LOCUS       NM_001108100            6248 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dual specificity tyrosine phosphorylation
            regulated kinase 2 (Dyrk2), mRNA.
ACCESSION   NM_001108100 XM_001081013 XM_006241391 XM_235179
VERSION     NM_001108100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6248)
  AUTHORS   Sharma,S., Findlay,G.M., Bandukwala,H.S., Oberdoerffer,S.,
            Baust,B., Li,Z., Schmidt,V., Hogan,P.G., Sacks,D.B. and Rao,A.
  TITLE     Dephosphorylation of the nuclear factor of activated T cells (NFAT)
            transcription factor is regulated by an RNA-protein scaffold
            complex
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11381-11386 (2011)
   PUBMED   21709260
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17235]
REFERENCE   2  (bases 1 to 6248)
  AUTHORS   Taira,N., Yamamoto,H., Yamaguchi,T., Miki,Y. and Yoshida,K.
  TITLE     ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in
            the apoptotic response to DNA damage
  JOURNAL   J Biol Chem 285 (7), 4909-4919 (2010)
   PUBMED   19965871
REFERENCE   3  (bases 1 to 6248)
  AUTHORS   Maddika,S. and Chen,J.
  TITLE     Protein kinase DYRK2 is a scaffold that facilitates assembly of an
            E3 ligase
  JOURNAL   Nat Cell Biol 11 (4), 409-419 (2009)
   PUBMED   19287380
REFERENCE   4  (bases 1 to 6248)
  AUTHORS   Varjosalo,M., Bjorklund,M., Cheng,F., Syvanen,H., Kivioja,T.,
            Kilpinen,S., Sun,Z., Kallioniemi,O., Stunnenberg,H.G., He,W.W.,
            Ojala,P. and Taipale,J.
  TITLE     Application of active and kinase-deficient kinome collection for
            identification of kinases regulating hedgehog signaling
  JOURNAL   Cell 133 (3), 537-548 (2008)
   PUBMED   18455992
REFERENCE   5  (bases 1 to 6248)
  AUTHORS   Taira,N., Nihira,K., Yamaguchi,T., Miki,Y. and Yoshida,K.
  TITLE     DYRK2 is targeted to the nucleus and controls p53 via Ser46
            phosphorylation in the apoptotic response to DNA damage
  JOURNAL   Mol Cell 25 (5), 725-738 (2007)
   PUBMED   17349958
REFERENCE   6  (bases 1 to 6248)
  AUTHORS   Gwack,Y., Sharma,S., Nardone,J., Tanasa,B., Iuga,A., Srikanth,S.,
            Okamura,H., Bolton,D., Feske,S., Hogan,P.G. and Rao,A.
  TITLE     A genome-wide Drosophila RNAi screen identifies DYRK-family kinases
            as regulators of NFAT
  JOURNAL   Nature 441 (7093), 646-650 (2006)
   PUBMED   16511445
REFERENCE   7  (bases 1 to 6248)
  AUTHORS   Woods,Y.L., Cohen,P., Becker,W., Jakes,R., Goedert,M., Wang,X. and
            Proud,C.G.
  TITLE     The kinase DYRK phosphorylates protein-synthesis initiation factor
            eIF2Bepsilon at Ser539 and the microtubule-associated protein tau
            at Thr212: potential role for DYRK as a glycogen synthase kinase
            3-priming kinase
  JOURNAL   Biochem J 355 (Pt 3), 609-615 (2001)
   PUBMED   11311121
REFERENCE   8  (bases 1 to 6248)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 15, 2022 this sequence version replaced
            XM_006241391.4, NM_001108100.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.19634.1,
                                           SRR26643288.30060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               JAXUCZ010000007.1  56248210-56248660   c
            452-600             JAXUCZ010000007.1  56247640-56247788   c
            601-6248            JAXUCZ010000007.1  56235276-56240923   c
FEATURES             Location/Qualifiers
     source          1..6248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..6248
                     /gene="Dyrk2"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 2"
                     /db_xref="GeneID:314862"
                     /db_xref="RGD:1312039"
     exon            1..451
                     /gene="Dyrk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..2205
                     /gene="Dyrk2"
                     /EC_number="2.7.12.1"
                     /note="dual-specificity tyrosine-(Y)-phosphorylation
                     regulated kinase 2"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 2"
                     /protein_id="NP_001101570.2"
                     /db_xref="GeneID:314862"
                     /db_xref="RGD:1312039"
                     /translation="MLTRKPSAAAPAAYPTGRGGDTAVRQLQASPGIGAGAPRSGVGT
                     GPPSPIALPPLRASNATTTSHTIGGGKHTMNDHLHISHSHGQIQVQQLFEDNSNKRTV
                     LTTQPNGLTTVGKTGLPVVPERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMK
                     QYIQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVA
                     YRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQD
                     KDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQC
                     LDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEV
                     ILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKR
                     AKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL
                     DFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTAVKRVTESTGAITSISKLP
                     PPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS"
     exon            452..600
                     /gene="Dyrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..6248
                     /gene="Dyrk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcgaac gcgcgcaggc ccgggaggag gctcccgagc gagtgggtcc cggcggccgc
       61 agcccgctcc ccgcggcccc gatgtgaggg agtcggggag gccagcggtg cggcagggga
      121 gggcgaggca tgtgcacggg ccggggggta cagcagccgc ccgaggacga gggggacggc
      181 ggaggcgagg aggagagcgg ggggctcgcg gcggcgggtc cgggccgagg ggatgcagtg
      241 gactgcgtgt gtctggctgt agcgggagag aggaagcgac gaggcgcggg ggacccgcgt
      301 gaggggcgac caggaggcgg cggcggcggc ggcggcggcg aggagtagcg gcgggaccgg
      361 cggcgagggc agcactgcca tgcacgttcc tctcccgcgg ccatgttaac caggaaacct
      421 tcggccgccg ctcccgccgc ctacccgacc ggccgaggag gggacaccgc cgttcgccag
      481 cttcaggctt ccccggggat cggcgcgggg gctccccgaa gcggagtggg gaccggccca
      541 ccctccccca tcgccctgcc gcctctccgg gccagcaacg ctaccactac atcccacacg
      601 attggcggcg gtaagcacac catgaatgac cacctccaca tcagccacag ccacggacag
      661 atccaggttc agcagctgtt cgaggacaac agtaacaaaa ggacagtgct cacaacccaa
      721 cccaatgggc ttacgacggt gggcaagacg ggcttgcctg tggtgcctga gcggcagctg
      781 gagagcattc acagacggca ggggagttcc acctctctga agtccatgga aggcatgggg
      841 aaggtaaaag ccagccccat gacacctgaa caagcgatga agcaatacat tcaaaaactc
      901 acagccttcg aacaccacga gattttcagc taccccgaaa tctacttctt gggtccaaat
      961 gcaaagaagc gccaaggcat gacaggtgga cccaacaatg gcggttatga tgacgaccag
     1021 ggatcatacg tgcaggtgcc ccacgatcac gtggcttaca ggtacgaggt cctcaaagtc
     1081 atcgggaagg ggagctttgg gcaggtggtc aaggcctatg accacaaagt ccaccagcac
     1141 gtggccctga agatggtgcg gaacgagaag cgcttccacc ggcaggcggc agaggagatc
     1201 cggatcttgg aacacctacg gaagcaggac aaggacaaca ccatgaacgt cattcacatg
     1261 ctggagaact tcaccttccg caaccatatc tgcatgacgt tcgagctgct gagcatgaac
     1321 ctctatgagc tcatcaagaa gaataagttc caaggcttca gcctgcctct ggtgcgcaag
     1381 ttcgcccact ccattctgca gtgcttggat gctttgcaca aaaacagaat aatccactgt
     1441 gaccttaagc ccgagaacat tttgttaaag cagcagggtc ggagcagtat taaagtgatt
     1501 gactttggct ccagttgtta tgagcaccag cgcgtctaca cgtacatcca gtcgcgcttt
     1561 taccgggctc cggaagtgat ccttggagcc aggtatggca tgcccattga catgtggagc
     1621 ctgggttgca tcctcgcgga acttctgacg ggttaccccc tcttgcctgg ggaggatgaa
     1681 ggggaccagc tagcttgtat gatcgagctt ttgggcatgc cctctcaaaa actcctggat
     1741 gcttccaaac gagccaaaaa tttcgtgagc tctaagggtt acccccgata ctgcactgtt
     1801 acaactcttt cggatggctc tgtggtactc aacggaggca gatcccggag agggaaactg
     1861 aggggtccgc cagagagcag agagtggggg aatgcactga agggatgtga tgatcctctt
     1921 ttccttgact tcttaaaaca gtgtttggag tgggatcccg cggtccgaat gaccccggga
     1981 caggctctac ggcacccgtg gcttaggagg cgtttgccaa agcctccgac cggggagaag
     2041 actgcggtga agagggtcac agagagtact ggtgctatca cctccatttc caagttacct
     2101 ccaccttcca gctcagcttc caagctgagg actaatttgg cacagatgac agatgccaat
     2161 gggaatattc agcagaggac agtgttgccg aaactcgtta gctgagctcc agtcccctga
     2221 tgctggcaat ctgaaaaccg cgttatagct gagccttact gggttgaaaa ggtgtagctc
     2281 agacctgttt ttatttgctc aataactcga ctcatttgta tcttttcagc acttgatgta
     2341 agactgtttt tgtttttata aaatacacgg ggacaatgct ttaagttttt atactttctg
     2401 aaaccttttt tgtttttgtt tttttgtttt tttttttttt ttttgttttt gttttccttc
     2461 cttgtgttca aaaaatacga tgagccttac tgtatttagt gtggcagagt aatcacatcg
     2521 gtggcaggcc attgattctt catgactgcc acacatttac agattggtca aactcattca
     2581 ctctgttttc atggttcttc ctgctcccca gggaggtggc cccagaggcc ctccttccct
     2641 ctcctggctc caggttccca cggaagccgc acaccttggc ccagttctcc atgaattaat
     2701 ctgggtcaga gcggaggagg aggaaggggg tcaggggtga aaatctctta aggaaaactg
     2761 cactttagag attttctatt tcctcaccgt ctcttcaaat gattacaaaa taggaatgcc
     2821 cgccttcaac tgcccactta gcattctgat gttcttaagc cacccagcag catttagtgg
     2881 ccaagtggag tccgagatgt gtgagttccc ccccttgagg ctctgggatg gtggggggct
     2941 gtcacgatca ggaagccttc tggttacgga attgcttttg catcccattt taaggacctc
     3001 tccccaacac tgcgccctgc taccttttct cttccaccac acacatctgt tgcccgcatt
     3061 tagtttgccc ttggtcttca gctgtccatc ccagaccggt aacacacatt tgagacacat
     3121 ttgagccgcc attatggtca tggtttcgaa tcccagtttc caaaagaacc tcggcctggc
     3181 tacctaaggt ggggattccc atagttccaa agaagagtta gccgaccgac tggagtcagt
     3241 ccgcgctgca ggtgccacag aggttccctc agcctgggga agcgtcagct ctttcgttag
     3301 aaagaaaagg ggttggaaag ggaggagaaa ttccacgtca agttaaatgg tctgacttat
     3361 tctctccttc actagaagag ccacggggga ggggaaaatg gttcctctgt ttagttgact
     3421 ttcttttgaa tcgcactgag tggttttttt tttttgttgt tgttgttttt ttgctttttt
     3481 ggggggtttt tttggttttt ttttggtggg gaatgacgct ttacctgaga gagtaactga
     3541 gagttaggta aaagaatatt ttcttctctg aataataatt attttcacag tgaaaatttc
     3601 agtattttat cactaatgta tgaagtgata tatatcaatt tcaaggcacg tgggaagaat
     3661 ttttttagta tgtgcaattt aatagagaaa gatttctgcc tgtttggaca ataggttttg
     3721 gatagtaaaa attaggataa ataatctttt atatgcacag atattattgt attgcctgta
     3781 aatcgattta caagtactta aagcatggtc cccagtgagg ccaagaaagt ttctggttac
     3841 gttttttttt tttaattctg ttttctctta cttaaaaaaa aaaaaaagaa tagaaaaaga
     3901 aaaaaaatag aaagtgtcat tttgaataaa acatttttct tatcttgagg ctttgccagt
     3961 tgatggtgga aaaatatgct caggaattat ttcaaatatt tgccaaaaat cagtaataag
     4021 attagcttat taataagtta gtaatctcac tgtttgcttt actatttaag gatgtcattg
     4081 ataaattaat ttgtacctct gtacttagca aattgtagct tatttccctt agtcaaattc
     4141 tttggcatac tatacacagt tctgtgtaat ctgtgaagtg caataatacg tcagtaagtt
     4201 acataatgat tctcatgtga cagtgccccc aatcagtggc ttatagggct taaaaattgt
     4261 gtatttattt tttgaaactt ggcttaaagg cataagaaat atacagagtt ggtctgggga
     4321 ctttgtaaag ctacaagtct cttaatgatg gttattgtct ttcggtcatt aaaagaaatt
     4381 tttaaaaatg gaagctgttc ccccttccaa ggcccccttt ctctgttctc acttagttgc
     4441 tatgggaacc tgagcctgac attactaact cccctagacc gtcactagac ctgcaacagt
     4501 ttagaagtgg acgaagaccg cttgtctttc ccctaccaca caatactggt tcttcgtgga
     4561 tgccagcagg ccatttgtca tgagctttac ccgtacacgg aaccggaaac tttaaagcaa
     4621 actattatgt gcagtgctac aaggcttttt tttttttctc ctcctttccc ccaactacag
     4681 tgaaatttcc tttattcata aaaaccgtct cagcattttt actgatacgg ctgcttcgag
     4741 gagactccta cttaattatt gtgtctaaaa tgaaactgtt gcctcttcat gatcttaacc
     4801 taaataaagg gctctgatag gctactggga gttggcttgg aaacagtctt tggtctcaca
     4861 ggttaccatt gtctagggat gtctgagctg ttttcagatt taggaatagc acagtgtcgt
     4921 cttgtctctg gttgcagtct cacttggcgc tgtttcttgc actaccagag tgttcttagc
     4981 acaacggtgg aacacgcagg gatgcgaggc agtgtagatt aacatcgcag aggaggaatt
     5041 gtgcccttag tgttaatgtg ccttttgttc tgaatgccat gttacggggc atgcattttt
     5101 ttggcctctt tgactctttg aatgagaggt agtaaaggtg gaagccgcct ctgcaaagat
     5161 aacatctgtc ttaaatatct agatttatag gccttaatag aaaccataag gcgggagtcg
     5221 tcactgggcg ctgagcaaga ttaactattg gttaactaca ccaggaattc ccatgtttaa
     5281 gaggttaaag atggtctttc ttgtatctta acatcagact gattttttaa atgatacttt
     5341 ctttgttagg ctaacactag acaaaaatca actgtatttg taaaaattta cctcaaaacc
     5401 atttaatttt atagtgtgat taatcccagg gcatttggtc tgaaccaaag tgcattcttt
     5461 tttttaatgt gcctggctca aataaggagg gccagggatt tttacaattt gggtgcatgg
     5521 cacttaagcc acttttaaac ttactgggtg atgtggagcc ctgttaggtg actccatcag
     5581 aaggctggga aaaacacttt aggcatcagt agcattgggc catattggaa tcttaaaaag
     5641 tgtgaattat tttaaagaga acattcattt ttgtaatttt ttttcatcaa gaatatttct
     5701 ggtaagcaga agattttttt tttgaaatta aaaaaaaaat caactgattc ggttggtaaa
     5761 ggttttgata tcgcccaaca tgatgctgtg gtagcattga aaaaaaaaaa aaaacaaaag
     5821 tatttgtgga ctctgttttt taggggcttg tacatctctc tgcaaccgac atatatacga
     5881 tacatgatac attgtaattc tatcggctca actgctgcag ttctgtctag gcaggggctt
     5941 gggtttttat cgagcaacaa cttagacacg tgactaataa tgatgctgca actgtgtgta
     6001 ctgaaaaaca tgtgaaatgg ttgaatgtgg actgtgtata tatgtatgta cagatttctg
     6061 tgagatgctg ctgttgccac ttaacatgga aagtgttcta gtgggtttga atcctagtgg
     6121 ccagttctat gatactgtat gcattgtaca gccggaagca gaagtaaaga ctgtttagtg
     6181 aatatttgtt aaattttatt gttgtggcca gagataattt cagaataaaa ttttaatgtc
     6241 ctacctta
//
