LOCUS       NM_001399248            2948 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 22 (Dusp22),
            transcript variant 2, mRNA.
ACCESSION   NM_001399248 XM_006253889
VERSION     NM_001399248.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2948)
  AUTHORS   Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen
            AJ, Belmont JW and Tan TH.
  TITLE     The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and
            autoimmunity by inactivating Lck
  JOURNAL   Nat Commun 5, 3618 (2014)
   PUBMED   24714587
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2948)
  AUTHORS   Li JP, Fu YN, Chen YR and Tan TH.
  TITLE     JNK pathway-associated phosphatase dephosphorylates focal adhesion
            kinase and suppresses cell migration
  JOURNAL   J Biol Chem 285 (8), 5472-5478 (2010)
   PUBMED   20018849
REFERENCE   3  (bases 1 to 2948)
  AUTHORS   Sekine Y, Tsuji S, Ikeda O, Sato N, Aoki N, Aoyama K, Sugiyama K
            and Matsuda T.
  TITLE     Regulation of STAT3-mediated signaling by LMW-DSP2
  JOURNAL   Oncogene 25 (42), 5801-5806 (2006)
   PUBMED   16636663
REFERENCE   4  (bases 1 to 2948)
  AUTHORS   Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M,
            Meyer CF, Jurecic R, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher
            F, Tan TH and Belmont JW.
  TITLE     The dual specificity JKAP specifically activates the c-Jun
            N-terminal kinase pathway
  JOURNAL   J Biol Chem 277 (39), 36592-36601 (2002)
   PUBMED   12138158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000289.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399248.2.
            
            On Jan 5, 2022 this sequence version replaced XM_006253889.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB720826.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JACYVU010000289.1  2734292-2734353     c
            63-96               JACYVU010000289.1  2726377-2726410     c
            97-179              JACYVU010000289.1  2722935-2723017     c
            180-229             JACYVU010000289.1  2700307-2700356     c
            230-304             JACYVU010000289.1  2689961-2690035     c
            305-476             JACYVU010000289.1  2687310-2687481     c
            477-2948            JACYVU010000289.1  2684092-2686563     c
FEATURES             Location/Qualifiers
     source          1..2948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2948
                     /gene="Dusp22"
                     /note="dual specificity phosphatase 22"
                     /db_xref="GeneID:361242"
                     /db_xref="RGD:1307146"
     exon            1..62
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..659
                     /gene="Dusp22"
                     /note="isoform 2 is encoded by transcript variant 2; dual
                     specificity protein phosphatase 22"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 22 isoform
                     2"
                     /protein_id="NP_001386177.1"
                     /db_xref="GeneID:361242"
                     /db_xref="RGD:1307146"
                     /translation="MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPM
                     LEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLQGEGCLVHCLAGVSRSVTLVIAY
                     IMTVTDFGWEEALHTVRAGRSCANPNLGFQRQLQEFEKHEVRQYRQWLREEYGENPLR
                     DAEEAKSILGKYKEQGRMEPRPSSRRWSSLSALPALTYNNYTTET"
     exon            63..96
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
     exon            97..179
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
     exon            180..229
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
     exon            230..304
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
     exon            305..476
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
     exon            477..2948
                     /gene="Dusp22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctccc gcgagcgcgg agcggcgagc ccggcgcggc catggggagt gggatgagcc
       61 agatcctgcc gggcctgtac attggcaact tcaaagatgc aagagatgca gaacaattga
      121 gcaggaacaa ggtgacacac attctttctg tgcacgacac tgccaggccc atgctggagg
      181 gagttaaata cctgtgtatt ccagcagcag actcaccgtc tcaaaacctg acaagacatt
      241 tcaaagaaag tattaaattc attcatgagt gccgactcca gggtgagggc tgtcttgtac
      301 attgcctggc tggggtctcc aggagtgtga cactggtgat cgcatacatc atgactgtca
      361 ccgactttgg ctgggaagag gccttacaca ccgttcgtgc agggaggtcc tgtgccaacc
      421 ccaacctggg cttccaaagg cagctgcagg agtttgagaa acacgaagtg cggcagtatc
      481 ggcaatggct gagagaagaa tatggagaga accccttgcg ggatgcagaa gaagccaaaa
      541 gcattctggg taaatataaa gagcaagggc gcatggagcc ccggcctagc agcaggcggt
      601 ggagcagcct ttcagccctg cctgctctca cctacaataa ctacacaaca gagacctaac
      661 acagagagcc tgtgtctgcc tcctgctgca gggcttctgg gttgcctacc ctgtgctggt
      721 gtgcctggtg tgctggctcc cgcctctgag gactacaaga ggaggtcgca gcgaggtgga
      781 gcactcgggg ctcctcccca ggaccctgcc ccactcaggc cttttcagtc tcccgccttg
      841 gcccactctt ttcctcacct gaacttgccc agcctgggat gctacccagc cactgtgtat
      901 ttctcatatg tgtgtaagag catgtgtgtg tgtgtaagag tgtgcatata tacctaccaa
      961 tgtatgcaat gtgaaccagt atacatgtaa atgtgtctct gcatgtggga actgagtgtt
     1021 tatggtgctg aaagttataa gcccctgctg ctagaactgt gatgggcata ttgttcaatc
     1081 cgcatggaag tcatttgaac ttggcccctg aaaagctact caccaagtaa tagcccatcc
     1141 ctgtggtgag tgagagctca gggtgtgagc agctggaaac agtggtgttc cagatcctgg
     1201 tggtatagag gaaggaacag gacccccccc cccccagagg aagggtggca taatcccaga
     1261 aagttttatg tgtataggaa caagggaggt gctggtgagc attgtcttag acttgataag
     1321 tacatcagac ctcagcctcc ctgctggctc aagtcatgct ccactcatca tgtccctgag
     1381 ttccacttgg tgcctgctgt gtgtgggtcc agcatcattt gacttccatg gtgatccggt
     1441 atggtgacat ggaggacctg agacacagta accctatacc agaggtctgg cccaccttct
     1501 gtctgctttt acatactcaa acctctggcc agcctcttgc tgcaggggtc tcatctcagg
     1561 tctgcatgta cctggaggaa ctggaaagaa agaacaatca ttaaacacca tagcagtttg
     1621 tgatttaaaa tgcctaagcc ttcacggagc tcattgttgt atgctgtgga ctcgaccttt
     1681 gactcagcta cctcatgagg ttccttcctt ccgtccttcc tttcttcctt ccctccttct
     1741 tccatccatc catctatcct tctctccttc cttccttcct tctttaaggt tggggtttct
     1801 ttggtacccc aatcaaccct gcttcatagt tgagaatctt tgtcatgtgg cttttgtttt
     1861 tgaaaccaaa gagaagagca tacttatgtc attgagcaat ttaatatttg ccgtttggct
     1921 tccataaggt tttctagtgg gtcaatcccc acattctggc catgggagct ccttagctcg
     1981 aagtttgtgg cagcaggcac cccaagaagc tctgcacagt ctggggtcca gttctttatg
     2041 ccaattcaca tgtcttcagc atgcagaacc atgcaaatga aaaatacact caccctctcc
     2101 ctaaagacac tgcacccagg tctctctgaa ctgtaagaag actctgagta agaagcagca
     2161 gtcttcctgt gtgtatggag ccttttgggg ccagggaagt gaggttgaac tctccatgtg
     2221 tgcagtccct gcataggtag tgagaaaagg aaagatgtcc aataactcgg catcgttagc
     2281 taaactgaat taccgtaagc caaggaatag catagggagt gaagcttgaa tgtggtgccc
     2341 gtgtgaacag cgacatatgt ttccgtaggt tctccactgt cttagttttt gttgccagtg
     2401 atgttctttc tccacagctg ccccgggaat tctgaagtac tgggcctttc tcagaagact
     2461 gtaatgtacc tgaagtttct gaaatattac aaagctcagg ctggtgctgc caaaaagaaa
     2521 agtcacgtag agtttatttt taagaatgca atggtgattt gtatacttgt ttatttttca
     2581 ttttaaacgg aatgcatgta taatcatgtt ggaatatgtt aagaactatg gagcttctgt
     2641 agcaagagaa agtatctttg ccttaactcc actgctgtgg ttgttccttc cacctgacca
     2701 aggctcaaac aataatctca agagctctgt ctgtttccaa atattacctg cttctcatga
     2761 cgatacccaa gaaggaagcc tgcacctggg aaatgtgcag cgtgaactct gccctccagt
     2821 taagttctcc agctccagac atgtctcttg gtgtgtgttt tacccactgt tgttattcta
     2881 tacggtagaa ttaccaaacg ctattcagat ttcttaataa agggcaagtt aaccaagtct
     2941 gataccaa
//
