LOCUS       NM_001270625            2743 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dynein cytoplasmic 1 intermediate chain 2
            (Dync1i2), transcript variant 3, mRNA.
ACCESSION   NM_001270625
VERSION     NM_001270625.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Inaba,Y., Shinohara,K., Botilde,Y., Nabeshima,R., Takaoka,K.,
            Ajima,R., Lamri,L., Takeda,H., Saga,Y., Nakamura,T. and Hamada,H.
  TITLE     Transport of the outer dynein arm complex to cilia requires a
            cytoplasmic protein Lrrc6
  JOURNAL   Genes Cells 21 (7), 728-739 (2016)
   PUBMED   27353389
REFERENCE   2  (bases 1 to 2743)
  AUTHORS   Blasier,K.R., Humsi,M.K., Ha,J., Ross,M.W., Smiley,W.R.,
            Inamdar,N.A., Mitchell,D.J., Lo,K.W. and Pfister,K.K.
  TITLE     Live cell imaging reveals differential modifications to cytoplasmic
            dynein properties by phospho- and dephosphomimic mutations of the
            intermediate chain 2C S84
  JOURNAL   J Neurosci Res 92 (9), 1143-1154 (2014)
   PUBMED   24798412
  REMARK    GeneRIF: The data of this study suggest that the IC-2C S84 has a
            role in modulating dynein properties.
REFERENCE   3  (bases 1 to 2743)
  AUTHORS   Hirayama,M., Kobayashi,D., Mizuguchi,S., Morikawa,T., Nagayama,M.,
            Midorikawa,U., Wilson,M.M., Nambu,A.N., Yoshizawa,A.C., Kawano,S.
            and Araki,N.
  TITLE     Integrated proteomics identified novel activation of dynein
            IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease
            model cells
  JOURNAL   Mol Cell Proteomics 12 (5), 1377-1394 (2013)
   PUBMED   23358504
  REMARK    GeneRIF: Neurofibromatosis type I-related neural abnormalities are,
            in part, caused by up-regulation of dynein IC2-glucocorticoid
            receptor-COX-1 signaling.
REFERENCE   4  (bases 1 to 2743)
  AUTHORS   Allan,V.J.
  TITLE     Cytoplasmic dynein
  JOURNAL   Biochem Soc Trans 39 (5), 1169-1178 (2011)
   PUBMED   21936784
  REMARK    Review article
REFERENCE   5  (bases 1 to 2743)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   6  (bases 1 to 2743)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 2743)
  AUTHORS   Gorbea,C., Pratt,G., Ustrell,V., Bell,R., Sahasrabudhe,S.,
            Hughes,R.E. and Rechsteiner,M.
  TITLE     A protein interaction network for Ecm29 links the 26 S proteasome
            to molecular motors and endosomal components
  JOURNAL   J Biol Chem 285 (41), 31616-31633 (2010)
   PUBMED   20682791
REFERENCE   8  (bases 1 to 2743)
  AUTHORS   Salata,M.W., Dillman,J.F. 3rd, Lye,R.J. and Pfister,K.K.
  TITLE     Growth factor regulation of cytoplasmic dynein intermediate chain
            subunit expression preceding neurite extension
  JOURNAL   J Neurosci Res 65 (5), 408-416 (2001)
   PUBMED   11536324
REFERENCE   9  (bases 1 to 2743)
  AUTHORS   Pfister,K.K., Salata,M.W., Dillman,J.F. 3rd, Torre,E. and Lye,R.J.
  TITLE     Identification and developmental regulation of a neuron-specific
            subunit of cytoplasmic dynein
  JOURNAL   Mol Biol Cell 7 (2), 331-343 (1996)
   PUBMED   8688562
REFERENCE   10 (bases 1 to 2743)
  AUTHORS   Vaughan,K.T. and Vallee,R.B.
  TITLE     Cytoplasmic dynein binds dynactin through a direct interaction
            between the intermediate chains and p150Glued
  JOURNAL   J Cell Biol 131 (6 Pt 1), 1507-1516 (1995)
   PUBMED   8522607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB733957.1, FM110655.1, JAXUCZ010000003.1, BC078764.1 and
            FM076575.1.
            
            Transcript Variant: This variant (3) lacks two alternate in-frame
            exons compared to variant 1. The resulting isoform (3) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39046.1, SRR26643292.12686.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CB733957.1         2-59
            59-253              FM110655.1         1-195
            254-269             JAXUCZ010000003.1  76492767-76492782
            270-686             BC078764.1         1-417
            687-2307            BC078764.1         478-2098
            2308-2742           FM076575.1         229-663
            2743-2758           JAXUCZ010000003.1  76492767-76492782
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q22"
     gene            1..2743
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /note="dynein cytoplasmic 1 intermediate chain 2"
                     /db_xref="GeneID:116659"
                     /db_xref="RGD:620174"
     exon            1..345
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..462
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..2193
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     dynein, cytoplasmic, intermediate polypeptide 2;
                     cytoplasmic dynein 1 intermediate chain 2; DH IC-2; dynein
                     intermediate chain 2, cytosolic; cytoplasmic dynein
                     intermediate chain 2; dynein, cytoplasmic, intermediate
                     chain 2; oncofetal protein (OFP)"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 intermediate chain 2
                     isoform 3"
                     /protein_id="NP_001257554.1"
                     /db_xref="GeneID:116659"
                     /db_xref="RGD:620174"
                     /translation="MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAA
                     VSVQEESDLEKKRREAEALLQSMGLTTDSPIVPPPMSPSSKSVSTPSEAGSQDSGDGA
                     VGSRRGPIKLGMAKITQVDFPPREIVTYTKETQTPVTAQPKEDEEEEDDVAAPKPPVE
                     PEEEKILKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIF
                     FDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNN
                     EEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
                     DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHP
                     QDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQ
                     GPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSP
                     THPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEG
                     QIVIYDVGEQIAVPRNDEWARFGRTLAEINASRADAEEEAATRIPA"
     exon            463..580
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..671
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..787
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..883
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1046
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1146
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1272
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1419
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1533
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1667
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1812
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1953
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2079
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2743
                     /gene="Dync1i2"
                     /gene_synonym="Dnci2; Dncic2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgtactcc gccccaggat gtgaggtgta gttgtccagc ttttgccaaa gcggaaacgc
       61 ttcggatccc gcggccggtg tgtctctatt tcaccggtca gattctgttt tgcaaaaggt
      121 aagtcacgga aagggcgccc ttccgtgccg ggcggtaaag attctgtttt tgtgggagac
      181 cgcgtcggcg aagtcatttg tcccttggct cacgccgtag tggccgccgc ccatccctct
      241 ttgtgtgctt gggacgccag ggatctgcgg tggcgacagt tggagaggga cgttcccgga
      301 aagttaccgg tcagaagaaa ctatctccac atcaccacct gacaggtcac aaccatgtca
      361 gacaaaagtg aattaaaagc tgagttggaa cgtaagaagc aacggttggc ccaaatcaga
      421 gaagaaaaga agaggaaaga agaggaaagg aaaaaaaaag aaactgatca gaagaaggaa
      481 gctgcagtct ctgtgcagga agagtctgac cttgaaaaga agagaagaga agccgaagcc
      541 ttgcttcaga gcatggggct aactacagac tccccaattg tccctcctcc catgtctcca
      601 tcctccaagt cggtgagcac gccaagtgaa gctggaagcc aggactctgg agatggcgcc
      661 gtgggatcta gacgaggacc tattaaactt ggaatggcca aaattactca agtcgacttt
      721 ccccctcgag aaatcgtcac atatacaaag gaaactcaga ccccggttac agctcaaccc
      781 aaagaagatg aggaggagga agatgacgta gcagctccta agcctcctgt tgaacctgaa
      841 gaagagaaaa ttttaaaaaa agacgaagag aatgatagca aagctccccc tcatgaacta
      901 actgaagaag aaaagcaaca aattttacac tcagaagaat ttttaagttt ctttgaccat
      961 tctacaagaa ttgtagaaag agccctctct gagcagatta acatcttctt tgactacagt
     1021 gggagagatt tggaagacaa agaaggggag attcaagcag gtgctaagct gtcattaaat
     1081 cgacagtttt ttgatgagcg ttggtcaaag catcgagttg ttagttgctt ggattggtca
     1141 tcccagtatc cagaattact tgtggcttcc tataataaca atgaagaggc tcctcatgag
     1201 cctgatggtg tggccctcgt atggaatatg aagtacaaga aaactacccc agagtacgtg
     1261 ttccactgcc agtcagctgt aatgtctgct acatttgcaa aatttcatcc aaatcttgtt
     1321 gttggaggta catactcagg ccaaattgtg ctttgggata accgtagcaa taaaagaacc
     1381 cccgtccaga gaacaccact gtcagctgct gcacacacac accctgtcta ctgtgtaaat
     1441 gttgttggaa cacaaaatgc tcataatctg attagcatct ctactgatgg aaaaatttgc
     1501 tcctggagct tagacatgct ttcccatcca caggatagca tggagttggt tcataaacag
     1561 tcaaaggcag tagctgtaac atctatgtct ttccctgttg gagacgtcaa caactttgtt
     1621 gtgggcagtg aagaaggttc tgtgtataca gcatgccgcc atggcagcaa agccggaatc
     1681 agtgagatgt ttgagggaca ccagggaccc atcacgggaa tccactgtca cgcagctgtt
     1741 ggcgcagtag acttctcaca tctgttcgtc acttcgtctt ttgactggac agtaaaactt
     1801 tggacaacta agaataacaa gcctttgtac tcatttgaag ataattcaga ctatgtctat
     1861 gatgttatgt ggtcacccac ccacccagcc ctgtttgcct gtgtggatgg catggggaga
     1921 ctggatctat ggaatctcaa caatgacaca gaggtgccga ctgccagcat ttctgtggag
     1981 ggcaaccctg cccttaaccg tgtgagatgg acccactcgg gaagagagat cgccgtgggt
     2041 gattctgaag gacagattgt catatatgat gtgggcgagc agatcgctgt tccccgaaat
     2101 gatgaatggg caagatttgg ccgaacactc gcagagatta acgcaagccg agctgatgca
     2161 gaggaggaag cggctacccg gattcctgcc taggcctgga gggtggccgt agccttatcg
     2221 agtctggcaa agaggatgaa gtagatccta aactatttgc atgcttctga ttaaacgaga
     2281 attaaaagaa aactccatgg atagactggg tttaatacag gaagcaaagc ttaccgagcc
     2341 cttttatatt ctattccctt tgctttggat tggtgtcatt tttaatacag ctgacaactt
     2401 tacagaatgc agccttttct gaattctaac acatgggtgt atattgttaa ttattctttt
     2461 ggattctttt gaacttgtac tactatatat aattatttct aaagcacaga ctaagtgagt
     2521 tctgcatatt tctaaagagc cacagtccct tattatgcaa tacagtacat gggtccttgt
     2581 cagttatgtc ctcactgccc tgagtgagta ggaacattgt tcttagtgcc agcatgcatt
     2641 cgcctacctg ttttaagttt catgttgatg ccgttttcct tctctatagt tcatggtagt
     2701 tatctataaa taaaaacaaa tatgtgctaa cttttcaaat ttt
//
