LOCUS       NM_001106624            5172 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 16 (Dusp16), mRNA.
ACCESSION   NM_001106624 XM_001071525 XM_008763374 XM_232473
VERSION     NM_001106624.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Zhu,J., Shen,W., Gao,L., Gu,H., Shen,S., Wang,Y., Wu,H. and Guo,J.
  TITLE     PI3K/Akt-independent negative regulation of JNK signaling by MKP-7
            after cerebral ischemia in rat hippocampus
  JOURNAL   BMC Neurosci 14, 1 (2013)
   PUBMED   23280045
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Kondoh,K. and Nishida,E.
  TITLE     Regulation of MAP kinases by MAP kinase phosphatases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1227-1237 (2007)
   PUBMED   17208316
  REMARK    Review article
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Masuda,K., Shima,H., Watanabe,M. and Kikuchi,K.
  TITLE     MKP-7, a novel mitogen-activated protein kinase phosphatase,
            functions as a shuttle protein
  JOURNAL   J Biol Chem 276 (42), 39002-39011 (2001)
   PUBMED   11489891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_008763374.3, NM_001106624.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.12202.1,
                                           SRR26643292.20294.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               JAXUCZ010000004.1  169361154-169361508 c
            356-946             JAXUCZ010000004.1  169324723-169325313 c
            947-1085            JAXUCZ010000004.1  169322834-169322972 c
            1086-1249           JAXUCZ010000004.1  169307157-169307320 c
            1250-1409           JAXUCZ010000004.1  169288402-169288561 c
            1410-1533           JAXUCZ010000004.1  169283174-169283297 c
            1534-5172           JAXUCZ010000004.1  169278118-169281756 c
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..5172
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /note="dual specificity phosphatase 16"
                     /db_xref="GeneID:297682"
                     /db_xref="RGD:1310721"
     exon            1..355
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
     exon            356..946
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             719..2704
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 16"
                     /protein_id="NP_001100094.1"
                     /db_xref="GeneID:297682"
                     /db_xref="RGD:1310721"
                     /translation="MAHEMTGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILE
                     AININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQSSQDVGSLSSDC
                     FLTVLLGKLEKSFNSVHLLAGGFAEFSRCFPGLCEGKSTLVPTCISQPCLPVANTGPT
                     RILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEK
                     ILPWLDKSVDFIEKAKASNGCVLIHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKE
                     KRPTISPNFNFMGQLMDYEKTISSQTGMSGPKSKLKLLHLDKASEPVPAASEGGRKNA
                     LSLSPPCANSTSEAVGQRLVHPASVPSLQPSLLEDSPLVQALSGLQLSSEKLEDSNRL
                     KRSFSLDIKSVSYSASVAASLHGFSSEDAMEYYKPSATLDGTSKLCQFSPVQEVSEQT
                     PETSPDKEEAHIPRQPQATRPSESQTTRLHSVRTSSTGSTQRPFFSPLHRSGSVEDNY
                     HTNFLFGLSTSQQHLTKSAAGLGLKGWHSDILPPQSSAPSLTSGWYFATEPSHFYSAS
                     AIYGGNASYSAYSCSQLPTCSDQIYSVRRRQKPSDRADSRRSWHEESPFEKQFKRRSC
                     QMEFGESIMSENRSREELGKVGSQSSFSGSMEVIEVS"
     exon            947..1085
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1249
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1409
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1533
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..5172
                     /gene="Dusp16"
                     /gene_synonym="Mkp-7; Mkp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctcccc aacccccacc ctaccccccc tggtcccctc ctgcgggcat caccgtttgg
       61 gggggctctc atcccacttc cagccattta ccctccccct ctccactttt cccgcgcgga
      121 cccccccaac tttacctcaa cttcttcatc cctgtcgaca tttttttccc cctttcgggg
      181 ggcggtggaa gagaaagtga agaaaagttg caaacgcccg ggctctcgct aagctctccg
      241 cccacccctc agaggagaag ccccggcggc gaggaggacg cgctagcgac ggctgggcga
      301 cgcggtgaca aggctcgctc cccacacagc gagcctggag ccggccgccc ctcaagttgt
      361 cagtccagtg taaagctgtt ggagagaggg cgcaaaggta atggatgacg taataccctg
      421 gctgccccga agcatctttt gttgtggaat ggttattcct gtcctctctg tatgaatcca
      481 ctgtgagggg ctgctttgtg gacggaatcc tttgcaagag cacatcagca ggaaagagaa
      541 agagacattc agttggaggc tcttgctgaa atggatttaa ctctcctttc cacagccacc
      601 actagcctga cctcatacat ttctagtaca atggagtggc tgagcctttg agcacagccc
      661 cattacatca tcgtggcaaa ttaaagaact aggtggggaa agaggactta ctgttgtcat
      721 ggcccatgag atgactggaa ctcaaattgt tactgagagg ttggtggctc tgttggaaag
      781 cggcaccgag aaagtgctgc taattgacag ccggccattt gtggagtaca atacgtccca
      841 cattctggaa gccatcaata tcaactgctc caaactgatg aagcgaaggc tgcaacaaga
      901 caaagtatta attacagaac tcatccagca ttctgcaaaa cataaggttg acattgactg
      961 cagtcagaag gtggtagtgt atgatcagag ttcccaggat gttggttctc tgtcgtcaga
     1021 ctgctttctc actgtgcttc tgggtaagct ggagaagagc ttcaactctg ttcacctgct
     1081 tgcaggtggg tttgctgagt tctctcgttg tttccctggc ctctgtgaag gaaaatccac
     1141 tctagtccct acctgcatat ctcagccttg cctacctgtt gccaacactg ggccaactcg
     1201 aattcttccc aatctctatc tcggctgcca gcgagatgtc ctcaacaagg agctgatgca
     1261 acagaacggg attggctatg tgctaaatgc cagcaacacc tgtccaaagc ctgacttcat
     1321 acccgaatct cacttcctgc gagtgcctgt gaatgacagc ttttgtgaga aaatcctgcc
     1381 ctggttggac aagtctgtgg atttcattga gaaagcaaaa gcctccaacg gctgtgtgct
     1441 gatccactgc ttggctggga tctcccgctc ggccaccatt gctattgcct atatcatgaa
     1501 gaggatggac atgtctctgg atgaggctta cagatttgtg aaagaaaaaa gacctactat
     1561 atctccgaac tttaatttta tgggccaact catggactat gagaagacga ttagtagcca
     1621 gactggaatg tccgggccga agagcaaact caagctgctg cacctggaca aagccagtga
     1681 gcctgtgcct gcagcctcag agggcggacg gaagaatgca ctgtctctca gcccaccctg
     1741 tgccaactct acctcagagg cagtggggca aaggcttgtg catcctgcaa gtgtgcccag
     1801 cttacagcct tccctcttgg aggacagtcc gctggtacag gcgctcagtg ggctccagct
     1861 gtcctcagag aagctggaag acagcaacag gctcaagcgt tccttctctc tcgatatcaa
     1921 gtctgtttcg tattcagcca gtgtggcagc gtccttacac ggcttctcgt cagaggatgc
     1981 tatggagtac tacaaacctt ccgccacact ggatgggacc agcaagctct gccagttctc
     2041 ccccgttcag gaggtatcag aacagactcc agagaccagc cccgataagg aggaggccca
     2101 catccccagg cagccccaag ctaccagacc ttcagagagc cagaccacac ggctgcactc
     2161 agtgagaacc agcagtactg ggtctaccca gaggcccttc ttctcgccac tgcatcggag
     2221 cgggagtgtg gaggacaact accacaccaa cttccttttt ggcctttcca ccagccagca
     2281 gcacctcacc aagtctgctg cagggcttgg cctcaagggc tggcactcag acattctgcc
     2341 tccccagtcc tctgcccctt ccctgaccag cggttggtat tttgctacag agccttcaca
     2401 cttctactct gcttcagcca tctatggagg caacgccagt tactctgcct acagctgtag
     2461 ccagctgccc acttgcagtg accaaatcta ttctgttcgt aggcggcaga agcctagtga
     2521 cagagctgac tcacggcgga gctggcatga agagagcccc tttgagaagc agtttaaacg
     2581 caggagctgc caaatggaat ttggagagag cattatgtca gagaacaggt cgagggaaga
     2641 actgggcaaa gtggggagcc aatctagctt ttcaggaagc atggaggtca ttgaggtctc
     2701 ttgagaagac cgcgtaactt ctgttgacag ttttgtttcc tgttcacaaa aaaatattcc
     2761 ctgtaaatct gaaatatgta tatgtacata catatatatt tttggaatat agagctatgg
     2821 tataaaagca acagatggat caacacagtt gttctctcag cactgcactg agaatggcta
     2881 gttctctcag aagaggaagg gtagatgtta gaattctccc agccagagaa gagattttgt
     2941 tcagtgaatt gcacatcttc ttgttcctac aaaagcaagg gttttgtttg tttgtttgtt
     3001 gtttgtttgt ttttaatgtt agagggcaaa atccctccca ttttcatgtg caacaagagg
     3061 tctcagaact catctctgtc caggcccttc cctagtgcac cttagcgcta agactgagcc
     3121 agctgtgggt caggtgggaa gaccctccta gggacagatc ctaacggtaa atccaaggga
     3181 aatgaccccg tccaaagctg agcaatcaac ccaagctcca tcgacagctg atggatacgg
     3241 aatcgttctg cgggatgaac tgttaggagc cttgtctaga tctacttata gccaggccag
     3301 tacctcagac aagacatttg gggccatcac cactaccatg tctagtcgat cattttctag
     3361 gcattgtgaa taagtaggta acttgtcact ttccagacaa atgcatactg tctatgcaca
     3421 aaatcccagt gggcctgttg cccatgtacc cctcctgtca gcttgaatga agtggggaaa
     3481 ccaactagag tttttaactt agccagagac tgggcagtca gacagcttag agacttaagc
     3541 cagggatgga gcactaagag tctcccccct cctcctcctc ctcctcctcc tcctcctcct
     3601 cctcctcctc ctcataattt aagaattatt taaagtggga tggttcattc ttcagttgac
     3661 cagacttggt ttagagagaa acatgaatca ctgggcttgg tagtggagtg gcagaacctt
     3721 caggctctcg gccaaaacag gctttcactt ctgtctccct catggaataa aaatatggga
     3781 agacttggga aggtgcactg tgaagtaggc aatggatttc ctgggctttt ttctctatgg
     3841 tatgcaacaa gggtaatatt tctagaatcc tcttcgactt ccaaactttg catgggcatt
     3901 ggtaagcaag aaccagtcag aatagaacac actagaaagg ttaagaaggg gctgttgatt
     3961 ttggttagtc ttgatacagg aaagctcttc tccagagcta cccagcatgc ttcctgagga
     4021 aaggacacat cagagaagag gtacccagtg gcttcctggt ccctggcaca caatctctat
     4081 agacgcaatc ctggcagctg agaacaggag gtgataggaa caggtgtgta catgacagta
     4141 cgtagctgcc tttcaacttc ctggcttgag ctgtatcctc cagatacagc ctccttaagg
     4201 ccttaattca ctcacgtcag cagggtgtgg gagtgggtag atgttgtcat tgttctttac
     4261 tgtaagtgta gctaggggct gactcatatc tcaggttttc tatgtcagtg aatggatggt
     4321 cctttgacta ggatctgact taatgttcct atggtgattg taaaaccagc atagaatggc
     4381 gtggctcaaa gctgacgggc tggaccatga tgagcactgt gagcctcgtg ggcatactgg
     4441 ctctggacag ataagctatg tgtgggcctg agatgaacgc agagcagaga ctgcacagag
     4501 agcacgggcc actccaagac actggtcagc agcctgtgat tagattctca gagcctcaca
     4561 gtaaatttga tccattgtgt acacacactc agtacgtaag aacccacctt cttaaaatct
     4621 ggtcacacca gtgagacagt tccagaatga agcagcagct ccaacagtac gtctgttctg
     4681 ggaagactgg ggatttggct tcagtgtctt tgggcagtac attgcctaat gccatacgtc
     4741 atgtagggag gtgctctctg ggctgtggtt ccttccgtgt agcgtagtca tacactacag
     4801 ctgtcagtcc accatcacta atgtcctatc agttcttgga atcacaacta ccatgttgaa
     4861 agggctgccc ctaggcacat tgtgggtagt gtggtggtta ggtttcctca tgtaagcaca
     4921 gggaagcctg aagtctcctg ggacaatgca aaatggtgat tttaatgagc aaaactagac
     4981 tctgtgagaa atgctggaaa ctgtttagac cagttataaa gttagagagg aaagactgta
     5041 taaatgttta atatgaatat agtgttcttg gagtaaggca agctgttgaa tggttcactt
     5101 gtgcatttct cattttgaag tgtcatgtat gttaatacga tgaaataaaa tcaaaactgg
     5161 tacctgttta ta
//
