LOCUS       NM_001106133            2516 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dymeclin (Dym), mRNA.
ACCESSION   NM_001106133 XM_001054727 XM_214529
VERSION     NM_001106133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2516)
  AUTHORS   Denais,C., Dent,C.L., Southgate,L., Hoyle,J., Dafou,D.,
            Trembath,R.C. and Machado,R.D.
  TITLE     Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome,
            encodes a protein integral to extracellular matrix and golgi
            organization and is associated with protein secretion pathways
            critical in bone development
  JOURNAL   Hum Mutat 32 (2), 231-239 (2011)
   PUBMED   21280149
REFERENCE   2  (bases 1 to 2516)
  AUTHORS   Cohn,D.H., Ehtesham,N., Krakow,D., Unger,S., Shanske,A.,
            Reinker,K., Powell,B.R. and Rimoin,D.L.
  TITLE     Mental retardation and abnormal skeletal development
            (Dyggve-Melchior-Clausen dysplasia) due to mutations in a novel,
            evolutionarily conserved gene
  JOURNAL   Am J Hum Genet 72 (2), 419-428 (2003)
   PUBMED   12491225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB712341.1, BC098944.1, EV765460.1, JAXUCZ010000018.1, DV722630.1
            and CO558582.1.
            
            On Oct 12, 2007 this sequence version replaced NM_001106133.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               CB712341.1         1-246
            247-551             BC098944.1         199-503
            552-758             BC098944.1         528-734
            759-1198            EV765460.1         245-684
            1199-1207           JAXUCZ010000018.1  70998975-70998983
            1208-1386           JAXUCZ010000018.1  71004150-71004328
            1387-1437           JAXUCZ010000018.1  71008183-71008233
            1438-1775           DV722630.1         2-339
            1776-1827           JAXUCZ010000018.1  71094543-71094594
            1828-2283           CO558582.1         41-496
            2284-2516           BC098944.1         1294-1526
FEATURES             Location/Qualifiers
     source          1..2516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2516
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /note="dymeclin"
                     /db_xref="GeneID:291433"
                     /db_xref="RGD:1309111"
     exon            1..213
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            214..404
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2274
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /codon_start=1
                     /product="dymeclin"
                     /protein_id="NP_001099603.2"
                     /db_xref="GeneID:291433"
                     /db_xref="RGD:1309111"
                     /translation="MGSNSSKISDLPKNEYLKRLSGPEAISENDPFWNQLFSFSFSAP
                     TSSTELKLLEEATISVCKSLVENNPRTGNLAALTKVFLARTRELRLSAECQNHIFIWQ
                     THNALFIICCLLKVFICEMSEEELQLHFTYEEKLPGTYSSDSEDLLEELLCSLIQLIT
                     DTPLLDITYEISVEAISAMIVFLSCQLFHKEVLRQSISHKYLMQGPCLPYTSKLVKTL
                     LYNFIRQEKPPPPGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKAASPELT
                     SPLANQSLLLLLVLVNLTDAPDIPNPYRQAVTSFKNTQDSSPFPSSVPHTFQINFNSL
                     YTTLCEQQTSDQATLLLYTLLHQNANVRTYMLARTDMENLVLPILEILYHVEERNSHH
                     VYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNM
                     TRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQQADS
                     VTFVRLSDLQSPVAQDLSVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQ
                     FRTHPSFQDIMQNIDLVISFFSSRLLQSGAELSVERVLEIIKQGVVALPKDRLKKFPE
                     LKFKYVEEEQPEEFFIPYVWSLVYNSAVGLYWNPQDIQLFAMDSD"
     exon            405..457
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            458..551
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            552..685
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            686..758
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            759..884
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1027
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1207
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1386
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1512
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1626
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1721
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1775
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1827
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2010
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2124
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2500
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccctctt ctcacttcag ctcttgcgtc tccgcaccga cagccgctgg ggccgctggg
       61 gccgccggag cgcggtcgga gcaggagccg ctgagctacg gaaccatgga ggcctaagcc
      121 agcgtgcaca cccggccccc tgtgcgcccg cgctctcgct cccttgctgc ctgctcgccg
      181 cggctggaag cggagtccgc gccgctgaca caggttgtcc tgtggaaatg cccatgtgaa
      241 gacaagctgc ctaccacaga gaagatggga tcgaacagca gcaagatcag tgatctacct
      301 aagaatgagt acttaaagag gctgtcaggc cccgaggcta tctctgaaaa cgaccccttc
      361 tggaatcagc tcttctcttt ttctttctct gcaccaacca gcagtactga gttgaagctg
      421 ttagaagagg caaccatttc agtttgcaag tctttggttg aaaacaaccc tcgaacaggg
      481 aacctcgctg cgctaactaa ggtcttcctt gctagaacca gagagctcag gctttcggcc
      541 gagtgtcaga accacatctt catctggcag acacacaatg ccttgtttat catctgctgc
      601 ctgctgaagg tgttcatctg tgagatgtct gaggaagagc tgcagcttca cttcacgtat
      661 gaagaaaagt tgcccggcac ctacagttct gactctgaag atcttttgga agaattgctc
      721 tgcagcttga tacagttaat cactgacact ccactcctgg atatcacata tgagatatca
      781 gtggaggcca tctcagcaat gattgtcttc ctttcctgtc agctcttcca caaggaggtt
      841 ctgcggcaga gcatcagtca caagtacctg atgcaaggtc catgtcttcc ctacaccagc
      901 aaacttgtga aaaccttatt atataacttt atcagacaag aaaagccacc tccgcccgga
      961 acccatgtct tccctcagca gtcggacggg ggaggactgc tgtatggact ggcgtcagga
     1021 gtagcaactg gtctctggac cgtcttcacg ctaggcgggg tgggcagcaa agccgcctct
     1081 cccgaactta cttcccctct ggccaaccag agtctcctgc tgctgttggt gctggtgaac
     1141 ctgacggatg ccccagacat ccccaacccc tacagacagg ccgtcacgtc gttcaagaac
     1201 acacaagaca gcagtccgtt cccatcatcc gtcccgcaca ccttccagat taactttaac
     1261 agtttgtaca caaccctgtg tgaacagcag acgtctgacc aggcaacgct cctcctgtac
     1321 actctgttgc accagaacgc caatgtcagg acgtacatgc tggcccggac agacatggaa
     1381 aaccttgttt taccaattct ggagattcta tatcatgttg aggaaagaaa ctcgcaccat
     1441 gtctacatgg cccttataat cctgttgatc cttacggaag acgacggctt caatcggtcc
     1501 attcatgagg tgatattaaa aaacattact tggtattcag aaagagtctt aactgaaatt
     1561 tccctgggga gcctcctaat tctggtggta ataagaacca tccagtacaa tatgaccagg
     1621 actagagaca agtacctgca caccaattgc ctggcggcgt tagcaaacat gtcagcacag
     1681 tttcgctccc tccaccagta tgctgcccag aggatcatca gtttgttttc tttgctgtct
     1741 aaaaaacaca acaaggttct ggagcaagcc acgcagcagg cagactcggt tactttcgtg
     1801 cgtttgagcg acctgcagtc tcctgtggcc caggacctca gcgtcattga agaagtgatt
     1861 cggatgatgc tggagatcat caactcctgc ctgactaatt ctctccacca caacccgaac
     1921 ttggtgtatg ccctgcttta caaacgggac ctctttgagc aattccggac tcacccctca
     1981 ttccaagaca taatgcagaa cattgacctg gtaatttcct tctttagctc aagactgcta
     2041 caatctggag ctgagctgtc agtggaacgg gtcttggaaa tcattaaaca aggggttgtg
     2101 gcactaccca aagacagact aaagaaattt ccagaactga aattcaaata cgtggaggaa
     2161 gagcagcctg aggagttctt catcccatac gtctggtctc tggtctacaa ctcggcagtt
     2221 ggcctgtact ggaacccaca ggacatccaa ctgtttgcca tggactcaga ctgaagcagg
     2281 acacggccat gcctacccca gcccagctgc tagttacttc acgtccagga gcagagcaga
     2341 cagactgccc gcccggtgtg tcttctgcca cagagggtca cacagcctgc ttctctcaca
     2401 cactgtgact gtcgggagac ttctcagtta gcggtagttc actgagcttt gatgtactgc
     2461 aagggcgagc acagaaataa acggaaaaca tgctgttcaa aaaaaaaaaa aaaaaa
//
