LOCUS       NM_001173376            4232 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 3 (Dusp3), mRNA.
ACCESSION   NM_001173376 XM_001081500 XM_573199
VERSION     NM_001173376.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4232)
  AUTHORS   Chen YR, Chou HC, Yang CH, Chen HY, Liu YW, Lin TY, Yeh CL, Chao
            WT, Tsou HH, Chuang HC and Tan TH.
  TITLE     Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase,
            reveals its role in regulating cell adhesion and migration
  JOURNAL   Oncogene 36 (47), 6509-6517 (2017)
   PUBMED   28759036
REFERENCE   2  (bases 1 to 4232)
  AUTHORS   Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang
            HS, Ryu SY, Park H, Kim DS, Kim SJ and Ryu SE.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   3  (bases 1 to 4232)
  AUTHORS   Quiel A, Jurgen B, Greinacher A, Lassen S, Worl R, Witt S and
            Schweder T.
  TITLE     Sensitive detection of idiotypic platelet-reactive alloantibodies
            by an electrical protein chip
  JOURNAL   Biosens Bioelectron 36 (1), 207-211 (2012)
   PUBMED   22572157
REFERENCE   4  (bases 1 to 4232)
  AUTHORS   Arnoldussen YJ, Lorenzo PI, Pretorius ME, Waehre H, Risberg B,
            Maelandsmo GM, Danielsen HE and Saatcioglu F.
  TITLE     The mitogen-activated protein kinase phosphatase vaccinia
            H1-related protein inhibits apoptosis in prostate cancer cells and
            is overexpressed in prostate cancer
  JOURNAL   Cancer Res 68 (22), 9255-9264 (2008)
   PUBMED   19010898
REFERENCE   5  (bases 1 to 4232)
  AUTHORS   Henkens R, Delvenne P, Arafa M, Moutschen M, Zeddou M, Tautz L,
            Boniver J, Mustelin T and Rahmouni S.
  TITLE     Cervix carcinoma is associated with an up-regulation and nuclear
            localization of the dual-specificity protein phosphatase VHR
  JOURNAL   BMC Cancer 8, 147 (2008)
   PUBMED   18505570
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4232)
  AUTHORS   Schumacher MA, Todd JL, Rice AE, Tanner KG and Denu JM.
  TITLE     Structural basis for the recognition of a bisphosphorylated MAP
            kinase peptide by human VHR protein Phosphatase
  JOURNAL   Biochemistry 41 (9), 3009-3017 (2002)
   PUBMED   11863439
REFERENCE   7  (bases 1 to 4232)
  AUTHORS   Aoki N, Aoyama K, Nagata M and Matsuda T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
REFERENCE   8  (bases 1 to 4232)
  AUTHORS   Alonso A, Saxena M, Williams S and Mustelin T.
  TITLE     Inhibitory role for dual specificity phosphatase VHR in T cell
            antigen receptor and CD28-induced Erk and Jnk activation
  JOURNAL   J Biol Chem 276 (7), 4766-4771 (2001)
   PUBMED   11085983
REFERENCE   9  (bases 1 to 4232)
  AUTHORS   Denu JM, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper MA and Dixon JE.
  TITLE     The purification and characterization of a human dual-specific
            protein tyrosine phosphatase
  JOURNAL   J Biol Chem 270 (8), 3796-3803 (1995)
   PUBMED   7876121
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10358]
REFERENCE   10 (bases 1 to 4232)
  AUTHORS   Zhou G, Denu JM, Wu L and Dixon JE.
  TITLE     The catalytic role of Cys124 in the dual specificity phosphatase
            VHR
  JOURNAL   J Biol Chem 269 (45), 28084-28090 (1994)
   PUBMED   7961745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001173376.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001173376.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169043.1, SRR8487230.87591.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JACYVU010000220.1  43756543-43756693   c
            152-378             JACYVU010000220.1  43753639-43753865   c
            379-4232            JACYVU010000220.1  43744872-43748725   c
FEATURES             Location/Qualifiers
     source          1..4232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4232
                     /gene="Dusp3"
                     /gene_synonym="RGD1560049"
                     /note="dual specificity phosphatase 3"
                     /db_xref="GeneID:498003"
                     /db_xref="RGD:1560049"
     exon            1..151
                     /gene="Dusp3"
                     /gene_synonym="RGD1560049"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..584
                     /gene="Dusp3"
                     /gene_synonym="RGD1560049"
                     /note="vaccinia virus phosphatase VH1-related; dual
                     specificity phosphatase 3 (vaccinia virus phosphatase
                     VH1-related)-like"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 3"
                     /protein_id="NP_001166847.1"
                     /db_xref="GeneID:498003"
                     /db_xref="RGD:1560049"
                     /translation="MQGPAAAMSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRV
                     YVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQE
                     FNLSAYFERAADFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMLRQKMDVRSALST
                     VRQNREIGPNDGFLAQLCQLNDRLAEEGKVKL"
     exon            152..378
                     /gene="Dusp3"
                     /gene_synonym="RGD1560049"
                     /inference="alignment:Splign:2.1.0"
     exon            379..4232
                     /gene="Dusp3"
                     /gene_synonym="RGD1560049"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcatgca gggccccgcc gccgccatgt ccggctcttt tgagctctcg gtgcaagatc
       61 tcaacgacct gctctcggac ggcagcggct gctatagcct cccgagccag ccctgcaacg
      121 aggtcatccc gagggtctac gtgggcaacg cgtctgtggc tcaggacatc acccagctgc
      181 agaaattggg catcacccac gtcctgaatg ctgctgaggg caggtccttc atgcatgtca
      241 acaccagtgc tagcttctac aaggatacgg gcatcaccta catgggcatc aaggccaatg
      301 acacgcagga gttcaacctc agtgcttact ttgaaagggc tgcagacttc attgaccagg
      361 ccctggccca taaaaatggc cgggtgcttg tccattgccg tgagggctac agtcgctctc
      421 caacgctagt catcgcctac ctcatgttgc gacagaagat ggatgtcagg tctgctctga
      481 gcactgtgag gcagaatcgt gagatcggcc ccaacgatgg tttcctggcc caactctgcc
      541 agctcaatga cagactagcc gaggagggca aggtgaaact ctaggttgcc catagcctct
      601 tttgcagagg tctgactggg agggccctgg ctgccctact taggaaacac agtgtaccct
      661 gttccctgca ccaccaggca ctcgcccatg tctgtcccac tgtggtcccg gggccactcc
      721 acccttaggg agcaaatgaa gaagcttgct ggggaagcca ttttgctcct tggctgccct
      781 ttcctgtaat ttatgtcccc ctgaggtggg actcagggag gaaacctgtg gcatggatgc
      841 atctcagtga cccagggcag gaggcctatg agggtgcaag acctgagaca caggcacccc
      901 cttcataacc ccctccccaa cctgggttct tcctgagcgg tccagaaccg tggaccaaag
      961 gaactatgca aacaggggcc ctgatctccc cacatccatc gctggtcctc ccagcccgac
     1021 acaccctgct tagacagacg catggcataa gttctgaagc agagtggagg tagattagtg
     1081 actggatttc caaaaaagaa aaaaaaggct tttgcatttt atttccttag acttaaagac
     1141 actacgtagg ggcctgtggg tgagcaaagc tgtttttctc agagggctct cttgattctt
     1201 tgggatgttt aaagtgtgcc tcgctggaga gctttcgctc tgtatctgct gcttcagagc
     1261 cttccctatg gatggctctg ttccttcgct tgttagaaga gcgatgatgc cttgggcagg
     1321 gttttctctc ttttagaata cagggtgtga ggtccagcct atgaaaaaca agcaaacaaa
     1381 acaaacaaac aaaagccctc tgtttggaga attgcaaggg ttttatcctg aaccatagtc
     1441 ttgctgagct caagtcatca cgccaagggc ttgccatcct ggttgctatt ctaagaatag
     1501 ttagaaggaa gttggccaat tccagctcgt gtttgtgggt gtatgcacgg gtgcgtatgt
     1561 tgagggggtg cctgtcgcct tggggacaga aggaacacga aaggcccctg tgttcaccct
     1621 gtccatttac ggggtggctc tgatggttcc acggtgtctg tgcaggatcc ctggaactga
     1681 ctcgctggac agaaatgaga cttgaaggca tcaccaaaat ggatcccttt tattggagag
     1741 agacagagag agagagagag agagcgaaga aagaactgcc ttttaaagaa ctttctaagg
     1801 acggttttga aacacgctgg acctcgtgtg tgtgcacatt caccagaaat tgaacacaat
     1861 cttcttggga ctttatgttc ttgttattcg tatgtcccca gggtcacgca gagcagagag
     1921 gtggcagtca gccaccaccc cagcacctgg cacataagca ctcataaaag cctgtcttat
     1981 gctatccgga gctgtttgag gaccccgtgt atagagagtt gccgttgtgg gacacacgga
     2041 ttccagcatc ctggttgcct gcctgtaagg tgtctgacag gagtttgcag agaaatcttc
     2101 cttggaggga aagaaatatc agggattttc gttgaatgtt tcaaactcag ctttaagtgt
     2161 aggactcggc agtgttaatg gttaggataa ggagtgtgcc tttctcacag ctgctgaggg
     2221 gacatctggc aagagccaag agaagcagac ctgtcttagg gtgtcactcc cagggtgaag
     2281 acctccgatc ccagcaggag cagagctgtg cagcctggat ggtcattgtc ccctattctg
     2341 tgtgaccaca gcaggcttgg acacatgggg ctggtcatct cccccccccc cccgagtgga
     2401 atggccgtag cctcagtctg taggtgttca agtgactttc ttgcttaaga cacaacttgc
     2461 atctcaaaat agccctgtaa agttgacaga accaattcgt gtgttatgag aggggaaaaa
     2521 aaacccaaaa acccgcaaag caaaaacatc tgggctagcc cggtgtggtt gcacgtctgc
     2581 aggcctagtt cacaggaggc agagacagga agatcactgg aggattaagg atagcctggt
     2641 ctgcatactg agactccagc cagggctacg atccccagat cctgagtttt ggtttttggt
     2701 ttttgatttt tggttttcga gacagggtct ctctgtgtag ccctggatgt cctggaactc
     2761 actctgtaga ccaggctgac ctcaaactta gatatctgcc tgcctctgtg tctgaggggc
     2821 tgggactaaa gacttatgct accactgccc aactaagttc ctgtcttcta aaaaacaaaa
     2881 aattcaaggt aattaagagt tgccagttct ttaaagctaa gtggtggtag tttcagacct
     2941 gctgcttgag gaagctgggg tgttcttgac ttggccccga aatcagcccc aacaatgtcc
     3001 aagtaccctg cacatgactt tgagccatct ccagagaagg aagtgaaaat tgcagcttcc
     3061 cagttggtta ggacacagcc tcactttatc caggcatcac atggtgacac gtggccttga
     3121 actctccgct ctgaggctgg gctcccctcc ccctgcctca tctgagtgat caccccatag
     3181 gacagccaca ggacagtcac caacatctcc ctgaggcctc tttgtgggaa cattaaggaa
     3241 agggcctttg ggaggttcct ggctttcctt tggggctatt cactgaaagt tctgcatttc
     3301 ttggttggct ttacctcttg tttataagat tagctacaag tcttcaggtc aaatgctcac
     3361 gttgtggaaa agccaaccgc atgcctgccc gtgagtaggg gatggtggtg gggaatcctg
     3421 aatagtgttc tatccctgga aagagataga ataggaattc agggtgtccc tcctccttcc
     3481 tcagacccag tcactttctg tgactcataa aaatccaggt aaaaattaac aatgtaaaaa
     3541 tggtttctct tctcaatttt aaagtctgtc tgcgttttcc agggggtagg tctgtctcct
     3601 tgctgttcta ttatcttgag agcacagact aacacttacc aaatgagcga gcccttttgg
     3661 cccaccctaa ggatcttctg ggctccagca ctcttaagtt gttttaagaa tcctggcttg
     3721 acctttagca cccccaggga aatgggcgtg aatgatgacg ccacggccag cagggggcac
     3781 tgttgagaag gttggtgcct tccagccata ggttcacggt aagttgctca cagtatttaa
     3841 aatgctaaat gtttaaatca aaataagcac tgatcttaaa tatgaagata agggattttt
     3901 ctcacaggaa attttctctc tcataattct tttaacagac tctatcctga tcgtagagta
     3961 gagagaagaa tggttggata tttcacttgc gttcctcttt cctctgccag ctgttagggt
     4021 gacttgtaaa atgcgattta gtggacagaa aagttcaggg ggaaagggat ggtggagtga
     4081 ggcagagcac tgtcacctgc ctaatatggg aggacctgag ttcaattcct gccattgggg
     4141 aggaagagga aagtttaatg tctattacat caccgccagt gttagcgcac tatcaaactg
     4201 taaccaaaat aaatgtctta ccttacaaag aa
//
