LOCUS       NM_001393801            2403 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus dystrobrevin, beta (Dtnb), transcript variant 1,
            mRNA.
ACCESSION   NM_001393801
VERSION     NM_001393801.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2403)
  AUTHORS   Tian,X., Zhang,Y., Peng,M. and Hou,Y.
  TITLE     Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid
            cell leukemia 1 attenuates inflammation and apoptosis in
            caerulein-treated AR42J cells
  JOURNAL   Funct Integr Genomics 24 (5), 140 (2024)
   PUBMED   39160285
  REMARK    GeneRIF: Regulatory axis of circular RNA DTNB, microRNA-485-5p, and
            myeloid cell leukemia 1 attenuates inflammation and apoptosis in
            caerulein-treated AR42J cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2403)
  AUTHORS   Artegiani,B., Labbaye,C., Sferra,A., Quaranta,M.T., Torreri,P.,
            Macchia,G., Ceccarini,M., Petrucci,T.C. and Macioce,P.
  TITLE     The interaction with HMG20a/b proteins suggests a potential role
            for beta-dystrobrevin in neuronal differentiation
  JOURNAL   J Biol Chem 285 (32), 24740-24750 (2010)
   PUBMED   20530487
  REMARK    GeneRIF: beta-dystrobrevin interacts with the HMG20 proteins iBRAF
            and BRAF35
REFERENCE   3  (bases 1 to 2403)
  AUTHORS   Veroni,C., Grasso,M., Macchia,G., Ramoni,C., Ceccarini,M.,
            Petrucci,T.C. and Macioce,P.
  TITLE     beta-dystrobrevin, a kinesin-binding receptor, interacts with the
            extracellular matrix components pancortins
  JOURNAL   J Neurosci Res 85 (12), 2631-2639 (2007)
   PUBMED   17265465
REFERENCE   4  (bases 1 to 2403)
  AUTHORS   Ceccarini,M., Grasso,M., Veroni,C., Gambara,G., Artegiani,B.,
            Macchia,G., Ramoni,C., Torreri,P., Mallozzi,C., Petrucci,T.C. and
            Macioce,P.
  TITLE     Association of dystrobrevin and regulatory subunit of protein
            kinase A: a new role for dystrobrevin as a scaffold for signaling
            proteins
  JOURNAL   J Mol Biol 371 (5), 1174-1187 (2007)
   PUBMED   17610895
  REMARK    GeneRIF: dystrobrevin is a scaffold protein that may play a role in
            different cellular processes involving PKA signaling
REFERENCE   5  (bases 1 to 2403)
  AUTHORS   Macioce,P., Gambara,G., Bernassola,M., Gaddini,L., Torreri,P.,
            Macchia,G., Ramoni,C., Ceccarini,M. and Petrucci,T.C.
  TITLE     Beta-dystrobrevin interacts directly with kinesin heavy chain in
            brain
  JOURNAL   J Cell Sci 116 (Pt 23), 4847-4856 (2003)
   PUBMED   14600269
REFERENCE   6  (bases 1 to 2403)
  AUTHORS   Benson,M.A., Newey,S.E., Martin-Rendon,E., Hawkes,R. and Blake,D.J.
  TITLE     Dysbindin, a novel coiled-coil-containing protein that interacts
            with the dystrobrevins in muscle and brain
  JOURNAL   J Biol Chem 276 (26), 24232-24241 (2001)
   PUBMED   11316798
REFERENCE   7  (bases 1 to 2403)
  AUTHORS   Adams,M.E., Kramarcy,N., Krall,S.P., Rossi,S.G., Rotundo,R.L.,
            Sealock,R. and Froehner,S.C.
  TITLE     Absence of alpha-syntrophin leads to structurally aberrant
            neuromuscular synapses deficient in utrophin
  JOURNAL   J Cell Biol 150 (6), 1385-1398 (2000)
   PUBMED   10995443
REFERENCE   8  (bases 1 to 2403)
  AUTHORS   Blake,D.J., Hawkes,R., Benson,M.A. and Beesley,P.W.
  TITLE     Different dystrophin-like complexes are expressed in neurons and
            glia
  JOURNAL   J Cell Biol 147 (3), 645-658 (1999)
   PUBMED   10545507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000006.1  32286482-32286751
            271-338             JAXUCZ010000006.1  32306806-32306873
            339-419             JAXUCZ010000006.1  32311137-32311217
            420-633             JAXUCZ010000006.1  32316660-32316873
            634-719             JAXUCZ010000006.1  32335098-32335183
            720-874             JAXUCZ010000006.1  32347864-32348018
            875-980             JAXUCZ010000006.1  32354813-32354918
            981-1147            JAXUCZ010000006.1  32357639-32357805
            1148-1272           JAXUCZ010000006.1  32389677-32389801
            1273-1350           JAXUCZ010000006.1  32418009-32418086
            1351-1440           JAXUCZ010000006.1  32431777-32431866
            1441-1528           JAXUCZ010000006.1  32433883-32433970
            1529-1614           JAXUCZ010000006.1  32446810-32446895
            1615-1728           JAXUCZ010000006.1  32447730-32447843
            1729-1825           JAXUCZ010000006.1  32450147-32450243
            1826-1985           JAXUCZ010000006.1  32474642-32474801
            1986-2075           JAXUCZ010000006.1  32475594-32475683
            2076-2111           JAXUCZ010000006.1  32481198-32481233
            2112-2403           JAXUCZ010000006.1  32482716-32483007
FEATURES             Location/Qualifiers
     source          1..2403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2403
                     /gene="Dtnb"
                     /note="dystrobrevin, beta"
                     /db_xref="GeneID:362715"
                     /db_xref="RGD:1309579"
     exon            1..270
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            271..338
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2080
                     /gene="Dtnb"
                     /note="DTN-B; beta-dystrobrevin"
                     /codon_start=1
                     /product="dystrobrevin beta"
                     /protein_id="NP_001380730.1"
                     /db_xref="GeneID:362715"
                     /db_xref="RGD:1309579"
                     /translation="MIEEGGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFV
                     QKRCNLHLVDIWNMIEAFRDNGLNTLDHATEISVSRLETVISSIYYQLNKRLPSTHQI
                     NVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYIFSQMSDSNG
                     LMMFGKLDQFLKEALKLPTAVFEGPSFGYTEHAVRTCFPQQKKIMLNMFLDTMMADPP
                     PQCLVWLPLMHRLAHVENVFHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHA
                     GGPHSNQHQMKELSSWKSPAKKLSHAISKSLGCVPSREPPHPVFPEQPEKPLDLAHIV
                     PPRPLTNMNDTMVSHMSSGVPTPTKRLQYGQDMPNLLADEHALIASYVARLQHCTRVL
                     DSPSRLDEEHRLIARYAARLAAEAGNMTRPPTDASFNFDANKQQRQLIAELENKNREI
                     LQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
                     QLEGLMKLLKAQATGSPHTSPTHGGGRSMPMPVRSTSAGSTPTHGPQDSLSGVGGDVQ
                     EAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSG"
     exon            339..419
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            420..633
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            634..719
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            720..874
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            875..980
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1147
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1272
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1350
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1440
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1528
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1614
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1728
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1825
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1985
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2075
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2111
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2403
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggctccc ggtagacgaa cctgtctact caggtcacct ctgatgggca cagtgtcccg
       61 agaagagcga ggatgcagct gacgaatgct tactgttaaa ttcctgtgcc aggccttggg
      121 gaatcaggga gacctttcta gcattctctg caagcgttta ttgattagct acggagcagg
      181 agagaaccgc ggtcagcgcc cgggtcacga ctttatcact ctcaaccatc atttatttgc
      241 tgttgaagtg ctgacagtcc ggctgtgaaa gatgattgag gaaggtggga acaagcggaa
      301 gaccatggcg gagaagaggc agctcttcat agaaatgcgt gctcagaatt tcgatgtcat
      361 acgactatca acgtacagaa cagcgtgcaa gttacgattt gtgcagaagc ggtgtaacct
      421 tcatctcgtt gatatctgga acatgatcga agctttccga gacaatggcc ttaacacact
      481 ggaccacgcc acggagatca gcgtgtcccg cctggagacc gtcatttctt ccatctacta
      541 tcagttgaac aagcgccttc cttccactca ccaaatcaat gtggagcagt ccatcagtct
      601 cctcctcaac tttatgatcg ccgcctacga cagcgagggc cgaggcaagc tgaccgtctt
      661 ttcagttaaa gctatgttag caaccatgtg tggtggaaag atgctggaca aattgagata
      721 cattttctcc cagatgtcag attcgaatgg tttaatgatg tttggcaagc ttgaccagtt
      781 tctgaaggaa gccctgaaac tcccaacagc tgtctttgaa gggccatcct ttggttacac
      841 ggaacacgca gtccgtacct gtttcccaca gcagaagaag ataatgctga atatgttttt
      901 agacaccatg atggccgatc ctcctccaca gtgccttgtc tggctacctc tcatgcacag
      961 gcttgcccat gtcgagaatg tcttccatcc tgtggaatgc tcctactgtc actgcgagag
     1021 catgatgggc ttccgatacc gatgccagca atgccacaac tatcagctct gccagaactg
     1081 cttttggcgt ggccatgccg gtggccctca cagcaaccag caccagatga aggagctttc
     1141 ctcttggaaa tcccctgcaa agaagctgag ccatgcaatt agtaaatctt tgggatgtgt
     1201 accctccaga gaacccccac atcctgtttt tcctgagcaa ccagagaaac cacttgacct
     1261 tgcacatatc gttcctcctc gccctctgac caatatgaat gacaccatgg ttagccacat
     1321 gtcctctgga gtgcccactc ccaccaagag gttacagtat ggccaggaca tgcccaatct
     1381 cttggctgat gagcatgcac tgatagcctc ctatgtggcc cgtctgcaac actgcacacg
     1441 tgtcctggac agtcctagcc gactggatga ggaacaccgg cttatagccc gctatgctgc
     1501 ccggctagct gcagaggcag gaaacatgac tcgtcctccc actgatgcca gcttcaactt
     1561 tgatgccaac aaacaacagc gacagctcat cgcagaactg gaaaacaaga acagagagat
     1621 cctgcaggag atccagcgcc tgcggctgga gcatgaacag gcttcgcagc ccactcctga
     1681 gaaggcccag cagaacccca cgctgctcgc agagctgcgc ctgctgaggc aaaggaaaga
     1741 tgagctggag cagaggatgt cggcgctgca ggagagtagg cgggagctga tggtgcagct
     1801 ggaggggctg atgaagctgc taaaggctca agccacaggg tcaccacata catcacccac
     1861 tcacggaggt ggccgctcta tgcccatgcc cgtgcgttcc acatctgctg gctccacccc
     1921 gacccacggc ccgcaggatt cactgagtgg agttggggga gatgtgcagg aggcctttgc
     1981 acaaggtacg aggagaaacc tccgcaatga cctgctggtg gctgctgact ccattaccaa
     2041 caccatgtca tccctggtga aggagctcca ttcaggttag cccaggagcg gccgggacac
     2101 aggaagctca ggcgcagagg cggaggagca agctggcacc gacaagacaa gggaaggtct
     2161 tcccccagag gcacattcct atccgtcttt ctgctgcaca cctggaccag gcttgcaggc
     2221 tgccagactc attcaacctc cagagagaag agccaagcct atgggaagtg gggagggact
     2281 gcctgaggct gcagctggtg ggcctcctgc atgtactagc atctgcattc ctccctcagg
     2341 gcatggtctc atctctgcat caggaattta ccaggagatg gaaaagaaaa gaaaaagcgc
     2401 tga
//
