LOCUS       NM_053319               2070 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus dynein light chain LC8-type 1 (Dynll1), mRNA.
ACCESSION   NM_053319
VERSION     NM_053319.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Kahn,O.I., Schatzle,P., van de Willige,D., Tas,R.P., Lindhout,F.W.,
            Portegies,S., Kapitein,L.C. and Hoogenraad,C.C.
  TITLE     APC2 controls dendrite development by promoting microtubule
            dynamics
  JOURNAL   Nat Commun 9 (1), 2773 (2018)
   PUBMED   30018294
  REMARK    GeneRIF: It has been found that APC2 localizes as distinct clusters
            along microtubule bundles in dendrites, and that this localization
            is driven by LC8-binding and two separate microtubule-interacting
            domains.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Kirkham,J.K., Park,S.H., Nguyen,T.N., Lee,J.H. and Gunzl,A.
  TITLE     Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated
            Transcription in Trypanosoma brucei, Facilitating Assembly and
            Promoter Binding of Class I Transcription Factor A
  JOURNAL   Mol Cell Biol 36 (1), 95-107 (2015)
   PUBMED   26459761
  REMARK    GeneRIF: silencing of Dynein light chain LC8 or class I
            transcription factor A2 resulted in a loss of CITFA from RNA Pol I
            promoters
            Erratum:[Mol Cell Biol. 2017 May 31;37(12 ):. PMID: 28566454]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Gholkar,A.A., Senese,S., Lo,Y.C., Capri,J., Deardorff,W.J.,
            Dharmarajan,H., Contreras,E., Hodara,E., Whitelegge,J.P.,
            Jackson,P.K. and Torres,J.Z.
  TITLE     Tctex1d2 associates with short-rib polydactyly syndrome proteins
            and is required for ciliogenesis
  JOURNAL   Cell Cycle 14 (7), 1116-1125 (2015)
   PUBMED   25830415
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Goggolidou,P., Stevens,J.L., Agueci,F., Keynton,J., Wheway,G.,
            Grimes,D.T., Patel,S.H., Hilton,H., Morthorst,S.K., DiPaolo,A.,
            Williams,D.J., Sanderson,J., Khoronenkova,S.V., Powles-Glover,N.,
            Ermakov,A., Esapa,C.T., Romero,R., Dianov,G.L., Briscoe,J.,
            Johnson,C.A., Pedersen,L.B. and Norris,D.P.
  TITLE     ATMIN is a transcriptional regulator of both lung morphogenesis and
            ciliogenesis
  JOURNAL   Development 141 (20), 3966-3977 (2014)
   PUBMED   25294941
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Wu,K.L., Chao,Y.M., Tsay,S.J., Chen,C.H., Chan,S.H., Dovinova,I.
            and Chan,J.Y.
  TITLE     Role of nitric oxide synthase uncoupling at rostral ventrolateral
            medulla in redox-sensitive hypertension associated with metabolic
            syndrome
  JOURNAL   Hypertension 64 (4), 815-824 (2014)
   PUBMED   24958506
  REMARK    GeneRIF: Data suggest that redox-sensitive and protein inhibitor of
            nNOS (PIN)-mediated neuronal NO synthase (nNOS) uncoupling is
            engaged in a vicious cycle that sustains the production of reactive
            oxygen species in rostral ventrolateral medulla (RVLM).
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Gillardon,F., Krep,H., Brinker,G., Lenz,C., Bottiger,B. and
            Hossmann,K.A.
  TITLE     Induction of protein inhibitor of neuronal nitric oxide
            synthase/cytoplasmic dynein light chain following cerebral ischemia
  JOURNAL   Neuroscience 84 (1), 81-88 (1998)
   PUBMED   9522364
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Greenwood,M.T., Guo,Y., Kumar,U., Beausejours,S. and Hussain,S.N.
  TITLE     Distribution of protein inhibitor of neuronal nitric oxide synthase
            in rat brain
  JOURNAL   Biochem Biophys Res Commun 238 (2), 617-621 (1997)
   PUBMED   9299562
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Jaffrey,S.R. and Snyder,S.H.
  TITLE     PIN: an associated protein inhibitor of neuronal nitric oxide
            synthase
  JOURNAL   Science 274 (5288), 774-777 (1996)
   PUBMED   8864115
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   King,S.M., Barbarese,E., Dillman,J.F. 3rd, Patel-King,R.S.,
            Carson,J.H. and Pfister,K.K.
  TITLE     Brain cytoplasmic and flagellar outer arm dyneins share a highly
            conserved Mr 8,000 light chain
  JOURNAL   J Biol Chem 271 (32), 19358-19366 (1996)
   PUBMED   8702622
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Dick,T., Ray,K., Salz,H.K. and Chia,W.
  TITLE     Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects
            and apoptotic cell death in Drosophila melanogaster
  JOURNAL   Mol Cell Biol 16 (5), 1966-1977 (1996)
   PUBMED   8628263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000229.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_053319.5.
            
            On Jul 5, 2022 this sequence version replaced NM_053319.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063183.1, CN543019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JACYVU010000229.1  3908171-3908275
            106-243             JACYVU010000229.1  3908442-3908579
            244-2070            JACYVU010000229.1  3910137-3911963
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2070
                     /gene="Dynll1"
                     /gene_synonym="8kDLC; Dlc8; Dnclc1; Pin"
                     /note="dynein light chain LC8-type 1"
                     /db_xref="GeneID:58945"
                     /db_xref="RGD:619866"
     exon            1..105
                     /gene="Dynll1"
                     /gene_synonym="8kDLC; Dlc8; Dnclc1; Pin"
                     /inference="alignment:Splign:2.1.0"
     exon            106..243
                     /gene="Dynll1"
                     /gene_synonym="8kDLC; Dlc8; Dnclc1; Pin"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..381
                     /gene="Dynll1"
                     /gene_synonym="8kDLC; Dlc8; Dnclc1; Pin"
                     /note="8 kDa dynein light chain; dynein, cytoplasmic,
                     light chain 1; 8kD LC; dynein LC8; protein inhibitor of
                     neuronal nitric oxide synthase"
                     /codon_start=1
                     /product="dynein light chain 1, cytoplasmic"
                     /protein_id="NP_445771.1"
                     /db_xref="GeneID:58945"
                     /db_xref="RGD:619866"
                     /translation="MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKK
                     EFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG"
     exon            244..2070
                     /gene="Dynll1"
                     /gene_synonym="8kDLC; Dlc8; Dnclc1; Pin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttagatgcgc cacggcttcg gtagcgaccg gctgtccact gctgcttgag cggcgccagc
       61 accttcccta ggagctcgca gcagccggct ggcccctgct ccacggtaac catgtgcgac
      121 cggaaggcgg tgatcaaaaa tgcagacatg tcggaagaga tgcaacagga ctcggtggag
      181 tgcgctactc aggcgttgga gaagtacaac atagagaagg atatcgcggc ccatatcaag
      241 aaggagtttg acaagaagta caaccccacc tggcactgca tcgtgggccg gaacttcggt
      301 agctacgtga cacacgagac caaacacttc atctacttct acctgggtca ggtggccatt
      361 ctcctgttca aatctggtta atagcatgga ctgtgccaaa cacccagtga tccatccaaa
      421 aacaaggact gcatcctaaa ttccaaatac cagagactga atcttcagcc ttgctaaggg
      481 aacacctcgt ttgaatctgt tgtgttttgt acagggcacc attctctgta cacgtttgtg
      541 gttataaaat tagtaaaaca gcttacattt gtatttattt tctagtccat acttctgtac
      601 ccccattttt ttctccctta ggtcattcct ttaaaataaa tctgttggag atgtatatgt
      661 ctctgctagt ttgtttcaag gaagataggg ttgacgtagt ttgaccagtt ggtaagagcc
      721 tgaggactcc catgttttgt aggattagac agacagttta gttctctgga tggaatgttt
      781 ggcaggccac accagttttt ccagattatt tgggttatta gccacaggtc tgaggcccca
      841 tccctgtcag cctagcgctt gggaggctaa ggaaggagta gtgtaggttc taggccagcc
      901 tggattagag taccttaaga gttagcctgc taggctgttg ctttcactgg ctgcgctcag
      961 aaatcagtta ggtgaagctg tgactcacgt tcactaagta aagctgtgga acctgtagtc
     1021 accaagtttc cctgttgtca atttagagct accgtagctt aaggaggaaa gcctgcatag
     1081 gagactcccc caggtagggg ctgaagcagc caacccactt tttttctttc ttttttttcg
     1141 gagctgggga ccgaacccag ggccttgcga acccagggcc ttgcgctagg caagcgctct
     1201 accactgagc taaatcccca accccagcca acccactctt actttgggat tggcaagagt
     1261 ccctgtaggg ttgccggttc ctattttcac aggtaatgtg tttttactct agatcttgtt
     1321 ttgagagttt ctttgtgtag tccttgctgt cattgtgatt tttaagaagc caaaaggctg
     1381 ctacacagag tggcagaaga tgcttgttac agagaacgtc aggttagctt tgcaagtttc
     1441 tctatccact tgaactcggt tagacattgt gttttgtgag gaccaggagt gtgaaacttg
     1501 gctgtttgtg tgcatgtgtg tggcagtcag aggttctcta ctgtgtagat tctggactca
     1561 ctctgcagca agtctattca ttaagccatc ttgcaagcct gttttctgtg tgtgacagtg
     1621 tcttaggaag tctggtggtg gcctcaaact gtaatcttaa actactgttc cttggttcac
     1681 cttccaagtg ctgggggtgc agatgggcac ccctcctgat tgtttgaccc ttttgtgaca
     1741 gtcaacattt gtctcctatc tgcagagatg gggttcttgg atccaggtga ccacagatag
     1801 ggcaattcag tttatctatt tgaacaggta aaaatgttcc catgaattga gtccctcccc
     1861 ctccttatga cctgacactt tatttgaaac ccaacaggat tttggccctc aaactaattg
     1921 atttggtgca aggccacatg gcgggacact gaggagtcta atataatttg atagggccca
     1981 tgtttactgt caagagctgg tgacttattc tcaggttcag acgtgagaaa cgttgctata
     2041 gaaataaaat tggtttgatg gtgtatggaa
//
