LOCUS       NM_024141               5872 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dual oxidase 2 (Duox2), mRNA.
ACCESSION   NM_024141 XM_039105893
VERSION     NM_024141.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   Kim,H.J., Seo,Y.H., An,S., Jo,A., Kwon,I.C. and Kim,S.
  TITLE     Chemiluminescence imaging of Duox2-derived hydrogen peroxide for
            longitudinal visualization of biological response to viral
            infection in nasal mucosa
  JOURNAL   Theranostics 8 (7), 1798-1807 (2018)
   PUBMED   29556357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Bourque,D.L., Bhuiyan,T.R., Genereux,D.P., Rashu,R., Ellis,C.N.,
            Chowdhury,F., Khan,A.I., Alam,N.H., Paul,A., Hossain,L.,
            Mayo-Smith,L.M., Charles,R.C., Weil,A.A., LaRocque,R.C.,
            Calderwood,S.B., Ryan,E.T., Karlsson,E.K., Qadri,F. and Harris,J.B.
  TITLE     Analysis of the Human Mucosal Response to Cholera Reveals Sustained
            Activation of Innate Immune Signaling Pathways
  JOURNAL   Infect Immun 86 (2), e00594-17 (2018)
   PUBMED   29133347
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5872)
  AUTHORS   Kim,B.J., Cho,S.W., Jeon,Y.J., An,S., Jo,A., Lim,J.H., Kim,D.Y.,
            Won,T.B., Han,D.H., Rhee,C.S. and Kim,H.J.
  TITLE     Intranasal delivery of Duox2 DNA using cationic polymer can prevent
            acute influenza A viral infection in vivo lung
  JOURNAL   Appl Microbiol Biotechnol 102 (1), 105-115 (2018)
   PUBMED   28936773
REFERENCE   4  (bases 1 to 5872)
  AUTHORS   Li,H., Zhou,Y., Zheng,Y., Guo,H., Gao,L., Chen,P., Feng,D., Wu,L.,
            Yang,M., Qi,Y., Guo,H., Chang,Y., Chu,F.F. and Gao,Q.
  TITLE     The Gastric Mucosa from Patients Infected with CagA+ or VacA+
            Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression
            than Uninfected or Infected with CagA-/VacA- H. pylori
  JOURNAL   Dig Dis Sci 61 (8), 2328-2337 (2016)
   PUBMED   27048452
REFERENCE   5  (bases 1 to 5872)
  AUTHORS   Carre,A., Louzada,R.A., Fortunato,R.S., Ameziane-El-Hassani,R.,
            Morand,S., Ogryzko,V., de Carvalho,D.P., Grasberger,H., Leto,T.L.
            and Dupuy,C.
  TITLE     When an Intramolecular Disulfide Bridge Governs the Interaction of
            DUOX2 with Its Partner DUOXA2
  JOURNAL   Antioxid Redox Signal 23 (9), 724-733 (2015)
   PUBMED   25761904
REFERENCE   6  (bases 1 to 5872)
  AUTHORS   Pachucki,J., Wang,D., Christophe,D. and Miot,F.
  TITLE     Structural and functional characterization of the two human
            ThOX/Duox genes and their 5'-flanking regions
  JOURNAL   Mol Cell Endocrinol 214 (1-2), 53-62 (2004)
   PUBMED   15062544
REFERENCE   7  (bases 1 to 5872)
  AUTHORS   Geiszt,M., Witta,J., Baffi,J., Lekstrom,K. and Leto,T.L.
  TITLE     Dual oxidases represent novel hydrogen peroxide sources supporting
            mucosal surface host defense
  JOURNAL   FASEB J 17 (11), 1502-1504 (2003)
   PUBMED   12824283
REFERENCE   8  (bases 1 to 5872)
  AUTHORS   Morand,S., Dos Santos,O.F., Ohayon,R., Kaniewski,J.,
            Noel-Hudson,M.S., Virion,A. and Dupuy,C.
  TITLE     Identification of a truncated dual oxidase 2 (DUOX2) messenger
            ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and
            forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and
            porcine thyrocytes
  JOURNAL   Endocrinology 144 (2), 567-574 (2003)
   PUBMED   12538618
REFERENCE   9  (bases 1 to 5872)
  AUTHORS   Moreno,J.C., Bikker,H., Kempers,M.J., van Trotsenburg,A.S.,
            Baas,F., de Vijlder,J.J., Vulsma,T. and Ris-Stalpers,C.
  TITLE     Inactivating mutations in the gene for thyroid oxidase 2 (THOX2)
            and congenital hypothyroidism
  JOURNAL   N Engl J Med 347 (2), 95-102 (2002)
   PUBMED   12110737
REFERENCE   10 (bases 1 to 5872)
  AUTHORS   Dupuy,C., Pomerance,M., Ohayon,R., Noel-Hudson,M.S., Deme,D.,
            Chaaraoui,M., Francon,J. and Virion,A.
  TITLE     Thyroid oxidase (THOX2) gene expression in the rat thyroid cell
            line FRTL-5
  JOURNAL   Biochem Biophys Res Commun 277 (2), 287-292 (2000)
   PUBMED   11032719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Mar 19, 2021 this sequence version replaced
            XM_039105893.1, NM_024141.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.15306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000003.1  129698593-129698753 c
            162-280             JAXUCZ010000003.1  129698223-129698341 c
            281-370             JAXUCZ010000003.1  129697849-129697938 c
            371-535             JAXUCZ010000003.1  129697475-129697639 c
            536-723             JAXUCZ010000003.1  129696813-129697000 c
            724-925             JAXUCZ010000003.1  129696450-129696651 c
            926-1092            JAXUCZ010000003.1  129696125-129696291 c
            1093-1153           JAXUCZ010000003.1  129695658-129695718 c
            1154-1250           JAXUCZ010000003.1  129695446-129695542 c
            1251-1341           JAXUCZ010000003.1  129695031-129695121 c
            1342-1444           JAXUCZ010000003.1  129694356-129694458 c
            1445-1608           JAXUCZ010000003.1  129693685-129693848 c
            1609-1784           JAXUCZ010000003.1  129692969-129693144 c
            1785-1903           JAXUCZ010000003.1  129692640-129692758 c
            1904-2041           JAXUCZ010000003.1  129692249-129692386 c
            2042-2155           JAXUCZ010000003.1  129691880-129691993 c
            2156-2358           JAXUCZ010000003.1  129691513-129691715 c
            2359-2544           JAXUCZ010000003.1  129691034-129691219 c
            2545-2770           JAXUCZ010000003.1  129689919-129690144 c
            2771-2864           JAXUCZ010000003.1  129689744-129689837 c
            2865-3052           JAXUCZ010000003.1  129688258-129688445 c
            3053-3122           JAXUCZ010000003.1  129687729-129687798 c
            3123-3301           JAXUCZ010000003.1  129686391-129686569 c
            3302-3532           JAXUCZ010000003.1  129685980-129686210 c
            3533-3632           JAXUCZ010000003.1  129685798-129685897 c
            3633-3682           JAXUCZ010000003.1  129685108-129685157 c
            3683-3810           JAXUCZ010000003.1  129684710-129684837 c
            3811-3964           JAXUCZ010000003.1  129684319-129684472 c
            3965-4197           JAXUCZ010000003.1  129682939-129683171 c
            4198-4356           JAXUCZ010000003.1  129682594-129682752 c
            4357-4512           JAXUCZ010000003.1  129682139-129682294 c
            4513-4641           JAXUCZ010000003.1  129681916-129682044 c
            4642-5872           JAXUCZ010000003.1  129680546-129681776 c
FEATURES             Location/Qualifiers
     source          1..5872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..5872
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /note="dual oxidase 2"
                     /db_xref="GeneID:79107"
                     /db_xref="RGD:628761"
     exon            1..161
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            162..280
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..4764
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /EC_number="1.6.3.1"
                     /note="long NOX 2; large NOX 2; thyroid oxidase 2;
                     NADH/NADPH thyroid oxidase THOX2"
                     /codon_start=1
                     /product="dual oxidase 2 precursor"
                     /protein_id="NP_077055.2"
                     /db_xref="GeneID:79107"
                     /db_xref="RGD:628761"
                     /translation="MLPTSLKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNN
                     LKYHQRGAAGSQLRRLVPANYADGVYQALQEPLLPNARLLSDAVSKGKAGLPSAHNRT
                     VLGLFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRS
                     TGQSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNS
                     LLMWMAPDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHW
                     GDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVAASEQ
                     FLSTMVPPGVYMRNSSCHFREFPKEGSSSSPALRVCNNYWIRENPSLKTAQDVDQLLL
                     GMASQISELEDRIVIEDLRDYWPGPDRYSRTDYVASSIQSGRDMGLPSYSQALQALGL
                     EPPKNWSALNPKVDPQVLEATAALYNQDLSRLELFLGGLLESHGDPGPLFSNIILDQF
                     VRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGA
                     PCPQPQQLTTEGLPQCVPVTVIDYFEGSGAGYGVTLLAVCCFPVVSLIIAWVVARFRN
                     RERKMLLKKGKESLKKQTASDGVPAMEWPGPKESSYPVTVQLLPDRSLKVLDKRLTVL
                     RTIQLQPTQQVNLILSSSHGRRTLLLKIPKEYDLVLMFNSEEDRDAFVQLLQDLCVCS
                     TPGLRIAEMDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQV
                     REALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSP
                     QDKSRLMFTMYDLDGNGFLSKEEFFTMMRSFIEISNNCLSKDQLAEVVESMFRESGFQ
                     DKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTGDIFKQSNACRVSFLTRTPGNRV
                     MAPSPRLYTEALQEKMQRGFLAQKLKQFKRFVENYRRHIVCVTIFSAICAGLFADRAY
                     YYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIP
                     FDAAVDFHRWIAMAAVVLAVVHSLGHAVNVYIFSVSPLSLMTCVFPSVFVNDGSKLPP
                     KYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYALIIIH
                     GSYALIQLPSFHIYFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPK
                     TFEYKSGQWVRIACLSLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPV
                     GGTSARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGAQM
                     LCKKIYFIWVTRTQRQFEWLADIIREVEENDSRDLVSVHIYITQLAEKFDLRTTMLYI
                     CERHFQKVLNRSLFTGLRSVTHFGRPPFELFLDSLQEVHPQVHKIGVFSCGPPGMTKN
                     VEKACQLINRQDRAHFVHHYENF"
     exon            281..370
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..535
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..723
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..925
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1092
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1153
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1250
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1341
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1444
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1608
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1784
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1903
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2041
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2155
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2358
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2544
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2770
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2864
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3052
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3122
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3301
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3532
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3632
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3682
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3810
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3964
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4197
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4356
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4512
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4641
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..5872
                     /gene="Duox2"
                     /gene_synonym="Thox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcgcgag ctgacacctg cgagactgca cgcagagagg agggtgaaag tgcatccagg
       61 aaggtgaaga ttcttggagc cccgggcagg gagcggagaa gagaaacaaa atctccaagt
      121 acacggaaga ctgttgaacc cgaaccggag cattacacca ggaccaactg tgggagtgtg
      181 tgtcctcccg ccgccgggat caaggacagc atgcttccaa caagtctcaa gacattggtg
      241 ctcctgggcg ctctgttgac tggacccctg ggtccagcag gtggccagga tgcaccctca
      301 ctgccctggg aagtgcagcg ctacgacggc tggtttaata atctcaagta ccaccagcgc
      361 ggtgcagctg gctcgcagct gcgtcgccta gtacctgcta attacgctga cggtgtttat
      421 caggctctgc aggagccgct actccccaac gctcgcctgc taagcgacgc tgtcagtaag
      481 ggcaaagcag ggctgccctc ggcgcacaac cgcacagtgc ttgggctctt ctttggctat
      541 cacgtgctct cagacctggt gagtgtggaa acaccaggct gccccgcaga gttcctcaac
      601 atttacatcc cacgtgggga cccagtgttt gaccctgaca agcgcgggaa cgtggtgctg
      661 ccctttcaga ggagccgctg ggaccgcagc actggacaga gccctagcaa cccccgagac
      721 ctgaccaacc aggtgactgg ctggctagat ggcagcgcca tctatggctc ctctcattcc
      781 tggagcgaca ctctgaggag cttctctgga ggacagctgg cttctggccc tgaccctgct
      841 ttcccgagga actcccagaa ctctctgctc atgtggatgg caccagaccc cgccacgggg
      901 cagggcgggc cacaggggct gtatgccttc ggggcccagc gcgggaacag ggagcccttt
      961 ctgcaggcac tgggcttgtt gtggtttcga taccacaacc tgtgtgccaa gaggctggcg
     1021 caggagcacc cacactgggg ggatgaggag ctgttccagc atgctcgcaa gagggtcatt
     1081 gccacttacc agaacattgc tctataccaa tggttgccca gcttcctgca gaaaacaccc
     1141 ccagagtatt ccgggtaccg ccctttcatg gaccccagca tctccccaga gttcgtggcg
     1201 gcctcagagc agttcctctc taccatggtg cccccggggg tctatatgag aaactccagc
     1261 tgtcacttcc gggaattccc aaaggaaggt tccagcagct ctccagctct cagggtctgc
     1321 aacaactact ggattcggga gaaccccagt ctgaagactg ctcaggacgt ggaccagctg
     1381 ctgctgggaa tggcttccca gatttcagag ctggaggaca ggatagtgat tgaagatctg
     1441 agagattact ggcctggccc agacagatac tctcgcacag actacgtggc tagcagtatc
     1501 cagagtggcc gagatatggg gctgcccagt tatagccagg ctctgcaggc cttaggactg
     1561 gagcctccca agaattggag tgctctcaac cccaaagtgg atccccaggt gctggaggcc
     1621 acagctgctc tgtacaacca ggacctgtcc cggttggaac tattcctggg agggctcctg
     1681 gagagccatg gggaccctgg acctctattc agcaacatca ttcttgacca gtttgtaagg
     1741 ctccgggatg gtgatcgcta ctggtttgag aacactagga acgggctgtt ctccaaggag
     1801 gagattgcag aaatcagaaa caccaccttg cgggatgtac tggtagctgt ctccaatgtg
     1861 gaccccagtg ccttgcagcc caatgttttc ttctggcaag aaggtgcacc ctgcccacag
     1921 cctcagcaac tcacaactga aggcttgccc cagtgtgtgc ctgttactgt gattgactac
     1981 tttgagggca gtggtgctgg ctatggtgtc accctcctgg ctgtctgctg ctttccagta
     2041 gtgagtctga ttattgcttg ggtggtggct cgtttccgga accgagaacg caagatgcta
     2101 ctaaagaaag gcaaggagag tctaaagaaa cagacagcca gtgatggagt accagcgatg
     2161 gagtggccag gccccaagga gagcagctac ccagtcactg tccagctgct tccagacagg
     2221 agtctgaagg tccttgacaa aaggctcact gtgctccgta ccatccaact gcagcccaca
     2281 cagcaggtca acctcatcct gtccagcagc catggacgcc gcaccctgtt gctcaagatc
     2341 cccaaggagt acgacctggt gctgatgttt aactctgaag aggaccggga tgccttcgtg
     2401 cagctgttgc aagacctctg cgtctgctcc actcccggcc tccgcatagc tgagatggat
     2461 gagaaggagc tactgagaaa ggctgtgacc aagcagcagc gggcaggcat cttggagatc
     2521 ttcttcagac agctttttgc tcaggtgctg gacatcaatc aggccgacgc agggactctg
     2581 cctctggact catcccagca agtacgagag gctctgacct gtgaactgag cagagcggag
     2641 tttgcggact ccctgggcct caagccccag gatatgtttg tggagtccat gttttctctg
     2701 gccgacaagg atggcaatgg ctacatatcc ttccgggagt tcctggacat cctggtggtt
     2761 ttcatgaaag gttccccaca ggacaagtct cgcctaatgt ttaccatgta tgacctggat
     2821 ggaaatggct ttctctccaa ggaggaattc ttcaccatga tgcggtcctt catcgagatc
     2881 tccaacaact gcctgtccaa ggaccagctg gctgaggtgg tggaatccat gttccgggag
     2941 tcgggcttcc aggataagga ggagctgacc tgggaggact tccatttcat gctgcgcgac
     3001 cacgacagcg atctccgatt cacacagctc tgtgtcaaag gtggggctgg aggcaccggg
     3061 gacatcttta agcaaagcaa tgcctgtcga gtctcattcc tcacccggac tcctgggaac
     3121 agggtaatgg ctccctctcc ccggctgtac acggaagcac tgcaggagaa aatgcagagg
     3181 ggcttcctag cccagaagct caagcagttc aagcggtttg tggaaaacta ccggcgccac
     3241 atcgtgtgtg ttacaatctt ctcagccatc tgcgcaggcc tgtttgcaga ccgtgcctac
     3301 tactatggct ttgcctcgcc acccacggac attgaagaaa ccacctatgt gggcatcatc
     3361 ctgtcccggg gcacagcagc cagcatctcc ttcatgttct cctacatcct gctcaccatg
     3421 tgccgcaacc tcatcacctt cctgcgggag accttcctca accgctacat tccctttgat
     3481 gctgctgtgg acttccaccg ctggatcgcc atggctgcag ttgtcctagc tgttgtgcac
     3541 agtcttggac atgcagtcaa cgtgtacatc ttctcagtca gtcccctcag cctgatgacc
     3601 tgcgtcttcc ctagtgtctt tgtgaatgat gggtccaagc ttcccccaaa gtactactgg
     3661 tggttcttcg agacagttcc aggtatgaca ggagtactcc tgctcctggt cctggctatc
     3721 atgtatgtgt ttgcctccca ccacttccgc cgccacagtt tccggggctt ctggttgacc
     3781 caccacctct atgttgtgct ttatgccctg atcatcatcc atggcagcta tgccctcatc
     3841 caattaccca gcttccacat ctacttcctg gtccccgcca ttatctatgt gggggacaag
     3901 ctggtgagcc tgagccggaa gaaggtggag atcagtgtgg tgaaggctga gctgctgcct
     3961 tcaggggtga cctatctgca gttccagcgg cccaagactt ttgagtacaa atccgggcag
     4021 tgggtgcgga tcgcttgctt gagtctggga accaatgagt accacccctt cacgctgacc
     4081 tccgcacccc atgaggacac actcagcctg cacatccggg ctgtgggacc ttggactact
     4141 cgcctcaggg agatctactc acctccagtg ggtggcacca gcgccagata cccaaagctg
     4201 tacctcgatg gaccattcgg agagggccac caggaatggc acaagtttga ggtgtcggtg
     4261 ctggtaggag ggggcattgg ggtcaccccc tttgcctcca tcctcaaaga cctggtcttc
     4321 aaatcgtcca tgggtgccca gatgctatgt aagaagatct acttcatctg ggtgacaagg
     4381 actcagcggc agtttgagtg gctggctgac atcatccggg aagtggagga gaatgacagc
     4441 cgggacctgg tgtctgtgca catctatatc actcagctgg ctgagaagtt tgacctcagg
     4501 acgaccatgc tgtacatctg tgagaggcac ttccagaagg tgctgaacag gagtctgttc
     4561 acgggcctgc gctctgtcac ccactttggt cgccctccct ttgagctctt cttagactct
     4621 ctgcaggagg ttcatccaca ggtacataag attggtgtgt tcagctgtgg tcctccaggg
     4681 atgaccaaga atgtggagaa ggcctgtcag ctcatcaaca ggcaggaccg ggcccacttt
     4741 gtgcatcatt atgagaactt ctgagcctgc cctcctggat ccctgtccgg tctgctgccc
     4801 tctatcttct gttaccgtca cttgagacca cagtcaggga actggagccc ctcccctcat
     4861 agcatctatg ttctgggcag gtagacaagg tcagtccaat acctacctca tgacatagca
     4921 agttatggga tgtccagcaa ggaaaggaaa acccctattt ctgacaactg tggatgggaa
     4981 cagaacactg ggggtcgcct ctgacaggtc tatgtttctg ttttgccttc acaaaactgc
     5041 tgtgggtttt tcttgggggg gggaatcatt tgaggaaagc aggacaatct cctctgagtt
     5101 tgtctcagaa accacatacc aaaaacctgc acagcccacc tgcctcaact cgggctctgg
     5161 gtgccccctg ccccagcctc tgccctgcac cttcctgctc tgagagggcc acagagccag
     5221 agaacagatg ccctgagttc ccaatgtcat ccatgctgtg acccttcagt gaatcctcct
     5281 gtgagcatga aggtgttccc tgggccccaa ggtcaagaca gcaatggtct ctcttccaca
     5341 cactccaaac ccctcaactc cttttcccca gaggaggcaa gacagctttc ttcggttgtg
     5401 cagtgccgta agggaatcgg ctgcccaatc gcagcacaga gagatgtcac ctcgacctgt
     5461 gaagacccct ttccttcctt ccctggaatt ttactaaaaa gctgagctgt aacatatgta
     5521 tatttgcata aagtgtataa atcttacagt agctaccatc ctagtcaaga tggaaaacat
     5581 ttccacattc ccgtggcccc agaagcttct ccttcacgta aacacaacca ctatcgtgac
     5641 ttgtgtcact gcggtttggg tcatatggaa tgcactttcg atcttggcct ccttctcatc
     5701 ccgtgatgtt tttgtgattc atccaggcca ttgtgtctgt tggacgtttg ttccttttca
     5761 ttgctgagaa gccttccatt acagagatga atctgtttgt ttagtcattc tgctggtagg
     5821 cagctgggtt tgtttctggg cttggctgat tgtaaataaa gttgctataa ac
//
