LOCUS       NM_001105734            2704 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus dual specificity phosphatase 10 (Dusp10), mRNA.
ACCESSION   NM_001105734 XM_001064583 XM_223030
VERSION     NM_001105734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Gem JB, Kovacs KB, Szalai L, Szakadati G, Porkolab E, Szalai B,
            Turu G, Toth AD, Szekeres M, Hunyady L and Balla A.
  TITLE     Characterization of Type 1 Angiotensin II Receptor Activation
            Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes
            in Rat Vascular Smooth Muscle Cells
  JOURNAL   Cells 10 (12), 3538 (2021)
   PUBMED   34944046
  REMARK    GeneRIF: Characterization of Type 1 Angiotensin II Receptor
            Activation Induced Dual-Specificity MAPK Phosphatase Gene
            Expression Changes in Rat Vascular Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell
            RA, Dong C, Yang H and Zhang Y.
  TITLE     DUSP10 regulates intestinal epithelial cell growth and colorectal
            tumorigenesis
  JOURNAL   Oncogene 35 (2), 206-217 (2016)
   PUBMED   25772234
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang
            HS, Ryu SY, Park H, Kim DS, Kim SJ and Ryu SE.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Choi HR, Kim WK, Kim EY, Han BS, Min JK, Chi SW, Park SG, Bae KH
            and Lee SC.
  TITLE     Dual-specificity phosphatase 10 controls brown adipocyte
            differentiation by modulating the phosphorylation of p38
            mitogen-activated protein kinase
  JOURNAL   PLoS One 8 (8), e72340 (2013)
   PUBMED   23977283
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Papadopoulos P, Rosa-Neto P, Rochford J and Hamel E.
  TITLE     Pioglitazone improves reversal learning and exerts mixed
            cerebrovascular effects in a mouse model of Alzheimer's disease
            with combined amyloid-beta and cerebrovascular pathology
  JOURNAL   PLoS One 8 (7), e68612 (2013)
   PUBMED   23874687
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Kondoh K and Nishida E.
  TITLE     Regulation of MAP kinases by MAP kinase phosphatases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1227-1237 (2007)
   PUBMED   17208316
  REMARK    Review article
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Jeong DG, Yoon TS, Kim JH, Shim MY, Jung SK, Son JH, Ryu SE and Kim
            SJ.
  TITLE     Crystal structure of the catalytic domain of human MAP kinase
            phosphatase 5: structural insight into constitutively active
            phosphatase
  JOURNAL   J Mol Biol 360 (5), 946-955 (2006)
   PUBMED   16806267
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis
            RJ, Greenberg PD, Flavell RA and Dong C.
  TITLE     Regulation of innate and adaptive immune responses by MAP kinase
            phosphatase 5
  JOURNAL   Nature 430 (7001), 793-797 (2004)
   PUBMED   15306813
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Hofken T, Keller N, Fleischer F, Goke B and Wagner AC.
  TITLE     Map kinase phosphatases (MKP's) are early responsive genes during
            induction of cerulein hyperstimulation pancreatitis
  JOURNAL   Biochem Biophys Res Commun 276 (2), 680-685 (2000)
   PUBMED   11027531
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Tanoue T, Moriguchi T and Nishida E.
  TITLE     Molecular cloning and characterization of a novel dual specificity
            phosphatase, MKP-5
  JOURNAL   J Biol Chem 274 (28), 19949-19956 (1999)
   PUBMED   10391943
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_223030.4, XM_001064583.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2704
                     /gene="Dusp10"
                     /gene_synonym="Mkp-5; Mkp5"
                     /note="dual specificity phosphatase 10"
                     /db_xref="GeneID:63995"
                     /db_xref="RGD:1310844"
     exon            1..115
                     /gene="Dusp10"
                     /gene_synonym="Mkp-5; Mkp5"
                     /inference="alignment:Splign:2.1.0"
     exon            116..967
                     /gene="Dusp10"
                     /gene_synonym="Mkp-5; Mkp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1605
                     /gene="Dusp10"
                     /gene_synonym="Mkp-5; Mkp5"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 10"
                     /protein_id="NP_001099204.1"
                     /db_xref="GeneID:63995"
                     /db_xref="RGD:1310844"
                     /translation="MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSASPGSNNHTP
                     VIATAVVTLKAANLTYMPSSSGSARSLNCGCSSTSCCTVATYDKDHQAQTQAIAAGTA
                     TTAIGTSTTCPANQMVNNNENIGSLSPSGGVGSPVSGTPKQLASIKIIYPNDLAKKMT
                     KCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISC
                     REGKDSFKRIFSKEIIVYDENTNEPSRVTPSQPLHIVLESLKREGKEPLVLKGGLSSF
                     KQNHGNLCDNSLQLQECREVGGGASAASSVLPQSVPSTPDIESAELTPILPFLFLGNE
                     QDAQDLDAMQRLNVGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFE
                     FIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLN
                     FMGQLLEFEEDLNNGVTPRILTPKLMGMETVV"
     exon            968..1339
                     /gene="Dusp10"
                     /gene_synonym="Mkp-5; Mkp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..2704
                     /gene="Dusp10"
                     /gene_synonym="Mkp-5; Mkp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagtaactc tgtgttgctg ctggggatca atgaagctga gtgaatgggg gcgcactgcg
       61 cgagcgcata gctgaagcgg gcgccagatg gtagagggct acgcttattg atgaaactct
      121 tgagttcttc ttgaatcgcc agtcttcagc ctactcatgc ctccgtcccc tttagacgac
      181 agggtagtag tagcactgtc taggcctgtc cgacctcagg atctcaacct ttgtttagac
      241 tccagctacc tgggctctgc cagcccaggc agcaataacc acactcctgt cattgccaca
      301 gccgtcgtga ccctcaaggc tgcgaatctg acgtatatgc cctcatccag cggctctgcc
      361 cgctccctga attgcggatg cagcagcact agctgctgca ctgtggcaac ctacgacaag
      421 gatcatcagg cccagactca agccatcgct gcaggcactg ccaccactgc cataggaacc
      481 tcgaccacct gccctgctaa ccagatggtc aacaacaatg aaaatatagg ctctttaagt
      541 ccatcgggcg gggtgggcag ccccgtgtca gggactccca agcagctagc cagcatcaaa
      601 atcatctacc ccaatgacct ggcgaagaag atgaccaaat gcagcaagag tcacctgccc
      661 agccagggtc ctgtcatcat tgactgcagg cctttcatgg agtacaacaa gagtcacatc
      721 caaggagctg tccacattaa ctgtgcagat aagatcagcc ggcggaggct gcaacagggc
      781 aagatcactg tcttagactt gatttcctgt agagaaggca aagactcttt caagaggatt
      841 ttttccaaag aaatcatagt ttatgatgag aataccaatg agccgagccg tgtgacgcca
      901 tcccaaccac ttcacatagt tctcgagtcc ctgaagagag aaggcaaaga acccctggta
      961 ttgaaagggg gactcagtag ttttaaacag aaccatggaa acctctgtga caactccctc
     1021 cagctccaag agtgccggga ggtggggggt ggtgcctctg cggcctcgag cgtgctacct
     1081 cagtctgtcc cctccacccc tgacatcgag agcgcagagc tgacacccat cctgcccttc
     1141 ctgtttcttg gcaatgagca ggatgctcag gacctagacg ccatgcagag gctcaatgtc
     1201 ggctatgtca tcaacgtcac cacacacctt cctctctacc actatgagaa aggcctcttc
     1261 aactacaaga ggctgccagc cacagacagc aacaagcaga acttgcggca gtactttgaa
     1321 gaggcattcg aattcattga ggaagctcat cagtgtggga agggccttct catccactgc
     1381 caggccggcg tgtcccgttc tgccaccatt gtcatcgcct acctgatgaa gcacacacgg
     1441 atgaccatga ctgacgctta caaattcgtc aaaggcaaac gaccaattat ctccccgaac
     1501 ctcaacttca tggggcagtt gctggaattt gaggaagacc taaacaatgg cgtgacacca
     1561 cggatcctta caccaaagct gatgggcatg gagacagttg tgtgacagca gacaggctag
     1621 aaagggtcat gctctgttag gagcagaaca ggaaggaagg tggattctgg cttgtctttc
     1681 ttcctccttt ccttccttcc ttcctttttt ttttttttct tatttctttt tctttttttt
     1741 ttttttttaa ggtcaggggt gtttgtgaaa ggaaacaaac ttgtcgaaag actctatttt
     1801 taataagtgt aagaagactg taactttgga tgcccatgag actcacttct cttaaactgg
     1861 tattgcagtt aagctaaaga gatctttttt tttttttttt tttaagccaa caaataaaaa
     1921 tactataaaa cttgtttctc cccagtttcc cttgtaagct tactgtagag ttttgactca
     1981 atagtctgtg cgggctcata gacagaagat accacccttc aattacaaac aaccaaaagg
     2041 caacggaaaa gactctagac ctggaaccga cctggacaac catgtcgaaa gcaagcccgt
     2101 taaaccgtgc acagctgtgc tcaccggtgc gaagagaagg gcgggcaaac ccggtggtct
     2161 cagctcagct cacctcacac cttctctggg gagacaggct agcatcgatt ttgtgtgctc
     2221 catgctcccg acaactttct cccttctctg ggtctgagag aacttttgtg tgtgtgtgtg
     2281 tttgtttaac acaaagaaac tgacgttata ccgtgtgcct ttgctggcac ttgtgcaata
     2341 aaaatgtgtt tggagtgtga ggctaaggta gggctggcag ctgagtgagg actggagtca
     2401 gcttggaggc aggaattcaa caataccagt ggcttcccct ccctccttcc tcccttttcc
     2461 ccccctttct ttcttcctcc tcctccttta attttttttt tctttttgga tttgattctg
     2521 gttacagtgc cataaacctt gttacatatg tatatcagaa tgtaaaaaaa aaaaaaagac
     2581 aaaaatttat ttaaaaaata tttttcgcaa aaaaaaaaaa tccttggtgt gtttttgttg
     2641 atggtgtaag aatttatttt cattatataa atgaaactcg tttggggatg tgtcgttctt
     2701 tgca
//
