LOCUS       NM_012791               5035 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus dual specificity tyrosine phosphorylation
            regulated kinase 1A (Dyrk1a), mRNA.
ACCESSION   NM_012791
VERSION     NM_012791.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5035)
  AUTHORS   Wang,J., Xu,R.M., Cao,Q.M., Ma,B.C., Zhang,H. and Hao,H.P.
  TITLE     Mechanism of DYRK1a in myocardial ischemia-reperfusion injury by
            regulating ferroptosis of cardiomyocytes
  JOURNAL   Kaohsiung J Med Sci 39 (12), 1190-1199 (2023)
   PUBMED   37702441
  REMARK    GeneRIF: Mechanism of DYRK1a in myocardial ischemia-reperfusion
            injury by regulating ferroptosis of cardiomyocytes.
REFERENCE   2  (bases 1 to 5035)
  AUTHORS   Yang,T., Hei,R., Li,X., Ma,T., Shen,Y., Liu,C., He,W., Zhu,L.,
            Gu,Y., Hu,Y., Wei,W. and Shen,Y.
  TITLE     The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands
            for sebum synthesis
  JOURNAL   Cell Mol Biol Lett 28 (1), 60 (2023)
   PUBMED   37501148
  REMARK    GeneRIF: The role of NPY2R/NFATc1/DYRK1A regulatory axis in
            sebaceous glands for sebum synthesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5035)
  AUTHORS   Raveau,M., Shimohata,A., Amano,K., Miyamoto,H. and Yamakawa,K.
  TITLE     DYRK1A-haploinsufficiency in mice causes autistic-like features and
            febrile seizures
  JOURNAL   Neurobiol Dis 110, 180-191 (2018)
   PUBMED   29223763
REFERENCE   4  (bases 1 to 5035)
  AUTHORS   Garcia-Cerro,S., Rueda,N., Vidal,V., Lantigua,S. and
            Martinez-Cue,C.
  TITLE     Normalizing the gene dosage of Dyrk1A in a mouse model of Down
            syndrome rescues several Alzheimer's disease phenotypes
  JOURNAL   Neurobiol Dis 106, 76-88 (2017)
   PUBMED   28647555
REFERENCE   5  (bases 1 to 5035)
  AUTHORS   Lubelwana Hafver,T., Wanichawan,P., Manfra,O., de Souza,G.A.,
            Lunde,M., Martinsen,M., Louch,W.E., Sejersted,O.M. and Carlson,C.R.
  TITLE     Mapping the in vitro interactome of cardiac sodium (Na+)-calcium
            (Ca2+) exchanger 1 (NCX1)
  JOURNAL   Proteomics 17 (17-18) (2017)
   PUBMED   28755400
REFERENCE   6  (bases 1 to 5035)
  AUTHORS   Bescond,M. and Rahmani,Z.
  TITLE     Dual-specificity tyrosine-phosphorylated and regulated kinase 1A
            (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase
            associated protein 1 (PAHX-AP1), a brain specific protein
  JOURNAL   Int J Biochem Cell Biol 37 (4), 775-783 (2005)
   PUBMED   15694837
REFERENCE   7  (bases 1 to 5035)
  AUTHORS   Chen-Hwang,M.C., Chen,H.R., Elzinga,M. and Hwang,Y.W.
  TITLE     Dynamin is a minibrain kinase/dual specificity Yak1-related kinase
            1A substrate
  JOURNAL   J Biol Chem 277 (20), 17597-17604 (2002)
   PUBMED   11877424
  REMARK    GeneRIF: The result suggests that Mnbk/Dyrk1A can play a dual role
            in regulating the interaction of dynamin 1 with amphiphysin 1
REFERENCE   8  (bases 1 to 5035)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
REFERENCE   9  (bases 1 to 5035)
  AUTHORS   Song,W.J., Chung,S.H. and Kurnit,D.M.
  TITLE     The murine Dyrk protein maps to chromosome 16, localizes to the
            nucleus, and can form multimers
  JOURNAL   Biochem Biophys Res Commun 231 (3), 640-644 (1997)
   PUBMED   9070862
REFERENCE   10 (bases 1 to 5035)
  AUTHORS   Kentrup,H., Becker,W., Heukelbach,J., Wilmes,A., Schurmann,A.,
            Huppertz,C., Kainulainen,H. and Joost,H.G.
  TITLE     Dyrk, a dual specificity protein kinase with unique structural
            features whose activity is dependent on tyrosine residues between
            subdomains VII and VIII
  JOURNAL   J Biol Chem 271 (7), 3488-3495 (1996)
   PUBMED   8631952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000011.1.
            
            On Dec 13, 2016 this sequence version replaced NM_012791.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000011.1  47385802-47385852
            52-137              JAXUCZ010000011.1  47399328-47399413
            138-334             JAXUCZ010000011.1  47442438-47442634
            335-454             JAXUCZ010000011.1  47447276-47447395
            455-643             JAXUCZ010000011.1  47449357-47449545
            644-791             JAXUCZ010000011.1  47452467-47452614
            792-1078            JAXUCZ010000011.1  47456759-47457045
            1079-1225           JAXUCZ010000011.1  47458234-47458380
            1226-1366           JAXUCZ010000011.1  47461092-47461232
            1367-1673           JAXUCZ010000011.1  47468601-47468907
            1674-1798           JAXUCZ010000011.1  47469903-47470027
            1799-5035           JAXUCZ010000011.1  47475797-47479033
FEATURES             Location/Qualifiers
     source          1..5035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..5035
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 1A"
                     /db_xref="GeneID:25255"
                     /db_xref="RGD:2528"
     exon            1..51
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            52..137
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2419
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.12.1"
                     /note="MNBH; RP86; protein kinase minibrain homolog; Dual
                     Specificity Yak1-related kinase; dual-specificity
                     tyrosine-(Y)-phosphorylation regulated kinase 1A"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 1A"
                     /protein_id="NP_036923.1"
                     /db_xref="GeneID:25255"
                     /db_xref="RGD:2528"
                     /translation="MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRR
                     QPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIK
                     TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYE
                     IDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK
                     YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL
                     ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL
                     GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR
                     KFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL
                     KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTT
                     SSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPL
                     GWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQAL
                     GNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQN
                     RPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMR
                     QGADREESPMTGVCVQQSPVASS"
     exon            138..334
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            335..454
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            455..643
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            644..791
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1078
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1225
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1366
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1673
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1798
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..5035
                     /gene="Dyrk1a"
                     /gene_synonym="Dyrk; PSK47"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcaagt tttcagagtg gctttgctct tactgtgctt tcattcgcag ctgttatagt
       61 tttgccgctg gactcttccc tcccttcccc caccccatca ggatgatatg agacttgaaa
      121 gaagacgatg catacaggag gagagacttc agcatgcaaa ccttcatctg tccggctcgc
      181 accgtcattc tcattccatg ctgctggcct tcagatggct gcacagatgc cccattcaca
      241 tcagtacagt gaccgtcgcc agccaaacat aagtgaccag caggtttctg ccttatcata
      301 ttctgaccag attcagcaac ctctaactaa ccaggtgatg cctgacattg tcatgttaca
      361 gaggcggatg ccccaaacct tccgtgatcc agcaactgct cctctgagaa aactctctgt
      421 ggacttgatc aaaacataca agcatattaa tgaggtttac tatgcaaaaa agaagcgaag
      481 acaccaacag ggccaggggg acgattctag tcataagaag gagcggaagg tttacaacga
      541 tggttacgat gacgataact atgattacat tgtaaaaaac ggagaaaagt ggatggaccg
      601 ttatgaaatc gactccttaa taggcaaagg ttcatttgga caggttgtga aagcatatga
      661 cagagtggaa caagaatggg tcgccattaa aatcatcaag aacaagaagg cgtttctgaa
      721 tcaagcgcag atagaagtgc ggctgcttga gctcatgaac aaacatgaca ctgagatgaa
      781 gtactacata gtgcatttga aacgccactt tatgtttcgg aaccatctct gtctagtgtt
      841 tgaaatgctg tcctataatc tctatgattt gttgaggaac accaacttcc gaggggtctc
      901 tttgaacctg acacgaaagt ttgcacaaca gatgtgcaca gcattgcttt tccttgcgac
      961 tccagaactt agtatcattc actgtgactt aaagccggag aacatccttc tgtgtaaccc
     1021 caaacgaagt gcaatcaaga ttgttgactt tggcagctct tgtcagttgg ggcagaggat
     1081 ataccagtat attcagagtc gcttctatcg gtctccagag gtgctactgg gaatgcctta
     1141 tgaccttgct atcgacatgt ggtcccttgg atgtatcttg gttgaaatgc acactggaga
     1201 gcctctgttc agtggtgcca atgaggtgga tcagatgaat aaaatagtgg aagtcttggg
     1261 catcccacct gctcatattc ttgaccaagc accgaaagca agaaagttct ttgagaagtt
     1321 gcctgatggc acttggagct taaagaagac caaagatgga aaacgggagt acaaaccacc
     1381 aggaacccgt aaacttcata atattcttgg agtggaaaca ggaggacctg gcgggcggcg
     1441 tgctggggag tcaggtcaca ctgtagctga ctacttgaag ttcaaagacc tcattttaag
     1501 gatgcttgat tatgacccca aaactcggat tcaaccttat tatgccctgc agcacagttt
     1561 tttcaagaaa acagctgatg aaggtacaaa cacaagcaac agtgtgtcca ccagccctgc
     1621 catggagcag tcccagtctt caggcaccac ctccagcacc tcctccagct caggtggatc
     1681 ctcgggaacg agcaacagtg ggagagccag gtcggatccg acgcaccagc atcggcacag
     1741 tggcgggcac ttcgctgctg ctgtccaggc catggactgt gagacacata gtccccaggt
     1801 gcgccagcag tttccggctc ctctgggctg gtcaggcact gaagctccta cacaagtcac
     1861 tgttgaaact catcctgttc aagaaacaac ctttcatgta gcccctcagc agaatgcatt
     1921 gcatcatcac catggaaaca gttcccatca tcaccaccac caccatcacc accaccacca
     1981 ccatggacag caagccttgg gtaaccggac caggccaagg gtctacaatt ctccaacaaa
     2041 tagctcctct acccaggatt ctatggaggt tggccacagt caccactcca tgacatccct
     2101 gtcttcctca acaacttctt cctcgacatc ttcctcctct actggtaatc aaggcaatca
     2161 ggcctatcag aaccgcccag tggctgctaa caccttggac tttggacaga atggagctat
     2221 ggacgttaat ttgaccgtct actccaatcc ccgccaagag actggcatag ctggacatcc
     2281 aacataccaa ttttctgcta atacaggtcc tgcacattac atgactgaag gacatctgac
     2341 gatgaggcaa ggggctgata gagaagagtc tcccatgaca ggagtttgtg tgcaacagag
     2401 tcctgtagct agctcgtgac tacattgaaa cttgagtttg tttcttgtgt gtttttatag
     2461 aagtggtgtt tttttcccaa aaacaaaagt gcaaagctgc ttgaatcaga aggagattaa
     2521 cacactgaac cgctacgaga gggcaaagct gacttttttt tttaacttga aaagattgca
     2581 aagggacaat gaagttttta agagccatgt ccacccatct tcatggagcg ctcagagtgt
     2641 cctctttctg cctcccccat ttaacttcca tctcccggtc acagtgggtt ttgtctttct
     2701 atccaacaaa agttaatgtt cagctgttgg tcttggtcat ttgccaacta attttaaaat
     2761 aaaaaggcac tgcacataat ttgcataaag ggccccatag ggtgttttgg ttttttcatt
     2821 tttatttttt ccccttctcc cctgttttct tttgtttcgt tttgggttgg gggtggggtg
     2881 ggagatttgg gtttttatgt cctctacaca cttgggcacg gaaatgcagt actgtaagga
     2941 agagggacct ccagcacaca caaacatcat cttcagctgt gtgaaaggga cgattgtgtt
     3001 ggcgtttgta aggcacacta agcatgctaa gtggcgggat caggactctc ctgtctgaac
     3061 atactgagga gcaaagcagc cattgcgtgg gatcctgtgg tctcctgtcg gagaggccac
     3121 aggacgacgg gatggagcgt gactgctcgc cttaccaagg cgcactgaga agcaatcagc
     3181 gggtcggtcg cttgtggcca gtcctgggga ggtctgagtg gtggtccttg ggataacctt
     3241 tggccttatg gatttggact cggagttaga agagcccacc atttcagatg caatcacttg
     3301 tggacatgcg tttgcagaca gtccttaatg ctgaaaacac agagaatggg taattcaaga
     3361 ggcctttctt ttaaaataga cttttgtgac ccactaattg taaggtattg ccaggtcact
     3421 ttgcgtgtgt cataaagctg actcccttct tggttgaagg ccacagaggt agtggtttgc
     3481 tttgacggaa atagctacag ctgtgtccct tcctgctttt accttttctt tggctttttc
     3541 tcggcacgtg gtgtctccac catttcttct gcacaaagac gtcttctgtt catcctgaac
     3601 attttaaaat gcagaatttt atgtgactgc ttttttgcct cacaattatg ctgtgaattt
     3661 tacaaaaatt tattttcttt tttgataatt tattgtacca aagctgtttt tatagcacat
     3721 agatgtctgt aaccaataat gtagccgttc tgcactttga cacaaggtgt acctagacca
     3781 tttttaaatg tcagttgaaa attatggctg tactattgct taaacaaaac tggaactgtt
     3841 gttgactcca tagccaatcc acttacagca ctctgtgtac tggacagaat agattgacat
     3901 ctaattcaag attacaccac ctgtctgtca cattctgaat gtgctcaggc ttctgaaggg
     3961 aaagggatgc tggacccaga ggctgtggag ccagcagttg gtcttgtttc ctgattaact
     4021 tccttgtaaa cttgaacttg agaccttgac tgacccggca ggtccccagt aggaacagga
     4081 ggaaggcaga gctctaatgt gacctgaagt gagcaggcgg cacgaagagg caccgtgtct
     4141 ggagactact gccttcctgt aacagtctgg cagtggctaa atctgtattc acatttaaat
     4201 tgagcaattt tagggtgtga tactctgagg cggttgaatt gggagaatga agatagagta
     4261 atttccctgt ccaggatcaa aagaagccta gagagaagca gtaatctacc tctgccgata
     4321 acctgttgga agcaactcag cagaacgcca cgttactttt tattggttaa ctccatgtgg
     4381 ctcactaggt cacttttttt tttccctgag caaaaggagg tttttttttt taatgtaaac
     4441 tttgacaaca gaaaggccca agctctgtga gtgcagtgga gactcggaga gccccgtttc
     4501 tataaacaca gacacttggg gtgttaatca ggaaatccat atttattttg taattaaatg
     4561 tcacgcctgt ggattgtttt gaacttggta gttcctgaga gtttgcgtac agaggcctct
     4621 tgagcacagc actgttggga gggatcagcg tctgcggctg cggagcccag gccacaccac
     4681 gtggctcagg tcattctttt ttctttctgt gctggttgcc acattttagc aagcaccaaa
     4741 aaagaaagca gtttttaaac cgatatttac ataaagaaaa ccacagaatc cagtgcttct
     4801 gcatactgtg ttatgttgca gtccagtttt gtgtgcttta ctacacagtt tggttacagg
     4861 acttctgtgc attgtaaaca tgagcagcat ggagaggcta aatgcctgtg ttcagattgt
     4921 aagatctagt ccggacttgc tgtgtatatt gtaacgttaa atgaaaaaag accccctttg
     4981 tattatagtc atgcggtctt atgtatgata aacagttgaa taatttgtcc tcaga
//
