LOCUS       XM_223074               4332 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus denticleless E3 ubiquitin protein
            ligase homolog (Dtl), transcript variant X1, mRNA.
ACCESSION   XM_223074
VERSION     XM_223074.9
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051348.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 23, 2024 this sequence was replaced by
            NM_001427431.1.
            
            On Jan 21, 2021 this sequence version replaced XM_223074.8.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4332
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4332
                     /gene="Dtl"
                     /note="denticleless E3 ubiquitin protein ligase homolog;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 7 ESTs, 3 long SRA reads, 6 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 124 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:305073"
                     /db_xref="RGD:1310439"
     CDS             140..2491
                     /gene="Dtl"
                     /codon_start=1
                     /product="denticleless protein homolog isoform X1"
                     /protein_id="XP_223074.5"
                     /db_xref="GeneID:305073"
                     /db_xref="RGD:1310439"
                     /translation="MTSVWRGVWRPGLAVAGVGGKTVSRCGGRKRRLRRNLGAISSAF
                     SSAESSPQDEMLFNSVLRQPQLGVLRNGWSSHYPLQSLLSGYRCSCNDEHTSYGETGV
                     PVPPFGCTFCTAPSMEHILAVANEEGFVRLYNTESQTSKKTCFKEWMAHWNAVFDLAW
                     VPGELKLVTAAGDQTAKFWDVKAGELMGTCKGHQCSLKSVAFSKFQKAVFCTGGRDGN
                     IMIWDTRCNKKDGFYRQVNQISGAHNTADKQTPSKPKKKQNSKGLAPSVDSQQSVTVV
                     LFQDENTVVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGTSTRKLGYSSLVLD
                     STGSTLFANCTDDNIYMFNMTGLKTSPLAVFNGHQNSTFYVKSSLSPDDQFLISGSSD
                     EAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEE
                     KPEGDKHSIVGWTSQKKKEVKAGPVSAPNSLSTPAKAPRSQCSPSASSPSSARTPSCA
                     GDLPLPSNTSTFSVKTTPVTTRSPVSRRGSSSSVSPKPPSSFKMSLRNWVTRTPSSSP
                     PVTPPASETKISSPRKALIPVSQKSSQADACSESRNRVKRRLDSSCLESVKQKCVKSC
                     NCVTELDGQVESLHLDLCCLSGTQEVLSQDSAGPTKSSKTEGTGTSISEPPSPVSPFA
                     SEGCGPLPLPLGPCGEGSEMVGKENSSPENKNWLLAMAAKHKAENSSPRSPSSQTPSS
                     RRQSRKTSPGPVTITPNSMRKICTYFRRKTQDDFCSPEHSTEL"
ORIGIN      
        1 tctgtggccc cccccgcgca ggcgctcagg gggtttgtga accctgggtt cccgcggctg
       61 agcgagagga aggcggggct tagaatgggg ccgagcctcc gaggctccag aacgctgcga
      121 cgagagccaa tcagagagca tgacgtcagt ttggcgcgga gtttggcggc cggggctcgc
      181 agtggcggga gttggaggca aaaccgtgtc gcgctgtgga gggcgcaagc ggaggctccg
      241 gcggaacttg ggggcgatct cctcggcgtt ctcctcagct gagtcttctc ctcaggacga
      301 aatgctcttc aactcggtgc tccgccagcc gcagctcggc gtcctgagga acgggtggtc
      361 ttcacattat cctctgcaat ctctcctaag tggttatcgg tgcagctgta acgatgagca
      421 cacatcttac ggagaaacgg gagtcccagt tcctcctttt ggatgcacct tctgtactgc
      481 tcccagtatg gagcatatat tagcagttgc taatgaagaa ggctttgtca gattatataa
      541 tacagaatca caaactagca aaaagacatg cttcaaggag tggatggctc actggaatgc
      601 tgtctttgac ctggcgtggg tccctggtga acttaaactt gttacagcag ccggtgatca
      661 gacagccaaa ttttgggatg taaaagctgg tgagctaatg ggaacatgca aaggccacca
      721 gtgcagcctc aagtctgtag ctttttccaa gtttcaaaaa gctgtgttct gtactggtgg
      781 gagagacggc aacattatga tctgggacac caggtgcaac aaaaaagatg gattttatag
      841 acaagtgaat caaatcagtg gcgctcacaa tactgcagac aagcaaaccc cttcaaaacc
      901 caagaagaaa caaaattcaa aaggacttgc tccatctgtg gattcccagc agagtgttac
      961 tgtggtcctc tttcaggatg agaatacagt agtctcagca ggagccgtgg atggaataat
     1021 caaagtatgg gatttacgca agaattacac tgcttatcga caagaaccca tagcatccaa
     1081 gtctttcctg tacccaggta ccagcactag aaaactagga tactcgagtt tggttctaga
     1141 ctctactggc tctactctgt ttgctaactg cacagatgac aacatctata tgttcaatat
     1201 gactggctta aagacttctc cactggctgt cttcaatgga caccagaact ctacctttta
     1261 tgtaaaatca agtcttagtc cagatgacca gtttttaatc agtggttcaa gtgacgaagc
     1321 tgcctacatt tggaaggttt ctatgccatg gcatcctcct accgtactcc tgggtcattc
     1381 tcaagaagtc acgtctgtgt gctggtgtcc atcagacttc accaagattg caacctgctc
     1441 tgatgataat acactaaaaa tctggcgctt gaacagaggc ctagaggaga aaccagaagg
     1501 tgataaacat tccatagtag gttggacctc tcagaagaaa aaggaagtga aagccggccc
     1561 agtatcggca ccaaatagcc tgagcacccc tgccaaagcc cccaggtccc agtgcagccc
     1621 atctgcttcc tctccttcat cagctcgtac tccaagctgt gcgggagacc tcccccttcc
     1681 ctcaaatacc tccaccttct cagtcaaaac cactccggtc acgacccgtt ctccagtcag
     1741 cagaagaggt tccagctctt ctgtgtctcc caagccaccc tcatctttca agatgtcact
     1801 tagaaactgg gtgacccgaa caccttcctc atcaccacct gtcactccac ctgcttctga
     1861 gacaaagatc tcatctccga gaaaagccct tattcctgtg agccagaagt catcacaagc
     1921 agatgcttgc tctgaatcta gaaatagagt gaagaggcgt ctcgactcga gctgtctgga
     1981 gagtgtgaaa caaaagtgtg tgaagagttg caactgtgtc actgagcttg acggccaagt
     2041 ggagagtctt catttggatc tgtgctgcct ttccggcacc caggaagtcc ttagccaaga
     2101 ttctgcgggt cctaccaaat caagcaagac ggaaggtact ggcacgagca tctcagagcc
     2161 cccttctcct gtcagtcctt ttgcttctga aggctgtgga ccactgcctc ttcctttggg
     2221 accttgtgga gaaggatctg aaatggtggg caaagagaat agctccccag agaataagaa
     2281 ctggttgttg gccatggcag ccaaacacaa ggcggagaat tcatccccaa gaagtccatc
     2341 atcccagaca cccagttcca ggagacagag tagaaagacg tcaccaggcc cggtcaccat
     2401 tacccccaac tccatgagga agatatgcac atattttcgc agaaagactc aagatgactt
     2461 ctgtagtcct gaacattcaa ctgagttata aattctaatc tcaaagtttg atgaacttgg
     2521 gtctacaaag atttttttaa aaacctttaa aatctggtct ttaagaaaat ggtcatgttt
     2581 tgattttgga aaaaagttct aatactcttt ggcagaccta gtcaaacccc actgtgtata
     2641 gacacagcag cctgggtgag tgctgtatcc agttcacggg gcggcttgtc ctctgcagtc
     2701 tgtgataacc acatccagct catggatgca gaaagccagg catgcttcta tggctatgga
     2761 gagtgtccac tagcccagca tagggcccat ctgtgaggcc agtctgaagt catcctttgc
     2821 agaaggtaga tgccttaagc aatcgtgagc ttatttgaaa tacataattt gttcactata
     2881 cttttgtgtg tgtgtttctc aaactgtatg aagatgtgat attcatggag tacattcata
     2941 ctgttttcat ggaccgtatt ttgagttgag gtcgtgatta ttttaaatgc ggtgatcaat
     3001 gtcatgtctt tggagaacat aggagaaaac aacagagagc tggatttgtt tccatgaaag
     3061 ctggggaggt cccatatttt ttttaccaga tttctattac aaaccagcat cactcatgtg
     3121 tgggggaggc actttcttga gagggatcct ttataaaatc agtatacact aaaaccagag
     3181 tctacattta agtgtaattc tcagttttct aggtctgtga cttttttaaa atgccattag
     3241 atttttaaga taaagtaatt tcttactagt gttttttata aaagacgata ctacaaaact
     3301 gaaaatctag aacctgggtt tttttgtttt tttttttttt ctttttttca aaaggcactg
     3361 gccctctagt atattggtaa gcaaaaaata aacacagcac tttatctaga cagtgcacag
     3421 agtgtgacag ctgactctaa atagtatttg aaattctgca gcctctgcct taaatgctac
     3481 atgtgggtcc tcatgaaatg agcatcatgc ctccctttgc agactcctgg agaggaagaa
     3541 actatgtttg agaaaggcat tcattccctt acaattagga cagagtttgt tccattcaaa
     3601 tctctgggga ctggttaaac tttatttcta ttatgatttt taaatctttt attaaaaact
     3661 ttaagtcctt tgagattgta aattaagctt ataaaacaaa ccaaactgag attaagtaat
     3721 aagcattggt tttcggtaat tttattcaaa aaaaaattaa aggaagtcag attagtcaga
     3781 ccacatacac acacacacac acacacacac acacacacac acacacacag agagtggctt
     3841 tcactgagtg ctggatgtct gcagtaatgt tagcgttttg agcagtaggc agtgggaaga
     3901 aatttttaat aacgcagaac tgccaataat gttgcatatc tgttgctctg agagcaggta
     3961 gtggtggtca gtaaagcaga tgacttgtgt ctgtgtctgg aggcactgcc aggtgaagct
     4021 ggggtgagcg gctgtcagga actccaggct gtgcttgaaa agtagtccac agatgggtgt
     4081 ccaaggttat gtgtaacgaa gtagtgatta tccctgctgt gtgattttca gctgaccctg
     4141 aataataagc cttttacctt gtctgatagt gtcctttcct aagcttttta cagtgacctg
     4201 aaagcaatcc acacaaaagg aagtaatcat ctgagtccct tctgcttgct tgtagaataa
     4261 aatgtgtttg tttccaaagg tataatctaa gaaagaggtt ctaataaatg ttttatttca
     4321 tcaaaccttg aa
//
