LOCUS       NM_022248               1281 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 12 (Dusp12), mRNA.
ACCESSION   NM_022248
VERSION     NM_022248.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Cheng,J., Ji,M., Jing,H. and Lin,H.
  TITLE     DUSP12 ameliorates myocardial ischemia-reperfusion injury through
            HSPB8-induced mitophagy
  JOURNAL   J Biochem Mol Toxicol 37 (5), e23310 (2023)
   PUBMED   36644958
  REMARK    GeneRIF: DUSP12 ameliorates myocardial ischemia-reperfusion injury
            through HSPB8-induced mitophagy.
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Munoz-Alonso,M.J., Guillemain,G., Kassis,N., Girard,J., Burnol,A.F.
            and Leturque,A.
  TITLE     A novel cytosolic dual specificity phosphatase, interacting with
            glucokinase, increases glucose phosphorylation rate
  JOURNAL   J Biol Chem 275 (42), 32406-32412 (2000)
   PUBMED   10913113
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Muda,M., Manning,E.R., Orth,K. and Dixon,J.E.
  TITLE     Identification of the human YVH1 protein-tyrosine phosphatase
            orthologue reveals a novel zinc binding domain essential for in
            vivo function
  JOURNAL   J Biol Chem 274 (34), 23991-23995 (1999)
   PUBMED   10446167
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022248.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF217233.1, SRR26643290.42876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676789 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               JAXUCZ010000013.1  85663649-85664007   c
            360-473             JAXUCZ010000013.1  85661285-85661398   c
            474-592             JAXUCZ010000013.1  85660819-85660937   c
            593-689             JAXUCZ010000013.1  85660383-85660479   c
            690-876             JAXUCZ010000013.1  85659930-85660116   c
            877-1281            JAXUCZ010000013.1  85654914-85655318   c
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1281
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /note="dual specificity phosphatase 12"
                     /db_xref="GeneID:64014"
                     /db_xref="RGD:68375"
     exon            1..359
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1038
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="glucokinase-associated dual specificity
                     phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 12"
                     /protein_id="NP_071584.1"
                     /db_xref="GeneID:64014"
                     /db_xref="RGD:68375"
                     /translation="MLEVQSSNHGCERQAPTTSPASSAGHAVEVRPGLYLGGAAAVAG
                     PDYLREAGITAVLTVDSEPAFPAGAGFEGLQSLFVPALDKPETDLLSHLDRCVAFIGQ
                     ARSEGRAVLVHCHAGVSRSVAVVTAFIMKTEQLTFEKAYENLQTIKPEAKMNEGFEWQ
                     LKLYEAMGHEVHTSSAVYKQYRLQKVTEKYPELRNLPRELFAVDPTTVSQGLKDDILY
                     KCRKCRRSLFRRSSILDHSEGSGPVAFAHKRTGLSSVLTTGNQAQCTSYFIEPVQWME
                     SALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEVKTLPALGS
                     QTKKP"
     exon            360..473
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            474..592
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            593..689
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            690..876
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1281
                     /gene="Dusp12"
                     /gene_synonym="GKAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcttcctg gcgccgccat gttggaagta cagagctcta accatggctg cgagcgtcag
       61 gctccgacta ccagccccgc cagctcggca gggcacgcgg tggaagtgcg gcccgggctg
      121 tatctgggtg gggcggcggc agtggctgga ccggactacc tgagggaggc gggcatcacc
      181 gccgtgctga cggtggactc ggaaccggct ttcccggccg gggctggttt cgaaggtctc
      241 cagagcctct tcgtgcccgc gctggacaaa cccgagaccg acctgctcag tcacttggat
      301 cggtgcgtgg ctttcatcgg ccaggctcgc tccgaaggcc gtgcggtgtt ggtgcactgt
      361 catgcaggag tcagccgcag tgttgctgta gtgacggctt tcataatgaa gaccgaacag
      421 cttacctttg aaaaagccta tgaaaacctc cagaccatca agccagaggc taagatgaat
      481 gaggggttcg agtggcaact gaagctctat gaggcgatgg gacacgaagt ccatacctcc
      541 agtgccgttt acaagcagta ccgtttgcaa aaggtgactg agaagtatcc agaacttcgg
      601 aatttgcctc gagaactctt tgctgtcgac ccaactaccg tttcacaagg attaaaagat
      661 gacatcctct acaaatgtag aaagtgcagg cgatctttat ttagacgttc cagcattttg
      721 gatcatagtg aaggaagtgg gccagtagcc tttgctcaca agagaacagg actgtcttcc
      781 gtacttacca cagggaatca ggctcagtgt acatcttact tcatcgaacc tgtgcagtgg
      841 atggagtctg ctttgttggg ggttatggat ggacagcttc tttgcccaaa atgcagtgcc
      901 aagttgggtt cctttaactg gtatggtgaa cagtgctcgt gtggccgatg gataacccct
      961 gctttccaaa tccacaagaa cagagtggat gaagtgaaaa cattgccagc gctgggatca
     1021 caaacaaaga aaccatgaac ttaggactca gcttgggatg gaccctggga aaggcgcttc
     1081 tccattggca tctttcatgg cgatgtcaaa tttcagttgg atgtccaagg ataattactg
     1141 actgtaacag ctgtggggtg gtggcttatt atgtcacaca cacacacaca cacacacaca
     1201 cacacacacg gtactctgct tggccatcca gactgttagt catgtaaatt ggatttgata
     1261 ttaaaatctt ttggggctgg a
//
