LOCUS       NM_080697               2370 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus dynein light chain LC8-type 2 (Dynll2), mRNA.
ACCESSION   NM_080697
VERSION     NM_080697.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Suyama,S., Kodaira-Hirano,M., Otgon-Uul,Z., Ueta,Y., Nakata,M. and
            Yada,T.
  TITLE     Fasted/fed states regulate postsynaptic hub protein DYNLL2 and
            glutamatergic transmission in oxytocin neurons in the hypothalamic
            paraventricular nucleus
  JOURNAL   Neuropeptides 56, 115-123 (2016)
   PUBMED   26344333
  REMARK    GeneRIF: Results suggest that feeding increases excitatory synaptic
            input on paraventricular nucleus oxytocin neurons via mechanisms
            involving DYNLL2 upregulation and NMDA receptor-mediated synaptic
            reorganization.
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Goggolidou,P., Stevens,J.L., Agueci,F., Keynton,J., Wheway,G.,
            Grimes,D.T., Patel,S.H., Hilton,H., Morthorst,S.K., DiPaolo,A.,
            Williams,D.J., Sanderson,J., Khoronenkova,S.V., Powles-Glover,N.,
            Ermakov,A., Esapa,C.T., Romero,R., Dianov,G.L., Briscoe,J.,
            Johnson,C.A., Pedersen,L.B. and Norris,D.P.
  TITLE     ATMIN is a transcriptional regulator of both lung morphogenesis and
            ciliogenesis
  JOURNAL   Development 141 (20), 3966-3977 (2014)
   PUBMED   25294941
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Du,H., Grob,S.R., Zhao,L., Lee,J., El-Sahn,M., Hughes,G., Luo,J.,
            Schaf,K., Duan,Y., Quach,J., Wei,X., Shaw,P., Granet,D. and
            Zhang,K.
  TITLE     Myotonia congenita with strabismus in a large family with a
            mutation in the SCN4A gene
  JOURNAL   Eye (Lond) 26 (8), 1039-1043 (2012)
   PUBMED   22653516
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Moutin,E., Raynaud,F., Fagni,L. and Perroy,J.
  TITLE     GKAP-DLC2 interaction organizes the postsynaptic scaffold complex
            to enhance synaptic NMDA receptor activity
  JOURNAL   J Cell Sci 125 (Pt 8), 2030-2040 (2012)
   PUBMED   22328512
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Allan,V.J.
  TITLE     Cytoplasmic dynein
  JOURNAL   Biochem Soc Trans 39 (5), 1169-1178 (2011)
   PUBMED   21936784
  REMARK    Review article
REFERENCE   6  (bases 1 to 2370)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   7  (bases 1 to 2370)
  AUTHORS   Wang,W., Lo,K.W., Kan,H.M., Fan,J.S. and Zhang,M.
  TITLE     Structure of the monomeric 8-kDa dynein light chain and mechanism
            of the domain-swapped dimer assembly
  JOURNAL   J Biol Chem 278 (42), 41491-41499 (2003)
   PUBMED   12904292
REFERENCE   8  (bases 1 to 2370)
  AUTHORS   Fuhrmann,J.C., Kins,S., Rostaing,P., El Far,O., Kirsch,J.,
            Sheng,M., Triller,A., Betz,H. and Kneussel,M.
  TITLE     Gephyrin interacts with Dynein light chains 1 and 2, components of
            motor protein complexes
  JOURNAL   J Neurosci 22 (13), 5393-5402 (2002)
   PUBMED   12097491
REFERENCE   9  (bases 1 to 2370)
  AUTHORS   Naisbitt,S., Valtschanoff,J., Allison,D.W., Sala,C., Kim,E.,
            Craig,A.M., Weinberg,R.J. and Sheng,M.
  TITLE     Interaction of the postsynaptic density-95/guanylate kinase
            domain-associated protein complex with a light chain of myosin-V
            and dynein
  JOURNAL   J Neurosci 20 (12), 4524-4534 (2000)
   PUBMED   10844022
REFERENCE   10 (bases 1 to 2370)
  AUTHORS   King,S.M., Barbarese,E., Dillman,J.F. 3rd, Patel-King,R.S.,
            Carson,J.H. and Pfister,K.K.
  TITLE     Brain cytoplasmic and flagellar outer arm dyneins share a highly
            conserved Mr 8,000 light chain
  JOURNAL   J Biol Chem 271 (32), 19358-19366 (1996)
   PUBMED   8702622
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061874.1.
            
            On Oct 17, 2004 this sequence version replaced NM_080697.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061874.1, BU671206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132281, SAMD00132305
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2370
                     /gene="Dynll2"
                     /gene_synonym="Dlc2"
                     /note="dynein light chain LC8-type 2"
                     /db_xref="GeneID:140734"
                     /db_xref="RGD:619860"
     exon            1..252
                     /gene="Dynll2"
                     /gene_synonym="Dlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..391
                     /gene="Dynll2"
                     /gene_synonym="Dlc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..529
                     /gene="Dynll2"
                     /gene_synonym="Dlc2"
                     /note="dynein light chain-2"
                     /codon_start=1
                     /product="dynein light chain 2, cytoplasmic"
                     /protein_id="NP_542428.1"
                     /db_xref="GeneID:140734"
                     /db_xref="RGD:619860"
                     /translation="MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKK
                     EFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG"
     exon            392..2324
                     /gene="Dynll2"
                     /gene_synonym="Dlc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagcggac ggcgaggtat cagccgggac aggcggtcgg ccgggtggca cgaggcggag
       61 cgcgggcgtc cggggaagct cggagggcga acagcagcgc gagcgctcgg cccggggctg
      121 cgggagcagg gagataccgc ggcggcagcg actgctgctg ctggacgagc ccaggggaca
      181 ccgcccctgc ccgcgattcg tttcagccca gcgctgctcc ccaggggcct gtgcggactc
      241 gcctgcgtga cgtgtcacaa tgtctgaccg gaaggcagtg atcaagaacg cagacatgtc
      301 tgaggacatg caacaggatg ccgttgactg cgccactcag gccatggaga agtacaacat
      361 agagaaggac attgctgcct atatcaagaa ggaattcgac aagaaatata accctacctg
      421 gcattgtatc gtgggccgaa attttggcag ctatgtcaca cacgagacaa agcacttcat
      481 ctatttttac ttgggtcaag ttgcaatcct cctcttcaag tcaggctagg tggccgaggt
      541 gaaggtgtca gtggcggcgg cagcgatggc aagcaggcgg cgttgctggg actgttttgc
      601 actggggcca gcatcaggaa gtcctctcca atggctgtgc tactgcatgg actgtatact
      661 cgatttcatg tgtgtgtcgc agtaaacaaa aaccaaactt ctttctgttt agttgcctgg
      721 ggaagaaggc tgctttatgt ttaagacgtt aacattattt ttttggttgt actgcactag
      781 gaaatctctc ccacccctcc ttttctcttt ctctccctag ataaacataa aaggcctcag
      841 cgaagcccta aagactagga gggccgagga gtagaagtag gtctgaggcg gaagttaagc
      901 tgcagctgcc tcttggatgg tgggcactac tgtaggaggc cggggaggct gcgaggacag
      961 ggttagggtt gacagagagg gataggaagt tgggccaggg ggattgctct agtaccaggg
     1021 agatattcca ctgaactgtg acgctatggc ttggggcagg gtgggtgggg tgcagtctct
     1081 aaggggccct gagatatttg tggtgtagga gtggggagcc gactgtcgcc gtctgtcagg
     1141 gtttctaagt gtgtctttgt gggttacctt ccatgtcggg aggatgctgg gagtaggatt
     1201 agcttgactt ccccccctac attctgtctg ctccctgctt atcccttgtt ttttctcatt
     1261 cctcacaatt ctcttagagc agcccgttgt tggctggcaa gggaatttct ggtgactgta
     1321 gttccttagt taggtcttag caatcaaacc aaatcaatgt cccctcaatt cttctttgtg
     1381 tatgtttgtg tttgtctgtg tgcgtgtgtg gggtgggttt ggggtagaag ggtgggaagg
     1441 ggcaggataa gtggaatctt tagggtttat gggaggtagg ggcagttagt tctaagtggg
     1501 ctttcatgtt acctgatgtg tgagggtaag gacaggttgg tgtcaaacca tcctcctccc
     1561 ctcggttcat catgcttgaa cactgctttg cctgtggctg tctgttccct ggaaatgttt
     1621 ttggaaggtc acccagaaca ggatggccat actgccatct gtcctggagt tggatctggg
     1681 gcagggggca cttggtggct ggtctctagt gggaagtgag gatagaagta atgggggagg
     1741 ggctccttgg aacaggtctg aagtgtgtaa tgacctctgg gagtgaggag gtggaaaagg
     1801 gctgggaatg aggagattcc ggagagaagt gcaagggaaa tcttgtctgt tggtgaagtg
     1861 attggggtgg gtgggggttg tccttgccaa ttgagctgct gattcttacg gatcacattc
     1921 agaactcgtg tagggttgac actgtaaggg gtggggaaat atagccgttt tttccccagc
     1981 ccattcttgg gggttggggg aaggcaggag aatgcccctt cctcctaagc ccttagtgtg
     2041 tgttgaactt ttgtttttct tcagtgctgg caggggaggg tgggaactgg tggtgactga
     2101 gttccctgtt caaaccttta ttgggtacaa gattgaatgt ttgatttagg ttttattttt
     2161 cttacgaatg tccaggtctg tgttcctccc tgccctccca gactctggcc aggtggaagt
     2221 gtctcgtttt tgttcatctc tcatttctgt gcagggactg agaccctgcc acatctatgc
     2281 tctgcatcca cgcctctttt ggacattaaa ggtcgattga tgcaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
