LOCUS       NM_031820               2955 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dishevelled segment polarity protein 1 (Dvl1),
            mRNA.
ACCESSION   NM_031820
VERSION     NM_031820.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Zhu,Y., Li,Y., Jin,W., Li,Z., Zhang,L., Fang,Y. and Zhang,Y.
  TITLE     Hyperoxia exposure upregulates Dvl-1 and activates Wnt/beta-catenin
            signaling pathway in newborn rat lung
  JOURNAL   BMC Mol Cell Biol 24 (1), 4 (2023)
   PUBMED   36726071
  REMARK    GeneRIF: Hyperoxia exposure upregulates Dvl-1 and activates
            Wnt/beta-catenin signaling pathway in newborn rat lung.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2955)
  AUTHORS   Zhang,X., Zhang,X., Li,X., Ma,J., Xie,D. and Jiang,N.
  TITLE     Dishevelled-1 regulated apoptosis through NF-kappaB in cerebral
            ischemia/reperfusion injury in rats
  JOURNAL   Neurosci Lett 722, 134862 (2020)
   PUBMED   32105766
  REMARK    GeneRIF: Dishevelled-1 regulated apoptosis through NF-kappaB in
            cerebral ischemia/reperfusion injury in rats.
REFERENCE   3  (bases 1 to 2955)
  AUTHORS   Wei,X., Gong,J., Ma,J., Zhang,T., Li,Y., Lan,T., Guo,P. and Qi,S.
  TITLE     Targeting the Dvl-1/beta-arrestin2/JNK3 interaction disrupts
            Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during
            cerebral ischemia reperfusion
  JOURNAL   Neuropharmacology 135, 11-21 (2018)
   PUBMED   29510185
  REMARK    GeneRIF: results indicate that Wnt5a-mediated JNK3 activation
            participates in Ischemia/Reperfusion brain injury by targeting the
            Dvl-1-beta-arrestin2/JNK3 interaction
REFERENCE   4  (bases 1 to 2955)
  AUTHORS   Zhang,X., Yu,X., Jiang,G., Miao,Y., Wang,L., Zhang,Y., Liu,Y.,
            Fan,C., Lin,X., Dong,Q., Han,Q., Zhao,H., Han,Y., Han,X., Rong,X.,
            Ding,S., Wang,E. and Wang,E.
  TITLE     Cytosolic TMEM88 promotes invasion and metastasis in lung cancer
            cells by binding DVLS
  JOURNAL   Cancer Res 75 (21), 4527-4537 (2015)
   PUBMED   26359454
REFERENCE   5  (bases 1 to 2955)
  AUTHORS   Ciani,L., Marzo,A., Boyle,K., Stamatakou,E., Lopes,D.M., Anane,D.,
            McLeod,F., Rosso,S.B., Gibb,A. and Salinas,P.C.
  TITLE     Wnt signalling tunes neurotransmitter release by directly targeting
            Synaptotagmin-1
  JOURNAL   Nat Commun 6, 8302 (2015)
   PUBMED   26400647
  REMARK    GeneRIF: The interaction of Dvl1 with Syt-1, which is regulated by
            Wnts, modulates neurotransmitter release.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2955)
  AUTHORS   Lijam,N., Paylor,R., McDonald,M.P., Crawley,J.N., Deng,C.X.,
            Herrup,K., Stevens,K.E., Maccaferri,G., McBain,C.J., Sussman,D.J.
            and Wynshaw-Boris,A.
  TITLE     Social interaction and sensorimotor gating abnormalities in mice
            lacking Dvl1
  JOURNAL   Cell 90 (5), 895-905 (1997)
   PUBMED   9298901
REFERENCE   7  (bases 1 to 2955)
  AUTHORS   Wagner,U., Brownlees,J., Irving,N.G., Lucas,F.R., Salinas,P.C. and
            Miller,C.C.
  TITLE     Overexpression of the mouse dishevelled-1 protein inhibits
            GSK-3beta-mediated phosphorylation of tau in transfected mammalian
            cells
  JOURNAL   FEBS Lett 411 (2-3), 369-372 (1997)
   PUBMED   9271238
REFERENCE   8  (bases 1 to 2955)
  AUTHORS   Steitz,S.A., Tsang,M. and Sussman,D.J.
  TITLE     Wnt-mediated relocalization of dishevelled proteins
  JOURNAL   In Vitro Cell Dev Biol Anim 32 (7), 441-445 (1996)
   PUBMED   8856345
REFERENCE   9  (bases 1 to 2955)
  AUTHORS   Pizzuti,A., Amati,F., Calabrese,G., Mari,A., Colosimo,A.,
            Silani,V., Giardino,L., Ratti,A., Penso,D., Calza,L., Palka,G.,
            Scarlato,G., Novelli,G. and Dallapiccola,B.
  TITLE     cDNA characterization and chromosomal mapping of two human
            homologues of the Drosophila dishevelled polarity gene
  JOURNAL   Hum Mol Genet 5 (7), 953-958 (1996)
   PUBMED   8817329
REFERENCE   10 (bases 1 to 2955)
  AUTHORS   Pizzuti,A., Novelli,G., Mari,A., Ratti,A., Colosimo,A., Amati,F.,
            Penso,D., Sangiuolo,F., Calabrese,G., Palka,G., Silani,V.,
            Gennarelli,M., Mingarelli,R., Scarlato,G., Scambler,P. and
            Dallapiccola,B.
  TITLE     Human homologue sequences to the Drosophila dishevelled
            segment-polarity gene are deleted in the DiGeorge syndrome
  JOURNAL   Am J Hum Genet 58 (4), 722-729 (1996)
   PUBMED   8644734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF143546.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF143545.2, AF143546.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHRSP"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2955
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /note="dishevelled segment polarity protein 1"
                     /db_xref="GeneID:83721"
                     /db_xref="RGD:620632"
     exon            1..171
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..2089
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /note="DSH homolog 1; dishevelled-1; dishevelled, dsh
                     homolog 1"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-1"
                     /protein_id="NP_114008.1"
                     /db_xref="GeneID:83721"
                     /db_xref="RGD:620632"
                     /translation="MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHA
                     YKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDL
                     PPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTN
                     GHPRGDRRRELGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLIRK
                     HKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDG
                     GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLT
                     VAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSS
                     SLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADV
                     VDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLN
                     LNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSAG
                     SQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQL
                     SRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQK
                     AMGNPCEFFVDIM"
     exon            172..241
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..363
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..467
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..606
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..700
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..770
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..910
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..987
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1055
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1208
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1340
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1508
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1715
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2955
                     /gene="Dvl1"
                     /gene_synonym="dvl-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggcggag accaaaatca tctaccacat ggacgaggag gagacgccgt acctggtcaa
       61 gctgcccgta gctcccgagc gcgtcacgct ggcagacttc aagaacgtgc tcagcaaccg
      121 gccggtgcac gcctacaaat tcttcttcaa gtctatggac caggacttcg gggtggtgaa
      181 ggaggagatc ttcgacgaca atgccaagtt gccctgcttc aatggccgtg tggtttcctg
      241 gctggtcctg gctgagggcg ctcactcgga tgcagggtcc cagggcactg acagccacac
      301 ggacctgccc ccaccccttg agaggacagg cggcattggg gactccaggc ccccctcctt
      361 ccatccaaat gttgccagta gccgagatgg aatggacaat gagacaggca cagagtcaat
      421 ggtcagtcac cggcgggagc gagcccgacg tcgaaaccgt gatgaggctg cccggaccaa
      481 tgggcaccca agaggggacc ggcggcggga gctgggacta cctccagaca gtgcgtccac
      541 tgtactgagc agtgagcttg aatctagcag ctttattgac tcagatgagg aggacaacac
      601 gagccggctg agcagctcta cagagcagag tacctcctct cggctaattc gtaagcacaa
      661 atgccgtcgt cggaagcagc gcttgaggca gacagaccgg gcatcctcct tcagcagcat
      721 caccgactct accatgtccc tgaacatcat cactgtcacg ctcaacatgg agaggcacca
      781 cttcctgggc atcagcatcg tgggccagag caacgaccgg ggtgatggcg gcatctacat
      841 tggatccatc atgaagggcg gggctgtggc tgctgatggc cgcattgagc caggcgacat
      901 gttgctgcag gtgaatgatg tcaactttga gaacatgagc aacgatgatg ccgtgcgggt
      961 gcttcgggag atcgtatccc agacggggcc catcagtctc acagtggcca agtgctggga
     1021 cccaacccct cggagctact tcaccatccc aagggctgac ccagtgcgac ccatcgaccc
     1081 ggctgcctgg ctgtcccaca cagcagcact gaccggtgct ctgccccgct atggtacgag
     1141 tccctgctcc agcgccatca cacgcaccag ctcttcctca ctaaccagct cagtgcctgg
     1201 cgccccacag cttgaggagg caccactgac tgtgaagagt gacatgagtg ccattgtccg
     1261 cgtcatgcag ttgccagact cgggactgga gatccgggac cgcatgtggc ttaagatcac
     1321 cattgccaat gctgtcattg gggcggatgt ggtggactgg ctgtacacac acgtggaggg
     1381 cttcaaggag cgaagggagg cgaggaagta tgccagcagc atgctgaagc atggtttcct
     1441 gcggcacacg gtgaacaaga tcactttctc tgagcagtgc tactatgtct ttggtgacct
     1501 gtgcagcaac ctcgcatccc tgaacctcaa cagtggctcc agtggagcct cagatcagga
     1561 cacactggcc ccactgcccc acccatctgt accctggccc ttgggtcaag gctatcccta
     1621 ccagtaccca ggacccccgc cctgcttccc acctgcttac caggaccctg gcttcagcta
     1681 tggcagtggc agtgctggga gtcagcagag tgaagggagc aagagcagtg ggtccacacg
     1741 gagcagccat cgcaccccag gccgagagga gcgccgggca actggagctg ggggtagtgg
     1801 cagtgaatca gaccacacag taccaagtgg gtctggtagc actggctggt gggagcggcc
     1861 tgtcagccag cttagccgtg gcagtagccc tcgaagtcag gcttcagctg ttgccccagg
     1921 gctccctcca ctgcaccccc ttaccaaggc ctatgcagta gtgggtgggc cacctggagg
     1981 gccacctgtc cgggagctgg ctgctgttcc tccagaactt acaggtagcc gccagtcctt
     2041 ccaaaaggcc atgggaaacc cctgtgagtt ctttgtggac atcatgtgat gatcaaccag
     2101 tgtcttcagt gctgcctgtg gcgagagtct gtgttcctgc tgtgccagga gctctatggg
     2161 cttgccttag tggtggccgg ccaggatagg tcagtcgtag ggtctgggcc agggcagagg
     2221 gagcaggcaa cagaagaagg gctgagggca gccatacgac caagatatca gcttgatatt
     2281 ttgtctgctc ttggggctgc tggtggtggt gcagctcaag tatctgtagt cttgtaagga
     2341 gacatctctg tctttaagtc ctcagcacag atctcaggga ccacctcctg gttccttttt
     2401 tggaagtgac ctccatttag gacaagaaag gctctcttgg gctctgtcac ccctttcccc
     2461 aaagtctccc agaactgcac aggggcacag gctgactgtc actaagttta tgggcctcac
     2521 ctgtcaggcc aaggtggggt tcttgagggg ttagacagag ccctcaaacc tctctggctg
     2581 cccaggtggg gtctaactta cttatttatt gctagcttgc ctgctccaag ggcggcagct
     2641 ggtcacccag tggggcagtt tgcacgctcc tttcctcacc tgcaactcgg cacatgacag
     2701 cacagtttgt gttgaaggta tgtggaggat ggctagtagg gaagacagga gagaggcctg
     2761 gcacttatct actgtcttag tctcaatggc gggtgagagt gaacacaaga gctgaagatg
     2821 tggggtcctg tcctgtcact gttctcctgg tggctgccca tcagcatgtg ccactgccat
     2881 ctcggcacag cagccccaca catctacacg agacactgtg tcaagaagtc tgagcgactg
     2941 ggtagttcac ataga
//
