LOCUS       NM_001191965            1313 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus dual oxidase maturation factor 2 (Duoxa2), mRNA.
ACCESSION   NM_001191965 XM_575222
VERSION     NM_001191965.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1313)
  AUTHORS   Carre,A., Louzada,R.A., Fortunato,R.S., Ameziane-El-Hassani,R.,
            Morand,S., Ogryzko,V., de Carvalho,D.P., Grasberger,H., Leto,T.L.
            and Dupuy,C.
  TITLE     When an Intramolecular Disulfide Bridge Governs the Interaction of
            DUOX2 with Its Partner DUOXA2
  JOURNAL   Antioxid Redox Signal 23 (9), 724-733 (2015)
   PUBMED   25761904
REFERENCE   2  (bases 1 to 1313)
  AUTHORS   Chang,S., Linderholm,A., Franzi,L., Kenyon,N., Grasberger,H. and
            Harper,R.
  TITLE     Dual oxidase regulates neutrophil recruitment in allergic airways
  JOURNAL   Free Radic Biol Med 65, 38-46 (2013)
   PUBMED   23770197
REFERENCE   3  (bases 1 to 1313)
  AUTHORS   Hoste,C., Dumont,J.E., Miot,F. and De Deken,X.
  TITLE     The type of DUOX-dependent ROS production is dictated by defined
            sequences in DUOXA
  JOURNAL   Exp Cell Res 318 (18), 2353-2364 (2012)
   PUBMED   22814254
REFERENCE   4  (bases 1 to 1313)
  AUTHORS   Grasberger,H., De Deken,X., Mayo,O.B., Raad,H., Weiss,M., Liao,X.H.
            and Refetoff,S.
  TITLE     Mice deficient in dual oxidase maturation factors are severely
            hypothyroid
  JOURNAL   Mol Endocrinol 26 (3), 481-492 (2012)
   PUBMED   22301785
REFERENCE   5  (bases 1 to 1313)
  AUTHORS   Luxen,S., Noack,D., Frausto,M., Davanture,S., Torbett,B.E. and
            Knaus,U.G.
  TITLE     Heterodimerization controls localization of Duox-DuoxA NADPH
            oxidases in airway cells
  JOURNAL   J Cell Sci 122 (Pt 8), 1238-1247 (2009)
   PUBMED   19339556
REFERENCE   6  (bases 1 to 1313)
  AUTHORS   Grasberger,H. and Refetoff,S.
  TITLE     Identification of the maturation factor for dual oxidase. Evolution
            of an eukaryotic operon equivalent
  JOURNAL   J Biol Chem 281 (27), 18269-18272 (2006)
   PUBMED   16651268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 8, 2022 this sequence version replaced NM_001191965.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1080267.1,
                                           SRR22582416.1472528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               JAXUCZ010000003.1  129698938-129699223
            287-344             JAXUCZ010000003.1  129700189-129700246
            345-479             JAXUCZ010000003.1  129700616-129700750
            480-693             JAXUCZ010000003.1  129701233-129701446
            694-908             JAXUCZ010000003.1  129701710-129701924
            909-1313            JAXUCZ010000003.1  129702252-129702656
FEATURES             Location/Qualifiers
     source          1..1313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1313
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /note="dual oxidase maturation factor 2"
                     /db_xref="GeneID:499879"
                     /db_xref="RGD:1560628"
     exon            1..286
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1102
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /codon_start=1
                     /product="dual oxidase maturation factor 2"
                     /protein_id="NP_001178894.1"
                     /db_xref="GeneID:499879"
                     /db_xref="RGD:1560628"
                     /translation="MTAWDGVLPFYPQPRHAAGFSVPLLIVILVFLSLAASFLFILPG
                     IRGHSRWFWLVRVLLSLFIGAEIVAVHFSGDWFVGRVWTNTSYKAFSTSRVQVHVGLH
                     VGLEGVNITLRGTPMQQLNETIDYNEQFTWRLNEDYTKEYVQALEKGLPDPVLYLAEK
                     FTPNSPCGLYHQYHYAGHYAGATLWVAFCFWIIANALLSMPAPLYGGLALLITGAFTL
                     FSVFAFASISSVPLCHFRLGSAALTPHYGASFWVTLATGILSLLLGGLVVILHYTRPS
                     VLRALLDQNVKDCSNQADGNSHFILDNPQHRQSKTPDLNVTTLL"
     exon            287..344
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /inference="alignment:Splign:2.1.0"
     exon            345..479
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /inference="alignment:Splign:2.1.0"
     exon            480..693
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /inference="alignment:Splign:2.1.0"
     exon            694..908
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1313
                     /gene="Duoxa2"
                     /gene_synonym="RGD1560628"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacgctgcg cgaagcctca gagccaggag aaagagtttc gggacatcct gcctctgtgc
       61 ttcttaggag agccgcaggg ctcagacttt ttatcactca ctccagctcg ctgcgtgcgg
      121 gcacttctct tcttgcagga tgactgcttg ggacggggtg ctaccctttt accctcagcc
      181 caggcatgcc gccggtttca gcgtaccgct gctcatcgtt atcctggtat tcttgtcctt
      241 ggctgctagc ttcctgttca tcttgcctgg aatccggggg cactcgcgct ggttctggtt
      301 ggtgagagtt cttcttagcc tgttcatagg tgcagaaatt gtggctgtac acttcagtgg
      361 agactggttt gtggggagag tgtggaccaa tacatcctac aaagccttca gtacctcccg
      421 agttcaagtc catgtcggtc tgcacgtggg gctggagggc gttaatatca cactcagagg
      481 aacaccaatg cagcagctga acgagaccat tgactacaat gagcagttca cttggcgcct
      541 gaatgaagac tacaccaagg agtatgttca ggctctggag aagggactgc cggacccagt
      601 gctatacctg gcagagaagt tcacaccgaa cagtccttgc ggattgtacc accaatatca
      661 ctatgccggt cactatgccg gggcaacgct atgggtggcg ttctgcttct ggatcatcgc
      721 caatgcgctg ctctctatgc ccgctccgct ctatggaggt ctagctctgc tcatcacggg
      781 tgccttcacg ctcttctccg tcttcgcctt cgcctcgatc tccagcgtgc cgctctgcca
      841 cttccgcctg ggctccgccg ccctcacgcc tcactacggc gcctcctttt gggtcacgct
      901 ggccaccggc atcctgagcc tcctcctcgg agggctggtg gtgattctcc actacactcg
      961 acccagcgtc cttcgagcct tactggatca aaatgtcaaa gactgtagca atcaggctga
     1021 cggaaactca catttcatcc tcgacaaccc tcaacacaga cagtctaaga ctccagactt
     1081 aaatgttacc actctcctat gaaaagagtt aactccggat ttctatccgt ccttgggatc
     1141 ccacacacct gaagacagtg ttaagagcgc gtgccaggag cacagctgag tctggaggac
     1201 tgcataccca tgcgggaata caagggggcg ccccagatac acctttgctc tagagaatgg
     1261 atttctcagg agaactgtaa ataaactttt ttgtttcgtt ttttttttca aaa
//
