LOCUS       NP_001099603             669 aa            linear   ROD 27-APR-2025
DEFINITION  dymeclin [Rattus norvegicus].
ACCESSION   NP_001099603 XP_001054727 XP_214529
VERSION     NP_001099603.2
DBSOURCE    REFSEQ: accession NM_001106133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 669)
  AUTHORS   Denais,C., Dent,C.L., Southgate,L., Hoyle,J., Dafou,D.,
            Trembath,R.C. and Machado,R.D.
  TITLE     Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome,
            encodes a protein integral to extracellular matrix and golgi
            organization and is associated with protein secretion pathways
            critical in bone development
  JOURNAL   Hum Mutat 32 (2), 231-239 (2011)
   PUBMED   21280149
REFERENCE   2  (residues 1 to 669)
  AUTHORS   Cohn,D.H., Ehtesham,N., Krakow,D., Unger,S., Shanske,A.,
            Reinker,K., Powell,B.R. and Rimoin,D.L.
  TITLE     Mental retardation and abnormal skeletal development
            (Dyggve-Melchior-Clausen dysplasia) due to mutations in a novel,
            evolutionarily conserved gene
  JOURNAL   Am J Hum Genet 72 (2), 419-428 (2003)
   PUBMED   12491225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB712341.1, BC098944.1, EV765460.1, JAXUCZ010000018.1, DV722630.1
            and CO558582.1.
            
            On Oct 12, 2007 this sequence version replaced NP_001099603.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     Protein         1..669
                     /product="dymeclin"
                     /calculated_mol_wt=75917
     Region          1..646
                     /region_name="Dymeclin"
                     /note="Dyggve-Melchior-Clausen syndrome protein;
                     pfam09742"
                     /db_xref="CDD:462873"
     CDS             1..669
                     /gene="Dym"
                     /gene_synonym="RGD1309111"
                     /coded_by="NM_001106133.2:265..2274"
                     /db_xref="GeneID:291433"
                     /db_xref="RGD:1309111"
ORIGIN      
        1 mgsnsskisd lpkneylkrl sgpeaisend pfwnqlfsfs fsaptsstel klleeatisv
       61 ckslvennpr tgnlaaltkv flartrelrl saecqnhifi wqthnalfii ccllkvfice
      121 mseeelqlhf tyeeklpgty ssdsedllee llcsliqlit dtpllditye isveaisami
      181 vflscqlfhk evlrqsishk ylmqgpclpy tsklvktlly nfirqekppp pgthvfpqqs
      241 dgggllygla sgvatglwtv ftlggvgska aspeltspla nqslllllvl vnltdapdip
      301 npyrqavtsf kntqdsspfp ssvphtfqin fnslyttlce qqtsdqatll lytllhqnan
      361 vrtymlartd menlvlpile ilyhveerns hhvymaliil lilteddgfn rsihevilkn
      421 itwyservlt eislgsllil vvirtiqynm trtrdkylht nclaalanms aqfrslhqya
      481 aqriislfsl lskkhnkvle qatqqadsvt fvrlsdlqsp vaqdlsviee virmmleiin
      541 scltnslhhn pnlvyallyk rdlfeqfrth psfqdimqni dlvisffssr llqsgaelsv
      601 ervleiikqg vvalpkdrlk kfpelkfkyv eeeqpeeffi pyvwslvyns avglywnpqd
      661 iqlfamdsd
//
