LOCUS       NP_598262                384 aa            linear   ROD 02-MAY-2024
DEFINITION  dual specificity protein phosphatase 5 [Rattus norvegicus].
ACCESSION   NP_598262 XP_346589
VERSION     NP_598262.2
DBSOURCE    REFSEQ: accession NM_133578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Tang,C., Zhang,H., Border,J.J., Liu,Y., Fang,X., Jefferson,J.R.,
            Gregory,A., Johnson,C., Lee,T.J., Bai,S., Sharma,A., Shin,S.M.,
            Yu,H., Roman,R.J. and Fan,F.
  TITLE     Impact of knockout of dual-specificity protein phosphatase 5 on
            structural and mechanical properties of rat middle cerebral
            arteries: implications for vascular aging
  JOURNAL   Geroscience 46 (3), 3135-3147 (2024)
   PUBMED   38200357
  REMARK    GeneRIF: Impact of knockout of dual-specificity protein phosphatase
            5 on structural and mechanical properties of rat middle cerebral
            arteries: implications for vascular aging.
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Gem,J.B., Kovacs,K.B., Szalai,L., Szakadati,G., Porkolab,E.,
            Szalai,B., Turu,G., Toth,A.D., Szekeres,M., Hunyady,L. and Balla,A.
  TITLE     Characterization of Type 1 Angiotensin II Receptor Activation
            Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes
            in Rat Vascular Smooth Muscle Cells
  JOURNAL   Cells 10 (12), 3538 (2021)
   PUBMED   34944046
  REMARK    GeneRIF: Characterization of Type 1 Angiotensin II Receptor
            Activation Induced Dual-Specificity MAPK Phosphatase Gene
            Expression Changes in Rat Vascular Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Jia,Y., Liu,J., Hu,H., Duan,Q., Chen,J. and Li,L.
  TITLE     MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by
            targeting DUSP5
  JOURNAL   Neurosci Res 171, 103-113 (2021)
   PUBMED   33744332
  REMARK    GeneRIF: MiR-363-3p attenuates neonatal hypoxic-ischemia
            encephalopathy by targeting DUSP5.
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Wu,Z., Xu,L., He,Y., Xu,K., Chen,Z., Moqbel,S.A.A., Ma,C.,
            Jiang,L., Ran,J., Wu,L. and Zhong,Y.
  TITLE     DUSP5 suppresses interleukin-1beta-induced chondrocyte inflammation
            and ameliorates osteoarthritis in rats
  JOURNAL   Aging (Albany NY) 12 (24), 26029-26046 (2020)
   PUBMED   33361528
  REMARK    GeneRIF: DUSP5 suppresses interleukin-1beta-induced chondrocyte
            inflammation and ameliorates osteoarthritis in rats.
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Ohwada,W., Tanno,M., Yano,T., Ong,S.B., Abe,K., Sato,T., Kuno,A.,
            Miki,T., Sugawara,H., Igaki,Y. and Miura,T.
  TITLE     Distinct intra-mitochondrial localizations of pro-survival kinases
            and regulation of their functions by DUSP5 and PHLPP-1
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (10), 165851 (2020)
   PUBMED   32480039
  REMARK    GeneRIF: Distinct intra-mitochondrial localizations of pro-survival
            kinases and regulation of their functions by DUSP5 and PHLPP-1.
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Ke,X., McKnight,R.A., Caprau,D., O'Grady,S., Fu,Q., Yu,X.,
            Callaway,C.W., Albertine,K.H. and Lane,R.H.
  TITLE     Intrauterine growth restriction affects hippocampal dual
            specificity phosphatase 5 gene expression and epigenetic
            characteristics
  JOURNAL   Physiol Genomics 43 (20), 1160-1169 (2011)
   PUBMED   21828247
  REMARK    GeneRIF: Intrauterine growth retardation affects hippocampal DUSP5
            expression and epigenetic characteristics in a sex-specific manner.
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Fu,Q., McKnight,R.A., Yu,X., Callaway,C.W. and Lane,R.H.
  TITLE     Growth retardation alters the epigenetic characteristics of hepatic
            dual specificity phosphatase 5
  JOURNAL   FASEB J 20 (12), 2127-2129 (2006)
   PUBMED   16940436
  REMARK    GeneRIF: intrauterine growth retardation induced by uteroplacental
            insufficiency 1) affects the hepatic epigenetic characteristics and
            mRNA of the DUSP-5 and 2) increases hepatic insulin receptor
            substrate-1 phosphorylation at serine 612 in adult rats.
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Raghavendra Rao,V.L., Dhodda,V.K., Song,G., Bowen,K.K. and
            Dempsey,R.J.
  TITLE     Traumatic brain injury-induced acute gene expression changes in rat
            cerebral cortex identified by GeneChip analysis
  JOURNAL   J Neurosci Res 71 (2), 208-219 (2003)
   PUBMED   12503083
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Hevroni,D., Rattner,A., Bundman,M., Lederfein,D., Gabarah,A.,
            Mangelus,M., Silverman,M.A., Kedar,H., Naor,C., Kornuc,M.,
            Hanoch,T., Seger,R., Theill,L.E., Nedivi,E., Richter-Levin,G. and
            Citri,Y.
  TITLE     Hippocampal plasticity involves extensive gene induction and
            multiple cellular mechanisms
  JOURNAL   J Mol Neurosci 10 (2), 75-98 (1998)
   PUBMED   9699150
  REMARK    Review article
REFERENCE   10 (residues 1 to 384)
  AUTHORS   Ishibashi,T., Bottaro,D.P., Michieli,P., Kelley,C.A. and
            Aaronson,S.A.
  TITLE     A novel dual specificity phosphatase induced by serum stimulation
            and heat shock
  JOURNAL   J Biol Chem 269 (47), 29897-29902 (1994)
   PUBMED   7961985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 2, 2020 this sequence version replaced NP_598262.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013144.1, SRR26643299.7675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     Protein         1..384
                     /product="dual specificity protein phosphatase 5"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP-kinase phosphatase CPG21; candidate
                     plasticity-related gene 21; MAP-kinase phosphatase
                     (cpg21)"
                     /calculated_mol_wt=41999
     Region          5..140
                     /region_name="DSP_MapKP"
                     /note="N-terminal regulatory rhodanese domain of dual
                     specificity phosphatases (DSP), such as Mapk Phosphatase.
                     This domain is believed to determine substrate specificity
                     by binding the substrate, such as ERK2, and activating the
                     C-terminal catalytic domain by...; cd01446"
                     /db_xref="CDD:238723"
     Site            52..54
                     /site_type="active"
                     /note="putative substrate binding residues [active]"
                     /db_xref="CDD:238723"
     Region          53..74
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O54838.1)"
     Region          179..316
                     /region_name="DSP_DUSP5"
                     /note="dual specificity phosphatase domain of dual
                     specificity protein phosphatase 5; cd14639"
                     /db_xref="CDD:350487"
     CDS             1..384
                     /gene="Dusp5"
                     /gene_synonym="Cpg21"
                     /coded_by="NM_133578.2:175..1329"
                     /db_xref="GeneID:171109"
                     /db_xref="RGD:620854"
ORIGIN      
        1 mkvtsldgrr lrkmlrkeae arcvvldcrp ylafaassvr gslnvnlnsv vlrrarggav
       61 saryvlpdea ararllqegg ggvaavvvld qgsrhwqklr eesaarvvlt sllaclpagp
      121 rvyflkggye tfysqypecc vdakpisqek legergllsq cgkpilsvay rpaydqggpv
      181 eilpflylgs ayhaskcefl anlhitalln vsrrtseact thlhykwipv edshtadiss
      241 hfqeaidfid cvreeggkvl vhceagvsrs pticmaylmk tkqfrlkeaf eyikqrrsvv
      301 spnfgfmgql lqyeseilps tptpqppscq geaasstfig hlqtlspdmq gayctfptsv
      361 lapvpthatv aelhrspvat atsc
//
