LOCUS       NM_001107157            2592 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus deltex E3 ubiquitin ligase 2 (Dtx2), mRNA.
ACCESSION   NM_001107157 XM_001070652 XM_006249158 XM_347157
VERSION     NM_001107157.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2592)
  AUTHORS   Kishi,N., Tang,Z., Maeda,Y., Hirai,A., Mo,R., Ito,M., Suzuki,S.,
            Nakao,K., Kinoshita,T., Kadesch,T., Hui,C., Artavanis-Tsakonas,S.,
            Okano,H. and Matsuno,K.
  TITLE     Murine homologs of deltex define a novel gene family involved in
            vertebrate Notch signaling and neurogenesis
  JOURNAL   Int J Dev Neurosci 19 (1), 21-35 (2001)
   PUBMED   11226752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Jul 22, 2021 this sequence version replaced
            XM_006249158.2, NM_001107157.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166738.1, SRR26360186.942150.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000012.1  26319364-26319507   c
            145-300             JAXUCZ010000012.1  26317836-26317991   c
            301-642             JAXUCZ010000012.1  26303162-26303503   c
            643-1279            JAXUCZ010000012.1  26301056-26301692   c
            1280-1383           JAXUCZ010000012.1  26291988-26292091   c
            1384-1521           JAXUCZ010000012.1  26286609-26286746   c
            1522-1595           JAXUCZ010000012.1  26284705-26284778   c
            1596-1754           JAXUCZ010000012.1  26284043-26284201   c
            1755-1916           JAXUCZ010000012.1  26282259-26282420   c
            1917-2006           JAXUCZ010000012.1  26281591-26281680   c
            2007-2592           JAXUCZ010000012.1  26279899-26280484   c
FEATURES             Location/Qualifiers
     source          1..2592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2592
                     /gene="Dtx2"
                     /note="deltex E3 ubiquitin ligase 2"
                     /db_xref="GeneID:304591"
                     /db_xref="RGD:1561790"
     exon            1..144
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            145..300
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..642
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..2234
                     /gene="Dtx2"
                     /EC_number="2.3.2.27"
                     /note="deltex 2 homolog; protein deltex-2; deltex homolog
                     2; deltex 2, E3 ubiquitin ligase"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase DTX2"
                     /protein_id="NP_001100627.1"
                     /db_xref="GeneID:304591"
                     /db_xref="RGD:1561790"
                     /translation="MAMAPSSSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQ
                     QFIRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRSVRRHLFSQ
                     NSAPGQGIVWEWLGDDGSWIAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLT
                     QTNKTSSFCRSVRRQVGPVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYRHSM
                     TNLPAYPAPQAPHRTATVSGAHQAFAPYNKPSLSGARSAPRLNTTSPWGATPPVPGNQ
                     SLLHSSLSHLGPQLLPSGPSTSSGTSASFPSGPSSSSPGSAPTTVPVQMPKPSRVQQA
                     LAGMTSVLSAIGLPVCLSRAPRPTGPPASRPTSKSHSSVKRLRKMSVKEGAPKPEPEQ
                     VIRKYTEELKVAPEEDCIICMEKLSVASGYSDVTDSKALGPMVVGRLTKCSHAFHLLC
                     LLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRFHMSLPGHEDCGTILIVYN
                     IPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWKRRLIFTVGTSST
                     TGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ"
     exon            643..1279
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1383
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1521
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1595
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1754
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1916
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2006
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2592
                     /gene="Dtx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggctgcg acgccgagtt tcactccggc tgcctcctgc tcggagtcgg agatatactc
       61 gggggttctt cccaggccga gccggagctg agcccggagg tcggcgctcc tctcaacctg
      121 ttccttctgc ttccctcaga ctcggtacct cggaattggt gtggctgagt cagcaagccc
      181 tcggattttc ccggttcttg tttgctgttc atatcaagat gggagcccag acaagttatt
      241 gcttctgacg atctccatca agaagggaca gtttggtgcc agcccttcag tgaagaggag
      301 gtccccagag gtgctgggca atgaacctga acctgcagcc cagagtggtg tgaagtcttc
      361 agagaaagcg gaagatggcc atggccccaa gctcgtctct gccgcaggtg taccctagcc
      421 atgtggtggt ggctgtgtgg gaatggcagg atggtcttgg catttggcac ccctacagtg
      481 ccactgtctg ctcctttatt gagcagcagt ttatccggca gaggggccag cattttggac
      541 tggggagcct ggcccacagc atccccttag gccaagctga tccttcactg gccccttaca
      601 tcatcgacct ccccagctgg actcagttcc gccaggacac tggcaccatg aggtccgtgc
      661 gcagacacct gttctcacag aattctgccc caggccaggg catcgtctgg gagtggctgg
      721 gtgatgacgg atcttggata gcctacgaag ctagaatctg tgactatctg gaacagcaag
      781 tggcccgggg catccaggtc gtggacttgg ccccactggg gtacaactac actgtcaact
      841 atgccaccct aacccaaacc aacaagactt ccagcttctg ccggagtgtg cgacgccaag
      901 tggggccagt ttacccagtg acttcagaca tcgctgtccc acgtcaaatg ggactcatct
      961 gcttttgcca acagtgcctc catggtagcg gaactggccc tgtgtcaggt cgctaccgcc
     1021 actccatgac caacctgcct gcctatcctg ccccccaagc accccaccgg accgccactg
     1081 tctctggggc ccaccaggcc tttgccccat acaataaacc ttcactgtct ggggccagat
     1141 ctgcgccaag gttgaacacc accagcccct ggggtgccac acctcctgtt ccaggcaacc
     1201 agtccctgtt gcactccagc ctctcccacc tggggccaca gctcctgccc tcaggaccgt
     1261 ccacctccag tggaaccagt gcctccttcc ccagcggtcc ctcctccagc agcccaggga
     1321 gcgcccccac cactgtgccc gtgcagatgc caaagcccag cagggtccag caggcgcttg
     1381 caggcatgac gagtgtgctg tcagccattg gactccctgt gtgtcttagc cgtgcacccc
     1441 ggcccaccgg ccctcccgcc tcccgtccga cctctaaaag tcacagctca gttaagaggc
     1501 tgaggaaaat gtccgtaaaa gaaggggcgc ctaagcccga gccggagcag gtgatcagaa
     1561 agtacacgga ggagctgaaa gtggcccccg aagaggactg catcatctgt atggagaaac
     1621 tgtctgtggc ctctgggtac agtgacgtga ctgacagcaa ggcccttggg cccatggtcg
     1681 tgggccgcct caccaagtgc agccatgcct tccacctgct gtgcctgctg gccatgtatt
     1741 gcaacgggaa caaggatggg agtctgcagt gtccgtcctg caaaaccatc tatggggaga
     1801 agactggaac gcagccgtgg gggaagatgg aggtgttcag gttccacatg tccctgccag
     1861 gccacgaaga ctgtgggact atactcattg tttacaacat ccctcatggc atccagggac
     1921 cggagcaccc cagccctggg aaaccattca ctgcccgagg ctttccccgg cagtgctacc
     1981 tgccagatag ccctcagggc cgcaaggtcc tggagctcct gaaggtggcc tggaagagac
     2041 ggctcatctt tactgtgggg acttccagca ccacaggtga gacggacacc gtagtgtgga
     2101 acgagatcca ccacaagact gagatggacc gaaacgtgac aggccacggc tatccagacc
     2161 ccaactacct gcagaacgtg ctggctgagc ttgctgccca gggagtgacc gaagactgcc
     2221 tggagcagca gtgacagctt caggcctgcc tctgtggacc actccaaagc ccctggcggc
     2281 tgggcaggaa ggtgcgcctt tgttgagagg caagagtatt tgttgggttt gtgtagccca
     2341 ctggggttgc acctccctaa agtttgggct tcttcttgtc tctttgccac catcctgtct
     2401 gagctggggt ctgcctggaa aaggggcgcc ctcagtttgt acttgtggga gcttggactg
     2461 gagctacctc agtgcacagg tgggcccggc ctggtgacct ggaagggatc agcagggact
     2521 accacactcc cagcttctgg tcagcttctc gtacctcaga ttttatttgc aataaagact
     2581 ctatagccaa ca
//
