LOCUS       NM_053883               2755 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 6 (Dusp6), mRNA.
ACCESSION   NM_053883
VERSION     NM_053883.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2755)
  AUTHORS   Zhou,X., Zhang,C., Wu,X., Hu,X., Zhang,Y., Wang,X., Zheng,L.,
            Gao,P., Du,J., Zheng,W., Shang,H., Hu,K., Jiang,Z., Nie,Y., Hu,S.,
            Xiao,R.P., Zhu,X. and Xiong,J.W.
  TITLE     Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in
            the acute inflammatory phase of myocardial infarction
  JOURNAL   Nat Commun 13 (1), 6672 (2022)
   PUBMED   36335128
  REMARK    GeneRIF: Dusp6 deficiency attenuates neutrophil-mediated cardiac
            damage in the acute inflammatory phase of myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2755)
  AUTHORS   Mao,Z., Gao,M., Zhao,X., Li,L. and Peng,J.
  TITLE     Neuroprotective Effect of Dioscin against Parkinson's Disease via
            Adjusting Dual-Specificity Phosphatase 6 (DUSP6)-Mediated Oxidative
            Stress
  JOURNAL   Molecules 27 (10), 3151 (2022)
   PUBMED   35630630
  REMARK    GeneRIF: Neuroprotective Effect of Dioscin against Parkinson's
            Disease via Adjusting Dual-Specificity Phosphatase 6
            (DUSP6)-Mediated Oxidative Stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2755)
  AUTHORS   Gem,J.B., Kovacs,K.B., Szalai,L., Szakadati,G., Porkolab,E.,
            Szalai,B., Turu,G., Toth,A.D., Szekeres,M., Hunyady,L. and Balla,A.
  TITLE     Characterization of Type 1 Angiotensin II Receptor Activation
            Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes
            in Rat Vascular Smooth Muscle Cells
  JOURNAL   Cells 10 (12), 3538 (2021)
   PUBMED   34944046
  REMARK    GeneRIF: Characterization of Type 1 Angiotensin II Receptor
            Activation Induced Dual-Specificity MAPK Phosphatase Gene
            Expression Changes in Rat Vascular Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2755)
  AUTHORS   Zhao,W. and Wang,Q.
  TITLE     Knockdown of TRIM9 attenuates irinotecan-induced intestinal
            mucositis in IEC-6 cells by regulating DUSP6 expression via the P38
            pathway
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34676875
  REMARK    GeneRIF: Knockdown of TRIM9 attenuates irinotecaninduced intestinal
            mucositis in IEC6 cells by regulating DUSP6 expression via the P38
            pathway.
REFERENCE   5  (bases 1 to 2755)
  AUTHORS   Zavala,M.R., Diaz,R.G., Medina,A.J., Acosta,M.P., Escudero,D.S.,
            Ennis,I.L., Perez,N.G. and Villa-Abrille,M.C.
  TITLE     p38-MAP Kinase Negatively Regulates the Slow Force Response to
            Stretch in Rat Myocardium through the Up-Regulation of Dual
            Specificity Phosphatase 6 (DUSP6)
  JOURNAL   Cell Physiol Biochem 52 (2), 172-185 (2019)
   PUBMED   30816666
  REMARK    GeneRIF: data support the notion that p38-MAPK activation after
            myocardial stretch restricts the SFR by limiting ERK1/2-p90RSK
            phosphorylation, and consequently NHE-1 phosphorylation/activity,
            through a mechanism that involves DUSP6 up-regulation.
REFERENCE   6  (bases 1 to 2755)
  AUTHORS   Muda,M., Theodosiou,A., Gillieron,C., Smith,A., Chabert,C.,
            Camps,M., Boschert,U., Rodrigues,N., Davies,K., Ashworth,A. and
            Arkinstall,S.
  TITLE     The mitogen-activated protein kinase phosphatase-3 N-terminal
            noncatalytic region is responsible for tight substrate binding and
            enzymatic specificity
  JOURNAL   J Biol Chem 273 (15), 9323-9329 (1998)
   PUBMED   9535927
REFERENCE   7  (bases 1 to 2755)
  AUTHORS   Camps,M., Chabert,C., Muda,M., Boschert,U., Gillieron,C. and
            Arkinstall,S.
  TITLE     Induction of the mitogen-activated protein kinase phosphatase MKP3
            by nerve growth factor in differentiating PC12
  JOURNAL   FEBS Lett 425 (2), 271-276 (1998)
   PUBMED   9559664
REFERENCE   8  (bases 1 to 2755)
  AUTHORS   Groom,L.A., Sneddon,A.A., Alessi,D.R., Dowd,S. and Keyse,S.M.
  TITLE     Differential regulation of the MAP, SAP and RK/p38 kinases by
            Pyst1, a novel cytosolic dual-specificity phosphatase
  JOURNAL   EMBO J 15 (14), 3621-3632 (1996)
   PUBMED   8670865
REFERENCE   9  (bases 1 to 2755)
  AUTHORS   Muda,M., Boschert,U., Dickinson,R., Martinou,J.C., Martinou,I.,
            Camps,M., Schlegel,W. and Arkinstall,S.
  TITLE     MKP-3, a novel cytosolic protein-tyrosine phosphatase that
            exemplifies a new class of mitogen-activated protein kinase
            phosphatase
  JOURNAL   J Biol Chem 271 (8), 4319-4326 (1996)
   PUBMED   8626780
REFERENCE   10 (bases 1 to 2755)
  AUTHORS   Mourey,R.J., Vega,Q.C., Campbell,J.S., Wenderoth,M.P.,
            Hauschka,S.D., Krebs,E.G. and Dixon,J.E.
  TITLE     A novel cytoplasmic dual specificity protein tyrosine phosphatase
            implicated in muscle and neuronal differentiation
  JOURNAL   J Biol Chem 271 (7), 3795-3802 (1996)
   PUBMED   8631996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053883.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087003.1, AY724528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-833               JAXUCZ010000007.1  35979604-35980436
            834-1271            JAXUCZ010000007.1  35980906-35981343
            1272-2755           JAXUCZ010000007.1  35982351-35983834
FEATURES             Location/Qualifiers
     source          1..2755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2755
                     /gene="Dusp6"
                     /gene_synonym="Mkp3"
                     /note="dual specificity phosphatase 6"
                     /db_xref="GeneID:116663"
                     /db_xref="RGD:70978"
     exon            1..833
                     /gene="Dusp6"
                     /gene_synonym="Mkp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1579
                     /gene="Dusp6"
                     /gene_synonym="Mkp3"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MKP-3; MAP kinase phosphatase 3; mitogen-activated
                     protein kinase phosphatase 3"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 6"
                     /protein_id="NP_446335.1"
                     /db_xref="GeneID:116663"
                     /db_xref="RGD:70978"
                     /translation="MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQEL
                     YESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENS
                     SDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSP
                     PLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGC
                     AKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAI
                     SFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNF
                     NFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST"
     exon            834..1271
                     /gene="Dusp6"
                     /gene_synonym="Mkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..2755
                     /gene="Dusp6"
                     /gene_synonym="Mkp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcctggca cagggggtgt gctctcgcgg agtcctaggg actgcgagca aacccagtct
       61 tgaataatcc ggcgagaaac acggggttgg atctgaggtg cagcctcaga gggattagga
      121 gctgctagac ttttttcttt tttccttttt ctcctctcag tggcacggag tccgaattaa
      181 ttggatttca ttcactgggt aggaacaaaa ctgggcactt tcattcagag agattcattg
      241 actctgagag tgatctggtg cagagggacc accggcttgg cttctgtcgc cttccctaac
      301 cgctagcttc ggcttgggaa aggccgaatc aaacccggct ccgagagccg gagcttctca
      361 cggcgtgctt ggcctatgcc tgcctcgagg ggcgtctgct aggcaccccg ccttctcctg
      421 cagctcgacc cccatgatag atacgctcag acccgtgccc ttcgcgtcgg aaatggcgat
      481 cagcaagacg gtggcgtggc tcaacgagca gctggagctg ggcaacgaac agctgctgct
      541 gatggactgc cgaccgcagg agctgtacga gtcgtcgcac atcgaatctg ccatcaacgt
      601 ggccatcccg ggcatcatgc tgcggcgtct gcagaagggc aacctgccgg tgcgcgcgct
      661 attcacgcgc tgcgaggacc gggaccgctt taccaggcgc tgcggcaccg acaccgtggt
      721 gctctacgac gagaacagca gcgactggaa tgagaacaca ggtggagagt cggtcctcgg
      781 gctgctgctc aagaaactca aagacgaggg ctgccgggcg ttctaccttg aaggtggctt
      841 cagtaagttc caggccgagt tcgccctgca ctgcgagacc aatctagacg gctcgtgcag
      901 cagcagctcc ccgcccttgc cagtgctggg actcgggggc ctgaggatca gctccgactc
      961 ttcctcggac attgagtctg accttgaccg agaccccaat agtgcaacgg actccgatgg
     1021 cagcccgctg tccaacagcc agccttcctt cccggtggag attttgccct tcctttacct
     1081 gggctgtgcc aaggactcta ctaacttgga cgtgttggaa gagtttggca tcaagtacat
     1141 cttgaacgtc acccccaatc tgcccaatct gtttgagaat gcaggggagt tcaagtacaa
     1201 gcaaattcct atctctgatc actggagcca aaacctgtcc cagtttttcc ctgaggccat
     1261 ttctttcata gatgaagccc gaggcaaaaa ctgtggtgtc ctggtgcatt gcttggcggg
     1321 catcagccgc tccgtcacgg tgacagtggc ttaccttatg cagaagctca acttgtccat
     1381 gaacgatgct tatgacattg tcaaaatgaa gaagtccaac atctctccca acttcaactt
     1441 catgggccag ctgcttgact ttgaaaggac cctgggactc agcagcccct gtgacaatcg
     1501 tgtccccgca cagcagctct acttcaccgc gccctccaac cagaatgtct accaagtgga
     1561 ctccctgcaa tctacgtgaa aggcacccac ctttcctagc cgggagtgtc tcattccttc
     1621 agtttctctt gggcagcatc gaccaggctg ctttctttgt gtgtggcccc aggtgtcaaa
     1681 aatgtcacca gctgtctgta ttagacaagg ttgccaagtg caaaattggt tattacggag
     1741 ggagagattt gctccattca ttgttttttg gaaggacagg gtatgctgtc tagatccagg
     1801 caataggttt gcttctgtac cccagcctac ccaagcaggg actggacctc catccagata
     1861 gagggtagga caaaggagcc ggggatagga gcatgtgttc cttagggcca catatggctg
     1921 tttcctgttg catctggaac caactatatt gtcttcagtg aagactgatt caactttgcg
     1981 tatagtggag ccaaagagat tttagctctg tatttgtggt atcggttttg aaaacaaaag
     2041 aactgatcct ttaatttgat tattgtaaat atttgatctt cacttgagag tgtttgtttg
     2101 gcttgtgttt ggtttttaat ctttgggttt aaacgagatc caaagggaga aagagcagta
     2161 tgccacttct tagaacaaaa aaaaaaaaat ggttcttttc taatccaaag ggtatatttg
     2221 cagcatgctt gaccttactg taccaattct ggttttcacg gatattatga tcactaagac
     2281 tttgttatga tgaggtcttc agtctctttc atgtatcttc cttgtaactt tattttttct
     2341 cttaatgtag ttttgactct gccttacctt tgtaaatatt tggcttacgt tgtctcaagg
     2401 ggtattttcg aaagacacca aaattgtgga ttcacttttt tttttttttt ttttagtaac
     2461 ttcagctgtg cttaaacagc ctattacctc tgtacaaaat tcttcaggga gtgtcacctc
     2521 aaatgcaata cgttgggttg gtctctttcc tttaaaaaaa aaatatacaa aactggaagt
     2581 gtgtgtatgt atgtatgtga gcatgctcgc ccattcaacg ggtgggatgc gacaggttgt
     2641 gaggaaggga aagttcactt gctccatgat gttcgtggtg taaagttttg agctggaatt
     2701 tattataaga atgtaaaacc ttaaattatt aataaataac tattttggct attga
//
