LOCUS       NM_133578               2435 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 5 (Dusp5), mRNA.
ACCESSION   NM_133578 XM_346588
VERSION     NM_133578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Tang,C., Zhang,H., Border,J.J., Liu,Y., Fang,X., Jefferson,J.R.,
            Gregory,A., Johnson,C., Lee,T.J., Bai,S., Sharma,A., Shin,S.M.,
            Yu,H., Roman,R.J. and Fan,F.
  TITLE     Impact of knockout of dual-specificity protein phosphatase 5 on
            structural and mechanical properties of rat middle cerebral
            arteries: implications for vascular aging
  JOURNAL   Geroscience 46 (3), 3135-3147 (2024)
   PUBMED   38200357
  REMARK    GeneRIF: Impact of knockout of dual-specificity protein phosphatase
            5 on structural and mechanical properties of rat middle cerebral
            arteries: implications for vascular aging.
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Gem,J.B., Kovacs,K.B., Szalai,L., Szakadati,G., Porkolab,E.,
            Szalai,B., Turu,G., Toth,A.D., Szekeres,M., Hunyady,L. and Balla,A.
  TITLE     Characterization of Type 1 Angiotensin II Receptor Activation
            Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes
            in Rat Vascular Smooth Muscle Cells
  JOURNAL   Cells 10 (12), 3538 (2021)
   PUBMED   34944046
  REMARK    GeneRIF: Characterization of Type 1 Angiotensin II Receptor
            Activation Induced Dual-Specificity MAPK Phosphatase Gene
            Expression Changes in Rat Vascular Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Jia,Y., Liu,J., Hu,H., Duan,Q., Chen,J. and Li,L.
  TITLE     MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by
            targeting DUSP5
  JOURNAL   Neurosci Res 171, 103-113 (2021)
   PUBMED   33744332
  REMARK    GeneRIF: MiR-363-3p attenuates neonatal hypoxic-ischemia
            encephalopathy by targeting DUSP5.
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Wu,Z., Xu,L., He,Y., Xu,K., Chen,Z., Moqbel,S.A.A., Ma,C.,
            Jiang,L., Ran,J., Wu,L. and Zhong,Y.
  TITLE     DUSP5 suppresses interleukin-1beta-induced chondrocyte inflammation
            and ameliorates osteoarthritis in rats
  JOURNAL   Aging (Albany NY) 12 (24), 26029-26046 (2020)
   PUBMED   33361528
  REMARK    GeneRIF: DUSP5 suppresses interleukin-1beta-induced chondrocyte
            inflammation and ameliorates osteoarthritis in rats.
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Ohwada,W., Tanno,M., Yano,T., Ong,S.B., Abe,K., Sato,T., Kuno,A.,
            Miki,T., Sugawara,H., Igaki,Y. and Miura,T.
  TITLE     Distinct intra-mitochondrial localizations of pro-survival kinases
            and regulation of their functions by DUSP5 and PHLPP-1
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (10), 165851 (2020)
   PUBMED   32480039
  REMARK    GeneRIF: Distinct intra-mitochondrial localizations of pro-survival
            kinases and regulation of their functions by DUSP5 and PHLPP-1.
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Ke,X., McKnight,R.A., Caprau,D., O'Grady,S., Fu,Q., Yu,X.,
            Callaway,C.W., Albertine,K.H. and Lane,R.H.
  TITLE     Intrauterine growth restriction affects hippocampal dual
            specificity phosphatase 5 gene expression and epigenetic
            characteristics
  JOURNAL   Physiol Genomics 43 (20), 1160-1169 (2011)
   PUBMED   21828247
  REMARK    GeneRIF: Intrauterine growth retardation affects hippocampal DUSP5
            expression and epigenetic characteristics in a sex-specific manner.
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Fu,Q., McKnight,R.A., Yu,X., Callaway,C.W. and Lane,R.H.
  TITLE     Growth retardation alters the epigenetic characteristics of hepatic
            dual specificity phosphatase 5
  JOURNAL   FASEB J 20 (12), 2127-2129 (2006)
   PUBMED   16940436
  REMARK    GeneRIF: intrauterine growth retardation induced by uteroplacental
            insufficiency 1) affects the hepatic epigenetic characteristics and
            mRNA of the DUSP-5 and 2) increases hepatic insulin receptor
            substrate-1 phosphorylation at serine 612 in adult rats.
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Raghavendra Rao,V.L., Dhodda,V.K., Song,G., Bowen,K.K. and
            Dempsey,R.J.
  TITLE     Traumatic brain injury-induced acute gene expression changes in rat
            cerebral cortex identified by GeneChip analysis
  JOURNAL   J Neurosci Res 71 (2), 208-219 (2003)
   PUBMED   12503083
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Hevroni,D., Rattner,A., Bundman,M., Lederfein,D., Gabarah,A.,
            Mangelus,M., Silverman,M.A., Kedar,H., Naor,C., Kornuc,M.,
            Hanoch,T., Seger,R., Theill,L.E., Nedivi,E., Richter-Levin,G. and
            Citri,Y.
  TITLE     Hippocampal plasticity involves extensive gene induction and
            multiple cellular mechanisms
  JOURNAL   J Mol Neurosci 10 (2), 75-98 (1998)
   PUBMED   9699150
  REMARK    Review article
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   Ishibashi,T., Bottaro,D.P., Michieli,P., Kelley,C.A. and
            Aaronson,S.A.
  TITLE     A novel dual specificity phosphatase induced by serum stimulation
            and heat shock
  JOURNAL   J Biol Chem 269 (47), 29897-29902 (1994)
   PUBMED   7961985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 2, 2020 this sequence version replaced NM_133578.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013144.1, SRR26643299.7675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               JAXUCZ010000001.1  262543774-262544326
            554-702             JAXUCZ010000001.1  262548606-262548754
            703-922             JAXUCZ010000001.1  262552713-262552932
            923-2435            JAXUCZ010000001.1  262555689-262557201
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2435
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /note="dual specificity phosphatase 5"
                     /db_xref="GeneID:171109"
                     /db_xref="RGD:620854"
     exon            1..553
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1329
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP-kinase phosphatase CPG21; candidate
                     plasticity-related gene 21; MAP-kinase phosphatase
                     (cpg21)"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 5"
                     /protein_id="NP_598262.2"
                     /db_xref="GeneID:171109"
                     /db_xref="RGD:620854"
                     /translation="MKVTSLDGRRLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLN
                     VNLNSVVLRRARGGAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREE
                     SAARVVLTSLLACLPAGPRVYFLKGGYETFYSQYPECCVDAKPISQEKLEGERGLLSQ
                     CGKPILSVAYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEA
                     CTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMA
                     YLMKTKQFRLKEAFEYIKQRRSVVSPNFGFMGQLLQYESEILPSTPTPQPPSCQGEAA
                     SSTFIGHLQTLSPDMQGAYCTFPTSVLAPVPTHATVAELHRSPVATATSC"
     exon            554..702
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /inference="alignment:Splign:2.1.0"
     exon            703..922
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /inference="alignment:Splign:2.1.0"
     exon            923..2435
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctttccgg ggcagcgagt ggcggggccg ggtgctgagc gagcggggcg tggagagcgt
       61 cgcgcggccc ctcgcgccgg gctccgtttg caggccacag cccccgcgag gtggcccgcc
      121 ggccctgggc cgcccgtcct ctggcagctg tggtgagcgc agcgtcgggc cggcatgaag
      181 gtcacgtcgc tcgacgggcg ccggctgcgc aagatgctcc gcaaggaggc ggaggcgcgc
      241 tgcgtggtgc tcgattgccg gccctacctg gccttcgccg cgtcgagcgt gcgcggctcg
      301 ctcaacgtca acctcaactc cgtggtgctg cggcgggccc ggggcggcgc ggtgtctgcg
      361 cgctacgtgc tgcccgacga ggcggcccgc gctcggctgc tgcaggaggg cggcggcggc
      421 gtggcggcgg tggtcgtgct ggaccagggc agccgccact ggcagaagct gcgggaggag
      481 agtgccgcgc gcgtcgtcct cacctcgctg ctggcctgtc tgcccgccgg cccgcgggtc
      541 tacttcctta aaggtgggta cgagaccttc tactcacagt atcctgagtg ctgtgtggat
      601 gcgaagccca tttcacaaga gaagctcgaa ggtgagagag gcctcctcag ccagtgcgga
      661 aagcccattc tcagcgtcgc ctacagacca gcttatgacc agggtggccc agttgaaatc
      721 cttcccttcc tctaccttgg aagtgcctac catgcatcca agtgcgagtt cctcgccaac
      781 ctgcacatca cagccctgct gaatgtttcc cgccggacct ctgaggcctg caccacccac
      841 ctacactaca agtggatccc tgtggaggac agccacaccg ccgacattag ctcccacttt
      901 caagaagcaa tagattttat tgactgtgtc agggaagagg gaggcaaggt cctggttcac
      961 tgtgaagccg gggtctcccg gtcgcccacc atctgcatgg cttacctcat gaagaccaag
     1021 cagttccgcc tgaaggaggc cttcgagtat atcaagcaga ggaggagcgt ggtctctccc
     1081 aactttggct tcatgggaca gctcctgcag tatgagtctg agatcctgcc ctccacaccc
     1141 accccccaac ctccctcctg ccaaggggag gcagccagct ccacctttat aggccactta
     1201 cagacactga gccctgatat gcagggtgcc tactgcacat tccctacctc agtgctggca
     1261 ccggtgccca cccacgccac cgtcgcagag ctccacagga gccccgtggc cacagccaca
     1321 tcctgctgag accggtgggc taccagcgca tccccaagag caactgtgac ctttggattt
     1381 tttaaacttg tggacatttc atacccgtgc aatactgaag acctctctct gtcccgctgc
     1441 cccggtgaga tggtgagggg tcagcaggct tgcagatgca cttcaggcta acccggagga
     1501 tggtttctcg cgattgtagg aaggccaagc catgcccccc tagcacagcg gcgtgctaac
     1561 tactgtactt ccagaagccc cgcccactca ggaccgcctc atccttgcac ctcagaagtc
     1621 ccggcttctc atttcaagtg taaggcaata cacagtcgca gcaaagtagg agcaagctgt
     1681 gctggaccag gaggggagga gtccgcccgt ctgggaggaa gcacaagttt cactgttaat
     1741 ttgaatttcg gccaactttg tctgtctctg tcctctgtca cttcagggaa gagagctggt
     1801 caccgctcag tcagaaaagt taaccccgct ggatttgtca agacaaaagg acctgcccgt
     1861 ctgaacccag tgtttctgag gttctgtcta ggatcccatg gaagctgttg gtgtaaggag
     1921 aagctcctga ctcattggag tttcttgctc accgagggct ccttggtgac cttggacttt
     1981 ggcatggttt ttacaaatac ttgaacctgt cccattgtat ctctccctaa agcacctctg
     2041 gtgtcattca gaaagttgtc agaccctaga ccaaaaacca cccctttgag ggggtagcag
     2101 gaactgcctg cgttctgggt cagtggtggt gactgacata ctttttcagt ttagtgtcct
     2161 gtgtgctttt tttgtcatcc attgtgacaa tgtttccctc cctaccctgg ggagtcgttt
     2221 tcaaactact gattctgggg tctacatcgt ttgcaatgtg gtactactat gtccttcgta
     2281 gattgttttt ccaagggggg aaaggcaata agtcaccccc aaacccatgt gaatgtgaag
     2341 aaaagcagtg ttgatgtttt tatatatata tatatatata catgtagtac aaaattaaaa
     2401 aaatgtcaaa aaataaaaag tgcttgttct tgtga
//
