LOCUS       NM_145772               1722 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus dynein cytoplasmic 1 light intermediate chain 1
            (Dync1li1), mRNA.
ACCESSION   NM_145772
VERSION     NM_145772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Goncalves,J.C., Dantas,T.J. and Vallee,R.B.
  TITLE     Distinct roles for dynein light intermediate chains in
            neurogenesis, migration, and terminal somal translocation
  JOURNAL   J Cell Biol 218 (3), 808-819 (2019)
   PUBMED   30674581
  REMARK    GeneRIF: LIC1, through BicD2, is required for apical nuclear
            migration in neural progenitors. In newborn neurons, we observe
            specific roles for LIC1 in the multipolar to bipolar transition and
            glial-guided neuronal migration. In contrast, LIC2 contributes to a
            novel dynein role in the little-studied mode of migration, terminal
            somal translocation.
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Schroeder,C.M., Ostrem,J.M., Hertz,N.T. and Vale,R.D.
  TITLE     A Ras-like domain in the light intermediate chain bridges the
            dynein motor to a cargo-binding region
  JOURNAL   Elife 3, e03351 (2014)
   PUBMED   25272277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Scherer,J., Yi,J. and Vallee,R.B.
  TITLE     PKA-dependent dynein switching from lysosomes to adenovirus: a
            novel form of host-virus competition
  JOURNAL   J Cell Biol 205 (2), 163-177 (2014)
   PUBMED   24778311
  REMARK    GeneRIF: PKA-mediated LIC1 phosphorylation causes only partial
            lyso/LE dispersal, suggesting a role for additional, parallel
            mechanisms for dynein recruitment to lyso/LEs.
REFERENCE   4  (bases 1 to 1722)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1722)
  AUTHORS   Allan,V.J.
  TITLE     Cytoplasmic dynein
  JOURNAL   Biochem Soc Trans 39 (5), 1169-1178 (2011)
   PUBMED   21936784
  REMARK    Review article
REFERENCE   6  (bases 1 to 1722)
  AUTHORS   Sivaram,M.V., Wadzinski,T.L., Redick,S.D., Manna,T. and Doxsey,S.J.
  TITLE     Dynein light intermediate chain 1 is required for progress through
            the spindle assembly checkpoint
  JOURNAL   EMBO J 28 (7), 902-914 (2009)
   PUBMED   19229290
REFERENCE   7  (bases 1 to 1722)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   8  (bases 1 to 1722)
  AUTHORS   Salata,M.W., Dillman,J.F. 3rd, Lye,R.J. and Pfister,K.K.
  TITLE     Growth factor regulation of cytoplasmic dynein intermediate chain
            subunit expression preceding neurite extension
  JOURNAL   J Neurosci Res 65 (5), 408-416 (2001)
   PUBMED   11536324
REFERENCE   9  (bases 1 to 1722)
  AUTHORS   Tynan,S.H., Purohit,A., Doxsey,S.J. and Vallee,R.B.
  TITLE     Light intermediate chain 1 defines a functional subfraction of
            cytoplasmic dynein which binds to pericentrin
  JOURNAL   J Biol Chem 275 (42), 32763-32768 (2000)
   PUBMED   10893222
REFERENCE   10 (bases 1 to 1722)
  AUTHORS   Purohit,A., Tynan,S.H., Vallee,R. and Doxsey,S.J.
  TITLE     Direct interaction of pericentrin with cytoplasmic dynein light
            intermediate chain contributes to mitotic spindle organization
  JOURNAL   J Cell Biol 147 (3), 481-492 (1999)
   PUBMED   10545494
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_145772.3.
            
            On Nov 27, 2020 this sequence version replaced NM_145772.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181992.1, SRR26643299.37586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  123254970-123255130
            162-235             JAXUCZ010000008.1  123255308-123255381
            236-352             JAXUCZ010000008.1  123272073-123272189
            353-583             JAXUCZ010000008.1  123272851-123273081
            584-753             JAXUCZ010000008.1  123276067-123276236
            754-847             JAXUCZ010000008.1  123279785-123279878
            848-983             JAXUCZ010000008.1  123281594-123281729
            984-1095            JAXUCZ010000008.1  123282085-123282196
            1096-1155           JAXUCZ010000008.1  123284414-123284473
            1156-1200           JAXUCZ010000008.1  123285338-123285382
            1201-1321           JAXUCZ010000008.1  123286133-123286253
            1322-1474           JAXUCZ010000008.1  123286809-123286961
            1475-1722           JAXUCZ010000008.1  123288249-123288496
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1722
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /note="dynein cytoplasmic 1 light intermediate chain 1"
                     /db_xref="GeneID:252902"
                     /db_xref="RGD:71072"
     exon            1..161
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1587
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /note="dynein, cytoplasmic, light intermediate polypeptide
                     1; DLC-A; dynein light chain A; dynein light intermediate
                     chain 1, cytosolic; dynein, cytoplasmic, light
                     intermediate chain 1; cytoplasmic dynein 1 light
                     intermediate chain 1-like"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 light intermediate chain 1"
                     /protein_id="NP_665715.2"
                     /db_xref="GeneID:252902"
                     /db_xref="RGD:71072"
                     /translation="MAAVGRVGSFGSSPPGLASTYASGPLANELASGSGGPAAGDDED
                     GQNLWSCILSEVSTRSRSKLPTGKNVLLLGEDGAGKTSLIRRIQGIEEYKKGRGLEYL
                     YLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLRDTLVMLVVDMSKPWTALD
                     SLQKWASVVREHVDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDFPASPQRRATAAQED
                     RDDSVVLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCL
                     QYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIG
                     ILHENFQTLKIEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAG
                     RPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNS
                     LLSKKTGSPGGPGVGGSPGGGAAGASTSLPPSAKKSGQKPVLSDVHAELDRITRKPAS
                     VSPTTPPSPTEGEAS"
     exon            162..235
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..352
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..583
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..753
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..847
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..983
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1095
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1155
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1200
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1321
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1474
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1722
                     /gene="Dync1li1"
                     /gene_synonym="Dncli1; Dnclic1; LIC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgattcccga ccaagatggc ggccgtgggg cgagtcggct cgttcggttc atctccaccc
       61 gggctagcct cgacttacgc cagcggaccc ctagccaacg agctggcttc gggcagcggc
      121 ggccccgcgg cgggcgacga tgaggacggg cagaaccttt ggtcctgcat cctcagcgaa
      181 gtctccacgc gctcgcgctc caagctcccg accgggaaga acgtgctgct gctgggtgag
      241 gatggagctg ggaaaacaag cctcataaga agaatccagg ggatagagga gtacaagaag
      301 ggacgaggac tggagtattt gtacttaaat gtgcatgacg aagacaggga tgatcaaaca
      361 agatgtaatg tatggatctt agatggagat ctataccaca aagggctact caagttctct
      421 ctggatgccc tttctctgag ggacactctg gtcatgttgg tcgtcgatat gtcaaagcct
      481 tggactgctt tggattcctt acagaagtgg gcaagtgtgg tgagagaaca tgttgacaaa
      541 ctgaaaatcc cccctgaaga aatgaaggaa atggagcaga agttgattag agacttccaa
      601 gagtacgtgg agccaggaga agacttccca gcctcccctc agcgaagagc cacggctgca
      661 caggaggaca gagatgacag tgtcgtccta cccctgggtg cagacacgct cacacacaac
      721 ctgggcctac ccgtgctcgt agtctgtaca aagtgtgatg ccattagtgt cttggagaaa
      781 gaacatgact atagagatga acacttcgat tttatccagt cacacatccg caagttctgt
      841 ttacagtacg gtgcagcgct gatttacacg tctgtcaaag agaacaagaa catagattta
      901 gtttataaat acatcgtcca gaagctgtac gggttcccct acaagatccc tgcggtggtg
      961 gtggaaaagg acgcagtgtt cattccagca gggtgggata atgataagaa aataggaata
     1021 ttacatgaaa attttcaaac tttgaaaata gaagataatt ttgaagacat cataaccaaa
     1081 cctcctgtcc gaaagtttgt gcatgagaag gagattatgg cagaagatga ccaagtgttt
     1141 cttatgaagc tacagtctct tttagcaaag caacctccaa ctgctgctgg aaggcctgtg
     1201 gatgcatcac caagagtccc tggaggctct cctcgaacac caaacagatc cgtgtcatcc
     1261 aatgttgcca gcgtgtcccc catccctgca ggatccaaaa aaattgatcc caacatgaaa
     1321 gctggagcaa ccagcgaagg ggtcctggca aatttcttca acagtctgtt gagtaagaag
     1381 actggctctc ctggaggccc cggggtcggg ggcagtcctg gaggaggggc tgcaggtgca
     1441 agcacgagtt tgccaccatc cgccaagaag tcaggccaga aacctgtgct ctcagatgtt
     1501 catgccgagc tcgacagaat cacacggaaa cctgcttctg tttctcctac aacacctcca
     1561 tctcctacgg aaggagaagc ctcctgaaac accaaacaaa gccgtttgtt cgttcttccg
     1621 ggtgacgaca gcttgtctct gccctctcct tcccagttgg aattatgatg gggcgggacc
     1681 ggaagctttt acacacaaag cttatgtcct tttttttttt tt
//
