LOCUS       NM_001244784            3140 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 15 (Dusp15),
            transcript variant 2, mRNA.
ACCESSION   NM_001244784
VERSION     NM_001244784.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Rodriguez-Molina,J.F., Lopez-Anido,C., Ma,K.H., Zhang,C., Olson,T.,
            Muth,K.N., Weider,M. and Svaren,J.
  TITLE     Dual specificity phosphatase 15 regulates Erk activation in Schwann
            cells
  JOURNAL   J Neurochem 140 (3), 368-382 (2017)
   PUBMED   27891578
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Schmidt,F., van den Eijnden,M., Pescini Gobert,R., Saborio,G.P.,
            Carboni,S., Alliod,C., Pouly,S., Staugaitis,S.M., Dutta,R.,
            Trapp,B. and Hooft van Huijsduijnen,R.
  TITLE     Identification of VHY/Dusp15 as a regulator of oligodendrocyte
            differentiation through a systematic genomics approach
  JOURNAL   PLoS One 7 (7), e40457 (2012)
   PUBMED   22792334
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Friedberg,I., Nika,K., Tautz,L., Saito,K., Cerignoli,F.,
            Friedberg,I., Godzik,A. and Mustelin,T.
  TITLE     Identification and characterization of DUSP27, a novel
            dual-specific protein phosphatase
  JOURNAL   FEBS Lett 581 (13), 2527-2533 (2007)
   PUBMED   17498703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB736780.1 and BC168211.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The resulting isoform (2)
            lacks an internal segment, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168211.1, CK597849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               CB736780.1         80-250
            172-3140            BC168211.1         1-2969
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3140
                     /gene="Dusp15"
                     /note="dual specificity phosphatase 15"
                     /db_xref="GeneID:362238"
                     /db_xref="RGD:1305990"
     exon            1..227
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..917
                     /gene="Dusp15"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2; dual
                     specificity protein phosphatase 15; dual specificity
                     phosphatase-like 15"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 15 isoform
                     2"
                     /protein_id="NP_001231713.1"
                     /db_xref="GeneID:362238"
                     /db_xref="RGD:1305990"
                     /translation="MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIVSIHESPQPL
                     LQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTVVIAY
                     VMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFR
                     DEEDLRALLPLCRRCRQGPGTSAPSATTASSAASEGTLQRLVPRSPRESHRPLPLLAR
                     VKQTFFCLPRCLSRKGGK"
     exon            228..261
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
     exon            262..344
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
     exon            345..394
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
     exon            395..469
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
     exon            470..641
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
     exon            642..3109
                     /gene="Dusp15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcagcagc tccatcactt ccctccgggg ccgggggtca gcgggcggcg gtggcgactg
       61 gacagggcta agcaaggtcg cggacgctcg gcccctggtt ctccatcaga ctgcaggctc
      121 cgggcctggg ccagtaaggc agctgtgaac ctagcgcttt ccaggcgctg agctgggcgt
      181 gcgccccgcc accctgcctc aggatcatgg gaaatggcat gaccaaggta cttcctggac
      241 tctaccttgg aaacttcatt gatgccaaag acccggatca gctgggccgg aataagatca
      301 cgcacatcgt ctctatccac gaatcacctc agcctctatt gcaggatatc acctatcttc
      361 gaatctcagt gtctgacact cctgaggtac ccatcaaaaa gcacttcaaa gaatgtgtcc
      421 actttatcca ctcttgtcgt ctcaacgggg ggaactgcct tgtgcactgc tttgcaggta
      481 tatcacgaag taccaccgta gtgatcgcct atgtgatgac agtgaccgga cttggctggc
      541 aggaagtact tgaagccatc aaggcctccc ggcccatcgc caacccaaac ccgggcttta
      601 ggcagcaact tgaggagttt ggctgggcaa actcccagaa gcttcgccgg cagctggagg
      661 agcgcttcgg ggagatcccg ttccgcgacg aggaggactt gcgcgcgctg ctgcctctct
      721 gcaggcgctg tcgccagggt ccggggactt cggccccgtc ggccaccaca gcgtcctcgg
      781 ccgcttccga ggggaccctg cagcgcctgg tgccgcgatc gccgcgggaa tcacaccggc
      841 cgctgccgct gctggcgcgc gtcaagcaga ctttcttctg cctcccccgg tgcctgtcgc
      901 gcaagggcgg caagtgagcg ccgtatccgc cgctccgccc gtcctgacgc ttcagccttc
      961 gcgggcggcg gggcttcccg cagctgggac gcacccagag ctcgtgggag cctcgccccc
     1021 gccccgtacc caccacgctt gtctgcgtcc gtcctcagtg tccgctctgt gagtctgtgt
     1081 tcggccggcc tgctgcaagc cacttggtgc cttagactcg ggagaaggat cctgggcctc
     1141 caccctgaca ggcgaaagcg gggagcagga gggaggatcg ggtgggacgg accggcctgg
     1201 aggagattaa agaagaatct ttaaagacgc agaagttgcc tggcccagtg cctctgtcat
     1261 tccgcagagc ttgggctcca gggcctgcag gagcagagca ggaacaactt ccagaggccc
     1321 ggggaagcac cattctccac cagtctccag agctgaaatc caagaccacg cccttctttg
     1381 acaccagccc acgccccctc catctctcag gggcctggac ttctgacacc gcccttgtgc
     1441 cccttttctc ccgacccttc acctctccga agccccttcc ttttctctaa ttctccttcc
     1501 ctctctgcac aaataactgg tcagtgtggt ccaattggtg gcgtggcctt catgtcaccg
     1561 ttcactgtct gagatggctt tatcctcagg gagaacaccc aggctcagag aggtcgggca
     1621 gctggcccaa gcacacacag caagggcaga tcattcccag ttgtgacaac agggaggagg
     1681 ttcctggaga gaaagaccca gcaggatgca gggggtggcg ggactctttt tttttttttt
     1741 tttaaggtaa ccaagccaat aaaacagtaa ccctatgggc aaacagagga atgggtgtca
     1801 tcagagctga cgacttgaaa gagcccaagt agactcttgg gacttcgtag cagatggaga
     1861 ggcagagatc tcagcaccga gctgagcgaa tggtgaaatg aggacaccaa cctccaattc
     1921 ctcatgtact caagtgttca agccagccgt gagccaggta ctgtgctggg ccctggggct
     1981 accacagtga gcaaagagct gcctgtatgc tgctgacatt ctagtggaaa acaccagata
     2041 aaaaaggggg taagggggtg gaaccatctt gcatctggct gggggtggga tgggggagca
     2101 gtacaaaggc cctgagttag gacaatgtga agcctgcatc ctcctcctga ttggttggtg
     2161 gcactgccac ctggccactg tttcctaacc cttagccact taacgagccc ctttggtgta
     2221 atgatccaga tgcttcccta gccgagtatc accaatacac cttatcgtaa cagtgagggc
     2281 tccctcctaa ggactctgtc actgtgctaa acactgcagc tcagccgatc ctcttcccat
     2341 cctccctaac agtgccccag gttataagca gaagacagga ctcagatgtg agctcagact
     2401 ccaatatgac tgcagggtcc actcttcatt atgatctaga aatatgaaag gctcctctga
     2461 cacaggggag tcgactgctt agaaggatag aacacctcat attggcttct aaaactccag
     2521 ccccagttag agtatagatg ggaaaatgtc tactgacttt tattcctagt caccgttccc
     2581 taaacaatgt atcaggcacc tgacatttgc ttcacattgg aagtattttt agaaaagggt
     2641 tcaaagtaca taggtgtatt cttgccggtt ctgtgtaaat agtccaccac ttggtttaaa
     2701 ggatttgcca tgcatttcaa cattcagtgg ggtcctggat ccagcccaac ttaaatggac
     2761 aactaattat tactcttgtt aatcacatga aataccttgt gcccatcccc caccccctag
     2821 ttcacaggtc tgagtgaccc tgactgcatg aatatcctgg gacagctgct ggtgtatggg
     2881 accgagagga ggaggaataa gaatgccctc ccacagatgc ttgtgaaggg aagacctgac
     2941 tccccacatc tctccatgct ggcttgaaca gccactgcac caggggattt ttttttcctt
     3001 tcagagcctc agttccaccc catatacagc aaggtctggg gcagcctgaa ctactcagca
     3061 tatttcataa tgcaaatatt tcttcataat aaaaaacaca gaccctaaaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa
//
