LOCUS       NM_053769               1937 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus dual specificity phosphatase 1 (Dusp1), mRNA.
ACCESSION   NM_053769
VERSION     NM_053769.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Feng,L., Wang,H., Chen,C., Fu,J., Zhao,L., Zhao,X., Geng,M.,
            Ren,M., Tong,L., Li,Y., Gu,J. and Wang,C.
  TITLE     MKP1 may be involved in the occurrence of depression by regulating
            hippocampal autophagy in rats
  JOURNAL   Behav Brain Res 465, 114962 (2024)
   PUBMED   38499157
  REMARK    GeneRIF: MKP1 may be involved in the occurrence of depression by
            regulating hippocampal autophagy in rats.
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Gil-Redondo,J.C., Queipo,M.J., Trueba,Y., Llorente-Saez,C.,
            Serrano,J., Ortega,F., Gomez-Villafuertes,R., Perez-Sen,R. and
            Delicado,E.G.
  TITLE     DUSP1/MKP-1 represents another piece in the P2X7R intracellular
            signaling puzzle in cerebellar cells: our last journey with M
            feminine Teresa along the purinergic pathways of Eden
  JOURNAL   Purinergic Signal 20 (2), 127-144 (2024)
   PUBMED   37776398
  REMARK    GeneRIF: DUSP1/MKP-1 represents another piece in the P2X7R
            intracellular signaling puzzle in cerebellar cells: our last
            journey with M feminine Teresa along the purinergic pathways of
            Eden.
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Geng,M., Shao,Q., Fu,J., Gu,J., Feng,L., Zhao,L., Liu,C., Mu,J.,
            Zhang,X., Zhao,M., Guo,X., Song,C., Li,Y., Wang,H. and Wang,C.
  TITLE     Down-regulation of MKP-1 in hippocampus protects against
            stress-induced depression-like behaviors and neuroinflammation
  JOURNAL   Transl Psychiatry 14 (1), 130 (2024)
   PUBMED   38424085
  REMARK    GeneRIF: Down-regulation of MKP-1 in hippocampus protects against
            stress-induced depression-like behaviors and neuroinflammation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Vlasov,I., Filatova,E., Slominsky,P. and Shadrina,M.
  TITLE     Differential expression of Dusp1 and immediate early response genes
            in the hippocampus of rats, subjected to forced swim test
  JOURNAL   Sci Rep 13 (1), 9985 (2023)
   PUBMED   37340011
  REMARK    GeneRIF: Differential expression of Dusp1 and immediate early
            response genes in the hippocampus of rats, subjected to forced swim
            test.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Fan,W., Qin,Y., Tan,J., Li,B., Liu,Y., Rong,J., Shi,W. and Yu,B.
  TITLE     RGD1564534 represses NLRP3 inflammasome activity in cerebral injury
            following ischemia-reperfusion by impairing miR-101a-3p-mediated
            Dusp1 inhibition
  JOURNAL   Exp Neurol 359, 114266 (2023)
   PUBMED   36336032
  REMARK    GeneRIF: RGD1564534 represses NLRP3 inflammasome activity in
            cerebral injury following ischemia-reperfusion by impairing
            miR-101a-3p-mediated Dusp1 inhibition.
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Chin,S., Ramirez,S., Greenbaum,L.E., Naji,A. and Taub,R.
  TITLE     Blunting of the immediate-early gene and mitogenic response in
            hepatectomized type 1 diabetic animals
  JOURNAL   Am J Physiol 269 (4 Pt 1), E691-E700 (1995)
   PUBMED   7485483
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Lewis,T., Groom,L.A., Sneddon,A.A., Smythe,C. and Keyse,S.M.
  TITLE     XCL100, an inducible nuclear MAP kinase phosphatase from Xenopus
            laevis: its role in MAP kinase inactivation in differentiated cells
            and its expression during early development
  JOURNAL   J Cell Sci 108 (Pt 8), 2885-2896 (1995)
   PUBMED   7593328
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Baas,A.S. and Berk,B.C.
  TITLE     Differential activation of mitogen-activated protein kinases by
            H2O2 and O2- in vascular smooth muscle cells
  JOURNAL   Circ Res 77 (1), 29-36 (1995)
   PUBMED   7540516
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Kwak,S.P., Hakes,D.J., Martell,K.J. and Dixon,J.E.
  TITLE     Isolation and characterization of a human dual specificity
            protein-tyrosine phosphatase gene
  JOURNAL   J Biol Chem 269 (5), 3596-3604 (1994)
   PUBMED   8106404
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Keyse,S.M. and Emslie,E.A.
  TITLE     Oxidative stress and heat shock induce a human gene encoding a
            protein-tyrosine phosphatase
  JOURNAL   Nature 359 (6396), 644-647 (1992)
   PUBMED   1406996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1, U02553.1, FM064786.1 and BI297083.1.
            
            On Mar 5, 2021 this sequence version replaced NM_053769.3.
            
            Sequence Note: This RefSeq record was created from transcript
            sequence data from multiple strains because no single transcript
            from the same strain was available for the full length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X84004.1, U02553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                JAXUCZ010000010.1  17184853-17184877
            26-387              U02553.1           1-362
            388-643             FM064786.1         362-617
            644-1803            U02553.1           619-1778
            1804-1937           BI297083.1         18-151              c
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1937
                     /gene="Dusp1"
                     /gene_synonym="3CH134; CL100; MKP-1; Mkp1; Ptpn16"
                     /note="dual specificity phosphatase 1"
                     /db_xref="GeneID:114856"
                     /db_xref="RGD:620897"
     exon            1..518
                     /gene="Dusp1"
                     /gene_synonym="3CH134; CL100; MKP-1; Mkp1; Ptpn16"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1255
                     /gene="Dusp1"
                     /gene_synonym="3CH134; CL100; MKP-1; Mkp1; Ptpn16"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="oxidative stress-inducible protein tyrosine
                     phosphatase; 3CH134/CL100 PTPase; mitogen-activated
                     protein (MAP) kinase phosphatase-1; MAP kinase
                     phosphatase-1; protein-tyrosine phosphatase CL100;
                     protein-tyrosine phosphatase non-receptor type 16;
                     mitogen-activated protein kinase phosphatase 1"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 1"
                     /protein_id="NP_446221.2"
                     /db_xref="GeneID:114856"
                     /db_xref="RGD:620897"
                     /translation="MVMEVGILDAGGLRALLRERAAQCLLLDCRSFFAFNAGHIVGSV
                     NVRFSTIVRRRAKGAMGLEHIVPNTELRGRLLAGAYHAVVLLDERSAALDGAKRDGTL
                     ALAAGALCREARSTQVFFLQGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESG
                     CSSCSTPLYDQGGPVEILSFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHY
                     QYKSIPVEDNHKADISSWFNEAIDFIDSIKDAGGRVFVHCQAGISRSATICLAYLMRT
                     NRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTS
                     TTTVFNFPVSIPVHPTNSALNYLQSPITTSPSC"
     exon            519..664
                     /gene="Dusp1"
                     /gene_synonym="3CH134; CL100; MKP-1; Mkp1; Ptpn16"
                     /inference="alignment:Splign:2.1.0"
     exon            665..884
                     /gene="Dusp1"
                     /gene_synonym="3CH134; CL100; MKP-1; Mkp1; Ptpn16"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1937
                     /gene="Dusp1"
                     /gene_synonym="3CH134; CL100; MKP-1; Mkp1; Ptpn16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcaaagg actggcgggc gggacgcgcg gtgaagccag attaggatca gcgagcactt
       61 gaggatttag ggccacaaaa aaccgcacaa gatcgacaga ctatttctgg agagctgcag
      121 aacgggcacg ctggggtcgc tggtgctggc catggtgatg gaggtgggca tcctggacgc
      181 cggggggctg cgcgcgctgc tgcgagagcg cgccgctcag tgcctgcttc tggattgtcg
      241 ctccttcttc gccttcaacg ccggccacat cgtgggctca gtgaacgtgc gcttcagcac
      301 catcgtgcgg cgccgcgcca agggcgccat gggcctggag catatcgtgc cgaacaccga
      361 actgcgcggc cgcctgctgg ccggagccta tcacgccgta gtgctgctgg acgaacgcag
      421 cgccgccctg gacggcgcca agcgcgacgg caccctggcc ctggccgcgg gcgcgctctg
      481 ccgagaagcg cgctccactc aagtcttctt cctccaagga ggatatgaag cgttttcggc
      541 ttcctgccct gagctgtgca gcaaacagtc cacccccatg gggctcagcc tcccgctgag
      601 tactagtgtg cctgacagtg cagaatccgg atgcagctcc tgtagcaccc ctctctacga
      661 ccaggggggc ccagtggaga tcctgtcctt cctgtacctg ggcagtgctt accatgcttc
      721 ccggaaagat atgctcgacg ccttgggtat cactgctttg atcaacgtct cggccaattg
      781 tcctaaccac tttgagggtc actaccagta caagagcatc cctgtggagg acaaccacaa
      841 ggcagacatt agctcctggt tcaacgaggc gattgacttt atagactcca tcaaggatgc
      901 tggaggaagg gtgtttgtgc actgccaggc cggcatctcc aggtcagcca ccatctgcct
      961 tgcttacctc atgaggacta accgagtgaa gctggacgag gcctttgagt tcgtgaagca
     1021 gaggcggagt attatctccc ccaacttcag cttcatgggc cagctgctgc aatttgagtc
     1081 ccaagtactg gcccctcact gttctgcaga agctgggagc ccggccatgg ctgtccttga
     1141 ccggggcacc tctactacaa cggtcttcaa cttccctgtc tccatccctg ttcaccccac
     1201 gaacagtgcc ctgaactacc ttcaaagccc catcacaacc tctccgagct gctgaagggc
     1261 caggggaggt gtggagtttc acgtgccacc gggacgacac tcctcccatg ggaggagcaa
     1321 tgcaataact ctgggagagg ctcatgtgag ctggtcctta tttatttaac accccccccc
     1381 ccaaacacct cccgagttcc actgagttcc caagcagtca taacaatgac ttgaccgcaa
     1441 gacatttgct gaactcagcc cgttcgggac caatatattg tgggtacatc gagcccctct
     1501 gacaaaacag ggcagaaggg aaaggactct gtttgagcca gtttcttccc ttgcctgttt
     1561 tttctagaaa cttcgtgctt gacataccta ccagtattaa ccattcccga tgacatacac
     1621 gtttgagagt tttaccttat ttatttttgt gtgggtgggt ggtctgccct cacaaatgtc
     1681 attgtctact catagaagaa cgaaatacct cactttttgt gtttgcgtac tgtactatct
     1741 tgtaaataga cccagagcag gctttcagca ctgatggacg aagccagtgt tggtttgttt
     1801 gtagctttta gctatcaaca gttgtatgtt tgtttattta tgatctgaag taatatattt
     1861 cttcttctga gaagacattt tgttactagg atgacttttt ttttatacag cagaataaat
     1921 tatgacattt ctattga
//
