LOCUS       NM_019234               2644 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus dynein cytoplasmic 1 intermediate chain 1
            (Dync1i1), mRNA.
ACCESSION   NM_019234
VERSION     NM_019234.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Cao,J., Lin,C., Wang,H., Wang,L., Zhou,N., Jin,Y., Liao,M. and
            Zhou,J.
  TITLE     Circovirus transport proceeds via direct interaction of the
            cytoplasmic dynein IC1 subunit with the viral capsid protein
  JOURNAL   J Virol 89 (5), 2777-2791 (2015)
   PUBMED   25540360
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Hehnly,H. and Doxsey,S.
  TITLE     Rab11 endosomes contribute to mitotic spindle organization and
            orientation
  JOURNAL   Dev Cell 28 (5), 497-507 (2014)
   PUBMED   24561039
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Siglin,A.E., Sun,S., Moore,J.K., Tan,S., Poenie,M., Lear,J.D.,
            Polenova,T., Cooper,J.A. and Williams,J.C.
  TITLE     Dynein and dynactin leverage their bivalent character to form a
            high-affinity interaction
  JOURNAL   PLoS One 8 (4), e59453 (2013)
   PUBMED   23577064
  REMARK    GeneRIF: the dynein-dynactin interaction proceeds through a
            disorder-to-order transition
            Erratum:[PLoS One. 2024 Jun 4;19(6):e0304916. doi:
            10.1371/journal.pone.0304916.. PMID: 38833489]
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Allan,V.J.
  TITLE     Cytoplasmic dynein
  JOURNAL   Biochem Soc Trans 39 (5), 1169-1178 (2011)
   PUBMED   21936784
  REMARK    Review article
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Villace,P., Marion,R.M. and Ortin,J.
  TITLE     The composition of Staufen-containing RNA granules from human cells
            indicates their role in the regulated transport and translation of
            messenger RNAs
  JOURNAL   Nucleic Acids Res 32 (8), 2411-2420 (2004)
   PUBMED   15121898
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Ligon,L.A., Tokito,M., Finklestein,J.M., Grossman,F.E. and
            Holzbaur,E.L.
  TITLE     A direct interaction between cytoplasmic dynein and kinesin I may
            coordinate motor activity
  JOURNAL   J Biol Chem 279 (18), 19201-19208 (2004)
   PUBMED   14985359
  REMARK    GeneRIF: the intermediate chain of dynein binds to kinesin light
            chains 1 and 2. The interaction is both direct and specific
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Mok,Y.K., Lo,K.W. and Zhang,M.
  TITLE     Structure of Tctex-1 and its interaction with cytoplasmic dynein
            intermediate chain
  JOURNAL   J Biol Chem 276 (17), 14067-14074 (2001)
   PUBMED   11148215
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Pfister,K.K., Salata,M.W., Dillman,J.F. 3rd, Torre,E. and Lye,R.J.
  TITLE     Identification and developmental regulation of a neuron-specific
            subunit of cytoplasmic dynein
  JOURNAL   Mol Biol Cell 7 (2), 331-343 (1996)
   PUBMED   8688562
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Paschal,B.M., Mikami,A., Pfister,K.K. and Vallee,R.B.
  TITLE     Homology of the 74-kD cytoplasmic dynein subunit with a flagellar
            dynein polypeptide suggests an intracellular targeting function
  JOURNAL   J Cell Biol 118 (5), 1133-1143 (1992)
   PUBMED   1387402
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019234.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66845.1, SRR26360176.661354.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000004.1  34819441-34819592
            153-269             JAXUCZ010000004.1  34853379-34853495
            270-384             JAXUCZ010000004.1  34862600-34862714
            385-520             JAXUCZ010000004.1  34865273-34865408
            521-580             JAXUCZ010000004.1  34880333-34880392
            581-696             JAXUCZ010000004.1  34903499-34903614
            697-786             JAXUCZ010000004.1  35011289-35011378
            787-949             JAXUCZ010000004.1  35018639-35018801
            950-1049            JAXUCZ010000004.1  35021417-35021516
            1050-1175           JAXUCZ010000004.1  35029055-35029180
            1176-1322           JAXUCZ010000004.1  35067539-35067685
            1323-1436           JAXUCZ010000004.1  35072090-35072203
            1437-1570           JAXUCZ010000004.1  35074790-35074923
            1571-1715           JAXUCZ010000004.1  35078308-35078452
            1716-1856           JAXUCZ010000004.1  35110862-35111002
            1857-1982           JAXUCZ010000004.1  35115149-35115274
            1983-2644           JAXUCZ010000004.1  35131986-35132647
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..2644
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /note="dynein cytoplasmic 1 intermediate chain 1"
                     /db_xref="GeneID:29564"
                     /db_xref="RGD:2512"
     exon            1..152
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            153..269
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2093
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /note="dynein, cytoplasmic, intermediate chain 1; DH IC-1;
                     dynein intermediate chain 1, cytosolic; cytoplasmic dynein
                     intermediate chain 1; Dnci 1; dynein cytoplasmic 1
                     intermediate chain 1C; dynein cytoplasmic 1 intermediate
                     chain 1B; dynein cytoplasmic 1 intermediate chain 1D;
                     dynein cytoplasmic 1 intermediate chain 1A"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 intermediate chain 1"
                     /protein_id="NP_062107.2"
                     /db_xref="GeneID:29564"
                     /db_xref="RGD:2512"
                     /translation="MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKE
                     PVPDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKS
                     VSTPSEAGSQDDLGPLTRTLQWDTDPSVLQLQSDSELGRRLNKLGVSKVTQVDFLPRE
                     VVSYSKETQTPLATHQSEEDEEDEEMVEPKVGHDSELENQDKKQETKEAPPRELTEEE
                     KQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQ
                     FYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWNMKFKKTTPEYV
                     FHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYC
                     VNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDV
                     NNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSF
                     DWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDTEV
                     PTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFARTLV
                     EIRANRADSEEEGAVELAA"
     exon            270..384
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            385..520
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            521..580
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            581..696
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            697..786
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            787..949
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1049
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1175
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1322
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1436
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1570
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1715
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1856
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1982
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2644
                     /gene="Dync1i1"
                     /gene_synonym="Dnci1; Dncic1; IC74-1A; IC74-1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagctcagg agagaggaag tgatcgctcc gggaggagcg ctagcctagc cgcgcagcgt
       61 gagacagcac atcctgctgg cgcgggcccg ctgctccccg tcctcccgcg cctcctccac
      121 cacctcagtg agcctccgca gacagcatcc aggaagcaaa tatgtctgac aagagcgacc
      181 taaaagctga gctggagcgc aaaaagcagc gcttagcgca gataagagag gagaagaaac
      241 ggaaggaaga ggagaggaaa aagaaagagg cagatatgca gcagaagaaa gagcccgttc
      301 cagatgactc cgatctggac cgcaaacgac gagagacaga agctttgctt cagagcatcg
      361 gcatatcgcc ggagccccct ctagtgcagc cgctgcattt tttaacatgg gatacctgtt
      421 attttcatta tttagtccca acccctatgt ctccctcttc gaaatcagtg agcactccca
      481 gtgaagctgg aagccaagac gatctggggc cattaacaag gaccctgcag tgggacacag
      541 acccctcagt gctccagctg cagtcagact cagaacttgg gagaagactg aacaagctgg
      601 gcgtgtcaaa ggttacccag gtggatttcc tgcctaggga ggtggtatcc tactccaagg
      661 agacacagac tcctcttgca actcatcagt cagaagagga tgaggaagat gaggagatgg
      721 ttgagcccaa agttggtcat gattctgaac tggaaaatca agacaaaaag caggagacaa
      781 aggaagcccc tccaagagag ctgacggaag aagaaaaaca gcagatcctg cactcagagg
      841 aattcctcat cttctttgac cgaacgatcc gagtgattga acgagctctg gctgaggact
      901 ctgacatctt ttttgactac agcggccgag agctggagga gaaagatggg gatgtacagg
      961 ctggagccaa cctttctttc aaccgtcagt tctatgatga gcattggtct aagcaccggg
     1021 tggtcacatg tatggactgg tctctccagt accctgagct gatggttgct tcttatagca
     1081 acaatgaaga tgctccccat gaaccagatg gagtggcctt ggtttggaac atgaagttca
     1141 agaaaaccac accagaatat gtcttccact gtcagtcctc tgtgatgtca gtctgctttg
     1201 cccgtttcca tcctaatttg gtggttggtg gcacctattc aggccagatt gtcctctggg
     1261 acaatcgcag tcatcgaaga acccctgtcc agaggacccc cttgtcagcc gctgcacaca
     1321 cacatcctgt gtactgtgtc aatgttgttg ggacccagaa tgctcacaac ctgatcactg
     1381 tctctaccga tggcaaaatg tgttcctgga gcctggacat gctctcaacc ccacaggaga
     1441 gcatggagct ggtgtacaac aagtccaagc ctgtggctgt tacaggaatg gccttcccga
     1501 cgggagatgt caacaacttc gtggtcggca gtgaggaagg taccgtctac acagcttgtc
     1561 gtcatggaag caaagcaggc attggtgagg tctttgaagg tcaccaaggg ccagtgacag
     1621 gcattaactg ccacatggca gtgggtccca tcgacttttc tcatctgttt gtcacatcat
     1681 catttgactg gactgtcaaa ctgtggacca caaagcacaa caagccgctc tactcctttg
     1741 aagacaatgc agactatgtg tacgatgtca tgtggtcccc cgtgcatccc gcgctctttg
     1801 cctgcgtgga cgggatgggg cgcttggacc tctggaacct caacagtgac accgaggtgc
     1861 caacagcaag tgtggctatt gagggggctt ctgccctaaa ccgggttcgt tgggcacaag
     1921 gtggtaagga agttgcagta ggtgactcag aaggccgcat ctggatctac gatgttggag
     1981 agcttgcggt tccccacaat gatgaatgga cgcgatttgc ccggaccctg gtggagatcc
     2041 gcgccaatag ggctgacagc gaggaggaag gtgcggttga gttagctgcc taaatgtgag
     2101 cccagtctgc acgctgtggc tcccatcctt ccattctaga actcagtctg cagccaaggc
     2161 ccctgtgcag tgtttggtgt cctttccgta tcggtgtccc cgtggcaact tgggtgccat
     2221 attgtgcagt gtttccccat atcctcccca tgtaccctac tcacccgaaa tccaccacag
     2281 catttctacc tttgtgtccc tgtctcaaga aacaaaatgg gggagggaac ccttaggggt
     2341 ttagttgttg ccttttaact acttggtagc tgtatttaat agctggaaac ctctggttga
     2401 atttgtgctt acatgtactt ctggcgtagt cctattaaat ccatatgaag ccagatatga
     2461 ttgggtgcag atgtggcgtg cctcgtgata cggtgcaggg ccaaagactt gagatgtggt
     2521 gttttacatg gtgattcaca ttatgaatgg atttactaca agaacattgc tgctccttat
     2581 ttattgtaac gtgctgcatg gaacatattt atttgaaagc attaaaataa acgatcttag
     2641 agca
//
