LOCUS       NM_001012089            1656 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus dual specificity phosphatase 2 (Dusp2), mRNA.
ACCESSION   NM_001012089 XM_230575
VERSION     NM_001012089.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1656)
  AUTHORS   Morente V, Perez-Sen R, Ortega F, Huerta-Cepas J, Delicado EG and
            Miras-Portugal MT.
  TITLE     Neuroprotection elicited by P2Y13 receptors against genotoxic
            stress by inducing DUSP2 expression and MAPK signaling recovery
  JOURNAL   Biochim Biophys Acta 1843 (9), 1886-1898 (2014)
   PUBMED   24851838
  REMARK    GeneRIF: P2Y13 receptors regulate DUSP2 expression and contribute
            to p38 signaling homeostasis and survival in granule neurons.
REFERENCE   2  (bases 1 to 1656)
  AUTHORS   Zhang Q, Muller M, Chen CH, Zeng L, Farooq A and Zhou MM.
  TITLE     New insights into the catalytic activation of the MAPK phosphatase
            PAC-1 induced by its substrate MAPK ERK2 binding
  JOURNAL   J Mol Biol 354 (4), 777-788 (2005)
   PUBMED   16288922
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088205.1.
            
            On Feb 11, 2005 this sequence version replaced XM_230575.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132275, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1656
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1656
                     /gene="Dusp2"
                     /note="dual specificity phosphatase 2"
                     /db_xref="GeneID:311406"
                     /db_xref="RGD:1305804"
     exon            1..466
                     /gene="Dusp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1023
                     /gene="Dusp2"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 2"
                     /protein_id="NP_001012089.1"
                     /db_xref="GeneID:311406"
                     /db_xref="RGD:1305804"
                     /translation="MPIAMGLEAACELECAALGALLREPREAERTLLLDCRPFLAFCR
                     SHVRAARPVPWNALLRRRARGTPAAALACLLPDRALRARLGRGELARAVVLDESSASV
                     AELPPDGPAHLLLAALQHEMRAGPMAVCFLRGGFESFQAYCPDLCSEAPAQALPPAGA
                     ENNSSDPRVPIYDQGGPVEILPYLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFE
                     GLFRYKSIPVEDNQMVEISAWFQEAIGFIDSVKNSGGRVLVHCQAGISRSATICLAYL
                     IQSHRVRLDEAFDFVKQRRGVISPNFSFMGQLLQLETQVLCH"
     exon            467..588
                     /gene="Dusp2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..808
                     /gene="Dusp2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1634
                     /gene="Dusp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgccacaca cacgccaccg ccgccggagc cgagggagag gaccgcggga agcaggaggc
       61 tttgcgatgc cgatcgccat gggactagag gcagcgtgcg agctagagtg cgcggcgctg
      121 ggcgcgctgc tgcgggagcc gcgggaggcc gagcgcacac tgctgctcga ctgtcgcccg
      181 ttcttggcct tctgtcgtag ccacgtgcgc gccgcgcgac ctgtgccctg gaacgcactg
      241 ctgcggcgcc gtgcgcgcgg cacccccgcc gccgccctcg cctgtctgct gccagaccgc
      301 gcgctccggg cgcgtctggg tcgcggagag ctggcccgcg ccgtggtgct ggacgaaagc
      361 agcgcatctg tggccgaact cccgcctgat ggcccggcgc acctgctgct agcagcactg
      421 caacacgaga tgcgcgcggg acccatggcc gtgtgcttct tgcgaggtgg ttttgaaagc
      481 ttccaggcat actgtccaga tctgtgctct gaagcccctg cccaggccct gcctcctgct
      541 ggggccgaaa ataacagctc tgacccgagg gttcctatct atgaccaggg tggtcctgtg
      601 gaaatcttgc cctacctata cttgggcagc tgcaaccact cctcagatct tcaggggctg
      661 caggcctgcg gaatcacagc ggttctcaat gtctctgcca gctgccccaa ccactttgag
      721 ggtcttttcc gctacaagag cattccagta gaagataatc agatggtgga gatcagtgcc
      781 tggttccagg aggctatcgg cttcattgac tcagtgaaga atagtggggg ccgggtgctg
      841 gtgcactgcc aagctggtat ctctcgctca gccaccatct gcctggcata cctgattcag
      901 agccatcgag tacggctgga tgaggccttt gactttgtta agcaacgtcg gggagtcatc
      961 tcccccaact tcagtttcat ggggcagctg ctgcagcttg agacccaggt gctgtgtcac
     1021 tgaggcaagg cccagcctgg ctccacccca cagctctggc tttcactgac tcctggggga
     1081 agctgctgtg ggctgctggg cctcctctct ggttcttccc tcctcacctt gtcgtcaaac
     1141 tggggtgcta ggaaatgcag gatgacggct tttctgacat ggtgctcttc tgagggggtt
     1201 taagggctgg cccttatttc ttctccctcc ttcaacttgc ggaaattaat tgaactctaa
     1261 acccatgtat tgccgtccca ctatattaaa gccctcggca acccaagggc tcagaaaaca
     1321 agctgtgaca agcagaaacc atgtctaggg gtgtgcagcc cttgaccgaa agcttaagcc
     1381 ttgtgcttcc aggggagcca ggaagcgatg tgtgtgtcat attaccgaca ttttacttct
     1441 gtgtgtgagt gtgtgggcat ctcgctgtaa ttggtgctga aaagttattt gtgttcaact
     1501 gacatttaac actccctccc tgtcttcctc ccagccctgt gggccaggga gggggcgttg
     1561 gaaacagcac tttatattta tatagaacat tgaggttgtg tcaataaaaa tagtgttttg
     1621 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
