LOCUS       NM_022199               4792 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 4 (Dusp4), mRNA.
ACCESSION   NM_022199
VERSION     NM_022199.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4792)
  AUTHORS   Chandrasekhar,A., Komirishetty,P., Areti,A., Krishnan,A. and
            Zochodne,D.W.
  TITLE     Dual Specificity Phosphatases Support Axon Plasticity and Viability
  JOURNAL   Mol Neurobiol 58 (1), 391-407 (2021)
   PUBMED   32959171
  REMARK    GeneRIF: Dual Specificity Phosphatases Support Axon Plasticity and
            Viability.
REFERENCE   2  (bases 1 to 4792)
  AUTHORS   Barajas-Espinosa,A., Basye,A., Jesse,E., Yan,H., Quan,D. and
            Chen,C.A.
  TITLE     Redox activation of DUSP4 by N-acetylcysteine protects endothelial
            cells from Cd(2)-induced apoptosis
  JOURNAL   Free Radic Biol Med 74, 188-199 (2014)
   PUBMED   24973647
  REMARK    GeneRIF: DUSP4 gene knockdown further supports the hypothesis that
            DUSP4 is an antioxidant gene, critical in the modulation of eNOS
            expression, and thus protects against Cd(2+)-induced stress.
REFERENCE   3  (bases 1 to 4792)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   4  (bases 1 to 4792)
  AUTHORS   Berasi,S.P., Huard,C., Li,D., Shih,H.H., Sun,Y., Zhong,W.,
            Paulsen,J.E., Brown,E.L., Gimeno,R.E. and Martinez,R.V.
  TITLE     Inhibition of gluconeogenesis through transcriptional activation of
            EGR1 and DUSP4 by AMP-activated kinase
  JOURNAL   J Biol Chem 281 (37), 27167-27177 (2006)
   PUBMED   16849326
  REMARK    GeneRIF: the inhibition of hepatic gluconeogenesis by AMPK may, in
            part, be mediated by an immediate early gene response involving
            EGR1 and its target, DUSP4
REFERENCE   5  (bases 1 to 4792)
  AUTHORS   Edwards,L. and Ernsberger,P.
  TITLE     The I(1)-imidazoline receptor in PC12 pheochromocytoma cells
            reverses NGF-induced ERK activation and induces MKP-2 phosphatase
  JOURNAL   Brain Res 980 (1), 71-79 (2003)
   PUBMED   12865160
  REMARK    GeneRIF: The I(1)-imidazoline receptor in PC12 pheochromocytoma
            cells induces MKP-2 phosphatase.
REFERENCE   6  (bases 1 to 4792)
  AUTHORS   Zhen,X., Torres,C., Cai,G. and Friedman,E.
  TITLE     Inhibition of protein tyrosine/mitogen-activated protein kinase
            phosphatase activity is associated with D2 dopamine receptor
            supersensitivity in a rat model of Parkinson's disease
  JOURNAL   Mol Pharmacol 62 (6), 1356-1363 (2002)
   PUBMED   12435803
REFERENCE   7  (bases 1 to 4792)
  AUTHORS   Hofken,T., Keller,N., Fleischer,F., Goke,B. and Wagner,A.C.
  TITLE     Map kinase phosphatases (MKP's) are early responsive genes during
            induction of cerulein hyperstimulation pancreatitis
  JOURNAL   Biochem Biophys Res Commun 276 (2), 680-685 (2000)
   PUBMED   11027531
REFERENCE   8  (bases 1 to 4792)
  AUTHORS   Misra-Press,A., Rim,C.S., Yao,H., Roberson,M.S. and Stork,P.J.
  TITLE     A novel mitogen-activated protein kinase phosphatase. Structure,
            expression, and regulation
  JOURNAL   J Biol Chem 270 (24), 14587-14596 (1995)
   PUBMED   7782322
REFERENCE   9  (bases 1 to 4792)
  AUTHORS   Guan,K.L. and Butch,E.
  TITLE     Isolation and characterization of a novel dual specific
            phosphatase, HVH2, which selectively dephosphorylates the
            mitogen-activated protein kinase
  JOURNAL   J Biol Chem 270 (13), 7197-7203 (1995)
   PUBMED   7535768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 29, 2022 this sequence version replaced NM_022199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.48344.1,
                                           SRR22582419.1583322.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840115,
                                           SAMN12840116 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-860               JAXUCZ010000016.1  64092841-64093700   c
            861-1006            JAXUCZ010000016.1  64085116-64085261   c
            1007-1226           JAXUCZ010000016.1  64084277-64084496   c
            1227-4792           JAXUCZ010000016.1  64079893-64083458   c
FEATURES             Location/Qualifiers
     source          1..4792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..4792
                     /gene="Dusp4"
                     /gene_synonym="Mkp-2; Mkp2"
                     /note="dual specificity phosphatase 4"
                     /db_xref="GeneID:60587"
                     /db_xref="RGD:620625"
     exon            1..860
                     /gene="Dusp4"
                     /gene_synonym="Mkp-2; Mkp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1612
                     /gene="Dusp4"
                     /gene_synonym="Mkp-2; Mkp2"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 2; mitogen-activated protein
                     kinase phosphatase 2"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 4"
                     /protein_id="NP_071535.2"
                     /db_xref="GeneID:60587"
                     /db_xref="RGD:620625"
                     /translation="MVTMEELREMDCSVLKRLMNRDENGGSAGSSGGSHGALGLLSGG
                     KCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGL
                     YSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCS
                     KTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDML
                     DALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGR
                     VLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQ
                     VLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTS
                     PSC"
     exon            861..1006
                     /gene="Dusp4"
                     /gene_synonym="Mkp-2; Mkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1226
                     /gene="Dusp4"
                     /gene_synonym="Mkp-2; Mkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..4792
                     /gene="Dusp4"
                     /gene_synonym="Mkp-2; Mkp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagcatt aataaatctc taagcagagg aggaaactct ggctggggca gtgcgtgcag
       61 ctccggcgga gcgttggggg aaaacggcgg tgcctaaggc aggagcagcc tagctagcaa
      121 aacacaccag gggcaacaaa ccgagaggag ccctctctct cgtaaacata ctcccctcct
      181 cggtcacttg ctccgggtgc cgtgcgcccg cctgctttgg cgccagagaa ggctcggact
      241 gctatgtaac gtcgaggctg cgggaggagg aggaaggggt gttgggagaa gagccttggg
      301 gccaagtttg cgggtcactt cggcaggcgc cttcttagcc ttcgcctgtt ccttcttgta
      361 gcctagctgg cttgggtgcc cttggtcttc tccggctccc cagctgctgt gctttgccgg
      421 cgacatggtg acgatggagg aactgcggga gatggactgc agcgtgctca aaaggctgat
      481 gaaccgagat gagaacggcg gcagcgcggg cagcagcggc ggcagccacg gcgccctggg
      541 gctgctgagc ggcggcaagt gcttgctgct ggactgcagg ccgtttctgg ctcacagcgc
      601 gggctacatc cgaggctcgg tgaacgtgcg ctgcaatacc atcgtgcggc ggagggccaa
      661 gggctccgtg agcctggagc agattctgcc cgccgaggaa gaggtgcgcg cccgcctgcg
      721 ctctggcctc tactcggctg tcatcgtcta cgatgagcgc agcccgcgcg ccgagagtct
      781 ccgggaggac agcacagtgt cgctggtcgt gcaggcgttg cgccggaacg cggagcgcac
      841 agacatctgc ctgcttaaag gtggctatga gaggttttct tctgagtacc cagaattctg
      901 ctctaaaact aaggccctgg ccgccatccc accccccgta cctcccagca caaatgagtc
      961 cttggatctg ggctgcagct cctgtgggac cccactgcac gaccaggggg gtcctgtgga
     1021 gatccttcct ttcctctacc tcggcagtgc ctaccacgct gcccgcaggg acatgcttga
     1081 tgccctgggg atcacggctc tactgaatgt ctcctcagac tgccccaatc actttgaggg
     1141 acattaccag tacaagtgca tcccggtaga agataaccac aaggctgaca tcagctcctg
     1201 gttcatggaa gccatcgaat acatagacgc agtgaaggac tgccgagggc gagtgctggt
     1261 tcactgccag gccggcatct ctagatcagc caccatctgc ctggcctacc tgatgatgaa
     1321 gaaacgggtg aggctggagg aggctttcga gttcgtcaag cagcgccgta gcatcatctc
     1381 gcccaacttc agcttcatgg gccagttgct gcagttcgag tctcaggtgc tcaccacgtc
     1441 ctgcgcagcg gaggccgcca gcccttccgg gcccctgcgg gagaggggga aggccactcc
     1501 cacccccacc tcgcagttcg tcttcagctt ccccgtgtcc gtgggtgtgc acgcggctcc
     1561 cagtaacctg ccgtacctgc acagccccat caccacctcc cccagctgtt aggactagtc
     1621 acgggacacc gagtccagag tcggccccag ccagtgtgca agccacatgt gaggagcgaa
     1681 tagggactga ccagtggggg accaggtgac cgtccccatc catttctcct tggccgacca
     1741 cagggccagc taggatggca ataactatga ctttgaatac acatttaaaa caaacacagc
     1801 taaacaccca cagcctagag caataagagc agcttccgct gccagagaag acttggattt
     1861 tgtgtccgtt tttcctttgc aggtagaaat ttacctcatt attattatta ttatttttta
     1921 aagcaatcaa gcttgaaagt tatgaagccc acagatcctg gcaaatgtgc ccaaccagtt
     1981 ttattgagtg gagagggaag gaggagaaag ttgagtttgc cagaaaagtg cctggttctg
     2041 tgtgcatatt cttctgttgt tggacccaca gcagttttgt tctagatcct tctaggccac
     2101 agtattctgg ttagccgtca actggataat tgatgtttaa tgagtattga gaacctgagc
     2161 atgtgtgtgt gtgcgtgtgt gtgcaggagt ctggtggctt tgggatatgt ttctgttgag
     2221 gtcacacaca gagacacaaa gctgtgctgg cggtgagggg agtgtggcag gtaggtggtc
     2281 gctggggtca ccgtctttca tcgttgccac tgagaagcag gcagggtgac ttgcaaggaa
     2341 caaggttggt cactttttgc agctggctcc tgggcccact gacccagccg ggcaagcttt
     2401 tctctctagt ttgactgcgg gtagagcatt tggcctagga tctggatatc gtctggggaa
     2461 atgccatctt ttctaaggtg ctcctggaaa actgggtgca attcagattt tcctaccgtg
     2521 aatcattttg gtaaggccag ctcagaacca gatcactgaa gatgaactaa aaatgaatct
     2581 cctcttggcg ttgatctcct ccctccctcg gataaattgg gcgtttcagt tctaggagtt
     2641 tacttgaagt atacatacca agaaattctt gttacgaaat ccctgtcaag tgaatacttt
     2701 gaaaagtcct ccctcttttg agtaaaaaga taagtgtatg tctgacttgg ggctccttac
     2761 ggtctggaag ggagagagca gagttggggg gctgcgtgct agctcctatc ttactgatag
     2821 tgactcagaa gccatgttgg gttctgactg ggccaacacc attttaaaag agcctttcca
     2881 agtggaggaa aggcattgga gtgtgttttc tagggggaag gtgcagggtg gggagggaac
     2941 ctgtttcgtc tgtagttttg ggggacagtt ttgtgacggc atgtcagatt agatagaggt
     3001 cactgcagac ctggcagaaa tgagcacggt cccgcccccc tcccccactt tgagcataaa
     3061 tataaaacta caagtgtcca cgttacatca tgatggaatg ctttctcatc cagagtccca
     3121 gacagcccgg gctcatggtt tttccgtcca tgaaaagggg acttacgttg ctatgacttg
     3181 tattgggtgg cctgtgtcaa accccacctt tggctgagaa gcaaggggtg tcctgattcc
     3241 ctgactgccg cttggctgaa ggcatggagg ggctgagctc ctcgacgctg gactgcctat
     3301 gcctagttgg atggtcctac gtttgccccc tgcttcctgg cagctgtttc atgtttggtg
     3361 aagaattaga tgagatgtgt ttttgtagct aggcaagtcc tgggttccca gagtaaaggg
     3421 tatgtggaga gcaggtatct gttagactac attcactttc tatatgagtg cttgccaaat
     3481 gtgtcctagt tcccagactg gatcccaact gcacaggcag tgggagctcc aaatgtccct
     3541 cccctgcttc ctaattcaaa cctcctatga cagtgtcaag gggctattta taaagtcatg
     3601 ttctttgtac ttgataacag catgagaccc aaaactctta gaaaatagga cactggtttg
     3661 attgaaaaaa ggggaggcac accttaaaca tattctccag aagcttctct gatggcttgg
     3721 aatagctcta atgacgaccg tgtcccaagg gtcaaggacc atttcccgtc catgagctga
     3781 tttctggtga tggggagttt tggaaagtca gaaagaaagc cattgagtat ttgtagtatt
     3841 tgtaggagaa tgaggttttc ctccggaaac ttggctccct ccatggtgtt cctgggaccc
     3901 tgagggctaa agtacaggtg aggcagtggc tggcagttct cagctccatt ctcccctgag
     3961 accttgtgct cttgttcttg gctttctgta agactgggga agccaaggga ggggtttgag
     4021 agtccttgag aaggaggcag gaaggaggaa gattgatagt tactcccaag gggaagggac
     4081 tgggtggtgg ccaaggaagc ctgtggcagt gataacagta gctcatctgg gttcataatc
     4141 acctgggtag cctttaaaat cctcatatct aggtgaccct tgaccaaata aaccaggacg
     4201 tggggggtgg gggggtggga aaacgggact tagacaccga tctgttacag tgttcactgt
     4261 tatgtgcttt gactggagac accattgctt ggggatggtg aaagccaggt cttgtaggca
     4321 cagagtagta aacagacggt acagtagggc tttgtaacag ggtcactgtg gtcccgctct
     4381 ccacagctgg ctgagggaat gctgtggttt ctttgtgggg agcccgaatg ggaaccaatt
     4441 tgtggagcat tgtgagtggg ctcaatatag tgtctgggtg ttgatgtgtt tccttaaatt
     4501 ttgtctgcag gaaagatgga gaaagtatgt gtctgttttg aagtcctcct tctagtgccc
     4561 tatccttcct tagaactcac gaatcattca agggacttca gaaagataac aatgcaatac
     4621 ttgtaacgtg tgtaaatagc ccccgtcttt ctgagtgctg tcatttctac atttgatatg
     4681 ctcgtatttc tgtaggttgt accttgtttt ctagaagagt caaacatgtc tgtttttatt
     4741 tattgcttga aaaaagatca tttgaagaaa aataaataca ttttcaacca tt
//
