LOCUS       NM_001107739             984 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 19 (Dusp19), mRNA.
ACCESSION   NM_001107739 XM_001068030 XM_230039
VERSION     NM_001107739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 984)
  AUTHORS   Yao,Z.Z., Hu,A.X. and Liu,X.S.
  TITLE     DUSP19 regulates IL-1beta-induced apoptosis and MMPs expression in
            rat chondrocytes through JAK2/STAT3 signaling pathway
  JOURNAL   Biomed Pharmacother 96, 1209-1215 (2017)
   PUBMED   29174854
  REMARK    GeneRIF: DSP19 up-regulation inhibited IL-1beta-induced
            chondrocytes apoptosis and MMPs expression through inactivating
            JAK2/STAT3 pathway.
REFERENCE   2  (bases 1 to 984)
  AUTHORS   Wang,Y., Xu,Z., Wang,J. and Xu,S.
  TITLE     DUSP19, a downstream effector of leptin, inhibits chondrocyte
            apoptosis via dephosphorylating JNK during osteoarthritis
            pathogenesis
  JOURNAL   Mol Biosyst 12 (3), 721-728 (2016)
   PUBMED   26751999
  REMARK    GeneRIF: the activity of JNK stimulated by leptin was suppressed by
            DUSP19 overexpression.
REFERENCE   3  (bases 1 to 984)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     Scaffold role of a mitogen-activated protein kinase phosphatase,
            SKRP1, for the JNK signaling pathway
  JOURNAL   J Biol Chem 277 (26), 23919-23926 (2002)
   PUBMED   11959862
REFERENCE   4  (bases 1 to 984)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     A novel dual specificity phosphatase SKRP1 interacts with the MAPK
            kinase MKK7 and inactivates the JNK MAPK pathway. Implication for
            the precise regulation of the particular MAPK pathway
  JOURNAL   J Biol Chem 277 (26), 23909-23918 (2002)
   PUBMED   11959861
REFERENCE   5  (bases 1 to 984)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 1, 2009 this sequence version replaced NM_001107739.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM114648.1, CK843997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               JAXUCZ010000003.1  85945303-85945683
            382-428             JAXUCZ010000003.1  85949097-85949143
            429-581             JAXUCZ010000003.1  85952386-85952538
            582-984             JAXUCZ010000003.1  85957411-85957813
FEATURES             Location/Qualifiers
     source          1..984
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..984
                     /gene="Dusp19"
                     /note="dual specificity phosphatase 19"
                     /db_xref="GeneID:311151"
                     /db_xref="RGD:1307457"
     exon            1..381
                     /gene="Dusp19"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..821
                     /gene="Dusp19"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 19"
                     /protein_id="NP_001101209.2"
                     /db_xref="GeneID:311151"
                     /db_xref="RGD:1307457"
                     /translation="MHSLNQEIKAFSRDNLRKQCTRVTTLTGKKLIETWKDATVHVVE
                     TETSGGGGCGYVQDLTLDLQVGVIKPWLLLGSQDAAHDLELLRQHKVTHILNVAYGVE
                     NVFLSEFTYKTISILDVPETNILSYFPECFEFIEQAKLKDGVVLVHCNAGVSRAAAVV
                     IGFLMSSEELAFTNALSLVKEARPSICLNPGFMEQLRTYRVGKESNGGDQVPAVATDH
                     GP"
     exon            382..428
                     /gene="Dusp19"
                     /inference="alignment:Splign:2.1.0"
     exon            429..581
                     /gene="Dusp19"
                     /inference="alignment:Splign:2.1.0"
     exon            582..984
                     /gene="Dusp19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgctct cttctctcca ggaggtgagg ttgtcactgc aggggccagc tccgctaagt
       61 gactagtggc tgactagccc tgcagcgtgc agtgccttcc ccccccttct ttctttcttt
      121 ttttttttcc ttgctgcttt tcctccttcg ctcatgtaat gcactccctg aaccaagaaa
      181 tcaaagcatt ctcccgggat aatctcagga agcagtgcac cagggtgacc acgctaactg
      241 gaaagaaact tatagaaact tggaaagatg ccacagttca tgttgtggaa acagagacca
      301 gcggtggggg tggttgtggc tatgtgcagg accttacctt ggacctgcaa gttggcgtta
      361 ttaagccctg gttgcttctg gggtcccagg atgctgcgca tgatctggag ctactgagac
      421 agcacaaggt gacccatatt ctcaacgtcg cgtatggagt tgagaacgtt ttcctcagtg
      481 agtttacata taagaccatt tctatactgg atgtgcctga aaccaatatc ctgtcctatt
      541 ttccagaatg ttttgagttt attgagcaag caaaactgaa ggatggcgtg gttcttgtcc
      601 actgtaacgc aggggtttcc agggctgctg cggttgtcat cggcttcctc atgagttctg
      661 aagaacttgc tttcaccaat gctttgtcgt tggtgaaaga ggcaagacca tccatatgtc
      721 tgaatcctgg cttcatggaa caactccgca cctaccgagt aggcaaagag agcaatggag
      781 gtgaccaagt gcccgcagtg gccaccgacc atggtccgtg atctgtactc tagctgaggc
      841 aaactactta tgcatctgcc tctgccctct cgcctgtgtt ttggacggta acttgtaaag
      901 cttccctttt ctgttgtctt ttaccagtgg aaatggaagc tacttttgtc gaccggaatt
      961 aatacatttt tacattttac cttt
//
