LOCUS       NM_001395083            1379 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1
            (Dync2li1), mRNA.
ACCESSION   NM_001395083 XM_006239695
VERSION     NM_001395083.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Kessler,K., Wunderlich,I., Uebe,S., Falk,N.S., Giessl,A.,
            Brandstatter,J.H., Popp,B., Klinger,P., Ekici,A.B., Sticht,H.,
            Dorr,H.G., Reis,A., Roepman,R., Seemanova,E. and Thiel,C.T.
  TITLE     DYNC2LI1 mutations broaden the clinical spectrum of dynein-2
            defects
  JOURNAL   Sci Rep 5, 11649 (2015)
   PUBMED   26130459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Taylor,S.P., Dantas,T.J., Duran,I., Wu,S., Lachman,R.S.,
            Nelson,S.F., Cohn,D.H., Vallee,R.B. and Krakow,D.
  CONSRTM   University of Washington Center for Mendelian Genomics Consortium
  TITLE     Mutations in DYNC2LI1 disrupt cilia function and cause short rib
            polydactyly syndrome
  JOURNAL   Nat Commun 6, 7092 (2015)
   PUBMED   26077881
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Ichikawa,M., Watanabe,Y., Murayama,T. and Toyoshima,Y.Y.
  TITLE     Recombinant human cytoplasmic dynein heavy chain 1 and 2:
            observation of dynein-2 motor activity in vitro
  JOURNAL   FEBS Lett 585 (15), 2419-2423 (2011)
   PUBMED   21723285
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Rana,A.A., Barbera,J.P., Rodriguez,T.A., Lynch,D., Hirst,E.,
            Smith,J.C. and Beddington,R.S.
  TITLE     Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts
            the embryonic organiser, formation of the body axes and
            specification of ventral cell fates
  JOURNAL   Development 131 (20), 4999-5007 (2004)
   PUBMED   15371312
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Perrone,C.A., Tritschler,D., Taulman,P., Bower,R., Yoder,B.K. and
            Porter,M.E.
  TITLE     A novel dynein light intermediate chain colocalizes with the
            retrograde motor for intraflagellar transport at sites of axoneme
            assembly in chlamydomonas and Mammalian cells
  JOURNAL   Mol Biol Cell 14 (5), 2041-2056 (2003)
   PUBMED   12802074
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Mikami,A., Tynan,S.H., Hama,T., Luby-Phelps,K., Saito,T.,
            Crandall,J.E., Besharse,J.C. and Vallee,R.B.
  TITLE     Molecular structure of cytoplasmic dynein 2 and its distribution in
            neuronal and ciliated cells
  JOURNAL   J Cell Sci 115 (Pt 24), 4801-4808 (2002)
   PUBMED   12432068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006239695.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.34110.1,
                                           SRR26643285.23506.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JAXUCZ010000006.1  15778058-15778166   c
            110-227             JAXUCZ010000006.1  15776271-15776388   c
            228-262             JAXUCZ010000006.1  15771820-15771854   c
            263-332             JAXUCZ010000006.1  15769816-15769885   c
            333-421             JAXUCZ010000006.1  15765626-15765714   c
            422-608             JAXUCZ010000006.1  15760360-15760546   c
            609-677             JAXUCZ010000006.1  15759511-15759579   c
            678-755             JAXUCZ010000006.1  15758887-15758964   c
            756-832             JAXUCZ010000006.1  15755005-15755081   c
            833-903             JAXUCZ010000006.1  15754639-15754709   c
            904-1001            JAXUCZ010000006.1  15752149-15752246   c
            1002-1094           JAXUCZ010000006.1  15751974-15752066   c
            1095-1379           JAXUCZ010000006.1  15745350-15745634   c
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1379
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /note="dynein cytoplasmic 2 light intermediate chain 1"
                     /db_xref="GeneID:298767"
                     /db_xref="RGD:1310286"
     exon            1..109
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1157
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /codon_start=1
                     /product="cytoplasmic dynein 2 light intermediate chain 1"
                     /protein_id="NP_001382012.1"
                     /db_xref="GeneID:298767"
                     /db_xref="RGD:1310286"
                     /translation="MPSETLWEIAKAEVEKRRCHGSDGDGMEIGEKSVFFIGSKNGGK
                     TTIILRCLDRDEPAKPTLALEYTYGRKTKGHNTPKDIAHFWELGGGTSLLDLISIPIT
                     VDTLRTFSIVLVLDLSKPNDLWPTMENLLQATKSHVDKVTMKLGKANSKASSEMRQRM
                     WSVMQKDHPDRELIDPFPIPLVIIGSKYDIFQDFDPEKRKVICKTLRFVAHYYGASLM
                     FTSKSEALLLKMRGVINQLAFGIDKSKSMCVDQNKPLFITAGLDSLCQIGSPPVPDSD
                     IGKLQAHSPMELWKKVYEKLFPPKSTSTLKAIQDPARDPQYAESEVDEMRVQKDQELE
                     QYKRSSSKTWKQIELDS"
     exon            110..227
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            228..262
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            263..332
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            333..421
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            422..608
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            609..677
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            678..755
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            756..832
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            833..903
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1001
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1094
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1379
                     /gene="Dync2li1"
                     /gene_synonym="RGD1310286"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgttctc tgggcccaac taggagcttg cagccccatc cggcctgggt cagggttgtc
       61 ccccacgcgg agcccagaac atctggggcg gcgcagtcac catgcccagt gaaactctct
      121 gggaaatcgc gaaggccgag gtagagaaac ggagatgcca tggaagtgac ggggatggaa
      181 tggagatcgg agaaaaatct gttttcttca ttggcagtaa aaatggggga aagactacga
      241 ttattctacg gtgtcttgac agggatgagc cggcaaagcc gaccttagct ctggaataca
      301 cgtacggaag gaaaaccaag gggcataaca caccaaaaga cattgctcac ttttgggagc
      361 tgggtggagg aacctcgtta ctggacttaa tcagcatccc aattacagtc gacaccttaa
      421 ggacgttttc tattgttctt gttttggatc tttccaaacc taatgatctt tggcccacca
      481 tggaaaatct gttgcaagcc acaaaaagcc acgtagacaa ggtgacaatg aagctgggca
      541 aggccaactc gaaggcctcg tctgagatga ggcagaggat gtggagcgtc atgcagaagg
      601 accatccgga tcgtgaatta attgacccat ttccaatacc tctggtcatt attggaagta
      661 aatatgacat tttccaggat tttgaccctg agaagagaaa ggtgatctgt aagaccctgc
      721 gctttgtggc gcattactac ggagcctcgc tgatgtttac cagcaaatca gaagctctgc
      781 tactgaagat gcgcggtgtc atcaaccagt tggcatttgg tattgataag agcaaatcaa
      841 tgtgtgtgga tcaaaataaa ccactgttta tcacagcagg attggattct ttatgtcaaa
      901 tagggtctcc tcctgttcct gatagtgaca ttggaaagct tcaggcccac tcacctatgg
      961 agctgtggaa aaaggtgtat gaaaagctct tcccaccaaa gagtaccagc accctgaagg
     1021 ccatccagga cccagcccgg gacccacagt atgcagaaag tgaagtggac gagatgaggg
     1081 ttcagaagga tcaggaacta gagcaataca agagaagttc ctccaagacc tggaaacaaa
     1141 tcgagctgga ctcctgagcc tgctacactg ttgtgggtta tgacttcctt cccaagttca
     1201 aggaagatta ttttcttacc ttctatggca acatgtgaag aaagttgaga catataatct
     1261 gttagggaaa acctatttct tgttctggta caacttcctg attattctga agtcctttag
     1321 aaggcaaata ttcactgtgt cattcttttc taaataaaag atttttctat cacttagca
//
