LOCUS       NM_001108510            2439 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 8 (Dusp8), mRNA.
ACCESSION   NM_001108510 XM_001063880 XM_341963
VERSION     NM_001108510.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2439)
  AUTHORS   Liao,C., Zhou,H., Chen,H., Cheng,G., Li,S., Ma,F., Yang,X., Xie,B.
            and Zhang,W.
  TITLE     DUSP8/TAK1 signaling mediates neuropathic pain through regulating
            neuroinflammation and neuron death in a spinal nerve ligation (SNL)
            rat model
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109284 (2022)
   PUBMED   36279673
  REMARK    GeneRIF: DUSP8/TAK1 signaling mediates neuropathic pain through
            regulating neuroinflammation and neuron death in a spinal nerve
            ligation (SNL) rat model.
REFERENCE   2  (bases 1 to 2439)
  AUTHORS   Huang,Z., Liu,Y., Zhu,J., Wu,H. and Guo,J.
  TITLE     Involvement of the dual-specificity phosphatase M3/6 in c-Jun
            N-terminal kinase inactivation following cerebral ischemia in the
            rat hippocampus
  JOURNAL   Int J Neurosci 123 (11), 802-809 (2013)
   PUBMED   23679081
  REMARK    GeneRIF: DUSP8 is upregulated following cerebral ischemia in
            hippocampus.
REFERENCE   3  (bases 1 to 2439)
  AUTHORS   Kondoh,K. and Nishida,E.
  TITLE     Regulation of MAP kinases by MAP kinase phosphatases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1227-1237 (2007)
   PUBMED   17208316
  REMARK    Review article
REFERENCE   4  (bases 1 to 2439)
  AUTHORS   Martell,K.J., Seasholtz,A.F., Kwak,S.P., Clemens,K.K. and
            Dixon,J.E.
  TITLE     hVH-5: a protein tyrosine phosphatase abundant in brain that
            inactivates mitogen-activated protein kinase
  JOURNAL   J Neurochem 65 (4), 1823-1833 (1995)
   PUBMED   7561881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341963.3, XM_001063880.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2439
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /note="dual specificity phosphatase 8"
                     /db_xref="GeneID:361679"
                     /db_xref="RGD:1306425"
     exon            1..73
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
     exon            74..395
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2075
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 8"
                     /protein_id="NP_001101980.1"
                     /db_xref="GeneID:361679"
                     /db_xref="RGD:1306425"
                     /translation="MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSCHVL
                     SSVNICCSKLVKRRLQQGKVTIAELIQPAARSQVDATEPQDVVVYDQSTRDASVLAAD
                     SFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPATLPSMSLSQPCLPVPSVG
                     LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRIPINDNYC
                     EKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFV
                     KDRRPSISPNFNFLGQLLEYERSLKLLAALQSDGPHLGTPEPLMGPAAGIPLPRLPPS
                     TSESAATGSEAATAAKEGSPSAGGDALIPSTAPATSALQQGLRGLHLSSDRLQDTNRL
                     KRSFSLDIKSAYAPSRRPDFPGPPDPGEAPKLCKLDSPSGGTLGLPSPSPDSPDSVPE
                     CRPRPRRRRPPVSSPARSPAHGLALNFGDTARQTPRHGLSALSAPGLPGPGQPSGPGG
                     WVPPLDSPGTPSPDGPWCFSPEGAQGPGAVFSAFGRASAGAPGPGSGSSGGGGGSSSS
                     SSSSSSGDLRRRDVRTSWPEEPAADAQFKRRSCQMEFEEGMVEGRARGEELAALGKQT
                     SFSGSVEVIEVS"
     exon            396..534
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
     exon            535..701
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
     exon            702..861
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
     exon            862..985
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
     exon            986..2439
                     /gene="Dusp8"
                     /gene_synonym="Hb5; M3/6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggagaaggt cgtccacggt tgcagtgggc aggggcagaa aaacctccga cgccagaggg
       61 tcggctctct gcggtctggg accatgcact agggtaccca gaacactgca aggccacgcc
      121 ctcctcactt caggggtcac tctccccact gctaccaccc caccatggct ggggatcggc
      181 tcccgaggaa ggtgatggat gcaaagaaac tggccagcct gctgcgcggc gggcccgggg
      241 gccctttggt catcgacagt cggtccttcg tggagtataa cagctgccac gtgctgagct
      301 ctgtgaacat ctgctgttcc aagctggtga agaggcgcct tcagcaggga aaagtgacca
      361 ttgctgagct catccagcct gctgcgcgaa gccaggtgga tgccacagaa ccacaggatg
      421 tggtggtgta tgaccagagc acacgagatg ccagtgtgct ggcagcagac agcttcctgt
      481 ccatcctgct cagcaagctg gacggctgct tcgacagtgt ggccatcctc acaggaggtt
      541 ttgccacgtt ctcctcctgc ttccctggcc tctgtgaggg caaacctgcc accctaccat
      601 ccatgagcct ctctcagccc tgcctgcctg tgcccagtgt cggcctgacc cgaatcctgc
      661 ctcacctcta cctgggctct cagaaagacg tcttgaacaa ggatctgatg acccaaaatg
      721 gaataagcta tgtcctcaat gccagcaact cctgccctaa accggacttc atctgtgaga
      781 gccgtttcat gcgtatcccc atcaatgaca actactgtga aaagctgctg ccctggctgg
      841 acaagtccat tgagtttatt gataaagcca agctgtccag ctgccaagtc atcgttcact
      901 gtctggctgg catttctcgc tctgccacca tcgccatcgc gtacatcatg aaaaccatgg
      961 gcatgtcttc tgacgacgca tacaggtttg tgaaggatcg gcgcccctcc atctcgccca
     1021 acttcaactt cctgggccag ttgctggagt atgagaggag tctgaagctg ctggctgccc
     1081 tgcagagtga tggacctcac ttggggaccc ctgagcccct catgggcccg gcagcaggca
     1141 tcccactgcc ccggctgcca ccatctacct cagagagcgc tgccaccggg agcgaggcag
     1201 ccactgcagc caaggagggc agccctagtg ctggagggga tgctctgatc cccagcacag
     1261 ctccagcgac cagtgcactg caacagggcc tgcgtggcct gcacctctcc tctgaccgcc
     1321 tccaggacac caaccgcctc aagcgctcct tctccctgga catcaagtcg gcctatgcac
     1381 ccagcaggag gcccgacttt cccggcccac ccgaccccgg tgaagcccca aagctctgca
     1441 agctggacag cccgtctggg ggcacactgg gcctgccctc gcccagcccc gacagcccgg
     1501 actccgttcc agagtgccgc ccacgacccc gccggcgacg tcccccggtc agttcgccgg
     1561 cccgctcccc cgctcatggc ctggccctaa actttggaga cacggcccgg cagactccgc
     1621 ggcacggcct ctcggccctg tcggcgcccg ggctgcctgg ccctggtcag ccgtctggcc
     1681 ctgggggctg ggtgccgcca ctggactccc caggcacacc gtcacccgac ggaccctggt
     1741 gcttcagccc cgagggcgcg cagggtccag gcgctgtgtt ctccgccttt ggccgggcga
     1801 gcgcaggcgc acctggaccc ggtagtggca gcagcggtgg cggcggcggc agcagcagca
     1861 gtagcagtag tagcagcagc ggcgacctgc ggcggcggga tgtgcggacc agctggcccg
     1921 aggagcctgc tgcagatgca cagttcaaga ggcgcagctg ccagatggag ttcgaagagg
     1981 gcatggtgga ggggcgggca cgtggcgagg agctggcagc cctgggcaag caaaccagct
     2041 tctctggcag cgtggaggtc atcgaagtat cgtgaccctt caggagtccc tgtgcccttg
     2101 ctccagccag gccaggtata aatatatatt atatataaaa cacacagaaa aggtaaatgg
     2161 ttttactgca atttttatca agaagtaaat atttcgattt ttttatttat ttaagctagt
     2221 gatctggcaa ctgtgcgggg cggccctaaa gctctgtttt tactgtctgg tatttaaact
     2281 gaaacaggtt tctaagcaat atgaggccac cttcaatccc aagctgggtt gacaggcctg
     2341 ggcccctcct ggcccctccc ctctggaaac attactgacc tttcaaagag ctgcccagct
     2401 ttcctgcact ttttacataa gaaagggggg agggatgaa
//
