LOCUS       NM_001172056            2785 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dishevelled segment polarity protein 2 (Dvl2),
            mRNA.
ACCESSION   NM_001172056
VERSION     NM_001172056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Cao,Y., Qiu,Y., Liu,M.X., Hu,Y. and Chen,F.W.
  TITLE     MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via
            targeted regulation of Dvl2 expression
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (2), 636-642 (2021)
   PUBMED   33577018
  REMARK    GeneRIF: MiR-29c-3p reduces bone loss in rats with diabetic
            osteoporosis via targeted regulation of Dvl2 expression.
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Liu,X.Z., Fan,J., Qi,K., Liu,S.P., Xu,W.D., Gao,Y., Gu,X.D., Li,J.,
            Bai,C.G., Shi,Y.Q., Zhang,L.L. and Zhao,D.B.
  TITLE     Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine
            secretion in rheumatoid arthritis fibroblast-like synoviocytes
            through crosstalk with the NF-kappaB pathway
  JOURNAL   Oncotarget 8 (8), 12649-12663 (2017)
   PUBMED   28187436
  REMARK    GeneRIF: Our findings reveal an underappreciated role of Dvl2 in
            regulating inflammation and rheumatoid arthritis-fibroblast-like
            synoviocyte apoptosis
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Ma,B., Liu,B., Cao,W., Gao,C., Qi,Z., Ning,Y. and Chen,Y.G.
  TITLE     The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2
            Degradation via Promoting Its Ubiquitination and Aggregate-induced
            Autophagy
  JOURNAL   J Biol Chem 290 (19), 12346-12354 (2015)
   PUBMED   25825496
  REMARK    GeneRIF: Dpr1 promotes the ubiquitination of Dvl2 by pVHL and
            mediates the protein aggregate-elicited autophagy initiation
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Gonzalez-Sancho,J.M., Greer,Y.E., Abrahams,C.L., Takigawa,Y.,
            Baljinnyam,B., Lee,K.H., Lee,K.S., Rubin,J.S. and Brown,A.M.
  TITLE     Functional consequences of Wnt-induced dishevelled 2
            phosphorylation in canonical and noncanonical Wnt signaling
  JOURNAL   J Biol Chem 288 (13), 9428-9437 (2013)
   PUBMED   23396967
  REMARK    GeneRIF: Wnt-induced dishevelled 2 phosphorylation has effects in
            in canonical and noncanonical Wnt3a and Wnt5a signaling
REFERENCE   5  (bases 1 to 2785)
  AUTHORS   Kordes,C., Sawitza,I. and Haussinger,D.
  TITLE     Canonical Wnt signaling maintains the quiescent stage of hepatic
            stellate cells
  JOURNAL   Biochem Biophys Res Commun 367 (1), 116-123 (2008)
   PUBMED   18158920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.43166.1,
                                           SRR26643298.61583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000010.1  55222286-55222513
            229-298             JAXUCZ010000010.1  55226278-55226347
            299-444             JAXUCZ010000010.1  55226623-55226768
            445-554             JAXUCZ010000010.1  55226877-55226986
            555-690             JAXUCZ010000010.1  55227104-55227239
            691-781             JAXUCZ010000010.1  55227389-55227479
            782-851             JAXUCZ010000010.1  55227597-55227666
            852-991             JAXUCZ010000010.1  55227752-55227891
            992-1068            JAXUCZ010000010.1  55227970-55228046
            1069-1136           JAXUCZ010000010.1  55228854-55228921
            1137-1265           JAXUCZ010000010.1  55229260-55229388
            1266-1397           JAXUCZ010000010.1  55229462-55229593
            1398-1577           JAXUCZ010000010.1  55229682-55229861
            1578-1796           JAXUCZ010000010.1  55230176-55230394
            1797-2785           JAXUCZ010000010.1  55230518-55231506
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2785
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /note="dishevelled segment polarity protein 2"
                     /db_xref="GeneID:303251"
     exon            1..228
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2245
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-2"
                     /protein_id="NP_001165527.1"
                     /db_xref="GeneID:303251"
                     /translation="MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFK
                     SVLQRPAGAKYFFKSMDQDFGVVKEEISDDSARLPCFNGRVVSWLVSSESPQPETAPP
                     AHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLR
                     RDRPRRRDSSEHGAGGHRPGVPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDSMS
                     RFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYN
                     FLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAV
                     RVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPA
                     YPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIP
                     NAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDL
                     SGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPP
                     PYHELSSYSYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEL
                     SSRGGSLRRGGEPGGTGDGGPPPSRGSAGGTPNLRALPGLHPYGPPPGMALPYNPMMV
                     VMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM"
     exon            229..298
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..444
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..554
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..690
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..781
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..851
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..991
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1068
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1136
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1265
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1397
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1577
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1796
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..2785
                     /gene="Dvl2"
                     /gene_synonym="Dvl-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggctga gcccgggagc gcgtgagcga gaccatggcg ggcagcagcg cggggggcgg
       61 tggtgtaggc gagacgaagg tgatttacca tctggatgaa gaagagactc cttacctggt
      121 gaagatccct gtcccggcgg agcgcatcac gctcggcgat ttcaagagcg ttttgcagcg
      181 gcccgcgggc gctaagtact ttttcaagtc tatggatcag gattttgggg tggtgaagga
      241 agagatctct gacgacagtg cccgcctacc ttgcttcaat ggaagggttg tctcctggct
      301 ggtgtcatca gagagccccc agcctgagac agcgccccct gcccatgagt ctcggacaga
      361 actggttcct ccacctccac cattaccccc tttgccacca gaaaggacca gtggcattgg
      421 ggactcaagg cctccatcct tccaccctaa tgtatccagt agccatgaaa atctagagcc
      481 tgagacagaa actgaatccg tcgtatcact gagacgagac cgacctagga ggagagacag
      541 cagtgagcat ggcgctggtg gccacaggcc tggcgtcccc tcaaggctgg agcgccacct
      601 ggctgggtat gagagctctt ccaccctcat gaccagcgaa ctggaaagta ccagcttagg
      661 agattcagat gaggatgaca gcatgagtag gttcagcagc tccactgagc agagcagtgc
      721 ctcccgcctc ctcaagcgcc accgaaggcg aaggaagcag cggccgccac gcatggagag
      781 gacctcatcc ttcagcagtg tcacagattc tacaatgtct ctcaacatca tcacagtcac
      841 actcaacatg gagaaataca acttcctggg tatctccatt gtgggccaaa gtaacgagcg
      901 tggtgacgga ggcatctata taggctccat catgaaaggg ggagcggtgg ctgcagatgg
      961 gcggatcgag cctggagaca tgcttttgca ggtaaacgac atgaactttg agaacatgag
     1021 caatgacgat gctgtgcggg tgctgagaga cattgtacac aagccaggcc ccatcgtgct
     1081 caccgtggcc aagtgttggg atccctctcc ccaggcctac ttcaccctcc cccgaaatga
     1141 gcccatacag ccaattgatc cagctgcctg ggtgtcccat tcagctgcgc taaccggtgc
     1201 cttccctgct taccccggct cttcatctat gagcactatc acatctggct cctctctgcc
     1261 tgatggctgt gaaggccggg gtctctctgt ccacatggac atggcctctg tgaccaaggc
     1321 catggcagcc ccagagtctg ggcttgaagt ccgggaccgc atgtggctca agatcaccat
     1381 cccaaacgcc tttctaggct cggatgtggt agactggctg tatcaccatg tggaaggctt
     1441 tcctgagcgc cgggaggccc gcaagtacgc cagtgggctg ttgaaggcgg gactcatccg
     1501 gcacactgtc aacaagatta ctttctctga gcagtgctac tatgttttcg gggacctcag
     1561 tggtggctgc gagagttacc tagttaacct gtctctgaat gacaacgatg gttccagtgg
     1621 ggcttcagac caggatactc tggctcctct tcctggagct actccctggc ccctgctgcc
     1681 taccttctcc taccaatacc cagccccgca cccctacagc ccacagcctc cgccctatca
     1741 tgagctttcg tcctacagct atggcggagg cagtgccagc agccagcaca gtgaggggag
     1801 ccggagcagt gggtcaacaa gaagtgatgg gggggccggg cgcacaggga ggcctgagga
     1861 acgggcccct gagtcaaagt ctggcagtgg cagtgagtct gaactctcca gccggggagg
     1921 cagccttcgg cggggtgggg aacctggtgg gactggtgat ggtggacccc ctccatccag
     1981 gggctcagca ggtggtactc ctaacctccg agctctccca ggcctccatc cctatggacc
     2041 tccacctggc atggctctcc cctataaccc catgatggta gtcatgatgc ctccaccccc
     2101 accccctgtc tcgacagcag tacagccccc tggtgcccct ccagtcagag acctgggctc
     2161 tgtgccccca gaactgacag ctagccgtca gagcttccac atggccatgg gcaaccccag
     2221 tgagtttttt gtagatgtta tgtaggaccc atcttgaggc cacattgggt ctgtgccctt
     2281 ggcctggtaa gtttcaactt ggtgctcttc ttagtgcctg ggctcagcct ggtggctggt
     2341 gcctaccaaa acgttttttg ccactgtgac tctcaccagc agtgcctggt ccttcccctt
     2401 cctcaggggt agatggggac ctttggttat ttttagcttt attttttata agctttttgg
     2461 ggggttaaaa tagactttct tatatttggg ggagtatttt tttaaataga cagttcttct
     2521 tttatatgga gagtcccttc atatacactt tcctaggtcc cttctaagcc cagaatatga
     2581 ccaccacctc cagttgttag tcagcttcat ggccagggtg ggtggtggtc agtggtaccc
     2641 tgggaagagg aagggttggg ctgggtaccc tagacagcag tccaaggagg ctgatggtgt
     2701 gttggggact gtgtagctgc ctttgttact ctatttattt tagtcacttg tataaaacac
     2761 caaataaagc aaatagaggc aactc
//
