LOCUS       NM_001107767            1665 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dual oxidase maturation factor 1 (Duoxa1), mRNA.
ACCESSION   NM_001107767 XM_001081001 XM_230527
VERSION     NM_001107767.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Chang,S., Linderholm,A., Franzi,L., Kenyon,N., Grasberger,H. and
            Harper,R.
  TITLE     Dual oxidase regulates neutrophil recruitment in allergic airways
  JOURNAL   Free Radic Biol Med 65, 38-46 (2013)
   PUBMED   23770197
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Hoste,C., Dumont,J.E., Miot,F. and De Deken,X.
  TITLE     The type of DUOX-dependent ROS production is dictated by defined
            sequences in DUOXA
  JOURNAL   Exp Cell Res 318 (18), 2353-2364 (2012)
   PUBMED   22814254
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Grasberger,H., De Deken,X., Mayo,O.B., Raad,H., Weiss,M., Liao,X.H.
            and Refetoff,S.
  TITLE     Mice deficient in dual oxidase maturation factors are severely
            hypothyroid
  JOURNAL   Mol Endocrinol 26 (3), 481-492 (2012)
   PUBMED   22301785
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Kennedy,K.A., Ostrakhovitch,E.A., Sandiford,S.D., Dayarathna,T.,
            Xie,X., Waese,E.Y., Chang,W.Y., Feng,Q., Skerjanc,I.S.,
            Stanford,W.L. and Li,S.S.
  TITLE     Mammalian numb-interacting protein 1/dual oxidase maturation factor
            1 directs neuronal fate in stem cells
  JOURNAL   J Biol Chem 285 (23), 17974-17985 (2010)
   PUBMED   20233719
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Christophe-Hobertus,C. and Christophe,D.
  TITLE     Delimitation and functional characterization of the bidirectional
            THOX-DUOXA promoter regions in thyrocytes
  JOURNAL   Mol Cell Endocrinol 317 (1-2), 161-167 (2010)
   PUBMED   20060878
REFERENCE   6  (bases 1 to 1665)
  AUTHORS   Luxen,S., Noack,D., Frausto,M., Davanture,S., Torbett,B.E. and
            Knaus,U.G.
  TITLE     Heterodimerization controls localization of Duox-DuoxA NADPH
            oxidases in airway cells
  JOURNAL   J Cell Sci 122 (Pt 8), 1238-1247 (2009)
   PUBMED   19339556
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081001.1, XM_230527.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760400, SAMEA5760476
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1665
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /note="dual oxidase maturation factor 1"
                     /db_xref="GeneID:311374"
                     /db_xref="RGD:1306601"
     exon            1..219
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     exon            220..332
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     exon            333..508
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1384
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /codon_start=1
                     /product="dual oxidase maturation factor 1"
                     /protein_id="NP_001101237.1"
                     /db_xref="GeneID:311374"
                     /db_xref="RGD:1306601"
                     /translation="MAALGHTLPFYTGPKPTFPMDTTLAVIITIFLTALVTFIIILPG
                     IRGKTRLFWLLRVVTSLFIGAVILAVNFSSEWSVGHINTNTTYKAFSPKRVSVHVGLQ
                     IGLGGLNITLTGTPVQQLNETINYNEEFTWRLGKSYAEEYAKALEKGLPDPVLYLAEK
                     FAPRSPCGLYNQYRLAGHYASAMLWVAFLCWLLANVMLSMPVLVYGGHMLLATGLFQL
                     LALFFFSMTTSLMSCPLRLGTAVLYTHHGPAFWITLATGLLCILLGLVMAVAHRMQPH
                     RLKALFNLSSEDPMLEWGSEEGGLLSPHYRSIAESPETQDIPMSEASSETCLKEECLK
                     ESDCSL"
     exon            509..566
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     exon            567..701
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     exon            702..915
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1130
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1665
                     /gene="Duoxa1"
                     /gene_synonym="RGD1306601"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggctcct gggtgccgag ggttcaagcc atttgggagg cgggaagggc aagtctccct
       61 ccccaagttc caactcttga gagttgagga agagggtgga agataaacgg ggtgcggggc
      121 aggagagcta ttcccaaatc ctccccacac agtcggggct ctaaaacaaa gataattacc
      181 caacattcac ctacagatca gacctggcgc caaagcaagg acgtctacgt ctggacccgg
      241 ttcctgacct attcccacga ccaggatcgc tgtgagttcc caaagacgag cagcgccagg
      301 tgccacgcgc acagtatctg aaagaaagga agcatcaaca cccctgtgta cctccaccaa
      361 gatggctgct cttggacaca cgctgccctt ctacactggc cccaagccaa ccttcccaat
      421 ggacaccact ttagctgtta ttatcacaat cttcctgact gccctggtca ccttcatcat
      481 catcctgcct ggcatccgtg ggaagacaag gctgttctgg ctgctacggg tggtgaccag
      541 cttattcatc ggggctgtga tcctggctgt gaatttcagt tctgagtggt ctgtgggcca
      601 tatcaacacc aacacaacct acaaagcctt cagtcccaag cgggtcagcg tgcacgtggg
      661 actgcagatt gggctcggag gactcaacat caccctcaca gggaccccag tgcagcagct
      721 gaatgaaacc atcaactaca atgaggagtt cacatggcgc ctgggcaaga gctatgcaga
      781 ggagtatgcc aaggccttgg agaagggcct tccagacccg gtgctatacc tggctgagaa
      841 gtttgcccct cgaagccctt gtggcctgta caaccagtac cgcctggcag gacactacgc
      901 ctcagccatg ctgtgggtag cattcctctg ctggctgctg gccaatgtga tgctgtctat
      961 gccagtgctg gtttatggtg gccacatgct gctggccact ggcctcttcc agctgttggc
     1021 actgttcttc ttctccatga ccacgtcact catgtcctgc ccgctgcgct tgggcactgc
     1081 tgtactgtac actcaccatg ggcctgcttt ctggatcaca ttagccacag gactgctgtg
     1141 cattctgctt ggcctggtca tggcagtggc ccacaggatg caacctcaca gactgaaggc
     1201 tcttttcaac ctgagctcag aggaccccat gttggagtgg ggctctgaag aagggggact
     1261 cctgagcccc cactaccggt ccatagctga gagtccggag actcaggaca ttcccatgtc
     1321 agaggcttcc tctgagacgt gtcttaaaga ggaatgcctc aaagagtccg actgttccct
     1381 gtaatgctct tctggtggat actgagtttc cagactggct gcaggcatca ctggagccca
     1441 cacaaaacca gcagaactgc ccaggaagtg ggtttgggtt gtgtcatgtg ctccaatttg
     1501 ttgatgtaac agagcaggga gacacaacct actaatgcaa aaaataaatg aacaaaagtc
     1561 ccaaggttct gaagacatgt ccgacaggcc cataaactgt tgtcatggca acagcacagg
     1621 ggtggctgtt aatgcacagt aacagccttc ttgaatgatt caagg
//
