LOCUS       NM_001107081            4582 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dishevelled segment polarity protein 3 (Dvl3),
            mRNA.
ACCESSION   NM_001107081 XM_001059597 XM_221304
VERSION     NM_001107081.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4582)
  AUTHORS   Li,L., Mao,B., Yan,M., Wu,S., Ge,R., Lian,Q. and Cheng,C.Y.
  TITLE     Planar cell polarity protein Dishevelled 3 (Dvl3) regulates
            ectoplasmic specialization (ES) dynamics in the testis through
            changes in cytoskeletal organization
  JOURNAL   Cell Death Dis 10 (3), 194 (2019)
   PUBMED   30808893
  REMARK    GeneRIF: Dvl3 is a regulator of Sertoli cell blood-testis barrier
            and also spermatid planar cell polarity function through its
            effects on the actin- and MT-based cytoskeletons in Sertoli cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4582)
  AUTHORS   Wang,Y., Wu,W., Zhu,M., Wang,C., Shen,W., Cheng,Y., Geng,L., Li,Z.,
            Zhang,J., Dai,J., Ma,H., Chen,L., Hu,Z., Jin,G. and Shen,H.
  TITLE     Integrating expression-related SNPs into genome-wide gene- and
            pathway-based analyses identified novel lung cancer susceptibility
            genes
  JOURNAL   Int J Cancer 142 (8), 1602-1610 (2018)
   PUBMED   29193083
REFERENCE   3  (bases 1 to 4582)
  AUTHORS   Zhang,X., Yu,X., Jiang,G., Miao,Y., Wang,L., Zhang,Y., Liu,Y.,
            Fan,C., Lin,X., Dong,Q., Han,Q., Zhao,H., Han,Y., Han,X., Rong,X.,
            Ding,S., Wang,E. and Wang,E.
  TITLE     Cytosolic TMEM88 promotes invasion and metastasis in lung cancer
            cells by binding DVLS
  JOURNAL   Cancer Res 75 (21), 4527-4537 (2015)
   PUBMED   26359454
REFERENCE   4  (bases 1 to 4582)
  AUTHORS   Bian,W.J., Miao,W.Y., He,S.J., Wan,Z.F., Luo,Z.G. and Yu,X.
  TITLE     A novel Wnt5a-Frizzled4 signaling pathway mediates
            activity-independent dendrite morphogenesis via the distal PDZ
            motif of Frizzled 4
  JOURNAL   Dev Neurobiol 75 (8), 805-822 (2015)
   PUBMED   25424568
REFERENCE   5  (bases 1 to 4582)
  AUTHORS   Cajanek,L., Ganji,R.S., Henriques-Oliveira,C., Theofilopoulos,S.,
            Konik,P., Bryja,V. and Arenas,E.
  TITLE     Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the
            differentiation of midbrain dopaminergic neurons
  JOURNAL   Mol Cell Biol 33 (1), 59-70 (2013)
   PUBMED   23109420
REFERENCE   6  (bases 1 to 4582)
  AUTHORS   Chen,J., Park,C.S. and Tang,S.J.
  TITLE     Activity-dependent synaptic Wnt release regulates hippocampal long
            term potentiation
  JOURNAL   J Biol Chem 281 (17), 11910-11916 (2006)
   PUBMED   16501258
REFERENCE   7  (bases 1 to 4582)
  AUTHORS   Hocevar,B.A., Mou,F., Rennolds,J.L., Morris,S.M., Cooper,J.A. and
            Howe,P.H.
  TITLE     Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
  JOURNAL   EMBO J 22 (12), 3084-3094 (2003)
   PUBMED   12805222
REFERENCE   8  (bases 1 to 4582)
  AUTHORS   Yan,D., Wallingford,J.B., Sun,T.Q., Nelson,A.M., Sakanaka,C.,
            Reinhard,C., Harland,R.M., Fantl,W.J. and Williams,L.T.
  TITLE     Cell autonomous regulation of multiple Dishevelled-dependent
            pathways by mammalian Nkd
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 3802-3807 (2001)
   PUBMED   11274398
REFERENCE   9  (bases 1 to 4582)
  AUTHORS   Strovel,E.T., Wu,D. and Sussman,D.J.
  TITLE     Protein phosphatase 2Calpha dephosphorylates axin and activates
            LEF-1-dependent transcription
  JOURNAL   J Biol Chem 275 (4), 2399-2403 (2000)
   PUBMED   10644691
REFERENCE   10 (bases 1 to 4582)
  AUTHORS   Kishida,S., Yamamoto,H., Hino,S., Ikeda,S., Kishida,M. and
            Kikuchi,A.
  TITLE     DIX domains of Dvl and axin are necessary for protein interactions
            and their ability to regulate beta-catenin stability
  JOURNAL   Mol Cell Biol 19 (6), 4414-4422 (1999)
   PUBMED   10330181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Oct 22, 2022 this sequence version replaced NM_001107081.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.46345.1,
                                           SRR21887622.3997584.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000011.1  93886612-93886903   c
            293-362             JAXUCZ010000011.1  93880802-93880871   c
            363-484             JAXUCZ010000011.1  93880254-93880375   c
            485-594             JAXUCZ010000011.1  93880024-93880133   c
            595-730             JAXUCZ010000011.1  93879694-93879829   c
            731-824             JAXUCZ010000011.1  93879329-93879422   c
            825-894             JAXUCZ010000011.1  93879049-93879118   c
            895-1034            JAXUCZ010000011.1  93878131-93878270   c
            1035-1111           JAXUCZ010000011.1  93877959-93878035   c
            1112-1179           JAXUCZ010000011.1  93877786-93877853   c
            1180-1329           JAXUCZ010000011.1  93877508-93877657   c
            1330-1461           JAXUCZ010000011.1  93876875-93877006   c
            1462-1629           JAXUCZ010000011.1  93876545-93876712   c
            1630-1845           JAXUCZ010000011.1  93872663-93872878   c
            1846-4582           JAXUCZ010000011.1  93869834-93872570   c
FEATURES             Location/Qualifiers
     source          1..4582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4582
                     /gene="Dvl3"
                     /note="dishevelled segment polarity protein 3"
                     /db_xref="GeneID:303811"
                     /db_xref="RGD:1308834"
     exon            1..292
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2282
                     /gene="Dvl3"
                     /note="dishevelled 3, dsh homolog; dishevelled, dsh
                     homolog 3"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-3"
                     /protein_id="NP_001100551.2"
                     /db_xref="GeneID:303811"
                     /db_xref="RGD:1308834"
                     /translation="MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKF
                     FFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPS
                     MERTGGIGDSRPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNG
                     TTKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHK
                     RRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGI
                     YIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVA
                     KCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSIT
                     SSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDW
                     LYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHD
                     HDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYAGGSAS
                     SQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSER
                     SGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAP
                     PGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM"
     exon            293..362
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..484
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..594
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..730
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..824
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..894
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1034
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1111
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1179
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1329
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1461
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1629
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1845
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..4582
                     /gene="Dvl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagggagctg gcgccccggc cggcggctga gcggggctaa gcagcgggcc tcgccgagcg
       61 ccgagctctg tcggagaggc ccggccccgc tgcccaagca ggccgcacgc cgcggggccg
      121 aggccggagc catgggcgag actaagatca tctaccactt ggacggccag gagacgccgt
      181 acctagtgaa gctgcccctg cccgccgagc gcgtcacctt ggcggacttt aagggcgttt
      241 tgcagcggcc cagctataag ttcttcttca agtctatgga cgacgatttt ggagtggtga
      301 aggaagagat ctcggatgac aatgccaagc tgccctgctt caatggccgg gtggtgtcct
      361 ggctggtatc ggccgagggc tcacacccag agccagcccc tttctgtgct gacaacccct
      421 cagagctgcc tccttcaatg gaacgcacag gaggcatcgg tgactctcgg cccccgtcct
      481 tccaccctca tgctagtggg ggcagccagg agaacttgga caatgacaca gagaccgact
      541 ccttggtatc tgcccaacga gagcggccca gacggaggga tggccctgag cacgcagccc
      601 gcctcaatgg aaccacaaag ggcgagcggc gacgggagcc aggtggctat gacagttcat
      661 ctaccctcat gagcagcgag ctggagacta ccagtttctt tgattcagat gaggatgact
      721 ccaccagcag gttcagcagc tccacagaac agagcagtgc ctcacgccta atgagaagac
      781 acaagcggcg gcgacggaag cagaaggtct cccggattga gcggtcctcc tccttcagca
      841 gcatcacaga ctccactatg tctctcaaca tcatcacagt gactctcaac atggaaaagt
      901 ataacttctt gggcatctcc attgtgggcc agagcaatga gcgaggtgat gggggcatct
      961 acattggctc catcatgaag ggtggggcag tggcggctga tggacgcatt gagccgggag
     1021 atatgctgtt gcaggtaaat gagatcaact tcgagaacat gagtaatgat gacgcagtca
     1081 gagtgcttcg ggagatcgtg cacaaaccag ggcccatcac tctgactgta gccaagtgct
     1141 gggacccaag tcctcgtggc tgcttcacat taccccggag tgagcccatc cgtcccattg
     1201 accctgcagc ctgggtctcc cacactgcag ccatgacagg aaccttccct gcctatggca
     1261 tgagcccctc cttaagcacc atcacctcca ccagctcctc catcaccagc tccatccccg
     1321 acacagaacg cctagatgat ttccacctct ccatccacag tgacatggcg gccatcgtaa
     1381 aagccatggc ctcccccgag tcagggctgg aggtccgaga ccgcatgtgg ctcaagatta
     1441 ccattcccaa tgctttcatc ggctcagatg tggtggactg gctgtatcac aatgtggaag
     1501 gattcaccga ccggcgggag gcccgcaagt acgctagcaa cctgctgaag gctggattca
     1561 tccgccacac ggtcaacaag atcacgttct ctgagcagtg ctactacatc tttggtgacc
     1621 tctgtggcaa catggccaac ctatcgctgc acgaccatga tggctccagt ggtgcctctg
     1681 accaggacac actggctcct ctgccgcacc caggggctgc cccttggcct atggctttcc
     1741 cttaccagta cccaccacct ccgcacccgt acaacccaca cccaggcttc ccggagctgg
     1801 gctacagcta cgctgggggc agcgccagca gtcagcacag tgaaggtagt aggagcagtg
     1861 gctccaaccg aagtggcagc gaccggcgca aggagaagga cccaaaagct ggggactcaa
     1921 agtcaggtgg tagcggcagc gagtcagacc acactacacg cagcagtctg cgggggccac
     1981 gggagcgggc accaagcgag cgctcaggcc cagcggccag cgagcacagc caccgcagtc
     2041 atcattcact gaccagtagc ctgcgcagcc accacacaca cccaagctat ggcccacccg
     2101 gagtgccccc tctctatggt cccccgatgc tgatgatgac cccaccgcct gcagccatgg
     2161 ggcccccagg agcccctcca gggcgtgacc tggcctcggt gcccccggaa ctgacggcca
     2221 gcagacagtc cttccgcatg gcaatgggaa accccagtga gttctttgtg gatgtgatgt
     2281 gatccgggcc cctctccagc tctcacccct cagccggctg cacccccatc tcagtcggcc
     2341 tttttttttt ttaaactttg gtacctgaaa gggaaataaa tggaactaac tgctactgct
     2401 tgctggtagc agcaaggatg agaagtcttt actcatccat gcttcagccc ctaacctgcc
     2461 tctagcccag ctggtgcctc tgtccactaa ccatccccat tccacccagt tccgggcttc
     2521 ccagggtttt tcatgtccct gcctctgcac tgctagtgtt aattcctgat gctcctccac
     2581 ccgcacgttt aggagctaac cccagcagtg ccacatctta tgcccacctt ccctcctcgg
     2641 tacccttttg cccacctccg taagcatgtg tacagagatc aggatattgc cccaccatac
     2701 tgacaccaaa aaatggtctt tcccttccta actggcctgc ccgctgcttc agaccttcac
     2761 cctacagctg tagccacctc tagtaggcat ctgtgctgtc tgtccctgct tggacccagc
     2821 cccaatcaga agcccagaga gccatcctgc ccctcccccc ccacaggtgc ctgggcccca
     2881 tccatgcctg ccctgtgctc tggttccccg agatctaacc ctactaacca ataggctctc
     2941 ctaacttctg agcctgaaac atttctcttc tttttttctt ccttcaaatt tccctgggtc
     3001 tggagcagcc aagaatttcg ggctctttga ctttctgtga gtccccagga aagggaggcc
     3061 cagcctccaa ggagaccagg aactctgctt cagctccctc agggcttccc aaggatgtcc
     3121 agcccccaca ggacccacac ttcaaggtca ctaggctttt gggaagggcc tcagcttccc
     3181 ccatgcataa ctgactactc ttttcagaga gaagtagaga agttcgctcc cctccacctc
     3241 atacacatag atatacatac acatgtgagt ctctcccccc aacccctggt ctctgtctct
     3301 ctgtctctgt ctctgtctct ctctcacgcc tatgcaagtt tacagaagcc tcagggctgg
     3361 tccctggcca gagggctgga ccctttttcc aagtcatctc ctagatagta gggctggtcc
     3421 ctgacgtcct cttcccttca gctagccctt aagcttccct tacatgttcc caacatcttt
     3481 gtacttagat aaaagtccaa aagctggggc tcaccagagg gctctccggt aactgacaga
     3541 tcattctcta cttcccttct gccccacatc tctgggtacc tgctctgttt catcttcccc
     3601 atgaaccctg gggacacagg ccagttgaag ctatacgagc agacaactgg ggcttccaga
     3661 ccgttccagt taactgtttt ctaccttaaa tcataatttc ctccttaaaa caccgctata
     3721 aactctgact tatccagact ctttaaattt tcagtcaagg gtgtcagctg aggaaatagc
     3781 tgtgtagtgc ttgcctagca tgccccagca aatgtctccc ccatcaagat gtccttagcc
     3841 caggtttggg ggcaacctga ggtagggata ttttgacatt catttaacat atttccaggg
     3901 actttaatga acaaagggct atgttagaag catgacttga tcttcgctgt cttcagttct
     3961 ctctgactct gccttttcct gttctcttga gaatccctca ccagtgctcc cattatcctg
     4021 cctttggctc atgtcccttt cttcccccct ttcccccata gtgtcagcca ctctcttctt
     4081 aagctgttga tgtgctggcc acttctaaat ctggatctcc caccccagct tcccctctct
     4141 ttagatctgt ttttattccc cactggacat ctccccaggc ttgtccatat gtccccagcc
     4201 aagtattatt cctctcgaat tcctgccctt gtgaccttca ttacaagcca cacctacacg
     4261 ggcttagtca gcatctcaca cccttatact cagacactct gaagttcagc tgttcctctc
     4321 ccttccttac attacagagc atgggatttg gagtcaggtt ggtttgggct tgatttccag
     4381 ctctatcatt tttgattgtg taatagagtt atttaacctc tctggagcct cagtcctccc
     4441 atatgtaaaa tgatgataat aatacctacc tcacagggtt gttgtgagga tttaaattag
     4501 atattgtacg aaaagtgcct agcacagtgc ctggcacata atagagtagg tgctcaataa
     4561 atggtagcta ttattattac ta
//
