LOCUS       NM_001013128            3571 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 18 (Dusp18), mRNA.
ACCESSION   NM_001013128 XM_223560
VERSION     NM_001013128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Rardin,M.J., Wiley,S.E., Murphy,A.N., Pagliarini,D.J. and
            Dixon,J.E.
  TITLE     Dual specificity phosphatases 18 and 21 target to opposing sides of
            the mitochondrial inner membrane
  JOURNAL   J Biol Chem 283 (22), 15440-15450 (2008)
   PUBMED   18385140
  REMARK    GeneRIF: Dual specificity phosphatases 18 and 21 target to opposing
            sides of the mitochondrial inner membrane
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Wu,Q., Gu,S., Dai,J., Dai,J., Wang,L., Li,Y., Zeng,L., Xu,J.,
            Ye,X., Zhao,W., Ji,C., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel dual-specificity
            phosphatase18 gene from human fetal brain
  JOURNAL   Biochim Biophys Acta 1625 (3), 296-304 (2003)
   PUBMED   12591617
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Hood,K.L., Tobin,J.F. and Yoon,C.
  TITLE     Identification and characterization of two novel
            low-molecular-weight dual specificity phosphatases
  JOURNAL   Biochem Biophys Res Commun 298 (4), 545-551 (2002)
   PUBMED   12408986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1 and BC079285.1.
            
            On Mar 21, 2013 this sequence version replaced NM_001013128.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079285.1, SRR26360181.2687986.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18385140
            NMD candidate                      :: PMID: 18385140
            RefSeq Select criteria             :: based on conservation,
                                                  longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                JAXUCZ010000014.1  83013850-83013867
            19-595              BC079285.1         1-577
            596-2807            JAXUCZ010000014.1  83018259-83020470
            2808-3570           BC079285.1         579-1341
            3571-5782           JAXUCZ010000014.1  83018259-83020470
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3571
                     /gene="Dusp18"
                     /note="dual specificity phosphatase 18"
                     /db_xref="GeneID:305477"
                     /db_xref="RGD:1306929"
     exon            1..163
                     /gene="Dusp18"
                     /inference="alignment:Splign:2.1.0"
     exon            164..788
                     /gene="Dusp18"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..840
                     /gene="Dusp18"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 18"
                     /protein_id="NP_001013146.2"
                     /db_xref="GeneID:305477"
                     /db_xref="RGD:1306929"
                     /translation="MTSPWSACPVQFPQPSISGLSQITKSLFISNGAAANDKLLLSSN
                     QITTVINVSVEVANTFYEDIQYVQVPVVDAPIARLSDFFDPIADHIHSVEMKQGRTLL
                     HCAAGVSRSAALCLAYLMKYHAMSLLDAHAWTKSRRPIIRPNSGFWEQLIHYEFQLFG
                     KNTMQMVNSPMGLIPDIYEKETRMMIPLSTPDGAFHKGKEKALL"
     exon            789..917
                     /gene="Dusp18"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1017
                     /gene="Dusp18"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..3571
                     /gene="Dusp18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggggttcc tgtaggccca gagctgtcca ttgttccgcg aggagaaatc gttgctactg
       61 agatccggaa tcatgaaggg ccctctctgt tttagagacg gtcgcccgcg gctccgccct
      121 gcagttgctt cctgaaagat ttccggggta ctgagggaag gagggttcat agcctagcag
      181 aaagatgaaa gcttaacacg tcaccaactg ttgacctcca ccttgatgac ttcaccttgg
      241 agtgcctgcc cagttcagtt cccacagccc tcaatcagtg gcctctcaca gatcaccaag
      301 agcctgttta tcagcaatgg cgcggctgcc aacgacaagc tcctactgtc cagcaatcag
      361 atcaccacgg tgatcaatgt ctcagtagag gtagcgaaca ccttctatga ggacatccag
      421 tacgtgcagg tgcctgtggt ggatgcgccc atcgcgcgcc tctccgattt cttcgacccc
      481 attgctgacc acatccattc ggtggagatg aagcagggcc gcacgctgct gcattgcgct
      541 gctggcgtga gccgctcggc cgccctgtgc ctcgcgtacc tcatgaagta ccatgccatg
      601 tccctcctag atgcccacgc ttggaccaaa tcacgcaggc ccatcatccg gcccaacagt
      661 ggcttttggg agcagctcat ccattatgag ttccagttgt ttggcaagaa tacgatgcag
      721 atggttaact ctcccatggg actgatcccc gacatctacg agaaggagac ccgtatgatg
      781 attccactga gtacaccaga tggtgctttt cataagggca aggaaaaagc gttgctatga
      841 catttaccct cgtaatccag ccaggtttgg tggtacatgc ctgtagcctc agattgctga
      901 agcaggaaga tgacaaggaa tcctgacaca aggcctcatg cagaattgca gaccacgaga
      961 tccagggtcc cagactggct gactgttgag gaactgtgag gacagaggtc agaacaagct
     1021 gagaggccaa cagttgcttg acccttgagg ctagatgccc agcagtggga gcagtccccc
     1081 agtggctgtc tctcaatgga gaggcccaca gcccaggagc tgctcggtct acaaggctgg
     1141 gacatcagca atcccgactt ggcagcaaaa acccgagtct tcctgaaagg tcactcatcc
     1201 ttagtccaga gaagcctgga aaaactggtt ttgatgccag tggagaggat caatcaactg
     1261 agcggcaagt gggaaggcct cgaggtcttc aggtcttcag gccttcacac cctccttacc
     1321 cgagctactt cccacccatt aaaggcaact gggcaaattc tcctgctatg gctccctgtc
     1381 agtgattctg atctgtgaca agttgacttt aaacaaacca ctacactccc tagatctacc
     1441 cttgccccat tttcacaaag ggactgccca ggggggttgg tatgaggcag tcaggagagg
     1501 aggaagctaa ctgctgctct agactactgt catccctcag caagaacaac cccacctcta
     1561 ctcacctcac agccgcaggg tggctaagcc cccgacaccg cacctttcag aagaagcagc
     1621 ccctacccaa cagattggtg tgacagagcc gccgccatgc aactctcttg gtaggaacac
     1681 agaatctttt ttaaaaactt tattcaagtc ttttggtcat taaaagaaga tatttgaagg
     1741 cggagagatg gctcggtgat tgtgagcact gactgctctt gcagaggacc tgggtttgat
     1801 tcccagcacc cacttagtgg ctcacaactg tctatggctc cagtaccaag gaacccattg
     1861 ctcttttctg gtctcctaga gcaccaggca cacagacaga cagtagggaa atacatgcag
     1921 tacacataca tatatgtagg gaaaacactc atacacagaa aataaaaata aatcttttta
     1981 aaaaaaacta aattagcaca taaaattaac tcaaattcaa agttctctgg gtcaaccgac
     2041 cctaattgga ctcaaaccta aggactcaca tgtgctaggc agatgctcca ccaccaacct
     2101 aatccctcgt ccagttctct gacattggtt ttgggtcagg gtctccctac gtaattctga
     2161 ctgccctgta acttgacatg tagtctagga tagcctccaa ttcagaccag cctggtgcac
     2221 agactgatat atttatcaca aatcaggact gtggcagttc tactgcacaa aatatcccat
     2281 ccggggtccc ttttgtggtc agacccccaa cccaaccctg cagtctctga taagctcgta
     2341 cctgtgtgga tcctatgggt ttactgctac tcggtgcagc ctggagtgca cgtttctcac
     2401 agttgcacgt ctttgctcta tggtgttgcg tgtggctatg ccactctgga ctcagtgaag
     2461 catacttgag tagttagttt taggggattg tagatacaat tactataaac atgtgtatac
     2521 aggttgctgt acttgtgggc atacatttcc atttctctag ggtgtggacg atggaatgag
     2581 atattagtca tgtgataatg gtgtgtgtaa ccatctttat gtttaaaatg ctaaccttac
     2641 agagtggccc tcttgccttc tcaccagact tggatgaaca ctacccaccc ctcgtttcct
     2701 ctctcacccc cctcccacat tttctgaaca ccttttccca gtaagttaca ttgctccccc
     2761 catacacatg atatttctgt gttcatgtct taaaaaacta tctgggccag cataaaagtc
     2821 aggttctctg ttgtagcagc ttcatacatg gtgttacact gttctaggtg tccccctcct
     2881 ggtccacatt tttatttttt aaacaatata gttttgggaa atatacatgg atagcatcta
     2941 ttagctcatc tccatttttc cagttcctcc agttcctcca gttcctccta ttgcccttgt
     3001 cctgcctccc tcccaacatg tccgcccttt tttgttctta acatcaataa ccctgaatcc
     3061 agttagtatt gcccatctgc tcatggtgtg ggatcatctg ctagggtgtg ggcaccttac
     3121 cagtggcagt gttgccaaag gagggtgacc tccctccctc agcaaccatt agtgccaaca
     3181 gctcctcccc caagggcagg tggataggca cataaccacc agtgctatga gctgacatga
     3241 cggcaacctt aagctagcca gcagccagca tccctctcct cctcaccctg cagctcagac
     3301 attcttccca ctcctggggc attaaaaaga gcaggaagct gtttgacacc tcctgcagaa
     3361 ttccagcacg attagcattt gttgtaagga ttgtcagctc gaacaacact ttttatttat
     3421 agatattttg tgttaaaata atagcgaacc ctgctcaagg cctaaattta ttcaggtatg
     3481 gccttactcc tacatagttt ctgggaattt aaaaaataag actaaacctt ttttttttta
     3541 aacaataaaa atgtcttaac ttcctctgta a
//
