LOCUS       NM_001415859            2566 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dual specificity tyrosine phosphorylation
            regulated kinase 1B (Dyrk1b), transcript variant 1, mRNA.
ACCESSION   NM_001415859 XM_006228621
VERSION     NM_001415859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2566)
  AUTHORS   Keramati,A.R., Fathzadeh,M., Go,G.W., Singh,R., Choi,M.,
            Faramarzi,S., Mane,S., Kasaei,M., Sarajzadeh-Fard,K., Hwa,J.,
            Kidd,K.K., Babaee Bigi,M.A., Malekzadeh,R., Hosseinian,A.,
            Babaei,M., Lifton,R.P. and Mani,A.
  TITLE     A form of the metabolic syndrome associated with mutations in
            DYRK1B
  JOURNAL   N Engl J Med 370 (20), 1909-1919 (2014)
   PUBMED   24827035
REFERENCE   2  (bases 1 to 2566)
  AUTHORS   Deng,X., Ewton,D.Z., Pawlikowski,B., Maimone,M. and Friedman,E.
  TITLE     Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle
            differentiation
  JOURNAL   J Biol Chem 278 (42), 41347-41354 (2003)
   PUBMED   12902328
REFERENCE   3  (bases 1 to 2566)
  AUTHORS   Lim,S., Jin,K. and Friedman,E.
  TITLE     Mirk protein kinase is activated by MKK3 and functions as a
            transcriptional activator of HNF1alpha
  JOURNAL   J Biol Chem 277 (28), 25040-25046 (2002)
   PUBMED   11980910
  REMARK    Erratum:[J Biol Chem. 2004 Feb 6;279(6):5047]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 4, 2023 this sequence version replaced XM_006228621.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2177.1,
                                           SRR26643296.1019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000001.1  92607454-92607669
            217-380             JAXUCZ010000001.1  92608755-92608918
            381-500             JAXUCZ010000001.1  92609600-92609719
            501-689             JAXUCZ010000001.1  92609816-92610004
            690-837             JAXUCZ010000001.1  92610299-92610446
            838-1124            JAXUCZ010000001.1  92611676-92611962
            1125-1271           JAXUCZ010000001.1  92612522-92612668
            1272-1412           JAXUCZ010000001.1  92612750-92612890
            1413-1728           JAXUCZ010000001.1  92613165-92613480
            1729-1835           JAXUCZ010000001.1  92613821-92613927
            1836-2566           JAXUCZ010000001.1  92614015-92614745
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2566
                     /gene="Dyrk1b"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 1B"
                     /db_xref="GeneID:308468"
                     /db_xref="RGD:1307223"
     exon            1..216
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2207
                     /gene="Dyrk1b"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dual-specificity tyrosine-(Y)-phosphorylation regulated
                     kinase 1b"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 1B isoform 1"
                     /protein_id="NP_001402788.1"
                     /db_xref="GeneID:308468"
                     /db_xref="RGD:1307223"
                     /translation="MLAARPPHWGPHRAPAPRGPSASPDPGLSGGGSRGAGCEKAPPG
                     RAPAPGLTPLRPSEPTMAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATS
                     APLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYI
                     VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRL
                     LELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRK
                     LAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYI
                     QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIP
                     PAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRR
                     AGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA
                     STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRAYRYSNRYCGGPGPPITDCEMNSPQ
                     VLPSQPLRPWAGGDVPHKTHQAPTSGSTLLGTGAQLPPQPRCLGRPPSPTSPPPPELM
                     DVSLVGSPPDCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPRLGLHGVP
                     QSTAASS"
     exon            217..380
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            381..500
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            501..689
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            690..837
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1124
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1271
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1412
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1728
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1835
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2566
                     /gene="Dyrk1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcggcg gctgctgttg tcacccaccg ggccgcctgt cccgcttgcc ctcactgccg
       61 cggggctggc taggctagcc gggccgggga caggcggcca cctcctcatc gccgccgccg
      121 ccaccgccgc tgccgccatg ctggccgctc gcccaccgca ctggggcccc catcgcgctc
      181 cagccccccg tgggcccagc gccagccctg acccgggtct cagcggcggt ggcagccgag
      241 gtgcaggatg cgagaaggcg ccccccggcc gggctcccgc tccaggcctc acacccctgc
      301 ggccctctga gcccaccatg gccgtcccac caggccatgg tcccttctct ggctttccgg
      361 ggccccagga acacacacag gtattgcctg atgtgcggct actgccacgg agactgcccc
      421 tggccttccg ggatgcgacc tcggccccgc tgcgcaagct ctcagtggac ctcatcaaga
      481 cctacaagca catcaatgag gtatactatg cgaagaagaa gcggcgggcc caacaggcgc
      541 caccccagga ctcgagcacc aaaaaggaga agaaggtcct gaatcacggc tatgacgatg
      601 acaaccacga ctacattgtg cgcagcggcg agcgctggct agagcgctat gaaattgact
      661 ctcttattgg caaaggctct tttggccagg tggtgaaagc ctatgatcac cagactcagg
      721 agctggtggc catcaagatc atcaagaaca aaaaggcctt cctgaaccag gcacagattg
      781 agctgaggct gctggagctg atgaatcagc atgatacaga gatgaagtac tacatagtac
      841 acctgaagcg gcacttcatg ttccggaatc acctgtgcct ggtgtttgag ctgctgtcct
      901 acaacctgta cgacctcctc cgcaacacac actttcgcgg tgtctcactg aacctgacga
      961 ggaagctggc acagcagctc tgcacagccc tgctctttct ggccacgcct gagctcagca
     1021 tcatccactg cgacctcaag cctgagaaca tcctgctctg caatcctaag cgcagcgcca
     1081 tcaagattgt ggacttcggc agctcctgcc agcttggcca gcggatctac cagtatatcc
     1141 agagccgctt ctaccgctca ccagaggtgc tcctgggtac accctatgac ctggccatcg
     1201 acatgtggtc cctgggctgc atccttgtgg agatgcacac cggagaaccc ctcttcagtg
     1261 gctctaatga ggtggaccag atgagccgga ttgtggaggt gttgggcatc cctcccgcac
     1321 ctatgctgga acaggcaccc aaagctcgca agtactttga gcggctgcct gggggtggct
     1381 ggaccctacg aaggacaaag gaactcagga aggattacca gggccctggg acacggcggc
     1441 tgcaggaggt gctgggcgtg cagacgggcg ggcccggggg ccggcgggcg ggggagccgg
     1501 gccacagccc cgccgactac ctccgcttcc aggacctggt gctgcgcatg ctggagtatg
     1561 agcccgccgc ccgcatcagc cctctgggcg ctctgcagca tggcttcttc cgccgcacgg
     1621 ccgacgaggc caccaacacg ggcccggcag gcagcagtgc ctccacctcg ccggcgcccc
     1681 ttgatacctg cccctcctct agcaccgcca gctccatctc cagctctgga ggctccagtg
     1741 gctcctccag tgacaacagg gcctaccgct acagcaaccg atattgtggg ggcccagggc
     1801 cccccatcac tgactgtgag atgaacagcc cccaggtcct accctcccag cctctgcgcc
     1861 cctgggcagg gggtgatgtg ccccacaaga cacatcaagc ccctacctct ggctcaacat
     1921 tgctggggac tggggcccag ttacccccac aaccccgttg ccttggacga cccccatcac
     1981 ccacctcacc acccccccca gagctgatgg atgtgagcct ggtgggcagc cctccagact
     2041 gctctccacc tcatccagca cctgctcccc agcacccggc tgcctcagcc ctccggactc
     2101 ggatgacggg aggtcgacca cctctcccgc cccctgatga ccctgccact ctggggcctc
     2161 gtctgggcct ccatggtgta ccccagagca cagcagccag ctcatgaccc tgccccctcc
     2221 ctggggcccc tcctgaagcc ataccccccc atctgggggc cctgggctcc catcctcatc
     2281 tctccccttg actggacttg ctgctaccca gctggggtgg gtgaggcctg cactgactgg
     2341 ggcccagggc agggggtcaa gggagaggag tttggccgca cccctcccca ctaagactgg
     2401 acccttgccc ccccttcctt gttttctatt tattgtacca aagacagtgg tggtccggta
     2461 gaggggagat tcccccttac ccagggccct aggaggggtg ggggcaggta gggggagatg
     2521 gccttgctcc tcctcgctgt accccccagt aaaaagcttt ctcaca
//
