LOCUS       NM_153739               5215 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus dual oxidase 1 (Duox1), mRNA.
ACCESSION   NM_153739 XM_346660
VERSION     NM_153739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5215)
  AUTHORS   Cui,P., Wang,Y., Li,Y. and Ge,L.
  TITLE     Vitamin D Attenuates Hypoxia-Induced Injury in Rat Primary Neuron
            Cells through Downregulation of the Dual Oxidase 1 (DUOX1) Gene
  JOURNAL   Med Sci Monit 26, e925350 (2020)
   PUBMED   32712621
  REMARK    GeneRIF: Vitamin D Attenuates Hypoxia-Induced Injury in Rat Primary
            Neuron Cells through Downregulation of the Dual Oxidase 1 (DUOX1)
            Gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5215)
  AUTHORS   Choi,S., Lim,J.Y., Kim,Y., Song,M.J., Jung,W.W., Seo,J.B., Lee,J.
            and Sul,D.
  TITLE     Plasma proteomic analysis of patients infected with H1N1 influenza
            virus
  JOURNAL   Proteomics 14 (16), 1933-1942 (2014)
   PUBMED   24888898
REFERENCE   3  (bases 1 to 5215)
  AUTHORS   Hoste,C., Dumont,J.E., Miot,F. and De Deken,X.
  TITLE     The type of DUOX-dependent ROS production is dictated by defined
            sequences in DUOXA
  JOURNAL   Exp Cell Res 318 (18), 2353-2364 (2012)
   PUBMED   22814254
REFERENCE   4  (bases 1 to 5215)
  AUTHORS   De Minicis,S., Seki,E., Paik,Y.H., Osterreicher,C.H., Kodama,Y.,
            Kluwe,J., Torozzi,L., Miyai,K., Benedetti,A., Schwabe,R.F. and
            Brenner,D.A.
  TITLE     Role and cellular source of nicotinamide adenine dinucleotide
            phosphate oxidase in hepatic fibrosis
  JOURNAL   Hepatology 52 (4), 1420-1430 (2010)
   PUBMED   20690191
REFERENCE   5  (bases 1 to 5215)
  AUTHORS   Kennedy,K.A., Ostrakhovitch,E.A., Sandiford,S.D., Dayarathna,T.,
            Xie,X., Waese,E.Y., Chang,W.Y., Feng,Q., Skerjanc,I.S.,
            Stanford,W.L. and Li,S.S.
  TITLE     Mammalian numb-interacting protein 1/dual oxidase maturation factor
            1 directs neuronal fate in stem cells
  JOURNAL   J Biol Chem 285 (23), 17974-17985 (2010)
   PUBMED   20233719
REFERENCE   6  (bases 1 to 5215)
  AUTHORS   Harper,R.W., Xu,C., Eiserich,J.P., Chen,Y., Kao,C.Y., Thai,P.,
            Setiadi,H. and Wu,R.
  TITLE     Differential regulation of dual NADPH oxidases/peroxidases, Duox1
            and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium
  JOURNAL   FEBS Lett 579 (21), 4911-4917 (2005)
   PUBMED   16111680
REFERENCE   7  (bases 1 to 5215)
  AUTHORS   Pachucki,J., Wang,D., Christophe,D. and Miot,F.
  TITLE     Structural and functional characterization of the two human
            ThOX/Duox genes and their 5'-flanking regions
  JOURNAL   Mol Cell Endocrinol 214 (1-2), 53-62 (2004)
   PUBMED   15062544
REFERENCE   8  (bases 1 to 5215)
  AUTHORS   Morand,S., Dos Santos,O.F., Ohayon,R., Kaniewski,J.,
            Noel-Hudson,M.S., Virion,A. and Dupuy,C.
  TITLE     Identification of a truncated dual oxidase 2 (DUOX2) messenger
            ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and
            forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and
            porcine thyrocytes
  JOURNAL   Endocrinology 144 (2), 567-574 (2003)
   PUBMED   12538618
REFERENCE   9  (bases 1 to 5215)
  AUTHORS   Edens,W.A., Sharling,L., Cheng,G., Shapira,R., Kinkade,J.M.,
            Lee,T., Edens,H.A., Tang,X., Sullards,C., Flaherty,D.B.,
            Benian,G.M. and Lambeth,J.D.
  TITLE     Tyrosine cross-linking of extracellular matrix is catalyzed by
            Duox, a multidomain oxidase/peroxidase with homology to the
            phagocyte oxidase subunit gp91phox
  JOURNAL   J Cell Biol 154 (4), 879-891 (2001)
   PUBMED   11514595
REFERENCE   10 (bases 1 to 5215)
  AUTHORS   De Deken,X., Wang,D., Many,M.C., Costagliola,S., Libert,F.,
            Vassart,G., Dumont,J.E. and Miot,F.
  TITLE     Cloning of two human thyroid cDNAs encoding new members of the
            NADPH oxidase family
  JOURNAL   J Biol Chem 275 (30), 23227-23233 (2000)
   PUBMED   10806195
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_153739.3.
            
            On Nov 27, 2020 this sequence version replaced NM_153739.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF542180.1, SRR26643295.15099.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000003.1  129715996-129716084
            90-173              JAXUCZ010000003.1  129718252-129718335
            174-338             JAXUCZ010000003.1  129718700-129718864
            339-526             JAXUCZ010000003.1  129719757-129719944
            527-728             JAXUCZ010000003.1  129720106-129720307
            729-895             JAXUCZ010000003.1  129720466-129720632
            896-956             JAXUCZ010000003.1  129721007-129721067
            957-1053            JAXUCZ010000003.1  129721159-129721255
            1054-1144           JAXUCZ010000003.1  129723635-129723725
            1145-1247           JAXUCZ010000003.1  129724438-129724540
            1248-1420           JAXUCZ010000003.1  129724763-129724935
            1421-1596           JAXUCZ010000003.1  129726872-129727047
            1597-1715           JAXUCZ010000003.1  129727290-129727408
            1716-1853           JAXUCZ010000003.1  129727947-129728084
            1854-1967           JAXUCZ010000003.1  129728706-129728819
            1968-2167           JAXUCZ010000003.1  129729527-129729726
            2168-2353           JAXUCZ010000003.1  129730306-129730491
            2354-2579           JAXUCZ010000003.1  129734178-129734403
            2580-2673           JAXUCZ010000003.1  129734580-129734673
            2674-2849           JAXUCZ010000003.1  129734889-129735064
            2850-2919           JAXUCZ010000003.1  129737105-129737174
            2920-3045           JAXUCZ010000003.1  129737533-129737658
            3046-3224           JAXUCZ010000003.1  129738474-129738652
            3225-3455           JAXUCZ010000003.1  129738798-129739028
            3456-3555           JAXUCZ010000003.1  129739515-129739614
            3556-3605           JAXUCZ010000003.1  129739826-129739875
            3606-3733           JAXUCZ010000003.1  129741293-129741420
            3734-3887           JAXUCZ010000003.1  129745275-129745428
            3888-4120           JAXUCZ010000003.1  129745794-129746026
            4121-4279           JAXUCZ010000003.1  129746254-129746412
            4280-4435           JAXUCZ010000003.1  129747501-129747656
            4436-4564           JAXUCZ010000003.1  129747751-129747879
            4565-5215           JAXUCZ010000003.1  129748511-129749161
FEATURES             Location/Qualifiers
     source          1..5215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..5215
                     /gene="Duox1"
                     /note="dual oxidase 1"
                     /db_xref="GeneID:266807"
                     /db_xref="RGD:628760"
     exon            1..89
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..4687
                     /gene="Duox1"
                     /EC_number="1.6.3.1"
                     /codon_start=1
                     /product="dual oxidase 1 precursor"
                     /protein_id="NP_714961.2"
                     /db_xref="GeneID:266807"
                     /db_xref="RGD:628760"
                     /translation="MAVYSAVAWILLFGMLASLGAQNSVSWEVQRFDGWYNNLMEHRW
                     GSKGSRLQRLVPASYADGVYQPLREPYLPNPRHLSNRVMRGPAGQPSLRNRTVLGVFF
                     GYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRSTGQSPS
                     NPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNSLLMWMA
                     PDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHWGDEELF
                     QHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYHPFLDPSISPEFVVASEQFLSTMV
                     PPGVYMRNASCHFQGIANRNSSVSGALRVCNSYWSRENPKLQRAEDVDALLLGMASQI
                     AEREDHLVVEDVQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLPPVSHW
                     QDINPALSRSNGTVLEATAALYNQDLSRLELLAGGLLESHGDPGPLFSAIVLDQFVRL
                     RDGDRYWFENNRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPSVFFWLAGDPCP
                     QPSQLSTQGLPACAPLFVRDYFKGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRMRNF
                     KRLQRQDRQSIMCEKLVGGVEALEWQGRKEPCRPVLVHLQPGQIRVVDGRLTVLRTIQ
                     LRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENIRAALKENGLSF
                     QEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREAL
                     TCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKS
                     RLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKDQLAEVVESMFWESGFQDKEE
                     LTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHC
                     ARNNTKTASSPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQT
                     VQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRG
                     TAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRFIASTAIILTVLHSA
                     GHVVNVYLFSISPLSVLSCLFPDLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAI
                     MYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVG
                     DKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP
                     FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWH
                     KFEVSVLVGAGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADII
                     REVEENDSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFG
                     RPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINKQDRTHFSHHYENF"
     exon            90..173
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..338
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..526
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..728
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..895
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..956
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1053
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1144
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1247
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1420
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1596
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1715
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1853
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1967
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2167
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2353
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2579
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2673
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2849
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2919
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3045
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3224
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3455
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3555
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3605
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3733
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3887
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4120
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4279
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4435
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4564
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..5215
                     /gene="Duox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacatttca tcccccatta ctattttcat catggcagtc tactcagctg tggcctggat
       61 cctccttttt gggatgctgg cttctttggg agctcagaat tccgtttctt gggaggtcca
      121 gcgatttgat ggatggtata acaacctcat ggagcacaga tggggcagca aaggctctcg
      181 gctgcagcgc cttgttccgg ccagctatgc agatggtgtg taccagccct tgagagaacc
      241 ctacctgcct aacccccgac accttagcaa cagggtcatg agaggtcccg cagggcagcc
      301 gtctcttcgg aaccgtacag tcctgggtgt cttcttcggc taccacgtgc tttcagacct
      361 ggtgagtgtg gaaacaccag gctgccccgc agagttcctc aacatttaca tcccacgtgg
      421 ggacccagtg tttgaccctg acaagcgcgg gaacgtggtg ctgccctttc agaggagccg
      481 ctgggaccgc agcactggac agagccctag caacccccga gacctgacca accaggtgac
      541 tggctggcta gatggcagcg ccatctatgg ctcctctcat tcctggagcg acactctgag
      601 gagcttctct ggaggacagc tggcttctgg ccctgaccct gctttcccga ggaactccca
      661 gaactctctg ctcatgtgga tggcaccaga ccccgccacg gggcagggcg ggccacaggg
      721 gctgtatgcc ttcggggccc agcgcgggaa cagggagccc tttctgcagg cactgggctt
      781 gttgtggttt cgataccaca acctgtgtgc caagaggctg gcgcaggagc acccacactg
      841 gggggatgag gagctgttcc agcatgctcg caagagggtc attgccactt accagaacat
      901 tgcgatgtat gagtggctgc ccagcttcct gaagcaaacg cccccagagt atccaggata
      961 ccatccattt ctggacccca gcatctcccc agagttcgtg gtggcctcag agcagttcct
     1021 ctctaccatg gtgccccctg gggtctacat gaggaatgcc agttgccact tccaggggat
     1081 tgccaatcgt aactcaagtg tctctggagc tctccgggtt tgcaacagct actggagtcg
     1141 agagaacccc aagctacaaa gggctgaaga tgtggatgca ttgctgctgg gcatggcctc
     1201 ccagattgct gagagagagg accacctagt cgttgaggat gtgcaagatt tttggcccgg
     1261 accactgaag ttttcccgta cagactacct ggccagctgc ctgcagaggg gccgggatct
     1321 aggcctacct tcatacacca aagccaggga ggcactgggc ctgcctcctg tttcccactg
     1381 gcaggacatc aaccctgcac tctcgaggag caatggcact gtgctggagg ccacggctgc
     1441 cctgtacaat caggatctgt cccggctgga gttacttgct ggggggcttc tggagagcca
     1501 cggagaccct ggaccccttt tcagtgctat tgtccttgac cagtttgtca ggctacgaga
     1561 tggtgaccgc tattggtttg aaaacaacag aaatggattg ttctctaagg aagagattgc
     1621 agagatccga aacacttccc tacgggatat tctagtggct gtcaccaacg tggaccccag
     1681 tgccctacag cccagtgtct tcttttggct tgcaggagac ccctgtccac agccaagcca
     1741 gctcagcacc cagggcctgc cagcctgtgc ccccctcttc gttcgggact atttcaaggg
     1801 gagtggattt ggcttcggac tcaccattgg gaccctttgc tgcttcccct tagtcagcct
     1861 cctcagtgcc tggattgttg cccggcttcg gatgaggaat ttcaagaggc tccagagaca
     1921 agaccgccag agcatcatgt gcgagaagct tgtaggggga gtggaagctt tggagtggca
     1981 gggccgcaag gaaccctgta ggccagtgct tgtgcactta cagcctggac agatccgagt
     2041 cgtggatggc aggctcactg tgctccgtac catccagctg cggcccccac agcaggtcaa
     2101 cctcatcctg tccagcaacc gtggacgccg caccctgctg ctcaagatcc ccaaggagta
     2161 cgacctggtg ctgttgttta acatggagga ggaacggcag gcactggtgg aaaacatcag
     2221 ggcagctctg aaggagaatg gactgagctt ccaggagtgg gagctgaggg agcaggagct
     2281 gatgagggca gcagtgacca ggcaacagcg gggtcacctc ctggagactt ttttcaggca
     2341 ccttttctcc caggtgttag acatcaatca agcagatgca gggactctgc cactggactc
     2401 ttcgacaaaa gtgcgtgagg ctctgacctg cgagctgagc agagctgagt ttgcggactc
     2461 cctaggcctc aagccccagg atatgtttgt ggagtccatg ttttctctgg ccgacaagga
     2521 tggcaatggc tacctgtcct tccgggagtt cctggacatc ctggtggtct tcatgaaagg
     2581 ctccccagag gagaagtctc gcctcatgtt ccgaatgtat gactttgacg ggaatggtct
     2641 catctctaag gatgagttca ttaggatgct aaggtccttc atcgagatct ccaacaactg
     2701 cctgtccaag gaccagctgg ctgaggtggt ggagtccatg ttctgggagt cgggcttcca
     2761 ggacaaggag gagctgacct gggaggactt ccatttcatg ctgcgcgacc acgacagcga
     2821 tctccgattc acacagctct gtgtcaaagg ggtggaagtg ccggaagtga tcaagaacct
     2881 ctgccggaga gcctcctaca tcagccagga gaagatctgc ccttcaccta gaatgagcgc
     2941 ccattgtgcc cgaaacaata cgaagacagc gtcatcccca cagagactgc agtgccccgt
     3001 ggacacggac cctcctcaag agattcgacg gaggtttggc aaaaaggtaa cttcattcca
     3061 gcccttactg ttcactgagg cgcaccgaga gaagtttcaa cgcagccgcc gccaccaaac
     3121 cgtgcagcag ttcaagcgct tcattgagaa ctacaggcgc cacattggct gtgtggcagt
     3181 gttctacacc atcactgggg cgctcttcct ggagagagcc tactactatg cgtttgccgc
     3241 gcaccacagc ggcatcaccg atactacccg tgtgggcatc atcctgtccc gaggcacggc
     3301 ggccagcatc tccttcatgt tttcctacat tttgctcact atgtgccgca acctcatcac
     3361 cttcctgcgg gagaccttcc tcaaccgcta cattcccttt gatgccgctg tggacttcca
     3421 ccgcttcatc gcctccacag ccatcatcct tacagtctta cacagtgctg gccacgtagt
     3481 gaatgtgtac ctgttctcca tcagccccct cagtgtcctc tcttgcctct tccctgacct
     3541 cttccacgat gacgggtcgg agttccctca gaagtattac tggtggttct tccagactgt
     3601 gccaggtctc actggggtcc tgctgctcct ggccctggcc atcatgtatg tcttcgcttc
     3661 ccaccacttc cgccgccgca gtttccgggg cttctggctg acccaccacc tctacatttt
     3721 tctctacatc ctgctcatca tccatggcag ctttgctctg atccagatgc cccgattcca
     3781 catcttcttc ctggtccccg ccattatcta tgtgggggac aagctggtga gcctgagccg
     3841 gaagaaggtg gagatcagcg tggtgaaggc tgagctgctg ccttcaggag tgacccacct
     3901 gcggttccag aggccccagg gctttgagta taagtcaggg cagtgggttc gaattgcatg
     3961 cctggctctg ggaaccaccg agtaccaccc tttcacactg acttctgcac cccacgagga
     4021 cacactcagc ctgcacatcc gggcagctgg accctggacc acccgcctca gggagatcta
     4081 ctcaccccca acgggtgaca cctgtgccag atacccaaag ctgtacctcg atggaccatt
     4141 tggagaaggc caccaggagt ggcataaatt tgaggtgtca gtactagtgg gagctggaat
     4201 tggggtcacc ccctttgcct ccatcctcaa agacctggtt ttcaagtcat cagtcagctg
     4261 ccaagtgttc tgtaagaaga tctacttcat ctgggtgaca aggactcagc ggcagtttga
     4321 gtggctggct gacatcatcc gggaagttga ggagaatgac agccgggacc tggtgtctgt
     4381 gcacatctat atcactcagc tggctgagaa gtttgacctc aggaccacca tgctgtacat
     4441 ctgtgagagg cacttccaga aggtgctgaa caggagtctg ttcacgggcc tgcgctctgt
     4501 cacccacttt ggtcgccctc cctttgagcc ctttttcaac tctctgcagg aggtccaccc
     4561 ccaagtgcga aagattggag tatttagctg tggtccccct ggcatgacca agaacgtgga
     4621 gaaggcctgt cagctcatca acaagcagga taggactcac ttctctcacc attatgagaa
     4681 cttctagcca gcaactatgc ccactctgcc ctgcgaggac agcaggggct ttggcctgtg
     4741 cctcaaccca gtgctcttcc tttctggcca cctcagcctt ggcccttccc acctgccaac
     4801 ttgatccaga cagccatgct caggcatcat atgtgggctc agagatctct agggccagag
     4861 tgtgtcgtga gctgagctcg gagaaagagc aatgtttaag aactacaggt tctgaagtag
     4921 gggaggtttg gggatgggac aatgtgagag tcgcaaaact tcagcagaca acctgtcaag
     4981 tgtgtgtagg taattgagtc tgagtgtagt atggatgctg gcatctttga gtcctcttca
     5041 ctctgttctt cctgtcttca aaatggttgg gagatgtcta gagtagccag gggccactta
     5101 cagaaagacc agcctaaccg cacaactgat ctctcgaact ttaaaatgta gtcagaccct
     5161 tctgtaccca ctaacctcct ggagcagtgc cctccagacc tctctccctc tcttt
//
