacatgc aaatggaaaa aaaaataatt gaagcccatt caccgatgga tatgtttttg
     1981 ttagactttt tttttttaac aaggcagaac atttttatat gactataaac aaacgcttca
     2041 agggctaatg tctaaccagc ttgtattggc catctggagt atacattaaa tgacttttta
     2101 ataggtcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
